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1. 发明申请

WO2011003557A8 A COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 审中-公开
标题翻译：双重特异性抗体复合物和联合治疗或诊断代谢物的二氢吉他宁
公开(公告)号：WO2011003557A8
公开(公告)日：2012-01-26
申请号：PCT/EP2010004051
申请日：2010-07-05
申请人： HOFFMANN LA ROCHE , BRINKMANN ULRICH , CROASDALE REBECCA , LAU WILMA , GEORGES GUY , HAAS ALEXANDER , HOFFMANN EIKE , METZ SILKE , MUNDIGL OLAF , SCHEUER WERNER , STRACKE JAN OLAF
发明人： BRINKMANN ULRICH , CROASDALE REBECCA , LAU WILMA , GEORGES GUY , HAAS ALEXANDER , HOFFMANN EIKE , METZ SILKE , MUNDIGL OLAF , SCHEUER WERNER , STRACKE JAN OLAF
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及a）双特异性抗体和针对靶蛋白的抗体片段的复合物，以及b）与治疗或诊断试剂缀合的地高辛素，其生产方法，它们作为治疗或诊断试剂递送平台的用途，含有所述抗体的药物组合物及其用途。

2. 发明申请

WO2011157713A4 CELL-PENETRATING PEPTIDES AND USES THEROF 审中-公开
标题翻译：细胞穿刺肽及其用途
公开(公告)号：WO2011157713A4
公开(公告)日：2012-04-12
申请号：PCT/EP2011059853
申请日：2011-06-14
申请人： HOFFMANN LA ROCHE , BRINKMANN ULRICH , HAAS ALEXANDER , MAISEL DANIELA
发明人： BRINKMANN ULRICH , HAAS ALEXANDER , MAISEL DANIELA
IPC分类号： A61K47/48 , C07K14/00
CPC分类号： C07K14/47 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K14/00 , C07K14/435
摘要： The present invention relates to a peptide molecule capable of being internalized into a cell, wherein the peptide molecule (a) has a length of at least 10, preferably of at least 15 amino acid residues; (b) comprises in its primary amino acid sequence at least 25%, preferably at least 30% positively charged amino acid residues; and (c) is internalized into a cell with an efficacy being at least 80%, preferably at least 90% of the internalization efficacy of the TAT peptide having the amino acid sequence GRKKRRQRRRPPQ. The invention is also directed to a corresponding nucleic acid molecule encoding such peptide as well as to a composition comprising at least one such peptide being attached to any one of the group consisting of one or more nucleic acid molecules, one or more peptides or proteins, one or more small molecules, and one or more nanoparticles, wherein the attachment is accomplished by a linkage selected from the group consisting of a covalent linkage and a non-covalent linkage. Furthermore, the invention relates to a method of detecting the internalization behavior of such peptide or such composition, comprising (a) administering the peptide or composition to one or more cells; and (b) detecting the internalization of the peptide or composition. Finally, the invention concerns the use of such peptide or such composition for the transformation or transfection of one or more cells as well as in the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.
摘要翻译：本发明涉及能够内化到细胞中的肽分子，其中肽分子（a）的长度至少为10，优选至少15个氨基酸残基; （b）在其主要氨基酸序列中包含至少25％，优选至少30％带正电荷的氨基酸残基; 并且（c）被内化成细胞，其功效为具有氨基酸序列GRKKRRQRRRPPQ的TAT肽的内在功效的至少80％，优选至少90％。本发明还涉及编码这种肽的相应核酸分子以及包含至少一种这样的肽的组合物，其连接到由一种或多种核酸分子，一种或多种肽或蛋白质组成的组中的任何一种，一种或多种小分子和一种或多种纳米颗粒，其中所述连接通过选自共价键和非共价键的键进行。此外，本发明涉及检测这种肽或这种组合物的内化行为的方法，其包括（a）将肽或组合物施用于一种或多种细胞; 和（b）检测肽或组合物的内在化。最后，本发明涉及这样的肽或这种组合物用于转化或转染一种或多种细胞以及预防和/或治疗选自以下的病症：癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎性疾病。

