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1. 发明申请

WO2009080555A2 CARBOXYL- OR HYDROXYLSUBSTITUTED BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：羧基或羟基取代苯并咪唑衍生物
公开(公告)号：WO2009080555A2
公开(公告)日：2009-07-02
申请号：PCT/EP2008067399
申请日：2008-12-12
申请人： HOFFMANN LA ROCHE , BENSON GREGORY MARTIN , BLEICHER KONRAD , GRETHER UWE , KUHN BERND , MARTIN RAINER E , PLANCHER JEAN-MARC , RICHTER HANS , TAYLOR SVEN , YANG MINMIN
发明人： BENSON GREGORY MARTIN , BLEICHER KONRAD , GRETHER UWE , KUHN BERND , MARTIN RAINER E , PLANCHER JEAN-MARC , RICHTER HANS , TAYLOR SVEN , YANG MINMIN
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D235/12 , C07D401/12 , C07D401/14
摘要： This invention relates to novel carboxyl- or hydroxylsubstituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as 5 physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型羧基或羟基取代的苯并咪唑衍生物，其中R 1至R 6如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。这些化合物与FXR结合，可用作药物。

2. 发明申请

WO2009062874A3 BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS 审中-公开
标题翻译：苯并咪唑衍生物及其作为FXR AGONISTS的用途
公开(公告)号：WO2009062874A3
公开(公告)日：2009-07-09
申请号：PCT/EP2008065012
申请日：2008-11-05
申请人： HOFFMANN LA ROCHE , BENSON GREGORY MARTIN , BLEICHER KONRAD , GRETHER UWE , MARTIN RAINER E , PLANCHER JEAN-MARC , RICHTER HANS , TAYLOR SVEN , YANG MINMIN
发明人： BENSON GREGORY MARTIN , BLEICHER KONRAD , GRETHER UWE , MARTIN RAINER E , PLANCHER JEAN-MARC , RICHTER HANS , TAYLOR SVEN , YANG MINMIN
IPC分类号： C07D235/06 , A61K31/4184 , A61P3/00 , C07D405/12 , C07D409/12
CPC分类号： C07D235/06 , C07D405/12 , C07D409/12
摘要： The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型取代的苯并咪唑衍生物，其中R 1至R 10如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。这些化合物可以用作药物。

3. 发明申请

WO2007062999A3 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES 审中-公开
标题翻译： 1,5-取代的吲哚-2-基酰胺衍生物
公开(公告)号：WO2007062999A3
公开(公告)日：2007-07-26
申请号：PCT/EP2006068655
申请日：2006-11-20
申请人： HOFFMANN LA ROCHE , NETTEKOVEN MATTHIAS , PLANCHER JEAN-MARC , RICHTER HANS , ROCHE OLIVIER , RUNTZ-SCHMITT VALERIE , TAYLOR SVEN
发明人： NETTEKOVEN MATTHIAS , PLANCHER JEAN-MARC , RICHTER HANS , ROCHE OLIVIER , RUNTZ-SCHMITT VALERIE , TAYLOR SVEN
IPC分类号： C07D401/12 , A61K31/4439 , A61P3/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula I wherein R 1 to R 4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。该化合物可用于治疗和/或预防与H3受体调节相关的疾病。

4. 发明申请

WO2012117000A8 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS 审中-公开
标题翻译： 3-AMINO-PYRIDINES作为GPBAR1 AGONISTS
公开(公告)号：WO2012117000A8
公开(公告)日：2013-03-07
申请号：PCT/EP2012053386
申请日：2012-02-29
申请人： HOFFMANN LA ROCHE , BISSANTZ CATERINA , DEHMLOW HENRIETTA , ERICKSON SHAWN DAVID , KARNACHI PRABHA SABA , KIM KYUNGJIN , MARTIN RAINER E , MATTEI PATRIZIO , OBST SANDER ULRIKE , PIETRANICO-COLE SHERRIE LYNN , RICHTER HANS , ULLMER CHRISTOPH
发明人： BISSANTZ CATERINA , DEHMLOW HENRIETTA , ERICKSON SHAWN DAVID , KARNACHI PRABHA SABA , KIM KYUNGJIN , MARTIN RAINER E , MATTEI PATRIZIO , OBST SANDER ULRIKE , PIETRANICO-COLE SHERRIE LYNN , RICHTER HANS , ULLMER CHRISTOPH
IPC分类号： C07D213/75 , A61K31/4418 , A61K31/4433 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
CPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
摘要： This invention relates to novel 3-aminopyridines of the formula (I) wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译：本发明涉及式（I）的新的3-氨基吡啶，其中B1，B2和R1至R6如说明书和权利要求书中所定义，以及其药学上可接受的盐。这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。

