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1. 发明申请

WO2015089635A1 COMBUSTIBLE FLUID CUTTING SAFETY SYSTEM 审中-公开
标题翻译：可燃液体切割安全系统
公开(公告)号：WO2015089635A1
公开(公告)日：2015-06-25
申请号：PCT/CA2014/000896
申请日：2014-12-19
申请人： LOGAN, David J. , LOGAN, Jonathan A. , HORNE, Allan M. , CHRISTENSEN, Paul E.
发明人： LOGAN, David J. , LOGAN, Jonathan A. , HORNE, Allan M. , CHRISTENSEN, Paul E.
IPC分类号： B23K7/00 , B23K7/10 , F23D14/38 , F23D14/72 , G05G25/00 , G08C17/02
CPC分类号： B23K37/006 , B23K7/00 , B23K7/10
摘要： Embodiments of the present invention provide components and a system for providing a safer environment for using a cutting torch. The system includes a cutting torch and a control box. There is communication from the user to the control box to allow fluids to flow to the torch. The control box includes closed biased valve(s) such that if there is a condition where there is no instruction from the troch to the control box and/or power is lost, the valves will shut, preventing fluid from flowing into the torch.
摘要翻译：本发明的实施例提供了用于为使用割炬提供更安全环境的部件和系统。该系统包括割炬和控制箱。有从用户到控制箱的通信，以允许流体流向割炬。控制箱包括闭合偏压的阀，使得如果存在没有从滑车到控制箱的指令和/或电力损失的情况，则阀将关闭，防止流体流入手电筒。

2. 发明申请

WO2005069967A2 METHOD AND APPARATUS FOR APPLYING MATERIALS TO AN OPTICAL SUBSTRATE 审中-公开
标题翻译：将材料应用于光学基板的方法和装置
公开(公告)号：WO2005069967A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002052
申请日：2005-01-21
申请人： GERBER SCIENT INC , INCERA ALEXANDER F , STROBEL WOLFGANG M , GORDON THOMAS A , LOGAN DAVID J
发明人： INCERA ALEXANDER F , STROBEL WOLFGANG M , GORDON THOMAS A , LOGAN DAVID J
IPC分类号： B05B13/04 , B05D1/00 , B05D3/12 , B05D7/02 , B29D11/00 , G02B6/00
CPC分类号： B29D11/00865 , B05B13/0442 , B05D1/002 , B05D3/12 , B05D7/02
摘要： The apparatus and method described utilizes a discrete deposition process to apply materials to an optical substrate. The materials can be applied to an optical substrate to create an ophthalmic lens or apply a coating to a lens or other optical surface. Average surface roughness below 10 nanometers can be achieved using the described apparatus and method. Localized error is minimized to less than 1 micron over a 1 mm linear distance to avoid a lens anomaly such as a localized power distortion or power wave. Coating is applied to an entire substrate surface or selected portions. Material can be deposited on the optical substrate to provide the substrate with desired refracting properties. One or more surfaces of the substrate can be coated. Waste material is minimized and a uniform coating is applied for the improvement of optical qualities of the substrate.
摘要翻译：所描述的装置和方法利用离散沉积工艺将材料施加到光学衬底。这些材料可以应用于光学基底以产生眼科镜片或将涂层施加到透镜或其它光学表面。使用所述的装置和方法可以获得低于10纳米的平均表面粗糙度。局部误差在1 mm线性距离下最小化到小于1微米，以避免透镜异常，例如局部功率失真或功率波。将涂层施加到整个基板表面或选定部分。材料可以沉积在光学基底上，为基底提供所需的折射特性。可以涂覆基材的一个或多个表面。废料被最小化并且施加均匀的涂层以提高基材的光学质量。

