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1. 发明申请

WO2009151598A1 DIAZACARBAZOLES AND METHODS OF USE 审中-公开
标题翻译： DIAZACARBAZOLES和使用方法
公开(公告)号：WO2009151598A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/003492
申请日：2009-06-10
申请人： GENENTECH, INC. , DYKE, Hazel, Joan , ELLWOOD, Charles , GANCIA, Emanuela , GAZZARD, Lewis, J. , GOODACRE, Simon, Charles , KINTZ, Samuel, S. , LYSSIKATOS, Joseph, P. , MACLEOD, Calum , WILLIAMS, Karen
发明人： DYKE, Hazel, Joan , ELLWOOD, Charles , GANCIA, Emanuela , GAZZARD, Lewis, J. , GOODACRE, Simon, Charles , KINTZ, Samuel, S. , LYSSIKATOS, Joseph, P. , MACLEOD, Calum , WILLIAMS, Karen
IPC分类号： C07D471/14 , A61K31/437 , A61P35/00
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D491/107 , C07D495/04 , C07D513/04 , C07D519/00
摘要： The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及可用作激酶抑制剂的式（I），（I-a）和（I-b）的1,7-二氮杂咔唑化合物，更具体地用作检查点激酶1（chkl）抑制剂，因此可用作癌症治疗剂。本发明还涉及包含这些化合物的组合物，更具体地是包含这些化合物的药物组合物以及使用该组合物治疗各种形式的癌症和过度增殖性疾病的方法，以及将该化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况。

2. 发明申请

WO2009151589A1 DIAZACARBAZOLES AND METHODS OF USE 审中-公开
标题翻译： DIAZACARBAZOLES和使用方法
公开(公告)号：WO2009151589A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/003481
申请日：2009-06-10
申请人： GENENTECH, INC. , DYKE, Hazel, Joan , GANCIA, Emanuela , GAZZARD, Lewis, J. , GOODACRE, Simon, Charles , LYSSIKATOS, Joseph, P. , MACLEOD, Calum , WILLIAMS, Karen
发明人： DYKE, Hazel, Joan , GANCIA, Emanuela , GAZZARD, Lewis, J. , GOODACRE, Simon, Charles , LYSSIKATOS, Joseph, P. , MACLEOD, Calum , WILLIAMS, Karen
IPC分类号： C07D471/14 , A61K31/519 , A61P35/00
CPC分类号： C07D471/14
摘要： The invention relates to 1,5-diazacarbazole compounds of Formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) and (I-h) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及有用的式（I），（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig）和（Ih）的1,5-二氮杂咔唑化合物作为激酶抑制剂，更具体地用作检查点激酶1（chk1）抑制剂，因此可用作癌症治疗剂。本发明还涉及包含这些化合物的组合物，更具体地是包含这些化合物的药物组合物以及使用该组合物治疗各种形式的癌症和过度增殖性疾病的方法，以及将该化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况。

3. 发明申请

WO2012051318A1 SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：磺酰胺化合物及其制备方法和使用方法
公开(公告)号：WO2012051318A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055987
申请日：2011-10-12
申请人： ZAFGEN CORPORATION , ZAHLER, Robert , DYKE, Hazel, Joan , PALLIN, Thomas, David , CRAMP, Susan, Mary
发明人： ZAHLER, Robert , DYKE, Hazel, Joan , PALLIN, Thomas, David , CRAMP, Susan, Mary
IPC分类号： C07D209/42 , C07D333/26 , C07D333/68 , C07D409/04 , C07D495/04 , A61K31/381 , A61K31/404 , A61P3/04
CPC分类号： C07D333/68 , C07D209/42 , C07D333/38 , C07D333/50 , C07D409/04 , C07D495/04
摘要： The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
摘要翻译：本发明提供磺酰胺化合物及其在治疗医学疾病如肥胖症中的用途。提供制备各种砜化合物的药物组合物和方法。化合物被认为具有抗甲硫氨酰氨基肽酶2的活性。

