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1. 发明申请

WO2012076697A1 RADIOTRACER COMPOSITIONS 审中-公开
标题翻译：放射性组合物
公开(公告)号：WO2012076697A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/072352
申请日：2011-12-09
申请人： GE HEALTHCARE LIMITED , ENGELL, Torgrim , GRIGG, Julian , MANTZILAS, Dimitrios
发明人： ENGELL, Torgrim , GRIGG, Julian , MANTZILAS, Dimitrios
IPC分类号： A61K51/08 , C07B63/00
CPC分类号： A61K51/088 , A61K51/0497 , A61K51/082 , C07B59/008 , C07K1/13
摘要： The present invention relates to improved radiotracer imaging agent compositions, which comprises 18 F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
摘要翻译：本发明涉及改进的放射性示踪剂成像剂组合物，其包含18F标记的生物靶向部分，其中鉴定和抑制影响体内成像的杂质。还提供了包含所述改进的组合物的放射性药物，以及可用于制备所述放射性示踪剂组合物的放射性氟化醛组合物。本发明还包括使用所述放射性药物组合物进行成像和/或诊断的方法。

2. 发明申请

WO2011044422A2 SOLID PHASE EXTRACTION PURIFICATION METHOD 审中-公开
标题翻译：固相萃取净化法
公开(公告)号：WO2011044422A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051919
申请日：2010-10-08
申请人： GE HEALTHCARE LIMITED , MEDI-PHYSICS, INC. , PETTITT, Roger , GRIGG, Julian , ENGELL, Torgrim , WICKMANN, Carina
发明人： PETTITT, Roger , GRIGG, Julian , ENGELL, Torgrim , WICKMANN, Carina
IPC分类号： A61K51/08
CPC分类号： C07D277/66 , A61K51/088 , C07B59/002 , C07B63/00 , C07K7/06
摘要： A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Fluciclatide ( 18 F) Injection for the imaging of malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma and anti-angiogenic therapies including high-grade glioma, renal cell carcinoma, melanoma and invasive breast tumours and distant metastases as well as head and neck tumours and methods and devices for preparing the same are described including the automated synthesis and purification of [ 18 F]fluciclatide by means of solid phase extraction (SPE).
摘要翻译：描述了用于正电子发射断层摄影（PET）成像的诊断成像剂以及用于生产这种成像剂的改进的硬件。 Fluciclatide（18 F）用于恶性疾病，心脏疾病，子宫内膜异位症，炎症相关疾病，类风湿性关节炎和卡波西肉瘤的成像以及包括高级别胶质瘤，肾细胞癌的抗血管生成疗法的注射剂，黑素瘤和浸润性乳腺肿瘤和远处转移以及头颈部肿瘤，并描述了用于制备该肿瘤的方法和装置，包括通过固相提取自动化合成和纯化[18 F] fluciclatide （SPE）。

3. 发明申请

WO2006037950A1 METHOD OF DEPROTECTION 审中-公开
标题翻译：保护方法
公开(公告)号：WO2006037950A1
公开(公告)日：2006-04-13
申请号：PCT/GB2005/003692
申请日：2005-09-23
申请人： GE HEALTHCARE LIMITED , GRIGG, Julian , OSBORN, Nigel
发明人： GRIGG, Julian , OSBORN, Nigel
IPC分类号： C07C227/18 , C07C227/20 , C07C213/08 , C07H5/02 , C07D239/54 , C07D239/553 , C07D277/66 , C07D401/06 , C07C229/36 , C07C229/46 , C07C215/52
CPC分类号： C07D239/54 , A61K51/0406 , A61K51/0491 , C07B59/00 , C07B2200/05 , C07D239/553 , C07D277/66 , C07D401/06
摘要： The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.
摘要翻译：本发明提供了一种合成18 F标记产物的方法，该产物包含使用包含弱酸的去保护剂脱保护了受保护的18F标记化合物，并且其中去保护产物的中和和缓冲是通过加入中和剂。去保护的产物在适合于随后的高压灭菌和配制成可注射放射性药物的pH范围内缓冲。

