会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明申请
    • NUCLEOTIDE ANALOGS
    • 核素类似物
    • WO1998004569A1
    • 1998-02-05
    • PCT/US1997013244
    • 1997-07-25
    • GILEAD SCIENCES, INC.
    • GILEAD SCIENCES, INC.ARIMILLI, Murty, N.CUNDY, Kenneth, C.DOUGHERTY, Joseph, P.KIM, Choung, U.OLIYAI, RezaSTELLA, Valentino, J.
    • C07F09/6561
    • C07F9/65616C07F9/6512
    • Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure -OC(R )2OC(O)X(R)a, wherein R independently is H, C1-C12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR in which R is C1-C12 alkyl; X is N or O; R is independently H, C1-C12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro, -O-, -N=, -NR -, -N(R )2- or OR , R independently is -H or C1-C8 alkyl, provided that at least one R is not H; and a is 1 or 2, with the proviso that when a is 2 and X is N, (a) two R groups can be taken together to form a carbocycle or oxygen-containing heterocycle, or (b) one R additionally can be OR . The compounds are useful as intermediates for the preparation of antiviral compounds or oligonucleotides, or are useful for administration directly to patients for antiviral therapy or prophylaxis. Embodiments are particularly useful when administered orally.
    • 提供新的化合物,其包含抗病毒膦基甲氧基核苷酸类似物与具有结构-OC(R 2)2 OC(O)X(R)a的碳酸酯和/或氨基甲酸酯的酯,其中R 2独立地是H,C1- C 2 -C 12烷基,芳基,烯基,炔基,烷基芳基,炔基芳基,烷芳基,芳基炔基,芳基烯基或芳烷基,其未被取代或被卤素,叠氮基,硝基或OR 3取代,其中R 3是C 1 -C 12烷基; X为N或O; R是独立的H,C 1 -C 12烷基,芳基,烯基,炔基,链烯基芳基,炔基芳基,烷芳基,芳基炔基,芳基烯基或芳基烷基,其未被取代或被卤素,叠氮基,硝基,-O - , - N = 4, - (R 4)2 - 或OR 3,R 4独立地是-H或C 1 -C 8烷基,条件是至少一个R不是H; 和a为1或2,条件是当a为2且X为N时,(a)两个R基团可以一起形成碳环或含氧杂环,或(b)一个R另外可以是OR <3>。 该化合物可用作制备抗病毒化合物或寡核苷酸的中间体,或可用于直接给患者施用抗病毒治疗或预防。 当口服给药时,实施方案特别有用。