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1. 发明申请

WO1996031476A1 AROMATIC HYDROXYETHERS 审中-公开
标题翻译：芳香羟基
公开(公告)号：WO1996031476A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000854
申请日：1996-04-04
申请人： RHONE-POULENC RORER LIMITED , COX, Paul, Joseph , NEWTON, Christopher, Gregory , PALFREYMAN, Malcolm, Norman
发明人： RHONE-POULENC RORER LIMITED
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07D213/61 , C07D213/81 , C07D213/89
摘要： This invention is directed to physiologically active compounds of formula (I), wherein R is optionally substituted alkyl, R is optionally substituted aryl or heteroaryl, A is cycloalkyloxy, cycloalkylalkoxy or alkoxy carrying one or more hydroxy moieties, the cycloalkyl moieties optionally further substituted by one or more methylene or lower alkyl groups, Q , Q and Q each represents CH or CX or nitrogen, Z is oxygen or sulphur, Z is an NH or methylene and X is halogen and N-oxides thereof, and their esters, and prodrugs, pharmaceutically acceptable salts, and solvates (e.g. hydrates), thereof. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions containing compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译：本发明涉及式（I）的生理活性化合物，其中R 1是任选取代的烷基，R 2是任选取代的芳基或杂芳基，A是环烷氧基，环烷基烷氧基或含有一个或多个羟基部分的烷氧基，任选进一步被一个或多个亚甲基或低级烷基取代的环烷基部分，Q 1，Q 2和Q 3各自表示CH或CX或氮，Z 1为氧或硫，Z 2为氧或硫，是NH或亚甲基，X是卤素及其N-氧化物及其酯及其前药，药学上可接受的盐和溶剂合物（例如水合物）。这些化合物抑制TNF的产生或生理作用并抑制环AMP磷酸二酯酶。本发明还涉及含有式（I）化合物的药物组合物，其药物用途及其制备方法。

2. 发明申请

WO1991010672A1 PYRAN DERIVATIVES 审中-公开
标题翻译：派兰衍生物
公开(公告)号：WO1991010672A1
公开(公告)日：1991-07-25
申请号：PCT/EP1991000012
申请日：1991-01-07
申请人： RHONE-POULENC RORER S.A. , CLARK, Stanley, Frederick , JONES, Ronald, Henry , NEWTON, Christopher, Gregory
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07H15/04
CPC分类号： C07H5/02 , C07H15/04 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein R represents alkyl, R represents an acid-labile protecting group and X represents a halogen atom, which are useful in the synthesis of mevalonic acid derivatives.
摘要翻译：本发明提供式（I）化合物，其中R 1表示烷基，R 2表示酸不稳定保护基，X 1表示卤素原子，它们可用于合成甲羟戊酸衍生物。

3. 发明申请

WO2005035521A1 SUBSTITUTED QUINOLINES AS MCR MODULATORS 审中-公开
标题翻译：作为MCR调制器的替代金刚石
公开(公告)号：WO2005035521A1
公开(公告)日：2005-04-21
申请号：PCT/GB2004/004304
申请日：2004-10-11
申请人： ARGENTA DISCOVERY LTD. , DYKE, Hazel, Joan , CRAMP, Susan, Mary , WREN, Stephen, Paul , NEWTON, Christopher, Gregory
发明人： DYKE, Hazel, Joan , CRAMP, Susan, Mary , WREN, Stephen, Paul , NEWTON, Christopher, Gregory
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04
摘要： Quinolines of formula (I) are useful as MCH mediators, and in the therapy of obesity.
摘要翻译：式（I）的喹啉可用作MCH介质和用于肥胖症的治疗。

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