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1. 发明申请

WO0185780A8 NUCLEIC ACID BINDING POLYPEPTIDES 审中-公开
标题翻译：核酸结合多肽
公开(公告)号：WO0185780A8
公开(公告)日：2002-03-21
申请号：PCT/GB0102017
申请日：2001-05-08
申请人： GENDAQ LTD , CHOO YEN , DEMAISON CHRISTOPHE , MOORE MICHAEL , PAPWORTH MONIKA ANNA , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER GRAEME , ISALAN MARK
发明人： CHOO YEN , DEMAISON CHRISTOPHE , MOORE MICHAEL , PAPWORTH MONIKA ANNA , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER GRAEME , ISALAN MARK
IPC分类号： C07K14/47 , C12N15/10
CPC分类号： C12N15/1055 , C07K14/4702
摘要： We disclose a polypeptide capable of binding to a nucleic acid comprising a viral nucleotide sequence. Preferably, the viral nucleotide sequence comprises a viral promoter sequence, for example, an HIV promoter or a herpesvirus promoter sequence.
摘要翻译：我们公开了能够结合包含病毒核苷酸序列的核酸的多肽。优选地，病毒核苷酸序列包含病毒启动子序列，例如HIV启动子或疱疹病毒启动子序列。

2. 发明申请

WO0185780A3 NUCLEIC ACID BINDING POLYPEPTIDES 审中-公开
标题翻译：核酸结合多肽
公开(公告)号：WO0185780A3
公开(公告)日：2002-09-06
申请号：PCT/GB0102017
申请日：2001-05-08
申请人： GENDAQ LTD , CHOO YEN , DEMAISON CHRISTOPHE , MOORE MICHAEL , PAPWORTH MONIKA ANNA , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER GRAEME , ISALAN MARK
发明人： CHOO YEN , DEMAISON CHRISTOPHE , MOORE MICHAEL , PAPWORTH MONIKA ANNA , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER GRAEME , ISALAN MARK
IPC分类号： C07K14/47 , C12N15/10 , A61K38/17 , A61P31/12 , C12N15/12
CPC分类号： C12N15/1055 , C07K14/4702
摘要： We disclose a polypeptide capable of binding to a nucleic acid comprising a viral nucleotide sequence. Preferably, the viral nucleotide sequence comprises a viral promoter sequence, for example, an HIV promoter or a herpesvirus promoter sequence.
摘要翻译：我们公开了能够与包含病毒核苷酸序列的核酸结合的多肽。优选地，病毒核苷酸序列包含病毒启动子序列，例如HIV启动子或疱疹病毒启动子序列。

3. 发明申请

WO02057308A3 ZINC FINGER POLYPEPTIDES AND THEIR USE 审中-公开
标题翻译： ZINC指纹聚合物及其使用
公开(公告)号：WO02057308A3
公开(公告)日：2003-02-06
申请号：PCT/GB0200246
申请日：2002-01-22
申请人： SANGAMO BIOSCIENCES INC , MOORE MICHAEL , ISALAN MARK , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER , GIRDLESTONE JOHN , DEMAISON CHRISTOPHE , CHOO YEN
发明人： MOORE MICHAEL , ISALAN MARK , REYNOLDS LINDSEY , ULLMAN CHRISTOPHER , GIRDLESTONE JOHN , DEMAISON CHRISTOPHE , CHOO YEN
IPC分类号： A61K38/00 , C07K14/47 , C12N15/62 , C12Q1/68
CPC分类号： C07K14/4703 , A61K38/00
摘要： Polypeptides comprising a zinc finger motif having the consensus sequence: X0-2CX1-5CX2-7XXXXXXXHX3-6H/C and their use to modulate the transcription of a nucleotide sequence encoding a receptor.
摘要翻译：包含具有共有序列的锌指基序的多肽：X0-2CX1-5CX2-7XXXXXXXHX3-6H / C及其用于调节编码受体的核苷酸序列的转录的用途。

4. 发明申请

WO02099084A9 COMPOSITE BINDING POLYPEPTIDES 审中-公开
标题翻译：复合结合聚合物
公开(公告)号：WO02099084A9
公开(公告)日：2004-12-16
申请号：PCT/US0222272
申请日：2002-04-04
申请人： GENDAQ LTD , MOORE MICHAEL , SEPP ARMIN , ISALAN MARK , CHOO YEN
发明人： MOORE MICHAEL , SEPP ARMIN , ISALAN MARK , CHOO YEN
IPC分类号： C07K14/00 , C07K14/47 , C07K19/00 , A61K38/00 , C07K1/00 , C07K17/00
CPC分类号： C07K14/001 , C07K14/4703 , C07K19/00 , C07K2299/00 , C07K2319/00
摘要： Disclosed herein are polypeptides with novel DNA binding specificities, constructed from combinations of zinc fingers, and methods for their preparation and use.
摘要翻译：本文公开了具有新的DNA结合特异性的多肽，其由锌指的组合构成，以及用于其制备和使用的方法。