4. 发明申请

WO2006100471A2 STRIPPING METHOD 审中-公开
标题翻译：剥离方法
公开(公告)号：WO2006100471A2
公开(公告)日：2006-09-28
申请号：PCT/GB2006/001034
申请日：2006-03-21
申请人： GE HEALTHCARE LIMITED , OSBORN, Nigel, John , GRIGG, Julian
发明人： OSBORN, Nigel, John , GRIGG, Julian
IPC分类号： B01J20/08 , B01J20/34 , C02F1/66
CPC分类号： B01J20/08 , B01J20/3433 , B01J20/3475 , B01J2220/62 , C02F1/281 , C02F1/66 , C02F2101/006 , C02F2101/14 , C02F2201/006 , C02F2209/02 , C02F2303/16
摘要： The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [ 18 F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.
摘要翻译：本发明描述了一种剥离氧化铝的方法，其特别适用于从氧化铝中除去氟化物，并且包括用酸或碱水溶液在升高的温度下洗涤所述氧化铝。该方法可用于在放射性氟化反应之后从氧化铝中除去未反应的放射性氟化物，例如[16 F]氟化物。还要求保护适用于执行该方法的自动化合成装置及其盒。

5. 发明申请

WO2006054098A3 FLUORIDATION PROCESS FOR THE SYNTHESIS OF 2- [18F] FLUORO-2-DEOXY-D-GLUCOSE 审中-公开
公开(公告)号：WO2006054098A3
公开(公告)日：2006-05-26
申请号：PCT/GB2005/004451
申请日：2005-11-18
申请人： GE HEALTHCARE LIMITED , OSBORN, Nigel, John , GRIGG, Julian , PETTITT, Roger, Paul , WILSON, Anthony , POWELL, Nigel, Anthony
发明人： OSBORN, Nigel, John , GRIGG, Julian , PETTITT, Roger, Paul , WILSON, Anthony , POWELL, Nigel, Anthony
IPC分类号： C07H13/04 , C07H13/10 , C07H1/00
摘要： The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.

6. 发明申请

WO2002078788A2 FIRE AND EXPLOSION SUPPRESSION 审中-公开
标题翻译：消防和爆炸抑制
公开(公告)号：WO2002078788A2
公开(公告)日：2002-10-10
申请号：PCT/GB2002/001495
申请日：2002-03-28
申请人： KIDDE PLC , DUNSTER, Robert, George , DAVIES, Simon, James , LADE, Robert, James , GRIGG, Julian
发明人： DUNSTER, Robert, George , DAVIES, Simon, James , LADE, Robert, James , GRIGG, Julian
IPC分类号： A62C5/00
CPC分类号： A62C5/008 , A62C5/002
摘要： A fire and explosion suppression system comprises a source (5) of high pressure water which is fed to a misting nozzle (13) or other water mist generating means at one input of a mixing unit (6), and a source (14) of high pressure inert gas, such as nitrogen, which is fed along a pipe (20) to another input of the mixing unit (6). Inside the mixing unit (6), water mist, in the form of an atomised mist of very small droplet size is mixed with the pressurised gas and exits the mixing unit (6) at high pressure and high velocity along a pipe (22) and is thence discharged through spreaders (26, 28). Separation of the mist production from the actual discharge of the mist, and the entraining and transporting of the mist between these two stages at high pressure and high velocity, produces an output mist of very small droplet size which is carried by the entraining and transporting high pressure gas into the area to be protected, enabling a total flooding capability.
摘要翻译：一种消防和爆炸抑制系统，包括一个高压水源（5），该源（5）被供给到混合单元（6）的一个输入处的喷雾喷嘴（13）或其它水雾发生装置，以及源高压惰性气体，例如氮气，其沿着管道（20）输送到混合单元（6）的另一输入端。在混合单元（6）的内部，将雾滴非常小的雾化水雾与加压气体混合，并以高压和高速沿着管道（22）离开混合单元（6），并且通过吊具排出（26,28）。雾气的生成与雾的实际分离以及高压和高速下的这两个阶段之间的雾的夹带和输送产生了非常小的液滴尺寸的输出雾，其通过夹带和输送高压力气体进入要保护的区域，实现全面的淹水能力。

