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1. 发明申请

WO2009106551A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009106551A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009052244
申请日：2009-02-26
申请人： GE HEALTHCARE AS , PRIEBE HANNO , AUKRUST AUDUN
发明人： PRIEBE HANNO , AUKRUST AUDUN
IPC分类号： C07C237/46 , A61K49/04
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CO-CH3)-X-N(CO-CH3)-R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个通式为RN（CO-CH 3）-XN（CO-CH 3）-R的连接碘化苯基的化合物及其盐或光学活性异构体，其中X表示C3至C4直或支链亚烷基部分，其中亚烷基部分被一个或两个羟基，任选羟基化的烷基和/或烷氧基取代; 并且每个R表示进一步被亲水部分取代的三碘代苯基残基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这种化合物的造影剂。

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