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1. 发明申请

WO2009002794A3 METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于动态过滤药物产品的方法和装置
公开(公告)号：WO2009002794A3
公开(公告)日：2009-03-05
申请号：PCT/US2008067440
申请日：2008-06-19
申请人： GEN ELECTRIC , LEACH ANDREW MICHAEL , MILLER PETER , TELFEYAN ERIC JOHN , WHITT DAVID BRANDON
发明人： LEACH ANDREW MICHAEL , MILLER PETER , TELFEYAN ERIC JOHN , WHITT DAVID BRANDON
IPC分类号： B01D69/14 , B01J47/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译：提供了用于药物动力过滤的装置。该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。在某些实施方案中，该装置在过滤之前不需要立即进行调节。

2. 发明申请

WO2008137642A3 APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM OPTICAL MEASUREMENT OF VOLUME 审中-公开
标题翻译：全自动封闭系统的光学测量装置和方法
公开(公告)号：WO2008137642A3
公开(公告)日：2009-01-08
申请号：PCT/US2008062366
申请日：2008-05-02
申请人： GEN ELECTRIC , MILLER PETER , LEACH ANDREW MICHAEL
发明人： MILLER PETER , LEACH ANDREW MICHAEL
IPC分类号： G01N21/01
CPC分类号： G01N21/31 , G01F23/292 , G01N21/0303
摘要： The present invention provides an apparatus and method for a noninvasive optical determination of the volume of a fluid in a compartment within a closed system comprising a compartment wherein a fluid resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a fluid for at least one wavelength, a processor adapted to determine the volume of the fluid by correlating the spectral data for a fluid at a known path length with the spectral data for the fluid at an unknown path length and wherein the processor is further configured to control the release of the substance from the compartment to its end use.
摘要翻译：本发明提供了一种用于非封闭光学确定封闭系统内的隔室中的流体体积的装置和方法，所述封闭系统包括隔室，其中流体存在，所述隔室可透过至少一个波长的光，光源和光检测被配置为获得用于至少一个波长的流体的光谱数据的处理器，适于通过将已知路径长度处的流体的光谱数据与未知路径长度的流体的光谱数据相关联来确定流体的体积的处理器并且其中所述处理器还被配置为控制所述物质从所述隔室到其最终用途的释放。

3. 发明申请

WO2009023373A2 ARTICLE, DEVICE, AND METHOD 审中-公开
标题翻译：文章，设备和方法
公开(公告)号：WO2009023373A2
公开(公告)日：2009-02-19
申请号：PCT/US2008067461
申请日：2008-06-19
申请人： GEN ELECTRIC , POTYRAILO RADISLAV ALEXANDROVI , BOYETTE SCOTT MARTELL , JOHNSON GLENN ALFRED , MORRIS WILLIAM GUY , WROCZYNSKI RONALD JAMES , LEACH ANDREW MICHAEL , MILLER PETER , XIAO CAILBIN
发明人： POTYRAILO RADISLAV ALEXANDROVICH , BOYETTE SCOTT MARTELL , JOHNSON GLENN ALFRED , MORRIS WILLIAM GUY , WROCZYNSKI RONALD JAMES , LEACH ANDREW MICHAEL , MILLER PETER , XIAO CAILBIN
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L2200/025 , B01L2200/141 , B01L2200/143 , B01L2300/021 , B01L2300/0816 , B01L2300/0864 , B01L2300/168 , G01N21/03 , G01N2021/0325 , G01N2021/0346 , G01N2021/0382
摘要： An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.
摘要翻译：一种物品包括用于检测器系统的基底组件。基板组件包括基板; 固定到所述基板的样品接收结构; 延伸穿过衬底的测试窗口; 以及由衬底的表面限定并从样品接收结构延伸到测试窗口的流体通道。

4. 发明申请

WO2005049561A3 PROCESSES FOR PREPARING NOVEL METHYLENE BLUE DERIVATIVE 审中-公开
标题翻译：制备新型甲基蓝衍生物的方法
公开(公告)号：WO2005049561A3
公开(公告)日：2005-10-20
申请号：PCT/US2004037374
申请日：2004-11-10
申请人： VERIFICATION TECHNOLOGIES INC , VIG RAKESH , GERGER SCOTT , SELINFREUND RICHARD H , MILLER PETER , CUNNINGHAM MIKE , PHILLIPS CHRIS , COOK EWELL , SAGLIMBENI ANTHONY A
发明人： VIG RAKESH , GERGER SCOTT , SELINFREUND RICHARD H , MILLER PETER , CUNNINGHAM MIKE , PHILLIPS CHRIS , COOK EWELL , SAGLIMBENI ANTHONY A
IPC分类号： A61K31/5415 , C07D20060101 , C07D279/18 , C07D295/00
CPC分类号： C07D279/18
摘要： Methods for the preparation of 7-(dipropylamino)pheno-thiazin-3-ylidene]-dipropylamine.
摘要翻译：制备7-（二丙基氨基）苯基 - 噻嗪-3-亚基] - 二丙胺的方法。