4. 发明申请

WO2007054693A1 USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS 审中-公开
标题翻译：吡咯啉化合物杀死临床微生物的用途
公开(公告)号：WO2007054693A1
公开(公告)日：2007-05-18
申请号：PCT/GB2006/004178
申请日：2006-11-08
申请人： HELPERBY THERAPEUTICS LIMITED , BECK, Petra, Helga , BROWN, Marc, Barry , CLARK, David, Edward , COATES, Anthony , DYKE, Hazel, Joan , HU, Yanmin , LONDESBROUGH, Derek, John , MILLS, Keith , PALLIN, Thomas, David , REID, Gary, Patrick , STODDART, Gerlinda
发明人： BECK, Petra, Helga , BROWN, Marc, Barry , CLARK, David, Edward , COATES, Anthony , DYKE, Hazel, Joan , HU, Yanmin , LONDESBROUGH, Derek, John , MILLS, Keith , PALLIN, Thomas, David , REID, Gary, Patrick , STODDART, Gerlinda
IPC分类号： A61K31/4439 , C07D471/04
CPC分类号： A61K31/4709 , A01N43/90 , A61K31/43 , A61K31/4439 , A61K31/4706 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/497 , A61K31/546 , A61K31/7052 , A61L2/0088 , C07D471/04 , Y02A50/401 , Y02A50/404 , Y02A50/406 , Y02A50/411 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/483
摘要： There is provided the use of compounds of formula (I), wherein R 1 R 2 R 3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula (I) for treating microbial infections, as well as certain compounds of formula (I) per se .
摘要翻译：提供式（I）化合物的用途，其中R 1，R 2，R 3和X具有说明书中给出的含义，用于制备用于杀死临床潜在微生物的药物。还提供了式（I）化合物用于治疗微生物感染的用途，以及某些式（I）化合物本身。

5. 发明申请

WO2005075469A1 THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY 审中-公开
标题翻译：噻唑 - 羟肟酸和噻二唑 - 羟肟酸，以及其用于治疗与HISTONE脱乙酰酶活性相关的疾病的用途
公开(公告)号：WO2005075469A1
公开(公告)日：2005-08-18
申请号：PCT/GB2005/000282
申请日：2005-01-27
申请人： ARGENTA DISCOVERY LIMITED , BORDOGNA, Walter , SUTTON, Jonathan, Mark , HYND, George , DYKE, Hazel, Joan , PRICE, Stephen , HARRIS, Neil, Victor , GILL, Mathew, Iain, Andrew
发明人： BORDOGNA, Walter , SUTTON, Jonathan, Mark , HYND, George , DYKE, Hazel, Joan , PRICE, Stephen , HARRIS, Neil, Victor , GILL, Mathew, Iain, Andrew
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： A compound of formula: (I) in which A represents optionally substituted monocyclic heteroaryl or phenyl; B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl, or B represents H when L represents a single bond; L represents a single bond, alkylene, (CH 2 ) n X(CH 2 ) m , (CH2) n X(CH 2 ) p Y(CH 2 ) m ; Q represents N or CR 2 ; T represents N or CR 2 , provided that Q and T do not both represent CR 2 simultaneously; X represents -O-, -NR 3 -, -CO-, -SO 2 -, -NR 3 C0-, -NR 3 SO 2 -, -CONR 3 -, -SO 2 NR 3 -, -NR 1 CONR 1 -; Y represents -NR 3 - or -O-; R l represents H or alkyl; R 2 represents hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, CN; R 3 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR 4 , -NR 5 R 6 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -CONR 5 R 6 or -SO 2 NR 5 R 6 ; R 4 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R 5 represents H or alkyl; R 6 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR 5 R 6 represents a cyclic amine; R 7 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; n represents 0-3; m represents 0-3; p represents 1-3; and corresponding N-oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.
摘要翻译：式（I）的化合物，其中A表示任选取代的单环杂芳基或苯基; B表示任选取代的杂芳基，芳基，芳基稠合 - 杂环烷基，杂芳基 - 稠合环烷基，杂芳基 - 稠合 - 杂环烷基或芳基 - 稠合环烷基，或当L表示单键时，B表示H; L表示单键，亚烷基，（CH 2）n X（CH 2）m，（CH 2）n X（CH 2）p Y（CH 2）m; Q表示N或CR 2; T表示N或CR 2，条件是Q和T不同时同时表示CR 2; X代表-O - ， - NR 3 - ， - CO - ， - SO 2 - ， - NR 3 C 0 - ， - NR 3 SO 2 - ， - CONR 3 - ， - SO 2 NR 3 - ，-NR 1 CONR 1 - ; Y表示-NR 3 - 或-O-; R 1表示H或烷基; R 2表示氢，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，CN; R 3表示H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基或被-OR 4取代的烷基，-NR 5 R 6，-NR 6 COR 7， 6 SO 2 R 7，-CONR 5 R 6或-SO 2 NR 5 R 6; R 4表示H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基，芳基，杂芳基，杂环烷基或环烷基; R 5表示H或烷基; R 6代表H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基，芳基，杂芳基，杂环烷基或环烷基或NR 5 R 6表示环状胺; R 7表示烷基，芳基，杂芳基，环烷基，杂环烷基，芳烷基，杂芳基烷基，环烷基烷基或杂环烷基烷基; n表示0-3; m表示0-3; p表示1-3; 及其相应的N-氧化物，其药学上可接受的盐，溶剂合物和前药; 并且用于治疗组蛋白脱乙酰酶的抑制可以预防，抑制或改善疾病的病理学和/或症状学的疾病。

