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    • 1. 发明申请
    • METHODS AND COMPOSITIONS FOR TREATING METABOLIC BONE DISEASES RELATING TO HUMAN ENDOKINE ALPHA
    • 用于治疗与人内皮素ALPHA相关的代谢性骨髓疾病的方法和组合物
    • WO2003070763A1
    • 2003-08-28
    • PCT/US2002/025809
    • 2002-08-15
    • HUMAN GENOME SCIENCES, INC.YU, Guo-LiangNI, JianROSEN, Craig, A.NARDELLI, Bernadetta
    • YU, Guo-LiangNI, JianROSEN, Craig, A.NARDELLI, Bernadetta
    • C07K14/52
    • C07K14/5255A61K38/00
    • The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.
    • 本发明涉及使用细胞因子的肿瘤坏死因子(TNF)家族的新成员诊断和治疗代谢性骨疾病和病症的方法。 特别地,本发明提供了在代谢性骨疾病和病症的诊断,预后和治疗中使用含有内因激酶α的内因子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物的方法。 本发明还提供了使用含有内因激酶α的内含子α蛋白和/或同源多聚体和/或异源多聚体多肽复合物在与异常破骨细胞发育和/或活性相关的疾病和/或病症的诊断,预后和治疗中的方法。 本发明还提供编码本发明的多肽的分离的多核苷酸,其抗体及其激动剂和拮抗剂,用于代谢性骨疾病和病症的诊断,预后和治疗。