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1. 发明申请

WO0162378A3 MICROARRAY FABRICATION TECHNIQUES AND APPARATUS 审中-公开
标题翻译：微波炉制造技术和设备
公开(公告)号：WO0162378A3
公开(公告)日：2002-02-07
申请号：PCT/US0105844
申请日：2001-02-22
申请人： GENOSPECTRA INC , CHEN SHIPING , LUO YULING , CHEN ANTHONY C
发明人： CHEN SHIPING , LUO YULING , CHEN ANTHONY C
IPC分类号： G01N33/53 , B01J4/00 , B01J19/00 , B01L3/02 , B81B1/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/25 , G01N21/64 , G01N35/10 , G01N37/00 , B01L3/00
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00369 , B01J2219/00382 , B01J2219/00385 , B01J2219/00418 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/253 , G01N21/6452 , G01N35/1074 , G01N2021/6484 , G01N2035/1037
摘要： Disclosed is a microarray printing system and methods of printing probe microarrays 1000. The system has a print-head (102, 606, 706, 806) formed of one or more capillary bundle (104), such as light-guiding capillaries. The bundles (104) may especially be bundles (104) of capillaries that provide a large number of probes 1004 on the surface of a substrate. Methods of registering or correlating the distal 112 and proximal 110 ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays 1000 that are missing one or more probes from the surface of the microarray 1000.
摘要翻译：公开了一种微阵列打印系统和打印探针微阵列1000的方法。该系统具有由一个或多个毛细管束（104）形成的打印头（102,606,706,806），例如导光毛细管。束（104）可以特别地是在基底表面上提供大量探针1004的毛细管束（104）。还提供了注射或关联毛细血管的远端112和近端110端的方法。此外，本发明提供了用于鉴定从微阵列1000的表面缺少一个或多个探针的有缺陷的微阵列1000的方法和设备。

2. 发明申请

WO0162377A3 MICROARRAY FABRICATION TECHNIQUES AND APPARATUS 审中-公开
标题翻译：微波炉制造技术和设备
公开(公告)号：WO0162377A3
公开(公告)日：2002-03-14
申请号：PCT/US0105695
申请日：2001-02-22
申请人： GENOSPECTRA INC , CHEN SHIPING , LUO YULING , CHEN ANTHONY C
发明人： CHEN SHIPING , LUO YULING , CHEN ANTHONY C
IPC分类号： B41J2/01 , B01J19/00 , B01L3/00 , B01L3/02 , B81B1/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/25 , G01N21/64 , G01N33/53 , G01N35/10 , G01N37/00
CPC分类号： G01N21/6458 , B01J19/0046 , B01J2219/00369 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00673 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L3/563 , B01L2200/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/022 , B01L2400/027 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/6452 , G01N35/1074 , G01N2021/6484 , G01N2035/1037
摘要： Disclosed is a microarray printing system (100) and methods of printing probe microarrays (1101). The system has a print head (101, 200, 805, 1003, 1700, 1800, 1900) formed of one or more bundles (201-221, 604) of individual capillaries, (102, 301, 402a, 402b, 502a, 502b, 603a, 603b, 802) such as light-guiding capillaries. The bundles may especially be random bundles of capillaries that provide a large number of probes (807, 1006a, 1006b, 1206) on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.
摘要翻译：公开了一种微阵列打印系统（100）和打印探针微阵列（1101）的方法。该系统具有由单个毛细管（102,301,402a，402b，502a，502b）的一个或多个束（201-221,604）形成的打印头（101,200,880,1003,1700,1800,1900），603a，603b，802），例如导光毛细管。束可以特别是在衬底的表面上提供大量探针（807,1006a，1006b，1206）的无规毛细管束。还提供了注射或关联毛细管的远端和近端的方法。此外，本发明提供了用于鉴定从微阵列表面缺少一个或多个探针的有缺陷的微阵列的方法和设备。