5. 发明申请

WO2012112956A2 COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS 审中-公开
标题翻译：用于靶向低密度干细胞的化合物和方法
公开(公告)号：WO2012112956A2
公开(公告)日：2012-08-23
申请号：PCT/US2012025743
申请日：2012-02-17
申请人： BROAD INST INC , GEN HOSPITAL CORP , BRIGHAM & WOMENS HOSPITAL , HARVARD COLLEGE , SLOAN KETTERING INST CANCER , DANA FARBER CANCER INST INC , HARTWELL KIMBERLY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , MUNOZ BENITO , EBERT BENJAMIN , STERN ANDREW , MILLER PETER , GILLILAND D GARY , CARPENTER VAN DYK ANNE , LOGAN DAVID , NEGRI JOSEPH , TOLLIDAY NICOLA , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
发明人： HARTWELL KIMBERLY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , MUNOZ BENITO , EBERT BENJAMIN , STERN ANDREW , MILLER PETER , GILLILAND D GARY , CARPENTER VAN DYK ANNE , LOGAN DAVID , NEGRI JOSEPH , TOLLIDAY NICOLA , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
IPC分类号： A61K31/40 , A61K31/366 , A61K31/405 , A61K31/435 , A61P35/00 , A61P35/02
CPC分类号： G01N33/5011 , A61K31/167 , A61K31/22 , A61K31/366 , A61K31/395 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
摘要翻译：本发明涉及用于鉴定有效靶向白血病干细胞的化合物的高通量半自动化方法，以及通过这些方法鉴定的化合物及其用于治疗白血病的用途。

6. 发明申请

WO2012061066A3 HYDRAULIC SYSTEM FOR HEAVY EQUIPMENT 审中-公开
标题翻译：液压系统用于重型设备
公开(公告)号：WO2012061066A3
公开(公告)日：2012-07-26
申请号：PCT/US2011057491
申请日：2011-10-24
申请人： CATERPILLAR GLOBAL MINING LLC , WOJCICKI MARK , ONSAGER MICHAEL G , HELFRICH JOSEPH , CHMIEL WAYNE G , MILLER PETER
发明人： WOJCICKI MARK , ONSAGER MICHAEL G , HELFRICH JOSEPH , CHMIEL WAYNE G , MILLER PETER
IPC分类号： E02F3/43 , E02F3/42 , E02F9/22
CPC分类号： E02F9/2242 , E02F9/2292 , F15B11/17 , F15B2211/20515 , F15B2211/20576 , F15B2211/265 , F15B2211/2654 , F15B2211/3059 , F15B2211/3138 , F15B2211/31547 , F15B2211/633 , F15B2211/6333 , F15B2211/6346 , F15B2211/6652 , F15B2211/71 , F15B2211/781 , F15B2211/857
摘要： Heavy equipment includes first and second hydraulic pumps, and first and second hydraulic actuators, where the first hydraulic actuator facilitates a first work function of the heavy equipment and the second hydraulic actuator facilitates a second work function of the heavy equipment. The heavy equipment further includes valving and a computerized controller. The valving is configured to allow the first hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator, and to allow the second hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator. The computerized controller is coupled to the valving, and has a logic module. The logic module provides instructions to the computerized controller to operate the valving as a function of inputs from an operator command, a sensor input, and prioritization logic associated with the first and second work functions, so as to optimize performance of the work functions facilitated by the hydraulic actuators with respect to available output of the hydraulic pumps.
摘要翻译：重型设备包括第一和第二液压泵以及第一和第二液压致动器，其中第一液压致动器促进重型设备的第一功能，第二液压致动器便于重型设备的第二功能。重型设备还包括阀门和电脑控制器。阀构造成允许第一液压泵联接到第一液压致动器和第二液压致动器，并且允许第二液压泵联接到第一液压致动器和第二液压致动器。计算机控制器耦合到阀门，并具有逻辑模块。逻辑模块向计算机控制器提供指令，以根据来自操作员命令，传感器输入和与第一和第二功能相关联的优先化逻辑的输入来操作阀门，以便优化由相对于液压泵的可用输出的液压致动器。