5. 发明申请

WO2006077025A3 MORPHOLINES AS 5HT2C AGONISTS 审中-公开
标题翻译：吗啡啉作为5HT2C激动剂
公开(公告)号：WO2006077025A3
公开(公告)日：2006-09-08
申请号：PCT/EP2006000126
申请日：2006-01-10
申请人： HOFFMANN LA ROCHE , VERNALIS RES LTD , BENTLEY JONATHAN MARK , DAWSON CLAIRE ELIZABETH , GUBA WOLFGANG , HEBEISEN PAUL , MONCK NATHANIEL , PRATT ROBERT MARK , RICHTER HANS , ROEVER STEPHAN , RUSTON VICKI
发明人： BENTLEY JONATHAN MARK , DAWSON CLAIRE ELIZABETH , GUBA WOLFGANG , HEBEISEN PAUL , MONCK NATHANIEL , PRATT ROBERT MARK , RICHTER HANS , ROEVER STEPHAN , RUSTON VICKI
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/04 , A61P3/10
CPC分类号： C07D265/30
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
摘要翻译：本发明涉及式（I）的化学化合物及其药学上可接受的盐和酯，其中R 1至R 5具有权利要求1中给出的含义。这些化合物可以用于制备药物。

6. 发明申请

WO02072584A2 PIPERAZINE DERIVATIVES 审中-公开
标题翻译：哌嗪衍生物
公开(公告)号：WO02072584A2
公开(公告)日：2002-09-19
申请号：PCT/EP0202443
申请日：2002-03-06
申请人： HOFFMANN LA ROCHE , VERNALIS RES LTD
发明人： HEBEISEN PAUL , MATTEI PATRIZIO , MULLER MARC , RICHTER HANS , ROEVER STEPHAN , TAYLOR SVEN
IPC分类号： A61K31/337 , A61K31/4985 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R to R have the significance given in the description and the claims. The compounds can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, type II diabetes, obesity and sleep apnoea.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，溶剂合物和酯，其中R 1至R 7具有在说明书和权利要求书中给出的含义。化合物可以以用于治疗或预防中枢神经系统疾病，中枢神经系统损害，心血管疾病，胃肠道疾病，尿崩症，II型糖尿病，肥胖症和睡眠呼吸暂停的药物制剂的形式使用。

7. 发明申请

WO0243110A2 TERMINAL BLOCK FOR A MONOLITHIC MULTILAYER PIEZOACTUATOR 审中-公开
标题翻译：电气安排单片叠层式压电致动器 -
公开(公告)号：WO0243110A2
公开(公告)日：2002-05-30
申请号：PCT/DE0104405
申请日：2001-11-26
申请人： RICHTER HANS
发明人： RICHTER HANS
IPC分类号： H01L41/04 , H01L41/047 , H01L41/083 , H02N2/04 , H01L
CPC分类号： H01L41/04 , H01L41/0472 , H01L41/0475 , H01L41/083
摘要： The invention relates to a terminal block for a monolithic multilayer piezoactuator (P) with electrical terminal lugs (A1, A2) that are provided with multiple slots transversely to the stack of piezoelectric elements that forms the piezoactuator (P) to give individual fingers (F). The terminal lugs are linked with the inner electrodes of the piezoactuator, their fingers resting on the respective stack side.
摘要翻译：为单片的多层压电致动器（P）与该横向经常狭缝形成的压电元件的压电致动器（P）的量的电端子接线片（A1，A2）电连接装置堆叠以形成单独的手指F和在每种情况下的手指上的相应桩侧嵌合被连接到压电致动器的内部电极。

