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1. 发明申请

WO2003014101A1 HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：羟基酸衍生物
公开(公告)号：WO2003014101A1
公开(公告)日：2003-02-20
申请号：PCT/GB2002/003656
申请日：2002-08-07
申请人： CELLTECH R & D LIMITED , DYKE, Hazel, Joan , WATSON, Robert, John
发明人： DYKE, Hazel, Joan , WATSON, Robert, John
IPC分类号： C07D309/08
CPC分类号： C07D405/12
摘要： A compound of formula (I) wherein : R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one of R?1 ¿or R 2 is a hydrogen atom the other is a CF 3 , CF 2 H or CFH 2 group ; and the salts, solvates or hydrates thereof. The compounds are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. The compounds may be expected to be of use in medicine, especially where the avoidance of side effects such as joint pain is desired.
摘要翻译：式（I）化合物其中：R 1和R 2可以相同或不同，各自为氢原子或CF 3，CF 2 H或CFH 2基团，条件是当R 1或R 2中的一个为一个氢原子另一个是CF 3，CF 2 H或CFH 2基团; 及其盐，溶剂合物或水合物。这些化合物是有效的MMP抑制剂，其有利地不会在相关动物模型中引起腱炎。预期该化合物可用于医药，特别是在需要避免副作用如关节疼痛的地方。

2. 发明申请

WO2003070242A1 PIPERIDIN-4-YL UREA DERIVATIVES AND RELATED COMPOUNDS AS CHEMOKINE RECEPTOR INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译：作为用于治疗炎症性疾病的化学受体抑制剂的哌啶-4-氨基脲衍生物及相关化合物
公开(公告)号：WO2003070242A1
公开(公告)日：2003-08-28
申请号：PCT/GB2003/000720
申请日：2003-02-19
申请人： CELLTECH R & D LIMITED , WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , CHRISTIE, Mark, Ian , OWEN, David, Alan
发明人： WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , CHRISTIE, Mark, Ian , OWEN, David, Alan
IPC分类号： A61K31/4468
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D409/12
摘要： Cyclic amino derivatives of formula (1) are described: (1) wherein: m and n, which may be the same or different, is each zero or the integer 1 or 2; AIk 3 is a covalent bond or a straight or branched C 1-6 alkylene chain; R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a straight or branched C 1-6 alkyl group; D is an optionally substituted aromatic or heteroaromatic group; E is an optionally substituted C 7-10 cycloalkyl, C 7-10 cycloalkenyl or C 7-10 polycycloaliphatic group; and the salts, solvates, hydrates, tautomers or N-oxides thereof. The compounds are potent and selective modulators of the interaction between CXCR3 and its chemokine ligands and are thus of use in medicine, for example in the prevention or treatment of conditions involving inappropriate T-cell trafficking such as certain inflammatory, autoimmune and immunoregulatory disorders as described hereinafter.
摘要翻译：描述式（1）的环状氨基衍生物：（1）其中：m和n可以相同或不同，分别为零或整数1或2; Alk3是共价键或直链或支链C 1-6亚烷基链; R 1和R 2可以相同或不同，分别为氢原子或直链或支链C 1-6烷基; D是任选取代的芳族或杂芳族基团; E是任选取代的C7-10环烷基，C7-10环烯基或C7-10多环脂族基团; 及其盐，溶剂化物，水合物，互变异构体或N-氧化物。这些化合物是CXCR3与其趋化因子配体之间相互作用的有效和选择性调节剂，因此可用于医学中，例如用于预防或治疗涉及不适当的T细胞运输的病症，例如所述的某些炎症，自身免疫和免疫调节性疾病以下。

3. 发明申请

WO2005003127A1 BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF CXCR3 FUNCTION 审中-公开
标题翻译：作为CXCR3功能的调节剂的双相异构体衍生物
公开(公告)号：WO2005003127A1
公开(公告)日：2005-01-13
申请号：PCT/GB2004/002735
申请日：2004-06-25
申请人： CELLTECH R & D LIMITED , OWEN, David, Alan , WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , ALLEN, Daniel, Rees
发明人： OWEN, David, Alan , WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , ALLEN, Daniel, Rees
IPC分类号： C07D413/12
CPC分类号： C07D401/12 , C07D413/12 , C07D417/12
摘要： A class of 1-substituted 4-(benzothiazol-2-ylamino) piperidine derivatives and related heterocyclic compounds, being potent and selective modulators of the interaction between CXCR3 and its chemokine ligands, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immunoregulatory disorders.
摘要翻译：一类1-取代的4-（苯并噻唑-2-基氨基）哌啶衍生物和相关的杂环化合物是CXCR3与其趋化因子配体之间相互作用的有效和选择性调节剂，因此可用于治疗和/或预防病症涉及不适当的T细胞运输，包括炎症，自身免疫和免疫调节性疾病。