3. 发明申请

WO2012112956A2 COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS 审中-公开
标题翻译：用于靶向低密度干细胞的化合物和方法
公开(公告)号：WO2012112956A2
公开(公告)日：2012-08-23
申请号：PCT/US2012025743
申请日：2012-02-17
申请人： BROAD INST INC , GEN HOSPITAL CORP , BRIGHAM & WOMENS HOSPITAL , HARVARD COLLEGE , SLOAN KETTERING INST CANCER , DANA FARBER CANCER INST INC , HARTWELL KIMBERLY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , MUNOZ BENITO , EBERT BENJAMIN , STERN ANDREW , MILLER PETER , GILLILAND D GARY , CARPENTER VAN DYK ANNE , LOGAN DAVID , NEGRI JOSEPH , TOLLIDAY NICOLA , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
发明人： HARTWELL KIMBERLY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , MUNOZ BENITO , EBERT BENJAMIN , STERN ANDREW , MILLER PETER , GILLILAND D GARY , CARPENTER VAN DYK ANNE , LOGAN DAVID , NEGRI JOSEPH , TOLLIDAY NICOLA , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
IPC分类号： A61K31/40 , A61K31/366 , A61K31/405 , A61K31/435 , A61P35/00 , A61P35/02
CPC分类号： G01N33/5011 , A61K31/167 , A61K31/22 , A61K31/366 , A61K31/395 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
摘要翻译：本发明涉及用于鉴定有效靶向白血病干细胞的化合物的高通量半自动化方法，以及通过这些方法鉴定的化合物及其用于治疗白血病的用途。

4. 发明申请

WO2005069967A3 METHOD AND APPARATUS FOR APPLYING MATERIALS TO AN OPTICAL SUBSTRATE 审中-公开
公开(公告)号：WO2005069967A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/002052
申请日：2005-01-21
申请人： GERBER SCIENTIFIC INTERNATIONAL, INC. , INCERA, Alexander, F. , STROBEL, Wolfgang, M. , GORDON, Thomas, A. , LOGAN, David, J.
发明人： INCERA, Alexander, F. , STROBEL, Wolfgang, M. , GORDON, Thomas, A. , LOGAN, David, J.
IPC分类号： B05D5/06 , B05B3/00 , B05B13/02
摘要： The apparatus and method described utilizes a discrete deposition process to apply materials to an optical substrate. The materials can be applied to an optical substrate to create an ophthalmic lens or apply a coating to a lens or other optical surface. Average surface roughness below 10 nanometers can be achieved using the described apparatus and method. Localized error is minimized to less than 1 micron over a 1 mm linear distance to avoid a lens anomaly such as a localized power distortion or power wave. Coating is applied to an entire substrate surface or selected portions. Material can be deposited on the optical substrate to provide the substrate with desired refracting properties. One or more surfaces of the substrate can be coated. Waste material is minimized and a uniform coating is applied for the improvement of optical qualities of the substrate.

6. 发明申请

WO2012018411A1 OPTIMIZED DATA STREAM UPLOAD 审中-公开
标题翻译：优化数据流上传
公开(公告)号：WO2012018411A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/025533
申请日：2011-02-18
申请人： KRYTERION, INC. , PERRYMAN, Laura , WALTON, Eric , LOGAN, David , COLLINS, Michael
发明人： PERRYMAN, Laura , WALTON, Eric , LOGAN, David , COLLINS, Michael
IPC分类号： G06F15/16
CPC分类号： H04L67/1021 , H04L47/125 , H04L67/1004 , H04L67/101 , H04L67/1023
摘要： Systems and methods utilize a distributed server network to allow for the optimization of the upload of a data stream from a computing device. Performance metrics are estimated for different network paths from the computing device to a variety of entry servers in the distributed server network. Based on the estimated performance metrics, one or more entry servers are then selected to receive the data stream from the computing device. As a result, the systems and methods described herein allow for high quality upload performance which addresses the first mile vulnerability issues of the data stream. The distributed server network can then transmit copies of the data stream in real-time to other computing devices.
摘要翻译：系统和方法利用分布式服务器网络来允许优化来自计算设备的数据流的上传。对于从计算设备到分布式服务器网络中的各种入口服务器的不同网络路径，估计性能度量。基于估计的性能度量，然后选择一个或多个入口服务器以从计算设备接收数据流。因此，本文描述的系统和方法允许高质量的上传性能，其解决数据流的第一英里漏洞问题。分布式服务器网络可以将数据流的副本实时传输到其他计算设备。