8. 发明申请

WO2010051797A3 ELECTRIC PIEZO MOTOR UNIVERSAL DRIVE 审中-公开
标题翻译：电动压片机通用驱动器
公开(公告)号：WO2010051797A3
公开(公告)日：2010-07-29
申请号：PCT/DE2009001536
申请日：2009-11-04
申请人： RICHTER BERTA , RICHTER HANS
发明人： RICHTER HANS
IPC分类号： H01L41/09 , F16D65/14
CPC分类号： H02N2/101 , F16D55/2245 , F16D65/54 , F16D2125/68 , H02N2/021
摘要： An electric universal drive, comprising a revolving or linearly movable output member (1), further comprising at least two sets of actuators arranged in dedicated carriers (3), in particular piezo actuators (4, 5, 6), which act on a base (7) supported on the output member (1), wherein the at least two sets of actuators alternately press the respectively associated base (7) against the output member (1) and deflect the output member (1) in the direction of the output movement in the spirit of a high-frequency step sequence, wherein furthermore the carriers (3) of the actuator sets are connected in a semi-rigid manner at a location that is laterally offset with respect to the base (7) parallel to the direction of movement of the output member (1), and the carriers (3) are supported on a stator preloaded by a preloading element (9) in a spring-elastic manner with respect to the output member (1), wherein between the preloading element (9) and the respective carrier (3) a toggle lever mechanism (10) having a first toggle lever (24) and transmitting the preloading force is arranged, which engages on the carrier (3) at a location that is offset to the other side compared to the carrier connecting location with respect to the base (7) parallel to the direction of movement of the output member (1), the toggle lever mechanism has a second toggle lever (25), which is arranged between the preloading element (9) and a counter bearing (27) fixed to the stator, wherein the toggle lever mechanism (10) is associated with an operating actuator (28), which is connected to the toggle links of the two toggle levers (24, 25) by way of a coupling member (29), and the arrangement of the toggle lever mechanism (10) is such that the second toggle lever (25) is collapsed when the first toggle lever (24) is extended, and vice versa, and the operating actuator (28) is used to jointly switch the two toggle levers (24, 25) between the extended position and the collapsed position.
摘要翻译：通用电动驱动器，具有旋转或线性移动的输出件（1），并且进一步被安排与每个在其自己的支持的至少两个（3）组的致动器，特别是压电致动器（4，5，6），每个一方面（在汽提部 1）支脚（7）的动作，其中，所述至少两组致动器的交替的各相关的脚（7）推压（在分别输出部分1）和（在部件1的驱动器的输出运动）的方向上产生的高频步骤序列的有义定向，进一步地，其中所述支撑台是在一个相对于基部（7）平行于输出构件的移动方向连接在所述致动器（1）根据在半刚性的方式和一侧移动的位置的载体（3）（3）在每种情况下通过偏置构件（9 ）被弹性地支撑在偏置在定子上的从动部件（1）上，其中，在偏置部件（9）和相应的载体（3）之间，d 即偏置力传递肘节机构（10），包括第一肘杆（24）布置，其由偏移相对于载体联合另一方面的相对（7）平行地接合到所述基部到所述输出构件（1）的运动方向，网站上的支撑件（3），肘节机构包括一个设置在所述偏置构件（9）和一个定子固定的支座（27），肘节机构（10）之间的第二肘杆（25）是一个Betätigungsaktor（28）相关联，通过连接部件（29）与所述膝关节既是肘杆（24，25）相连，并制成以使得如果所述第一肘杆（24）被拉伸时，第二肘杆（25）铰接在Kniehebelmechanimus（10）的布置，并且反之亦然，并且Betätigungsaktor（ 28），用于在延伸位置和Einknickstellung之间的两个肘杆（24,25）的共同切换。

9. 发明申请

WO0237535A3 PIEZO-ELECTRICAL ACTUATOR WITH AUTOMATIC RELEASE ON LOSS OF POWER 审中-公开
标题翻译：与自动激活停电压电作动器
公开(公告)号：WO0237535A3
公开(公告)日：2003-03-13
申请号：PCT/DE0104099
申请日：2001-11-02
申请人： RICHTER HANS
发明人： RICHTER HANS
IPC分类号： F16D65/18 , B06B1/06 , F16D65/14 , H01L41/09
CPC分类号： F16D65/18 , F16D2121/28 , F16D2125/40 , F16D2125/582 , F16D2127/02 , F16D2129/08 , H02N2/101 , H02N2/126
摘要： Piezo-electrical actuator with automatic release on loss of power, comprising a regulating element, embodied as an axially-acting plunger (11), axially supported by means of a pressure support (15) which is articulated by means of a toggle joint and held in the extended position by means of an electromagnet (14) during operation.
摘要翻译：其通过在延伸位置与自动激活压电致动器的电磁体（14）的装置电源故障时，其特征在于，形成为轴向作用的压力活塞（11）的致动器通过一肘杆状einknickbare压力支撑件（15）沿轴向支承在操作过程中被保持。

10. 发明申请

WO2005114232A3 METHOD AND APPARATUS FOR THE DETERMINATION OF THE CONCENTRATION OF IMPURITIES IN A WAFER 审中-公开
标题翻译：用于确定水中污染物浓度的方法和装置
公开(公告)号：WO2005114232A3
公开(公告)日：2006-08-31
申请号：PCT/EP2005052225
申请日：2005-05-13
申请人： IK IHP GMBH INNOVATIONS FOR HI , RICHTER HANS , AKHMETOV VLADIMIR D , LYSYTSKIY OLEKSANDR
发明人： RICHTER HANS , AKHMETOV VLADIMIR D , LYSYTSKIY OLEKSANDR
IPC分类号： G01N21/35 , G01N21/27 , G01N21/95 , G01R31/00
CPC分类号： G01N21/276 , G01N21/3563 , G01N21/9501
摘要： The invention relates to a method for the determination of the concentration of an impurity in a wafer. The method comprises repeatedly changing the position of the plate during the period of the registration t recording by displacing the plate along its plane of the surface, such that the light beam of the infrared spectrometer alternately passes through one of the samples at a time, thus recording partial spectra from both samples, accumulating recorded spectral information in the time intervals between the position changes of the plate, dividing the obtained spectral information into two sets of spectral information corresponding to the first sample and to the reference sample, and performing averaging and statistical analysis for each set of spectral information, in order to determine an average differential spectrum and its statistical error.
摘要翻译：本发明涉及一种用于确定晶片中杂质浓度的方法。该方法包括通过沿着其表面的平面移位板，在记录记录期间重复地改变印版的位置，使得红外光谱仪的光束交替地通过一次采样，从而记录来自两个样本的部分光谱，在板的位置变化之间的时间间隔中累积记录的光谱信息，将获得的光谱信息划分为对应于第一样本的两组光谱信息和参考采样，并对每组光谱信息执行平均和统计分析，以确定平均差分光谱及其统计误差。

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