7. 发明申请

WO2005108763A3 METHOD AND APPARATUS FOR MEASURING AND CORRECTING AN IN-CYLINDER PRESSURE MEASUREMENT 审中-公开
标题翻译：用于测量和校正气缸内压力测量的方法和装置
公开(公告)号：WO2005108763A3
公开(公告)日：2006-04-20
申请号：PCT/GB2005001631
申请日：2005-04-28
申请人： RICARDO UK LTD , MILLER PETER , TRUSCOTT ANTHONY JOHN
发明人： MILLER PETER , TRUSCOTT ANTHONY JOHN
IPC分类号： F02D35/02 , F02D41/14
CPC分类号： F02D35/023 , F02D35/024 , F02D35/026 , F02D41/1402 , F02D2041/1416 , F02D2041/1433 , F02D2041/1434 , F02D2041/281 , F02D2041/286
摘要： A method and apparatus for obtaining a corrected engine operational parameter value, using cylinder pressure information. A real pressure sensor signal output from a sensor (41D) is compared for discrepancies with an estimated output from engine pressure model (42A), including an engine model and a sensor model. The engine pressure model is corrected dependent on the discrepancy and the model engine pressure is then taken as the output value.
摘要翻译：一种使用气缸压力信息获得校正的发动机操作参数值的方法和装置。将来自传感器（41D）的输出的实际压力传感器信号与发动机压力模型（42A）的估计输出进行比较，包括发动机模型和传感器模型。发动机压力模型根据差异进行校正，然后将模型发动机压力作为输出值。

8. 发明申请

WO2012112958A3 HIGH-THROUGHPUT ASSAYS TO PROBE LEUKEMIA WITHIN THE STROMAL NICHE 审中-公开
标题翻译：高通量测定探针在白细胞介素中的白血病
公开(公告)号：WO2012112958A3
公开(公告)日：2012-11-22
申请号：PCT/US2012025745
申请日：2012-02-17
申请人： BROAD INST INC , GEN HOSPITAL CORP , BRIGHAM & WOMENS HOSPITAL , HARVARD COLLEGE , SLOAN KETTERING INST CANCER , DANA FARBER CANCER INST INC , HARTWELL KIMBERLY , GILLILAND D GARY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , EBERT BENJAMIN , CARPENTER VAN DYK ANNE , LOGAN DAVID , STERN ANDREW , MILLER PETER , NEGRI JOSEPH , TOLLIDAY NICOLA , STEWART ALISON , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
发明人： HARTWELL KIMBERLY , GILLILAND D GARY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , EBERT BENJAMIN , CARPENTER VAN DYK ANNE , LOGAN DAVID , STERN ANDREW , MILLER PETER , NEGRI JOSEPH , TOLLIDAY NICOLA , STEWART ALISON , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
IPC分类号： G01N33/15 , C12N5/071 , G06T7/00
CPC分类号： G01N33/5011 , A61K31/167 , A61K31/22 , A61K31/366 , A61K31/395 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
摘要翻译：本发明涉及用于鉴定有效靶向白血病干细胞的化合物的高通量，半自动化方法，以及通过这些方法鉴定的化合物及其用于治疗白血病的用途。

9. 发明申请

WO2010029355A3 STATE OF CHARGE ESTIMATION 审中-公开
标题翻译：费用估算状态
公开(公告)号：WO2010029355A3
公开(公告)日：2010-05-06
申请号：PCT/GB2009051151
申请日：2009-09-09
申请人： RICARDO UK LTD , MILLER PETER
发明人： MILLER PETER
IPC分类号： G01R31/36
CPC分类号： G01R31/3651 , G01R31/361 , G01R31/3679
摘要： A method of calculating the state of charge of a power source, the method comprising the steps of; providing a plurality of equivalent circuit models; selecting an equivalent circuit from the provided equivalent circuits; calculating the input power to the equivalent circuit; calculating the losses from the equivalent circuit; determining an initial state of charge for the power source from the calculated input power and losses of the equivalent circuit; subsequently recalculating the value of one or more of the component parts of the equivalent circuit based on the temperature behaviour of the cell; and determining a state of charge using one or more of the recalculated component parts.
摘要翻译：一种计算电源的充电状态的方法，所述方法包括以下步骤：提供多个等效电路模型; 从提供的等效电路中选择一个等效电路; 计算等效电路的输入功率; 从等效电路计算损耗; 根据所计算的等效电路的输入功率和损耗确定电源的初始充电状态; 随后基于电池的温度行为重新计算等效电路的一个或多个组成部分的值; 以及使用一个或多个重新计算的组成部分来确定充电状态。

10. 发明申请

WO2009027422A3 NOZZLE FOR A POLARIZER FOR DYNAMIC NUCLEAR SPIN POLARISATION (DNP) 审中-公开
标题翻译：用于动态核弹性极化极化的喷嘴（DNP）
公开(公告)号：WO2009027422A3
公开(公告)日：2009-09-03
申请号：PCT/EP2008061197
申请日：2008-08-27
申请人： GE HEALTHCARE LTD , ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
发明人： ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
IPC分类号： G01R33/30 , B01L99/00 , G01N1/10 , G01R33/62
CPC分类号： G01R33/307 , B01F1/0022 , B01L3/0293 , G01N1/38 , G01N2001/1025 , G01N2001/383 , G01R33/282 , G01R33/62
摘要： DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.
摘要翻译： DNP偏振器包括壳体，其容纳与由所述壳体支撑的喷嘴流体连通的管状流体导管的自由端，所述喷嘴包括输入端口，分配端口和锥形内表面或限定喷嘴流径的阶梯式内表面在所述输入端口和所述分配端口之间流体连通地延伸。

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