4. 发明申请

WO2004094381A1 CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 审中-公开
标题翻译：作为化合物受体的调节剂的循环季铵氨基转移酶
公开(公告)号：WO2004094381A1
公开(公告)日：2004-11-04
申请号：PCT/GB2004/001559
申请日：2004-04-08
申请人： CELLTECH R & D LIMITED , WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , OWEN, David, Alan
发明人： WATSON, Robert, John , MEISSNER, Johannes, Wilhelm, Georg , OWEN, David, Alan
IPC分类号： C07D211/58
CPC分类号： C07D409/12 , C07D211/58
摘要： Compounds of formula (1) wherein,m,n,R 1 ,R 2 ,R a ,ALK 3 , E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.
摘要翻译：式（1）的化合物，其中m，n，R 1，R 2，R a，ALK 3，E和Y如权利要求中所定义，是趋化因子结合的有效和选择性抑制剂 CXCR3受体相应地用于治疗和/或预防涉及不适当的T细胞运输的病症，包括炎性，自身免疫和非前路外疾病如类风湿性关节炎。

5. 发明申请

WO2008074445A1 NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：新型三聚异戊二烯衍生物，其制备方法及其药物组合物
公开(公告)号：WO2008074445A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/011061
申请日：2007-12-17
申请人： UCB PHARMA, S.A. , WATSON, Robert, John , HANNAH, Duncan , PEGURIER, Cécile , MEISSNER, Johannes, Wilhelm, Georg , OWEN, David , GALVIN, Frances
发明人： WATSON, Robert, John , HANNAH, Duncan , PEGURIER, Cécile , MEISSNER, Johannes, Wilhelm, Georg , OWEN, David , GALVIN, Frances
IPC分类号： C07D239/70 , C07D491/04 , A61K31/517 , A61K31/519 , A61P29/00
CPC分类号： C07D239/70 , C07D491/04
摘要： The present invention concerns novel tricyclic and heterotricyclic derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
摘要翻译：本发明涉及新型三环和异三环衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。

6. 发明申请

WO2008031556A2 NOVEL 2 AMINO-PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：新型二氨基吡啶衍生物，其制备方法及其药物组合物
公开(公告)号：WO2008031556A2
公开(公告)日：2008-03-20
申请号：PCT/EP2007/007898
申请日：2007-09-11
申请人： UCB PHARMA, S.A. , RAPHY, Gilles , WATSON, Robert, John , HANNAH, Duncan , PEGURIER, Cécile , ORTMANS, Isabelle , LOCK, Christopher, James , KNIGHT, Roland, Laurence , OWEN, David, Alan
发明人： RAPHY, Gilles , WATSON, Robert, John , HANNAH, Duncan , PEGURIER, Cécile , ORTMANS, Isabelle , LOCK, Christopher, James , KNIGHT, Roland, Laurence , OWEN, David, Alan
IPC分类号： C07D239/48 , C07D471/04 , C07D401/04 , C07D401/12 , C07D401/14 , A61P19/00 , A61K31/506
CPC分类号： C07D403/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D451/02 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10
摘要： The present invention concerns novel 2 amino pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
摘要翻译：本发明涉及新型2氨基嘧啶衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。

7. 发明申请

WO2005080713A1 LEVER HANDLE DOOR FURNITURE 审中-公开
标题翻译： LEVER手柄门家具
公开(公告)号：WO2005080713A1
公开(公告)日：2005-09-01
申请号：PCT/AU2005/000152
申请日：2005-02-08
申请人： ASSA ABLOY AUSTRALIA PTY LIMITED , NEWMAN, Donald, John , WATSON, Robert, John
发明人： NEWMAN, Donald, John , WATSON, Robert, John
IPC分类号： E05B1/00
CPC分类号： E05B3/065 , E05B3/00 , E05B63/0056 , Y10S292/61 , Y10T70/5832 , Y10T292/82 , Y10T292/85
摘要： A handle assembly comprises a handle (10), a handle spigot (11) to which the handle is attached, biasing means (13) to bias the handle (10) to a closed position, an operating plate (14) which is rotatable by the handle spigot (11), a mounting stock (15), and a housing (12), the spigot (11), biasing means (13), operating plate (14) and a majority of the mounting stock being positioned within the housing (12), the mounting stock (15) being securable to the housing (12) to hold all said the components within the housing (12). In this manner, the handle assembly can be made as a "complete" unit with all the internal components being in position and with the handle (10) being rotatably attached relative to the housing (12). Thus, no separate rose is required. Another advantage is that the unit can be assembled using a substantially concealed fixing arrangement to improve security and also to improve the aesthetic appeal of the assembly.
摘要翻译：手柄组件包括手柄（10），手柄连接到的手柄插口（11），用于将手柄（10）偏置到关闭位置的偏置装置（13），可旋转的操作板（14）手柄插头（11），安装件（15）和外壳（12），插口（11），偏置装置（13），操作板（14），大部分安装件定位在壳体（12），所述安装件（15）可固定到所述壳体（12）以将所有所述部件保持在所述壳体（12）内。以这种方式，手柄组件可以制成为“完整”单元，其中所有内部部件都在适当位置，并且手柄（10）相对于壳体（12）可旋转地附接。因此，不需要单独的玫瑰。另一个优点是可以使用基本上隐藏的固定装置来组装该单元以提高安全性并且还提高组件的美学吸引力。

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