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1. 发明申请

WO2003033658A3 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
公开(公告)号：WO2003033658A3
公开(公告)日：2003-04-24
申请号：PCT/US2002/032910
申请日：2002-10-16
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , LAIRD, Michael, W. , ULLRICH, Stephen
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , LAIRD, Michael, W. , ULLRICH, Stephen
IPC分类号： C07K2/00
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

2. 发明申请

WO2003033658A2 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：WO2003033658A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/032910
申请日：2002-10-16
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , LAIRD, Michael, W. , ULLRICH, Stephen
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , LAIRD, Michael, W. , ULLRICH, Stephen
IPC分类号： C12N
CPC分类号： A61K51/08 , A61K38/00 , C07K14/525
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码中性因子-α和/或中性因子-αSV多肽的核酸分子，包括胞外域的可溶形式。还提供了中性因子-α和/或中性因子-αSV多肽以及载体，宿主细胞和用于产生它们的重组方法。本发明还涉及特异性结合中性因子-α和/或中性因子-αSV的抗体或其部分以及使用这些抗体的诊断和治疗方法。还提供了用于检测免疫系统相关病症的诊断方法和使用本发明组合物治疗免疫系统相关病症的治疗方法。

3. 发明申请

WO2002018620A3 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
公开(公告)号：WO2002018620A3
公开(公告)日：2002-03-07
申请号：PCT/US2001/025549
申请日：2001-08-15
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen
IPC分类号： A61K39/395
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

4. 发明申请

WO2003070763A1 METHODS AND COMPOSITIONS FOR TREATING METABOLIC BONE DISEASES RELATING TO HUMAN ENDOKINE ALPHA 审中-公开
标题翻译：用于治疗与人内皮素ALPHA相关的代谢性骨髓疾病的方法和组合物
公开(公告)号：WO2003070763A1
公开(公告)日：2003-08-28
申请号：PCT/US2002/025809
申请日：2002-08-15
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , NI, Jian , ROSEN, Craig, A. , NARDELLI, Bernadetta
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A. , NARDELLI, Bernadetta
IPC分类号： C07K14/52
CPC分类号： C07K14/5255 , A61K38/00
摘要： The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.
摘要翻译：本发明涉及使用细胞因子的肿瘤坏死因子（TNF）家族的新成员诊断和治疗代谢性骨疾病和病症的方法。特别地，本发明提供了在代谢性骨疾病和病症的诊断，预后和治疗中使用含有内因激酶α的内因子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物的方法。本发明还提供了使用含有内因激酶α的内含子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物在与异常破骨细胞发育和/或活性相关的疾病和/或病症的诊断，预后和治疗中的方法。本发明还提供编码本发明的多肽的分离的多核苷酸，其抗体及其激动剂和拮抗剂，用于代谢性骨疾病和病症的诊断，预后和治疗。

5. 发明申请

WO1997018224A1 HUMAN STEM CELL ANTIGEN 2 审中-公开
标题翻译：人类干细胞抗原2
公开(公告)号：WO1997018224A1
公开(公告)日：1997-05-22
申请号：PCT/US1995015314
申请日：1995-11-13
申请人： HUMAN GENOME SCIENCES, INC.
发明人： HUMAN GENOME SCIENCES, INC. , NI, Jian , YU, Guo-Liang , GENTZ, Reiner , GOCAYNE, Jeannine, D.
IPC分类号： C07H17/00
CPC分类号： C07K14/705 , A61K38/00
摘要： A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了人干细胞抗原2多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽刺激胸腺细胞成熟和分化，保护神经元细胞，预防器官移植期间排斥反应，治疗PNH，阿尔茨海默氏病和炎症的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

6. 发明申请

WO1997017358A1 MAMMARY TRANSFORMING PROTEIN 审中-公开
标题翻译：母体转化蛋白
公开(公告)号：WO1997017358A1
公开(公告)日：1997-05-15
申请号：PCT/US1995014540
申请日：1995-11-08
申请人： HUMAN GENOME SCIENCES, INC.
发明人： HUMAN GENOME SCIENCES, INC. , NI, Jian , YU, Guo-Liang , GENTZ, Reiner
IPC分类号： C07H21/04
CPC分类号： C07K14/82 , A61K38/00 , A61K48/00 , C12N2799/026 , C12Q1/6886 , C12Q2600/136
摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example cancer, are also disclosed.
摘要翻译：公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

