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    • 9. 发明申请
    • INHIBITORS OF DESUMOYLATION ENZYMES AND METHODS FOR THEIR USE
    • 脱乙酰壳多糖的抑制剂及其使用方法
    • WO2012064887A1
    • 2012-05-18
    • PCT/US2011/060052
    • 2011-11-09
    • CHEN, YuanZAIA, JohnLI, ShirleyLI, Yi-JiaSU, YangWONG, Steven
    • CHEN, YuanZAIA, JohnLI, ShirleyLI, Yi-JiaSU, YangWONG, Steven
    • A01N33/26A61K31/655
    • A61K31/655A61K45/06C07C309/46C07C309/47
    • In one embodiment, a deSUMOylation inhibitor is provided. In another embodiment, a method for inhibiting infectivity of a retrovirus is provided. The method may include administering an effective amount of a deSUMOylation inhibitor compound to one or more immune cells. In some embodiments, the retrovirus is human immunodeficiency virus (HIV). In another embodiment, methods for treating HIV are provided. Such methods may include administering an effective amount of a pharmaceutical compound to a subject having HIV or is at risk of being infected with HIV. The pharmaceutical composition may comprise a deSUMOylation inhibitor described herein. In some embodiments, the treatment is a preventative treatment. In some embodiments, the methods for treating HIV may further comprise administering a highly active anti-retroviral therapy (HAART) regimen in combination with the pharmaceutical composition. A HAART regimen may include three or more active anti-retroviral medivations (ARVs).
    • 在一个实施方案中,提供了脱硫酸抑制剂。 在另一个实施方案中,提供了用于抑制逆转录病毒感染性的方法。 该方法可以包括向一种或多种免疫细胞施用有效量的deSUMO化抑制剂化合物。 在一些实施方案中,逆转录病毒是人免疫缺陷病毒(HIV)。 在另一个实施方案中,提供了用于治疗HIV的方法。 这样的方法可以包括向具有HIV的受试者施用有效量的药物化合物,或者有被HIV感染的风险。 药物组合物可以包含本文所述的脱硫酸抑制剂。 在一些实施方案中,治疗是预防性治疗。 在一些实施方案中,用于治疗HIV的方法可进一步包括与药物组合物组合施用高活性抗逆转录病毒疗法(HAART)方案。 HAART方案可以包括三种或更多种活性抗逆转录病毒介质(ARV)。