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1. 发明申请

WO2008092059A3 TANTALUM OXIDE NANOPARTICLES AS IMAGING AGENTS FOR X-RAY/ COMPUTED TOMOGRAPHY AND METHODS FOR MAKING SAME 审中-公开
标题翻译：氧化钛纳米颗粒作为X射线/计算机成像的成像剂及其制备方法
公开(公告)号：WO2008092059A3
公开(公告)日：2008-10-30
申请号：PCT/US2008052007
申请日：2008-01-25
申请人： GEN ELECTRIC , COLBORN ROBERT EDGAR , BALES BRIAN , BONITATIBUS JR PETER , KULKARNI AMIT , TORRES ANDREW , AXELSSON OSKAR , DEMOULPIED DAVID , BUCKLEY PAUL
发明人： COLBORN ROBERT EDGAR , BALES BRIAN , BONITATIBUS JR PETER , KULKARNI AMIT , TORRES ANDREW , AXELSSON OSKAR , DEMOULPIED DAVID , BUCKLEY PAUL
IPC分类号： A61K49/04
CPC分类号： A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01G35/00 , C01P2004/04 , C01P2004/64 , C09C3/12 , Y10T428/2991 , Y10T428/2993
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.
摘要翻译：本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。

2. 发明申请

WO2010076237A3 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于诊断成像的纳米对比剂
公开(公告)号：WO2010076237A3
公开(公告)日：2011-02-03
申请号：PCT/EP2009067468
申请日：2009-12-18
申请人： GEN ELECTRIC , GE HEALTHCARE AS , COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
发明人： COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
IPC分类号： A61K49/04 , A61K49/18
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Nanoparticles (10) functionalized with at least one zwitterionic moiety, and compositions comprising said nanoparticles are provided. The nanoparticles (10) have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle (10) comprises a core (20), having a core surface (30) essentially free of silica, and a shell (40) attached to the core surface (30). The shell (40) comprises at least one silane- functionalized zwitterionic moiety. Further, methods of making said nanoparticles and methods of their use as diagnostic agents are provided.
摘要翻译：提供用至少一个两性离子部分官能化的纳米颗粒（10）和包含所述纳米颗粒的组合物。与其他纳米颗粒相比，纳米颗粒（10）具有导致颗粒在体内的最小保留的特征。纳米颗粒（10）包括具有基本上不含二氧化硅的芯表面（30）和连接到芯表面（30）的壳体（40）的芯体（20）。壳（40）包含至少一个硅烷官能化的两性离子部分。此外，提供制备所述纳米颗粒的方法及其用作诊断剂的方法。

3. 发明申请

WO2010125088A2 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于诊断成像的纳米对比剂
公开(公告)号：WO2010125088A2
公开(公告)日：2010-11-04
申请号：PCT/EP2010055685
申请日：2010-04-28
申请人： GEN ELECTRIC , GE HEALTHCARE AS , COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
发明人： COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
IPC分类号： A61K49/04
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a coreand a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
摘要翻译：提供了用至少一个净正电荷基团和至少一个净负电荷基团官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。纳米颗粒包括芯和壳。壳包含多个硅烷部分; 多个的至少一个硅烷部分用净正电荷基团官能化，并且多个的至少一个硅烷部分用净带负电基团官能化。

4. 发明申请

WO2007055995A3 NANOPARTICLE-BASED IMAGING AGENTS FOR X-RAY/COMPUTED TOMOGRAPHY 审中-公开
标题翻译：用于X射线/计算机图像的基于纳米技术的成像剂
公开(公告)号：WO2007055995A3
公开(公告)日：2007-07-05
申请号：PCT/US2006042603
申请日：2006-10-31
申请人： GEN ELECTRIC , BONITATEBUS PETER JR , KULKARNI AMIT , TORRES ANDREW , AXELSSON OSKAR HANS ERIK , BALES BRIAN CHRISTOPHER , WALTER DEBORAH JOY , TREYNOR CHIAKI
发明人： BONITATEBUS PETER JR , KULKARNI AMIT , TORRES ANDREW , AXELSSON OSKAR HANS ERIK , BALES BRIAN CHRISTOPHER , WALTER DEBORAH JOY , TREYNOR CHIAKI
IPC分类号： A61K49/04 , C09C1/00 , C09C3/06 , C09C3/08
CPC分类号： C09C1/00 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01P2004/04 , C01P2004/64 , C09C1/24 , C09C3/08 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.
摘要翻译：本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。