5. 发明申请

WO0153478A9 REGULATED GENE EXPRESSION IN PLANTS, PROMOTER SYSTEMS FOR USE THEREIN AND METHODS OF USE THEREOF 审中-公开
标题翻译：植物中调控的基因表达，用于其中的启动子系统及其使用方法
公开(公告)号：WO0153478A9
公开(公告)日：2001-11-08
申请号：PCT/US0102051
申请日：2001-01-22
申请人： GENDAQ LTD , UNIV ROCKEFELLER , CHOO YEN , ULLMAN CHRISTOPHER GRAEME , CHUA NAM , SANCHEZ JUAN PABLO
发明人： CHOO YEN , ULLMAN CHRISTOPHER GRAEME , CHUA NAM , SANCHEZ JUAN PABLO
IPC分类号： C12N15/82 , C12N15/00
CPC分类号： C12N15/8238 , C12N15/8216
摘要： A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to the target DNA and modulates transcription of the coding sequence.
摘要翻译：提供了从包含与编码序列可操作地连接的靶DNA的DNA序列调节植物细胞中的转录的方法，所述方法包括在所述植物细胞中引入工程化锌指多肽，所述多肽与靶DNA结合并调节编码序列。

6. 发明申请

WO0153478A3 METHODS FOR REGULATING TRANSCRIPTION IN PLANTS BY INTRODUCTION OF ENGIREED ZINC FINGER POLYPEPTIDES 审中-公开
标题翻译：通过介绍ZINC指纹多孔介质调节植物转录的方法
公开(公告)号：WO0153478A3
公开(公告)日：2002-02-21
申请号：PCT/US0102051
申请日：2001-01-22
申请人： GENDAQ LTD , UNIV ROCKEFELLER , CHOO YEN , ULLMAN CHRISTOPHER GRAEME , CHUA NAM , SANCHEZ JUAN PABLO
发明人： CHOO YEN , ULLMAN CHRISTOPHER GRAEME , CHUA NAM , SANCHEZ JUAN PABLO
IPC分类号： C12N15/82 , C12N5/14
CPC分类号： C12N15/8238 , C12N15/8216
摘要： A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to the target DNA and modulates transcription of the coding sequence.
摘要翻译：提供了一种从包含与编码序列可操作地连接的靶DNA的DNA序列调节植物细胞中的转录的方法，该方法包括在所述植物细胞中引入工程化锌指多肽，该多肽与靶DNA结合并调节转录编码序列。

7. 发明申请

WO0153479A3 MOLECULAR SWITCHES II 审中-公开
标题翻译：分子开关II
公开(公告)号：WO0153479A3
公开(公告)日：2002-01-31
申请号：PCT/GB0100187
申请日：2001-01-18
申请人： SANGAMO BIOSCIENCES INC , CHOO YEN , ULLMAN CHRISTOPHER GRAEME , MOORE MICHAEL
发明人： CHOO YEN , ULLMAN CHRISTOPHER GRAEME , MOORE MICHAEL
IPC分类号： C07K14/47 , C12N15/10 , C12N15/82 , C40B40/02 , A01H5/00 , C07K16/00 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C40B40/02 , C07K14/4703 , C07K2319/71 , C07K2319/81 , C12N15/1037 , C12N15/1055 , C12N15/8217 , C12N15/8238
摘要： A method of selecting one or more components of a switching system, the switching system comprising: (i) a first molecule and (ii) a second molecule, in which the first molecule binds to the second molecule in a manner modulatable by a ligand, and (iii) a ligand, the method comprising the steps of: (a) determining the degree of binding between a candidate first molecule and a candidate second molecule in the presence of a candidate ligand; (b) determining the degree of binding between the candidate first molecule and the candidate second molecule in the absence of the candidate ligand; and (c) identifying a first molecule / second molecule pair in which the binding of the first molecule to the second molecule differs in the presence and absence of a ligand; and (d) optionally isolating and/or identifying first molecule, the second molecule or the ligand.
摘要翻译：一种选择交换系统的一个或多个组件的方法，所述交换系统包括：（i）第一分子和（ii）第二分子，其中所述第一分子以可配位体的方式与所述第二分子结合，和（iii）配体，所述方法包括以下步骤：（a）在候选配体存在下测定候选第一分子与候选第二分子之间的结合度; （b）在不存在候选配体的情况下确定候选第一分子与候选第二分子之间的结合程度; 和（c）鉴定第一分子/第二分子对，其中第一分子与第二分子的结合在配体存在和不存在的情况下不同; 和（d）任选地分离和/或鉴定第一分子，第二分子或配体。

