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1. 发明申请

WO2007066089A2 RADIOLABELLING METHOD USING POLYMERS 审中-公开
标题翻译：使用聚合物的放射标记方法
公开(公告)号：WO2007066089A2
公开(公告)日：2007-06-14
申请号：PCT/GB2006004533
申请日：2006-12-05
申请人： GE HEALTHCARE LTD , GACEK MICHEL , PRIEBE HANNO , OSBORN NIGEL JOHN
发明人： GACEK MICHEL , PRIEBE HANNO , OSBORN NIGEL JOHN
CPC分类号： C07B59/001 , A61K51/0402 , A61K51/1282
摘要： The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in solution. Also described are radiopharmaceutical compositions, automated versions of the radiolabelling method and disposable cassettes for use in the automated method.
摘要翻译：本发明提供了制备放射性同位素标记的显像剂组合物的方法。该方法使用与可溶性聚合物结合的前体，使得放射性标记反应在溶液中进行。还描述了放射性药物组合物，放射性标记方法的自动版本和用于自动化方法的一次性盒。

2. 发明申请

WO2009106551A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009106551A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009052244
申请日：2009-02-26
申请人： GE HEALTHCARE AS , PRIEBE HANNO , AUKRUST AUDUN
发明人： PRIEBE HANNO , AUKRUST AUDUN
IPC分类号： C07C237/46 , A61K49/04
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CO-CH3)-X-N(CO-CH3)-R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个通式为RN（CO-CH 3）-XN（CO-CH 3）-R的连接碘化苯基的化合物及其盐或光学活性异构体，其中X表示C3至C4直或支链亚烷基部分，其中亚烷基部分被一个或两个羟基，任选羟基化的烷基和/或烷氧基取代; 并且每个R表示进一步被亲水部分取代的三碘代苯基残基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这种化合物的造影剂。

3. 发明申请

WO2009106552A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009106552A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009052245
申请日：2009-02-26
申请人： GE HEALTHCARE AS , PRIEBE HANNO
发明人： PRIEBE HANNO
IPC分类号： C07C235/66 , A61K49/04 , C07C233/09 , C07C235/84 , C07D309/10
CPC分类号： A61K49/04 , A61K49/0438 , B22D11/1287 , B23K9/048 , B23K35/02 , B23K35/0261 , B23K35/30 , B23K35/3086 , B23K2201/04 , B23K2203/04 , C07C235/66 , C07C235/84 , C07D309/10 , C22C38/18 , C22C38/26
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CO-CH3) - X- N(CO-CH3)- R and salts or optical active isomers thereof, wherein X denotes a divalent linking moiety with 5 to 10 bridge elements of carbon, oxygen, sulphur and nitrogen separating the acetylated nitrogen atoms, and which may be further substituted by hydroxyl groups, by C1 to C4 alkyl moieties optionally substituted by hydroxyl groups, by C1 to C4 alkoxy groups, by amino groups and by C1 to C4 alkylamino groups, and wherein 2 or 3 carbon bridge elements together with alkyl or alkoxy groups form a cyclopentane, cyclohexane, pentahydropyran or tetrahydrofuran entity which may be alkyl- or hydroxyalkyl- substituted and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式RN（CO-CH 3）-X-N（CO-CH 3）-R）和其盐或光学活性异构体的两个连接的碘化苯基的化合物，其中X表示二价连接具有5至10个碳元素，氧，硫和氮的桥连元素，分隔乙酰化的氮原子，并且其可进一步被羟基取代，被任选被羟基取代的C1-C4烷基部分，C1-C4烷氧基，由氨基和C1至C4烷基氨基组成，其中2或3个碳桥元素与烷基或烷氧基一起形成环戊烷，环己烷，五氢吡喃或四氢呋喃实体，其可以是烷基或羟基烷基取代的，并且每个R表示三碘化物苯基残基进一步被亲水部分取代。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

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