5. 发明申请

WO2007069040A3 TARGETED NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的目标纳米颗粒
公开(公告)号：WO2007069040A3
公开(公告)日：2008-08-21
申请号：PCT/IB2006003584
申请日：2006-12-12
申请人： GEN ELECTRIC , TORRES ANDREW , SYUD FAISAL , KULKARNI AMIT , WOOD NICHOLE , BAILLIE MARK , MOASSER BAHRAM , BALES BRIAN , BELETSKII ANTON , BONITATEBUS JR PETER
发明人： TORRES ANDREW , SYUD FAISAL , KULKARNI AMIT , WOOD NICHOLE , BAILLIE MARK , MOASSER BAHRAM , BALES BRIAN , BELETSKII ANTON , BONITATEBUS JR PETER
IPC分类号： A61K49/18
CPC分类号： A61K49/1848 , A61K47/59 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/1857 , A61K49/1866 , B82Y5/00 , B82Y25/00 , G01N33/552 , G01R33/5601 , H01F1/0054
摘要： In some embodiments, the present invention is directed to novel targeted contrast agents for magnetic resonance imaging (MRI). The present invention is also directed to methods of making such targeted MRI contrast agents, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically afford enhanced blood clearance rates and biodistribution.
摘要翻译：在一些实施方案中，本发明涉及用于磁共振成像（MRI）的新型靶向造影剂。本发明还涉及制备这种靶向MRI造影剂的方法，以及使用这种MRI造影剂的方法。通常，这种靶向MRI造影剂提供增强的舒张度，改善的信噪比，靶向能力和抵抗聚集。制造这种MRI造影剂的方法通常能够更好地控制粒径，并且使用这种MRI造影剂的方法通常提供增强的血液清除率和生物分布。

6. 发明申请

WO2009135937A3 NOVEL PEI-PEG GRAFT COPOLYMER COATING OF IRON OXIDE NANOPARTICLES FOR INFLAMMATION IMAGING 审中-公开
标题翻译：用于荧光成像的氧化乙烯纳米粒子的新型PEI-PEG共聚物涂层
公开(公告)号：WO2009135937A3
公开(公告)日：2010-12-23
申请号：PCT/EP2009055598
申请日：2009-05-08
申请人： GEN ELECTRIC , GE HEALTHCARE AS , KULKARNI AMIT , GRIMMOND BRIAN , BALES BRIAN C , TREYNOR CHIAKI , MEYER DAN
发明人： KULKARNI AMIT , GRIMMOND BRIAN , BALES BRIAN C , TREYNOR CHIAKI , MEYER DAN
IPC分类号： A61K49/18
CPC分类号： A61K49/186 , A61K49/1839 , A61K49/1857
摘要： A nanostructure includes a nanoparticle core (110) and a ligand (120) bonded to the nanoparticle core (110). The ligand includesa linking group (130) having a first end bonded to a polyethylene imine (PEI) polymer (140) and a second end bonded to the nanoparticle core (110) and a polyethylene glycol (PEG) polymer (150) grafted to the PEI polymer (140). Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.
摘要翻译：纳米结构包括纳米颗粒核心（110）和与纳米颗粒核心（110）结合的配体（120）。配体包括具有与聚乙烯亚胺（PEI）聚合物（140）结合的第一末端的结合基团（130）和与纳米颗粒核心（110）结合的第二末端和接枝到所述聚乙二醇（PEG）聚合物上的聚乙二醇（PEG）聚合物（150） PEI聚合物（140）。提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。

7. 发明申请

WO2006068653A3 NANOPARTICLES WITH INORGANIC CORE AND METHODS OF USING THEM 审中-公开
标题翻译：无机碳纳米管及其使用方法
公开(公告)号：WO2006068653A3
公开(公告)日：2007-03-08
申请号：PCT/US2005011110
申请日：2005-04-01
申请人： GEN ELECTRIC , MALENFANT PATRICK , ACAR HAVVA , BONITATEBUS JR PETER , DIXON WILLIAM , KULKARNI AMIT
发明人： MALENFANT PATRICK , ACAR HAVVA , BONITATEBUS JR PETER , DIXON WILLIAM , KULKARNI AMIT
IPC分类号： A61K49/18
CPC分类号： A61K49/1848 , A61K49/186 , B82Y5/00
摘要： An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.
摘要翻译：本发明的一个方面包括纳米颗粒，其包括具有表面的基本上单分散的无机核，涂层基本覆盖基本上单分散的无机核的表面，其中该涂层至少包括涂层结构I，II或III，其中纳米颗粒是基本上非团聚并且具有在约1nm至约100nm范围内的直径。本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上单分散的表面无机芯，其中涂层包括涂层结构I，II或III。本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上单分散的表面无机芯，其中涂层包括涂层结构I，II或III。