6. 发明申请

WO2005075466A1 SUBSTITUTED THIENYL-MERCAPTOKETONES, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY 审中-公开
标题翻译：取代的三烯酰基甜菜碱及其用于治疗与组织脱乙酰酶酶活性相关的疾病
公开(公告)号：WO2005075466A1
公开(公告)日：2005-08-18
申请号：PCT/GB2005/000283
申请日：2005-01-27
申请人： ARGENTA DISCOVERY LIMITED , BORDOGNA, Walter , BULL, Richard , SUTTON, Jonathon, Mark , SMITH, Helen, Katherine , DYKE, Hazel, Joan , PRICE, Stephen , HARRIS, Neil, Victor
发明人： BORDOGNA, Walter , BULL, Richard , SUTTON, Jonathon, Mark , SMITH, Helen, Katherine , DYKE, Hazel, Joan , PRICE, Stephen , HARRIS, Neil, Victor
IPC分类号： C07D409/04
CPC分类号： C07D409/04
摘要： A compound of formula: (I): in which A represents optionally substituted monocyclic heteroaryl or phenyl; B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl, or B represents H when L represents a single bond; L represents a single bond, alkylene, (CH 2 ) n X(CH 2 ) m , (CH 2 ) n X(CH 2 ) p Y(CH 2 ) m ; X represents -O-, -NR 3 -, -CO-, -SO 2 -, -NR 3 CO-, -NR 3 SO 2 -, -CONR 3 -, -SO 2 NR 3 -, -NR 5 CONR 5a -; Y represents NR 3 - or -O-; R 1 represents H, COR 8 ; R 2 represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, CN; R 3 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR 4 , -NR 5 R 6 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -CONR 5 R 6 or -SO 2 NR 5 R 6 ; R 4 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R 5 and R 5a represent H or alkyl; R 6 represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR 5 R 6 represents a cyclic amine; R 7 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; R 8 represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; n represents 0-3; m represents 0-3; p represents 1-3; and corresponding disulphides, N -oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.
摘要翻译：式（I）的化合物：其中A表示任选取代的单环杂芳基或苯基; B表示任选取代的杂芳基，芳基，芳基稠合 - 杂环烷基，杂芳基 - 稠合环烷基，杂芳基 - 稠合 - 杂环烷基或芳基 - 稠合环烷基，或当L表示单键时，B表示H; L表示单键，亚烷基，（CH 2）n X（CH 2）m，（CH 2）n X（CH 2）p Y（CH 2）m; X表示-O - ， - NR 3 - ， - CO - ， - SO 2 - ， - NR 3 CO - ， - NR 3 SO 2 - ， - CONR 3 - ， - SO 2 NR 3 - ，-NR 5 CONR 5a - ; Y表示NR 3 - 或-O-; R 1表示H，COR 8; R 2表示卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，CN; R 3表示H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基或被-OR 4取代的烷基，-NR 5 R 6，-NR 6 COR 7， 6 SO 2 R 7，-CONR 5 R 6或-SO 2 NR 5 R 6; R 4表示H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基，芳基，杂芳基，杂环烷基或环烷基; R 5和R 5a代表H或烷基; R 6代表H，烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，环烷基烷基，芳基，杂芳基，杂环烷基或环烷基或NR 5 R 6表示环状胺; R 7表示烷基，芳基，杂芳基，环烷基，杂环烷基，芳烷基，杂芳基烷基，环烷基烷基或杂环烷基烷基; R 8表示烷基，芳基，杂芳基，环烷基，杂环烷基，芳基烷基，杂芳基烷基，环烷基烷基或杂环烷基烷基; n表示0-3; m表示0-3; p表示1-3; 和相应的二硫化物，N-氧化物，其药学上可接受的盐，溶剂化物和前药; 并且用于治疗组蛋白脱乙酰酶的抑制可以预防，抑制或改善疾病的病理学和/或症状学的疾病。