3. 发明申请

WO02078834A3 BUNDLED CAPILLARIES APPARATUS FOR HIGH THROUGHPUT SCREENING 审中-公开
标题翻译：用于高通量筛选的装配毛毯设备
公开(公告)号：WO02078834A3
公开(公告)日：2003-06-05
申请号：PCT/US0205316
申请日：2002-02-19
申请人： GENOSPECTRA INC , XIAO JIANMING , CHEN SHIPING , LUO YULING , BUTLER JOHN , QAZEN MASOUD , THIELE JOCHEN , CHEN ANTHONY
发明人： XIAO JIANMING , CHEN SHIPING , LUO YULING , BUTLER JOHN , QAZEN MASOUD , THIELE JOCHEN , CHEN ANTHONY
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , B01L9/00 , B81B1/00 , C07B61/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , G01N21/25 , G01N21/64 , G01N35/10 , B01J16/00 , B01L1/00 , G01N33/543
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00418 , B01J2219/00454 , B01J2219/0047 , B01J2219/00504 , B01J2219/00511 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00704 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/0241 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L9/523 , B01L9/54 , B01L2200/025 , B01L2200/0642 , B01L2300/0609 , B01L2300/0645 , B01L2300/0829 , B01L2300/087 , B01L2300/168 , B01L2400/0406 , B01L2400/0415 , B01L2400/0688 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , G01N21/253 , G01N21/645 , G01N35/1074 , G01N2021/6484 , G01N2035/1037
摘要： Disclosed are systems and methods involved in extreme high throughput screening of compounds which have an affinity for a biological target. The system is based on a capillary bundle with two distinguishable ends wherein capillaries on one end are connected to compounds stored in discrete reservoirs and capillaries on the other end are bound and processed to form a two dimensional microarray. A capillary bundle having reaction wells for hybridization and compound reaction in one end of the capillaries is disclosed. The capillaries may be light-condicting. Also disclosed are various methods of identifying a target compound in a liquid using this capillary bundle as well as methods of fabricating the bundle. A novel surface tension guided reaction chamber is also provided. Methods and chemistry for fabrication and use of a surface tension guided reaction chamber in binding and hybridization assays are also disclosed. Methods and systems for precise metering of fluids within the capillaries and at the reaction chambers, including the surface tension guided "virtual" reaction well is provided. Methods for performing high throughput screens using optical fiber lined capillaries of the invention are also provided. The capillary arrays are used with both liquid probes as well as probes immobilized on the walls of the capillary.
摘要翻译：公开了涉及对生物靶具有亲和力的化合物的极高通量筛选中涉及的系统和方法。该系统基于毛细管束，其具有两个可区分的端部，其中一端的毛细管连接到存储在离散储存器中的化合物，另一端的毛细血管被结合并加工以形成二维微阵列。公开了一种毛细管束，其具有在毛细血管的一端中用于杂交和化合物反应的反应孔。毛细血管可能是轻微的。还公开了使用该毛细管束在液体中鉴定目标化合物的各种方法以及制造束的方法。还提供了一种新颖的表面张力引导反应室。还公开了在结合和杂交测定中制造和使用表面张力引导反应室的方法和化学。提供了用于精确计量毛细管内和反应室内的流体的方法和系统，包括表面张力引导的“虚拟”反应井。还提供了使用本发明的光纤衬里毛细管进行高通量筛选的方法。毛细管阵列与两个液体探针以及固定在毛细管壁上的探针一起使用。

4. 发明申请

WO0216651A3 THREE-DIMENSIONAL PROBE CARRIERS 审中-公开
标题翻译：三维探头载体
公开(公告)号：WO0216651A3
公开(公告)日：2002-08-15
申请号：PCT/US0126561
申请日：2001-08-24
申请人： GENOSPECTRA INC , CHEN SHIPING , CHEN ANTHONY , LUO YULING
发明人： CHEN SHIPING , CHEN ANTHONY , LUO YULING
IPC分类号： B01J19/00 , B01L3/00 , B81B1/00 , C03B37/014 , C03B37/018 , C03B37/075 , C40B50/14 , G01N21/64 , G01N21/77 , G02B6/06 , C12Q1/68
CPC分类号： G01N21/7703 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00351 , B01J2219/00509 , B01J2219/00522 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00641 , B01J2219/00659 , B01J2219/00664 , B01J2219/00673 , B01J2219/00675 , B01J2219/00677 , B01J2219/00704 , B01J2219/0072 , B01L3/5025 , B01L3/5085 , B01L2400/0475 , B01L2400/0487 , B82Y30/00 , C03B37/01413 , C03B37/01807 , C03B37/0756 , C03B2201/20 , C03B2201/31 , C03B2203/16 , C40B50/14 , G01N21/645 , G01N21/648 , G01N2021/6484 , G01N2021/7786 , G02B6/06
摘要： The inventions disclosed herein provide a novel 3-dimensional arrangement of probes on a probe carrier with concomitant increases in the economy of reagents, compactness and readability of the probe carriers. Novel methods of fabricating probe carriers are also disclosed. Techniques for hybridization assays and reading results of such assays are also presented.
摘要翻译：本文公开的发明提供了探针载体上的探针的新颖的三维布置，伴随着试剂的经济性的增加，探针载体的紧凑性和可读性。还公开了制造探针载体的新方法。还提供了用于杂交测定和这些测定的阅读结果的技术。

5. 发明申请

WO2007001986A3 METHODS OF DETECTING NUCLEIC ACIDS IN INDIVIDUAL CELLS AND OF IDENTIFYING RARE CELLS FROM LARGE HETEROGENEOUS CELL POPULATIONS 审中-公开
标题翻译：检测个体细胞中的核酸和从大量异源细胞群体鉴定罕见细胞的方法
公开(公告)号：WO2007001986A3
公开(公告)日：2009-04-16
申请号：PCT/US2006023816
申请日：2006-06-19
申请人： LUO YULING , CHEN SHIPING
发明人： LUO YULING , CHEN SHIPING
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/682 , C12Q1/6841 , C12Q2537/143 , C12Q2537/125 , C12Q2565/543 , C12Q2525/313
摘要： Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided. Methods of assaying the relative levels of nucleic acid targets through normalization to levels of reference nucleic acids are also provided. Methods of detecting individual cells, particularly rare cells from large heterogeneous cell populations, through detection of nucleic acids are described. Related compositions, systems, and kits are also provided.
摘要翻译：提供了通过间接捕获标记到核酸来检测单个细胞中的多个核酸靶的方法。还提供了通过归一化到参考核酸水平来测定核酸靶的相对水平的方法。描述了通过检测核酸检测单个细胞，特别是来自大异质细胞群体的罕见细胞的方法。还提供了相关的组合物，系统和试剂盒。