7. 发明申请

WO2002078790A3 FIRE AND EXPLOSION SUPPRESSION AGENT 审中-公开
公开(公告)号：WO2002078790A3
公开(公告)日：2002-10-10
申请号：PCT/GB2002/001476
申请日：2002-03-28
申请人： KIDDE PLC , GRIGG, Julian
发明人： GRIGG, Julian
IPC分类号： A62D1/00
摘要： A fire or explosion suppression system comprises a source (30) of a liquid suppressant under pressure, and a source (32) of an inert gas under pressure. The liquid suppressant is a chemical substance having a low environmental impact, with a short atmospheric lifetime of less than 30 days. The inert gas may be nitrogen, carbon dioxide, argon, neon or helium or mixtures of any two or more of them. The suppressant and the inert gas are fed under pressure to an output unit (34) comprising a mixing chamber in which the liquid and the gas impinge to produce a mist of the liquid suppressant of very small droplet size which is entrained in the pressurised gas together with vapour from the liquid, the so-entrained mist and vapour and the gas being discharged by a nozzle (44) into an area to be protected. The mist and vapour are therefore carried by the entraining and transporting high pressure gas into regions of the areas to be protected, enabling a total flooding capability. The inert gas also performs a fire or explosion suppressing capability.

8. 发明申请

WO2022263594A1 METHOD FOR PREPARING AN [18F] RADIOLABELLED COMPOUND WITH LOW WATER CONTENT DURING LABELLING STEP 审中-公开
公开(公告)号：WO2022263594A1
公开(公告)日：2022-12-22
申请号：PCT/EP2022/066483
申请日：2022-06-16
申请人： GE HEALTHCARE LIMITED
发明人： ENGELL, Torgrim , MCROBBIE, Graeme , CLARKE, Alan , GRIGG, Julian , KHAN, Imtiaz Ahmed , WIKENE, Kristine , SHALES, Jonathan , JACKSON, Alexander
IPC分类号： C07B59/00 , A61K51/04
摘要： The invention relates to a method of preparing an [18F]radio-labelled compound, wherein the water content is controlled. Controlling the water content and the origin of the water within the reaction process has a significant effect on both the yield and the purity of the product of the radio-labelling process.

9. 发明申请

WO2022263592A1 PREPARATION OF A PH-ADJUSTED ASCORBIC ACID SOLUTION 审中-公开
公开(公告)号：WO2022263592A1
公开(公告)日：2022-12-22
申请号：PCT/EP2022/066481
申请日：2022-06-16
申请人： GE HEALTHCARE LIMITED
发明人： MCROBBIE, Graeme , ENGELL, Torgrim , WIKENE, Kristine , KHAN, Imtiaz Ahmed , GRIGG, Julian , JACKSON, Alexander , CLARKE, Alan , SHALES, Jonathan
IPC分类号： A61K47/22 , A61K51/00 , A61K9/00 , A61K47/02 , A61K47/08
摘要： Provided is a method of preparing an aqueous ascorbic acid solution having a pH of 2.0 to 4.0, the method comprising: providing an initial aqueous solution of ascorbic acid and a base, wherein the initial solution has a pH of 5.0 to 8.0; and combining the initial solution with a second acid to obtain an ascorbic acid solution having a pH of 2.0 to 4.0. Also provided is the use of an aqueous ascorbic acid solution having a pH of 2.0 to 4.0 prepared by a described method as a radiostabiliser of a radio-labelled compound.

10. 发明申请

WO2015091985A1 METHODS AND SYSTEMS FOR EMPTYING A WASTE VESSEL 审中-公开
标题翻译：用于废弃废水的方法和系统
公开(公告)号：WO2015091985A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078807
申请日：2014-12-19
申请人： GE HEALTHCARE LIMITED
发明人： OSBORN, Nigel, John , GRIGG, Julian , HORN, Eric , SHALES, Jonathan, Robert
IPC分类号： G21F9/06 , A61J1/20 , B65B3/00 , G21F9/20 , G21F9/22
CPC分类号： G21F9/22 , A61J3/002 , A61K51/00 , B65B3/003 , B67D7/0294 , G21F9/06 , G21F9/20
摘要： The present invention relates to methods and devices for evacuating the contents of a primary waste vessel to a secondary waste vessel, desirably between production runs of an automated synthesis device.
摘要翻译：本发明涉及用于将主废料容器的内容物抽出到二次废料容器的方法和装置，理想地在自动合成装置的生产运行之间。

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