3. 发明申请

WO2011157713A3 CELL-PENETRATING PEPTIDES AND USES THEROF 审中-公开
标题翻译：细胞渗透肽及其应用
公开(公告)号：WO2011157713A3
公开(公告)日：2012-02-23
申请号：PCT/EP2011059853
申请日：2011-06-14
申请人： HOFFMANN LA ROCHE , BRINKMANN ULRICH , HAAS ALEXANDER , MAISEL DANIELA
发明人： BRINKMANN ULRICH , HAAS ALEXANDER , MAISEL DANIELA
IPC分类号： A61K47/48 , C07K14/00
CPC分类号： C07K14/47 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K14/00 , C07K14/435
摘要： The present invention relates to a peptide molecule capable of being internalized into a cell, wherein the peptide molecule (a) has a length of at least 10, preferably of at least 15 amino acid residues; (b) comprises in its primary amino acid sequence at least 25%, preferably at least 30% positively charged amino acid residues; and (c) is internalized into a cell with an efficacy being at least 80%, preferably at least 90% of the internalization efficacy of the TAT peptide having the amino acid sequence GRKKRRQRRRPPQ. The invention is also directed to a corresponding nucleic acid molecule encoding such peptide as well as to a composition comprising at least one such peptide being attached to any one of the group consisting of one or more nucleic acid molecules, one or more peptides or proteins, one or more small molecules, and one or more nanoparticles, wherein the attachment is accomplished by a linkage selected from the group consisting of a covalent linkage and a non-covalent linkage. Furthermore, the invention relates to a method of detecting the internalization behavior of such peptide or such composition, comprising (a) administering the peptide or composition to one or more cells; and (b) detecting the internalization of the peptide or composition. Finally, the invention concerns the use of such peptide or such composition for the transformation or transfection of one or more cells as well as in the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.
摘要翻译：本发明涉及能够被内化到细胞中的肽分子，其中肽分子（a）具有至少10个，优选至少15个氨基酸残基的长度; （b）在其一级氨基酸序列中包含至少25％，优选至少30％带正电的氨基酸残基; 和（c）以具有氨基酸序列GRKKRRQRRRPPQ的TAT肽的内化效力的至少80％，优选至少90％的效力内化到细胞中。本发明还涉及编码此类肽的相应核酸分子以及包含至少一个此类肽的组合物，所述组合物连接至由一个或多个核酸分子，一个或多个肽或蛋白质组成的组中的任何一个，一个或多个小分子和一个或多个纳米颗粒，其中所述连接通过选自共价键和非共价键的键实现。此外，本发明涉及检测此类肽或此类组合物的内化行为的方法，其包括（a）将所述肽或组合物给予一种或多种细胞; 和（b）检测肽或组合物的内化。最后，本发明涉及这种肽或这种组合物用于转化或转染一种或多种细胞以及预防和/或治疗选自癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎症性疾病。

4. 发明申请

WO2005059708A2 TOUCH CONTROL ASSEMBLY 审中-公开
标题翻译：触控控制组件
公开(公告)号：WO2005059708A2
公开(公告)日：2005-06-30
申请号：PCT/US2004042067
申请日：2004-12-15
申请人： SCHOTT CORP , WEGERT THEODORE A , CARY KAREN , HOCHE JENS , WOLFF DAVID A , HAAS ALEXANDER , ZENKER THOMAS , ASTHEIMER STEFFEN
发明人： WEGERT THEODORE A , CARY KAREN , HOCHE JENS , WOLFF DAVID A , HAAS ALEXANDER , ZENKER THOMAS , ASTHEIMER STEFFEN
IPC分类号： G06F20060101 , G09G5/00 , H03K17/96 , G06F
CPC分类号： H03K17/96 , H03K17/9622 , H03K2217/96015 , H03K2217/960755
摘要： The present invention provides a touch control assembly including a substrate for interfacing with a user and a touch keypad removably connected to the substrate. The touch keypad includes a sensor.
摘要翻译：本发明提供了一种触摸控制组件，其包括用于与用户接口的基板和可移除地连接到基板的触摸键盘。触摸键盘包括传感器。

5. 发明申请

WO9700166A8 TWIN-SHAFT COMPACTOR 审中-公开
标题翻译：双波紧凑型压缩机
公开(公告)号：WO9700166A8
公开(公告)日：1999-09-10
申请号：PCT/DE9601071
申请日：1996-06-18
申请人： LINDEMANN MASCHFAB GMBH , LANGENBECK KONRAD , GRATZ MATTHIAS , HAAS ALEXANDER , BEEK AUGUST V D , DILLMANN JUERGEN , BUCH REYK , SCHUERMANN HERMANN JOSEF
发明人： LANGENBECK KONRAD , GRATZ MATTHIAS , HAAS ALEXANDER , VAN DER BEEK AUGUST , DILLMANN JUERGEN , BUCH REYK , SCHUERMANN HERMANN JOSEF
IPC分类号： B29C47/60 , B30B11/00 , B30B11/22 , B30B11/24
CPC分类号： B30B11/243 , B29C47/369 , B29C47/40 , B29C47/46 , B30B11/005 , B30B11/224 , B30B11/227 , B30B11/241 , B30B11/246
摘要： A device is proposed for use as a twin-shaft compactor in the form of an extruder press or a so-called double screw press (8) for the volume reduction and high-density compaction of different types of waste to form briquette-type mouldings, in particular for the compaction of a so-called light shredder fraction produced in dust-removal systems in shredder facilities. The proposed device has screw shafts (16, 17), each of which comprises a hollow base section (14.1) and a head section (14.2). The screw shafts (16, 17) are driven controllably and/or reversibly and the drive and extruder elements are separated from one another in such a way that the screw shafts (16, 17) are kept away from the wear-inducing compaction process and the rotary speed of the screw shafts (16, 17) can be adjusted to ensure an optimal compaction process.
摘要翻译：的装置如在挤出机中压或所谓的双螺旋压力机（8）体积减少和不同组合物团块压坯，特别是用于粉碎机所谓粉碎机轻馏分的所得集尘器的压实废物的高密度压实形式的两个波紧凑压缩机，具有螺杆轴（16，17）从一个空心基座部分（14.1）和头部部分（14.2），这取决于其中所述螺杆轴（16，17）调节和/或可逆地驱动，并且传动部分和挤出机部分是分开的，使得螺杆轴（16，17）的materialverschleissenden 压实被保持远离和反向旋转的螺杆轴（16，17）的速度是可变的，以确保最佳的Kompaktierungsvorganges。

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