7. 发明申请

WO2003087071A1 SULFONAMIDE DERIVATIVES 审中-公开
标题翻译：磺酰胺衍生物
公开(公告)号：WO2003087071A1
公开(公告)日：2003-10-23
申请号：PCT/GB2003/001418
申请日：2003-04-01
申请人： CELLTECH R & D LIMITED , HAUGHAN, Alan, Findlay , DYKE, Hazel, Joan , WILLIAMS, Sophie, Caroline , LOWE, Christopher , DRAFFAN, Alistair, George , OWEN, David, Alan
发明人： HAUGHAN, Alan, Findlay , DYKE, Hazel, Joan , WILLIAMS, Sophie, Caroline , LOWE, Christopher , DRAFFAN, Alistair, George , OWEN, David, Alan
IPC分类号： C07D275/04
CPC分类号： C07D275/04 , C07D417/12 , C07D417/14 , C07D491/10
摘要： Sulfonamide derivatives of formula (1) are described wherein X is an O or S atom; Y is an 0 or S atom; A is a group -S0 2 NR 1 R 2 ; m is zero or the integer 1; n is zero or the integer 1; provided that at least one but not both of m and n are the integer 1; R 3 is a hydrogen atom or an alkyl or cycloalkyl group; and the salts, solvates, hydrates, tautomers, isomers, N-oxides thereof. The compounds are potent inhibitors of IMPDH and are of use as immunosuppressants, anti-cancer agents, anti-inflammatory agents, antipsoriatic and anti-viral agents.
摘要翻译：描述了式（1）的磺酰胺衍生物，其中X是O或S原子; Y是0或S原子; A是-SO 2 NR 1 R 2基团; m为零或整数1; n为零或整数1; 条件是m和n中的至少一个不是二者都是整数1; R 3是氢原子或烷基或环烷基; 及其盐，溶剂合物，水合物，互变异构体，异构体，N-氧化物。这些化合物是IMPDH的有效抑制剂，可用作免疫抑制剂，抗癌剂，抗炎剂，抗牛皮癣和抗病毒剂。

8. 发明申请

WO2003014101A1 HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：羟基酸衍生物
公开(公告)号：WO2003014101A1
公开(公告)日：2003-02-20
申请号：PCT/GB2002/003656
申请日：2002-08-07
申请人： CELLTECH R & D LIMITED , DYKE, Hazel, Joan , WATSON, Robert, John
发明人： DYKE, Hazel, Joan , WATSON, Robert, John
IPC分类号： C07D309/08
CPC分类号： C07D405/12
摘要： A compound of formula (I) wherein : R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one of R?1 ¿or R 2 is a hydrogen atom the other is a CF 3 , CF 2 H or CFH 2 group ; and the salts, solvates or hydrates thereof. The compounds are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. The compounds may be expected to be of use in medicine, especially where the avoidance of side effects such as joint pain is desired.
摘要翻译：式（I）化合物其中：R 1和R 2可以相同或不同，各自为氢原子或CF 3，CF 2 H或CFH 2基团，条件是当R 1或R 2中的一个为一个氢原子另一个是CF 3，CF 2 H或CFH 2基团; 及其盐，溶剂合物或水合物。这些化合物是有效的MMP抑制剂，其有利地不会在相关动物模型中引起腱炎。预期该化合物可用于医药，特别是在需要避免副作用如关节疼痛的地方。

9. 发明申请

WO2012154676A9 PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2012154676A9
公开(公告)日：2012-11-15
申请号：PCT/US2012/036789
申请日：2012-05-07
申请人： ZAFGEN INC. , CRAMP, Susan, Mary , DYKE, Hazel, Joan , PALLIN, Thomas, David , ZAHLER, Robert
发明人： CRAMP, Susan, Mary , DYKE, Hazel, Joan , PALLIN, Thomas, David , ZAHLER, Robert
IPC分类号： C07D311/94 , C07D405/02 , C07D491/048 , C07D493/04 , A61K31/352 , A61K31/335 , A61K31/4355 , A61K31/397 , A61K31/4025 , A61P3/04
摘要： The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

10. 发明申请

WO2005035521A1 SUBSTITUTED QUINOLINES AS MCR MODULATORS 审中-公开
标题翻译：作为MCR调制器的替代金刚石
公开(公告)号：WO2005035521A1
公开(公告)日：2005-04-21
申请号：PCT/GB2004/004304
申请日：2004-10-11
申请人： ARGENTA DISCOVERY LTD. , DYKE, Hazel, Joan , CRAMP, Susan, Mary , WREN, Stephen, Paul , NEWTON, Christopher, Gregory
发明人： DYKE, Hazel, Joan , CRAMP, Susan, Mary , WREN, Stephen, Paul , NEWTON, Christopher, Gregory
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04
摘要： Quinolines of formula (I) are useful as MCH mediators, and in the therapy of obesity.
摘要翻译：式（I）的喹啉可用作MCH介质和用于肥胖症的治疗。

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