7. 发明申请

WO2012112958A3 HIGH-THROUGHPUT ASSAYS TO PROBE LEUKEMIA WITHIN THE STROMAL NICHE 审中-公开
标题翻译：高通量测定探针在白细胞介素中的白血病
公开(公告)号：WO2012112958A3
公开(公告)日：2012-11-22
申请号：PCT/US2012025745
申请日：2012-02-17
申请人： BROAD INST INC , GEN HOSPITAL CORP , BRIGHAM & WOMENS HOSPITAL , HARVARD COLLEGE , SLOAN KETTERING INST CANCER , DANA FARBER CANCER INST INC , HARTWELL KIMBERLY , GILLILAND D GARY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , EBERT BENJAMIN , CARPENTER VAN DYK ANNE , LOGAN DAVID , STERN ANDREW , MILLER PETER , NEGRI JOSEPH , TOLLIDAY NICOLA , STEWART ALISON , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
发明人： HARTWELL KIMBERLY , GILLILAND D GARY , MOORE MALCOME , SCADDEN DAVID , SCHREIBER STUART , GOLUB TODD , EBERT BENJAMIN , CARPENTER VAN DYK ANNE , LOGAN DAVID , STERN ANDREW , MILLER PETER , NEGRI JOSEPH , TOLLIDAY NICOLA , STEWART ALISON , SHAMJI ALYKHAN , MUKHERJEE SIDDHARTHA
IPC分类号： G01N33/15 , C12N5/071 , G06T7/00
CPC分类号： G01N33/5011 , A61K31/167 , A61K31/22 , A61K31/366 , A61K31/395 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
摘要翻译：本发明涉及用于鉴定有效靶向白血病干细胞的化合物的高通量，半自动化方法，以及通过这些方法鉴定的化合物及其用于治疗白血病的用途。

8. 发明申请

WO2012112958A2 HIGH-THROUGHPUT ASSAYS TO PROBE LEUKEMIA WITHIN THE STROMAL NICHE 审中-公开
标题翻译：高分辨率测量仪在探测器中探测亮片
公开(公告)号：WO2012112958A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/025745
申请日：2012-02-17
申请人： THE BROAD INSTITUTE, INC , THE GENERAL HOSPITAL CORPORATION , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANA FARBER CANCER INSTITUTE, INC. , HARTWELL, Kimberly , GILLILAND, D. Gary , MOORE, Malcome , SCADDEN, David , SCHREIBER, Stuart , GOLUB, Todd , EBERT, Benjamin , CARPENTER VAN DYK, Anne , LOGAN, David , STERN, Andrew , MILLER, Peter , NEGRI, Joseph , TOLLIDAY, Nicola , STEWART, Alison , SHAMJI, Alykhan , MUKHERJEE, Siddhartha
发明人： HARTWELL, Kimberly , GILLILAND, D. Gary , MOORE, Malcome , SCADDEN, David , SCHREIBER, Stuart , GOLUB, Todd , EBERT, Benjamin , CARPENTER VAN DYK, Anne , LOGAN, David , STERN, Andrew , MILLER, Peter , NEGRI, Joseph , TOLLIDAY, Nicola , STEWART, Alison , SHAMJI, Alykhan , MUKHERJEE, Siddhartha
IPC分类号： G01N33/15 , C12N5/071 , G06T7/00
CPC分类号： G01N33/5011 , A61K31/167 , A61K31/22 , A61K31/366 , A61K31/395 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4418 , A61K31/444 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
摘要翻译：本发明涉及用于鉴定有效靶向白血病干细胞的化合物的高通量半自动化方法，以及通过这些方法鉴定的化合物及其用于治疗白血病的用途。

9. 发明申请

WO2012018412A1 PEERED PROCTORING 审中-公开
标题翻译：同行处理
公开(公告)号：WO2012018412A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/025545
申请日：2011-02-18
申请人： KRYTERION, INC. , LOGAN, David , WALTON, Eric , COLLINS, Michael
发明人： LOGAN, David , WALTON, Eric , COLLINS, Michael
IPC分类号： G06F15/16
CPC分类号： G09B5/00 , G08B13/19656 , G08B13/19663 , G09B7/00 , G09B7/07 , H04L29/06176 , H04L43/50 , H04L65/60 , H04L65/601 , H04L67/104
摘要： Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to 'peek in' on the exam taker's environment during the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, a proctor or other test assessment authority can then make a final or early decision regarding disciplinary action.
摘要翻译：本文描述的系统和方法利用分布式服务器网络来允许从计算设备上传的数据流的副本的实时分发。上传的数据流对应于在执行用于检查的测试例程期间的计算设备的用户（考试者）周围的环境。提供数据流的副本实时允许医生以及其他测试评估机构在考试期间“考察”考生的环境。因此，可以实时监控考生周围的环境，以确定环境中的任何视觉或音频活动是否构成不符合考试协议的活动。经过肯定的确定，考生违反考试协议，考官或其他考试机构可以作出关于纪律处分的最终或早期的决定。

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