8. 发明申请

WO2012118968A2 HOOD PEDESTRIAN ENERGY ABSORBER 审中-公开
标题翻译：罩式行人吸能器
公开(公告)号：WO2012118968A2
公开(公告)日：2012-09-07
申请号：PCT/US2012027282
申请日：2012-03-01
申请人： SHAPE CORP , RALSTON DAN , REVANKAR VIDYA , SEITER DAVID R , KULKARNI AMIT
发明人： RALSTON DAN , REVANKAR VIDYA , SEITER DAVID R , KULKARNI AMIT
IPC分类号： B62D25/12 , B60R21/34 , B62D25/10
CPC分类号： B62D25/12 , B60R21/34 , B60R2021/343
摘要： An energy absorbing system includes a hood with inner and outer panels defining a rear edge cavity, and a pair of polymeric energy absorbers on hard components in the cavity. The hood and energy absorber are tuned to minimize an HIC value when a pedestrian's head contacts the hood during an impact to absorb energy prior to the hood bottoming out on the plenum of the vehicle. The energy absorber is preferably made of a polymeric material capable of withstanding high temperatures associated with going through a paint oven or e-coat process, such as high temperature nylon. The illustrated energy absorber has a hat-shaped cross section and includes criss-crossing flanges tuned to provide an optimal force-deflection curve during impact.
摘要翻译：能量吸收系统包括具有限定后边缘空腔的内部和外部面板的罩和在空腔中的硬质部件上的一对聚合物能量吸收器。发动机罩和能量吸收器被调整为当行人的头部在碰撞期间接触发动机罩以吸收能量，然后在发动机舱的气室最低点之前吸收能量，从而最小化HIC值。能量吸收器优选地由能够经受与通过烤漆炉或电涂处理相关的高温（例如高温尼龙）的聚合物材料制成。图示的能量吸收器具有帽形横截面并且包括调整为在冲击期间提供最佳力 - 挠曲曲线的交叉凸缘。

9. 发明申请

WO2016053966A2 TEMPERATURE REGULATION USING PHASE CHANGE MATERIALS CONTAINED IN AN EMI CAN 审中-公开
标题翻译：使用包含EMI CAN的相变材料进行温度调节
公开(公告)号：WO2016053966A2
公开(公告)日：2016-04-07
申请号：PCT/US2015052831
申请日：2015-09-29
申请人： HENKEL IP & HOLDING GMBH , KULKARNI AMIT , MASLYK DANIEL
发明人： KULKARNI AMIT , MASLYK DANIEL , BERHE MULUGETA
IPC分类号： H05K9/00
CPC分类号： H05K7/20454 , H05K7/20463 , H05K7/20481 , H05K9/0024
摘要： Provided herein are multicomponent shield can(s) for temporary heat storage and junction temperature regulation using a phase change material (PCM) contained therein. Invention articles can be applied to most electronic devices, especially to small portable electronic devices such as cell phones and tablets.
摘要翻译：本文提供了使用其中包含的相变材料（PCM）的临时储热和结温调节的多组分屏蔽罐。本发明的文章可以应用于大多数电子设备，特别是小型便携式电子设备，如手机和平板电脑。

10. 发明申请

WO2013040085A3 CONTROLLABLE COMFORT SHELL FOR VEHICLE SEAT 审中-公开
标题翻译：用于车辆座椅的可控舒适外壳
公开(公告)号：WO2013040085A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054933
申请日：2012-09-12
申请人： FAURECIA AUTOMOTIVE SEATING , KULKARNI AMIT , GOLIGORSKY DAVID , PROULX TIMOTHY R
发明人： KULKARNI AMIT , GOLIGORSKY DAVID , PROULX TIMOTHY R
IPC分类号： B60N2/68 , A47C7/40
CPC分类号： B60N2/667 , B60N2/028 , B60N2/66 , B60N2/68 , Y10T29/49826
摘要： A vehicle seat includes a seat back having a support frame coupled to a seat foundation. The seat back also further includes a deformable seat shell adapted to assume various shapes between initial position and final positions in response to variable rearward loads applied by a seated passenger. The seat shell is coupled to the support frame by a compliant shell-motion controller via upper and lower motion-control links. The motion-control links allow pivotal motion, and at least one of the links includes a spheroidal joint. A link foundation extends between and interconnects the upper and lower motion-control links and is coupled to the support frame so that the link foundation does not move during seat shell deformation. The shell-motion controller may be pre-assembled as part of a backrest or the motion-control links may be formed after the link foundation is attached to the support frame.
摘要翻译：车辆座椅包括具有联接到座椅基座的支撑框架的座椅靠背。座椅靠背还包括可变形座椅壳体，其适于在初始位置和最终位置之间呈现各种形状，以响应由乘坐人员施加的可变向后负载。座椅外壳通过上下运动控制链路的顺应性壳运动控制器耦合到支撑框架。运动控制链路允许枢转运动，并且至少一个链接包括球形接头。连杆基座在上部和下部运动控制链节之间延伸并互连，并且联接到支撑框架，使得在座椅壳体变形期间，连杆基座不移动。壳体运动控制器可以作为靠背的一部分预先组装，或者可以在连接基座附接到支撑框架之后形成运动控制连杆。

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