8. 发明申请

WO0125417A3 DNA LIBRARY AND ITS USE IN METHODS OF SELECTING AND DESIGNING POLYPEPTIDES 审中-公开
标题翻译： DNA图书馆及其在选择和设计多糖方法中的应用
公开(公告)号：WO0125417A3
公开(公告)日：2001-11-15
申请号：PCT/GB0003765
申请日：2000-10-02
申请人： GENDAQ LTD , CHOO YEN , KLUG AARON
发明人： CHOO YEN , KLUG AARON
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1055 , C12N15/1048
摘要： A library is provided of DNA sequences consisting of 4 sequences, where N is greater than or equal to three, each sequence varying from the other sequences by comprising a different one of the 4 possible permutations of a DNA sequence of length N, wherein the library of DNA sequences is immobilised on a solid substrate. Preferably, each sequence occupies a discrete position, and preferably, the library is arranged in two or more sub-libraries, preferably 4N sub-libraries, wherein for any one sub-library one base in the DNA sequence of length N is defined and the other N-1 bases are randomised. The library may be used in screening methods to identify and characterise zinc fingers having specificity for particular nucleotide sequences.
摘要翻译：提供由4个N序列组成的DNA序列的文库，其中N大于或等于3个，每个序列从其他序列变化，包括不同的4个可能的排列的DNA序列长度为N，其中将DNA序列文库固定在固体基质上。优选地，每个序列占据离散位置，并且优选地将文库排列在两个或更多个子文库中，优选4N子文库，其中对于任何一个子文库，定义长度为N的DNA序列中的一个碱基，并且其他N-1碱基是随机的。该文库可用于筛选方法以鉴定和表征具有特定核苷酸序列特异性的锌指。

9. 发明申请

WO0204488A2 NUCLEIC ACID BINDING POLYPEPTIDES 审中-公开
标题翻译：核酸结合多肽
公开(公告)号：WO0204488A2
公开(公告)日：2002-01-17
申请号：PCT/GB0103130
申请日：2001-07-12
申请人： SANGAMO BIOSCIENCES INC , UNIV CAMBRIDGE TECH , CHOO YEN , ISALAN MARK , LIU XIAOHAI , PATEL SACHIN , BALASUBRAMANIAN SHANKAR
发明人： CHOO YEN , ISALAN MARK , LIU XIAOHAI , PATEL SACHIN , BALASUBRAMANIAN SHANKAR
IPC分类号： C07K14/47 , C12N15/12 , C07K14/00
CPC分类号： A61K38/1709 , C07K14/4702 , C07K2319/00
摘要： We describe the use of a nucleic acid binding polypeptide capable of binding to one or more of telomeric, G-quadruplex, or G-quartet nucleic acid as an inhibitor of enzymatic activity, including a telomerase activity, a polymerase activity, an integrase activity and a gp120 activity. Telomerase assays as well as methods of identifying molecules capable of interacting with telomeric, G-quadruplex, or G-quartet nucleic acid are also described.
摘要翻译：我们描述了能够结合一种或多种端粒，G-四联体或G-四联体核酸作为酶活性抑制剂的核酸结合多肽的用途，所述酶活性包括端粒酶活性，聚合酶活性，整合酶活性和一个gp120活动。还描述了端粒酶测定以及鉴定能够与端粒，G-四联体或G-四联体核酸相互作用的分子的方法。

10. 发明申请

WO9947656A3 NUCLEIC ACID BINDING PROTEINS 审中-公开
标题翻译：核酸结合蛋白
公开(公告)号：WO9947656A3
公开(公告)日：1999-11-25
申请号：PCT/GB9900816
申请日：1999-03-17
申请人： MEDICAL RES COUNCIL , CHOO YEN , ISALAN MARK
发明人： CHOO YEN , ISALAN MARK
IPC分类号： C12N15/09 , C07K14/00 , C07K14/47 , C12N9/22 , C12N15/10 , C12P21/02 , C40B40/02 , C12N15/12 , C12N15/62 , C12Q1/48 , C12Q1/68
CPC分类号： C40B40/02 , C07K14/4702 , C07K2319/00 , C12N9/22 , C12N15/1037
摘要： The invention provides a method for producing a zinc finger polypeptide which binds to a target nucleic acid sequence containing a modified base but not to an identical sequence containing an equivalent unmodified base.
摘要翻译：本发明提供了一种制备锌指多肽的方法，所述锌指多肽与含有经修饰的碱基但不含有相当未改性碱基的相同序列的靶核酸序列结合。

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