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1. 发明申请

WO2021255135A1 DIFFUSION DEVICE 审中-公开
公开(公告)号：WO2021255135A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066332
申请日：2021-06-17
申请人： GAMBRO LUNDIA AB
发明人： LOERCHER, Joachim , FLIEG, Ralf , KNOER, Torsten , WAGNER, Steffen , BECK, Christof , LOEFFLER, Markus
IPC分类号： B01D63/02 , B01D63/022
摘要： The present disclosure relates to a diffusion device, such as a blood oxygenator or gas exchanger, and a process for its production. The diffusion device is used in the removal of carbon dioxide from blood.

2. 发明申请

WO2014079681A2 LIVER SUPPORT SYSTEM 审中-公开
标题翻译：肝支持系统
公开(公告)号：WO2014079681A2
公开(公告)日：2014-05-30
申请号：PCT/EP2013/073058
申请日：2013-11-05
申请人： GAMBRO LUNDIA AB
发明人： FLIEG, Ralf , ALDINGER, Stephan , STORR, Markus , KRAUSE, Bernd
IPC分类号： A61M1/36
CPC分类号： A61M1/1627 , A61M1/1633 , A61M1/3679 , A61M2210/1071 , B01D61/243 , B01D63/021 , B01D63/046 , B01D69/02 , B01D2313/40 , B01D2325/20 , B01J20/103 , B01J20/20 , B01J20/205 , B01J20/261 , B01J47/014
摘要： The present disclosure relates to an artificial, extracorporeal system for liver replacement and/or assistance, comprising a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure, which is characterized in that it comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer and wherein the filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.
摘要翻译：本公开涉及用于肝脏置换和/或辅助的人造体外系统，其包括用于对患有肝衰竭的患者进行血液透析的肝透析装置，其特征在于，其包括第一标准中空纤维膜透析器不允许将必需量的白蛋白通过膜壁并与患者的血液灌注;以及第二中空纤维膜透析器，其允许基本但限定量的白蛋白通过膜壁并且接收血液中的血液所述第一标准血液透析器，其中所述滤液空间与所述中空纤维的管腔空间封闭，并且由可包含一种或多种不同吸附剂的吸附材料填充。

3. 发明申请

WO2011051145A1 ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
标题翻译：酶功能化支持
公开(公告)号：WO2011051145A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/065770
申请日：2010-10-20
申请人： GAMBRO LUNDIA AB , FLIEG, Ralf , KLOTZ, Manuela , STORR, Markus , REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , KRAUSE, Bernd , HORNUNG, Markus
发明人： FLIEG, Ralf , KLOTZ, Manuela , STORR, Markus , REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , KRAUSE, Bernd , HORNUNG, Markus
IPC分类号： C12N11/14 , C12N9/18 , C12N9/80
CPC分类号： C12N9/18 , C09D133/14 , C12N9/80 , C12N11/06 , C12N11/08
摘要： The present disclosure relates to enzymes linked to a solid support by a spacer, a method for producing them and the use of such immobilized enzymes.
摘要翻译：本公开内容涉及通过间隔物与固体支持物连接的酶，其制备方法和这种固定化酶的用途。

4. 发明申请

WO2021130146A1 STERILE FILTER ASSEMBLY 审中-公开
公开(公告)号：WO2021130146A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087376
申请日：2020-12-21
申请人： GAMBRO LUNDIA AB
发明人： FLIEG, Ralf
IPC分类号： B01D61/18 , B01D63/02 , B01D2313/02 , B01D2313/06 , B01D2315/08
摘要： The present disclosure relates to a an assembly of sterile filters, a process for manufacturing the assembly, and a method of operating the assembly.

5. 发明申请

WO2013087552A1 DOPED MEMBRANES 审中-公开
标题翻译： DOPED膜
公开(公告)号：WO2013087552A1
公开(公告)日：2013-06-20
申请号：PCT/EP2012/074899
申请日：2012-12-10
申请人： GAMBRO LUNDIA AB
发明人： FLIEG, Ralf , STORR, Markus , KRAUSE, Bernd , HORNUNG, Markus , KLOTZ, Karl, Heinz
IPC分类号： B01D69/06 , B01D69/08 , B01D69/14 , B01D67/00
CPC分类号： B01D69/148 , B01D67/0011 , B01D69/06 , B01D69/08 , B01D69/087 , B01D69/088 , B01D69/141 , B01D69/147 , B01D2325/36 , B01D2325/38 , B01D2325/42
摘要： The present disclosure relates to synthetic membranes for the removal, isolation or purification of substances from a liquid, comprising at least one hydrophobic and at least one hydrophilic polymer, wherein 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 µm are entrapped and wherein the membrane has a wall thickness of below 150 µm. Further disclosed are methods for preparing such membranes in various geometries and their use for the adsorption, isolation and/or purification of substances from a liquid.
摘要翻译：本公开涉及用于从液体中除去，分离或纯化物质的合成膜，其包含至少一种疏水性和至少一种亲水性聚合物，其中5-40重量％的平均粒度为0.1 和15μm被截留，并且其中膜具有低于150μm的壁厚。进一步公开的是制备各种几何形状的这种膜的方法及其用于从液体中吸附，分离和/或纯化物质的用途。