6. 发明申请

WO0169302A3 FIBER OPTIC SCANNER 审中-公开
标题翻译：光纤扫描仪
公开(公告)号：WO0169302A3
公开(公告)日：2002-03-21
申请号：PCT/US0108043
申请日：2001-03-13
申请人： GENOSPECTRA INC , CHEN SHIPING
发明人： CHEN SHIPING
IPC分类号： G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N37/00 , G02B6/036 , G02B21/00 , G02B26/10
CPC分类号： G01N21/6452 , G01N21/645 , G01N21/6456 , G01N21/76 , G01N2021/6484 , G02B21/002
摘要： The disclosed scanning structure includes an apparatus for light delivery and light receiving from a light-excitable area on a substrate to be measured by the scanning structure. The light delivery and receiving apparatus may include an optical fiber having a proximal end and a distal end which transmits light having a certain wavelength or light with several varying wavelengths to excite the substrate samples. This optical fiber may also simultaneously receive light which may be emitted by fluorescing samples on the substrate. The scanning structure also may further include a holder for the optical fiber that is able to transverse variable distances over the substrate to be measured or examined. Holders may include galvano scanners as well as resonating suspension beams. A light source, e.g., a laser, may be optically coupled to the optic fiber's proximal end. And this light source may be of a certain wavelength, but multiple light sources each having a different wavelength may also be used simultaneously by coupling the light sources into either a single optic fiber through wavelength multiplexers or by placing individual optic fibers carrying differing wavelengths in close proximity to each other. As the light is transmitted down to the substrate through the optic fiber, the fiber is sufficiently close to the substrate microarray so that it can also receive the emitted fluorescing light.
摘要翻译：所公开的扫描结构包括用于通过扫描结构从待测量的基板上的可光发射区域进行光输送和光接收的装置。光输送和接收设备可以包括具有近端和远端的光纤，其透射具有若干波长的光或具有若干变化波长的光以激发衬底样品。该光纤还可以同时接收可以通过在衬底上发荧光的样品发射的光。扫描结构还可以进一步包括用于光纤的保持器，其能够横跨待测量或检查的基板上的可变距离。支架可能包括电动扫描仪以及谐振悬挂梁。诸如激光器的光源可以光耦合到光纤的近端。并且该光源可以具有一定的波长，但是每个具有不同波长的多个光源也可以通过将光源通过波长多路复用器耦合到单个光纤中或者通过将携带不同波长的各个光纤放置在紧密的位置来同时使用彼此接近。当光通过光纤向下传输到基板时，光纤足够靠近基板微阵列，使得其也可以接收发射的荧光。

7. 发明申请

WO2010132251A3 PROTECTION OF ENCRYPTION KEYS IN A DATABASE 审中-公开
标题翻译：保护数据库中的加密密钥
公开(公告)号：WO2010132251A3
公开(公告)日：2011-01-20
申请号：PCT/US2010033699
申请日：2010-05-05
申请人： SYBASE INC , BANKS BARBARA JANE , CHITKARA RAJNISH KUMAR , CHEN SHIPING
发明人： BANKS BARBARA JANE , CHITKARA RAJNISH KUMAR , CHEN SHIPING
IPC分类号： H04L9/08 , G06F17/30 , H04L9/32
CPC分类号： G06F21/6227 , H04L9/085 , H04L9/0863 , H04L9/0891 , H04L9/0894
摘要： System, method, computer program product embodiments and combinations and sub- combinations thereof for protection of encryption keys in a database are described herein. An embodiment includes a master key and a dual master key, both of which are used to encrypt encryption keys in a database. To access encrypted data, the master key and dual master key must be supplied to a database server by two separate entities, thus requiring dual control of the master and dual master keys. Furthermore, passwords for the master and dual master keys must be supplied separately and independently, thus requiring split knowledge to access the master and dual master keys. In another embodiment, a master key and a key encryption key derived from a user password is used for dual control. An embodiment also includes supplying the secrets for the master key and dual master key through server-private files.
摘要翻译：这里描述了用于保护数据库中的加密密钥的系统，方法，计算机程序产品实施例及其组合和子组合。一个实施例包括主密钥和双主密钥，它们都用于加密数据库中的加密密钥。要访问加密数据，主密钥和双主密钥必须由两个单独的实体提供给数据库服务器，因此需要双重控制主密钥和双主密钥。此外，主主密钥和双主密钥的密码必须单独和独立提供，因此需要拆分知识才能访问主密钥和双主密钥。在另一个实施例中，将主密钥和从用户密码导出的密钥加密密钥用于双重控制。实施例还包括通过服务器专用文件提供主密钥和双主密钥的秘密。

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