7. 发明申请

WO1997023640A1 HUMAN CHEMOTACTIC CYTOKINE I 审中-公开
标题翻译：人类化学细胞因子
公开(公告)号：WO1997023640A1
公开(公告)日：1997-07-03
申请号：PCT/US1995016871
申请日：1995-12-26
申请人： HUMAN GENOME SCIENCES, INC.
发明人： HUMAN GENOME SCIENCES, INC. , NI, Jian , YU, Guo-Liang , ALFONSO, Pedro , GENTZ, Reiner , SU, Jeffrey, Y.
IPC分类号： C12P21/02
CPC分类号： C07K14/52 , A61K38/00
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

8. 发明申请

WO2012149356A3 ANTI-CD40 ANTIBODIES AND METHODS OF USE 审中-公开
公开(公告)号：WO2012149356A3
公开(公告)日：2012-11-01
申请号：PCT/US2012/035502
申请日：2012-04-27
申请人： APEXIGEN, INC. , ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
发明人： ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
摘要： The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

9. 发明申请

WO2006050491A2 METHODS FOR ANTIBODY ENGINEERING 审中-公开
标题翻译：抗体工程方法
公开(公告)号：WO2006050491A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039930
申请日：2005-11-02
申请人： EPITOMICS, INC. , COUTO, Fernando Jose Rebelo Do , HENDRICKS, Kristin B. , WALLACE, Stacey Ellen , YU, Guo-Liang
发明人： COUTO, Fernando Jose Rebelo Do , HENDRICKS, Kristin B. , WALLACE, Stacey Ellen , YU, Guo-Liang
IPC分类号： G01N33/53 , G06F19/00 , C12P21/06 , A61K39/395 , C07K16/18 , C12N5/06
CPC分类号： G01N33/577 , C07K16/241 , C07K16/467
摘要： The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications.
摘要翻译：本发明提供了用于鉴定可以被修饰的抗体的位置而不显着降低抗体的结合活性的方法。在许多实施方案中，该方法包括通过将其氨基酸序列与许多相关抗体的氨基酸序列比较来鉴定亲本抗体中的可取代位置，所述相关抗体各自与亲本抗体结合相同的抗原。可取代位置的氨基酸可以被替代为不同的氨基酸，而不显着影响抗体的活性。在人源化方法或其他抗体工程方法中，可以采用主题方法来改变CDR的氨基酸序列而不显着降低抗体的抗体亲和力。本发明可用于各种治疗，诊断和研究应用。

10. 发明申请

WO2013009767A2 FACS-BASED METHOD FOR OBTAINING AN ANTIBODY SEQUENCE 审中-公开
标题翻译：基于FACS的方法获得抗体序列
公开(公告)号：WO2013009767A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046098
申请日：2012-07-10
申请人： EPITOMICS, INC. , KE, Yaohuang , YU, Guo-Liang , VROOM, Karin
发明人： KE, Yaohuang , YU, Guo-Liang , VROOM, Karin
IPC分类号： G01N21/64
CPC分类号： G01N33/56972 , G01N33/5032 , G01N33/5047 , G01N33/564 , G01N33/6854
摘要： In certain embodiments, the method may comprises: a) contacting a population of permeabilized, cross-linked antibody-producing cells with a labeled antigen to produce a labeled sample in which cells that produce an antibody that specifically binds to said antigen are intracellularly labeled; b) using FACS to isolate cells that are intracellularly labeled, thereby producing labeled cells; c) uncrosslinking said labeled cells to produce uncrosslinked cells; and d) amplifying heavy and light chain-encoding nucleic acid from individual uncrosslinked cells, thereby obtaining nucleic acid that encodes the variable domain of antibody that specifically binds to said antigen.
摘要翻译：在某些实施方案中，所述方法可以包括：a）将一组透化的，交联的产生抗体的细胞与标记的抗原接触以产生标记的样品，其中产生与所述抗原特异性结合的抗体的细胞是细胞内标记的; b）使用FACS分离细胞内标记的细胞，从而产生标记细胞; c）未交联所述标记的细胞以产生未交联的细胞; 和d）从单个未交联的细胞扩增重链和轻链编码核酸，从而获得编码与所述抗原特异性结合的抗体可变结构域的核酸。

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