6. 发明申请

WO2019034714A1 METHOD OF STERILIZING WATER-FILLED DEVICES 审中-公开
公开(公告)号：WO2019034714A1
公开(公告)日：2019-02-21
申请号：PCT/EP2018/072161
申请日：2018-08-16
申请人： GAMBRO LUNDIA AB
发明人： FLIEG, Ralf , FREUDEMANN, Wolfgang , KNOER, Torsten
IPC分类号： A61M1/16 , A61L2/00 , A61L2/07 , B65D51/16
摘要： The present disclosure relates to a method of steam- sterilizing liquid-filled medical devices, e.g., filtration and/or diffusion devices like ultrafilters and capillary dialyzers.

7. 发明申请

WO2018046461A1 LIVER SUPPORT SYSTEM 审中-公开
标题翻译：肝支持系统
公开(公告)号：WO2018046461A1
公开(公告)日：2018-03-15
申请号：PCT/EP2017/072154
申请日：2017-09-05
申请人： GAMBRO LUNDIA AB
发明人： FLIEG, Ralf , KRAUSE, Bernd , STORR, Markus
IPC分类号： A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： B01D61/243 , A61M1/1633 , A61M1/1676 , A61M1/1696 , B01D61/28 , B01D69/02 , B01D2311/06 , B01D2311/2626 , B01D2317/025 , B01D2325/20
摘要： The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.
摘要翻译：本公开涉及一种用于支持患有肝衰竭的患者的肝功能的人造体外系统，其特征在于其包含第一高通量或高截断值中空纤维膜透析器，其在腔侧与患者血液一起灌注，并且其中包含人血清白蛋白的缓冲水溶液以连续流动的方式通过所述第一透析器的滤液空间;第二中空纤维膜透析器，来自所述第一透析器的透析液的可溶性物质以及第三整体式中空纤维膜透析器，所述第三整体式中空纤维膜透析器与第二血液透析器的渗余物一起灌注并且允许一定量的白蛋白通过膜壁进入滤过空间，吸附材料。该系统可用于治疗急性肝衰竭和急慢性肝衰竭。

8. 发明申请

WO2013020967A1 SEPARATION MATERIAL 审中-公开
标题翻译：分离材料
公开(公告)号：WO2013020967A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065394
申请日：2012-08-07
申请人： GAMBRO LUNDIA AB , REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , FLIEG, Ralf , STORR, Markus
发明人： REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , FLIEG, Ralf , STORR, Markus
IPC分类号： A61M1/36 , B01J20/26 , B01J20/289 , B01J20/32
CPC分类号： A61M1/34 , A61M2205/3368 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/327 , B01J20/3274 , B01J20/3278 , B01J20/328
摘要： The present disclosure relates to a separation material comprising a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide, to a method for preparing such separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material. The present invention further relates to a device comprising a separation material for separating substances from a liquid that selectively bind to the saccharide of the separation material.
摘要翻译：本公开涉及一种分离材料，其包含与糖结合的基质，能够与选自结合糖的物质的液体分离，制备这种分离材料的方法和从液体中分离物质的方法，选择性地结合分离材料的糖。本发明还涉及一种装置，其包括用于从选择性地结合分离材料的糖的液体中分离物质的分离材料。

9. 发明申请

WO2019038211A1 METHOD FOR SEALING MEDICAL DEVICES 审中-公开
公开(公告)号：WO2019038211A1
公开(公告)日：2019-02-28
申请号：PCT/EP2018/072376
申请日：2018-08-20
申请人： GAMBRO LUNDIA AB
发明人： ASSMANN, Claudia , FLIEG, Ralf , FREUDEMANN, Wolfgang , KNOER, Torsten
IPC分类号： B29C65/68 , B29C65/56 , B29C65/10
摘要： The present disclosure relates to a method of sealing ports of medical devices, e.g., filtration and/or diffusion devices like ultrafilters and capillary dialyzers.

10. 发明申请

WO2019034678A1 PROCESS FOR TESTING FILTERS 审中-公开
公开(公告)号：WO2019034678A1
公开(公告)日：2019-02-21
申请号：PCT/EP2018/072092
申请日：2018-08-15
申请人： GAMBRO LUNDIA AB
发明人： ASSMANN, Claudia , FLIEG, Ralf , FREUDEMANN, Wolfgang , KNOER, Torsten , YILDIRIM, Mehmet
IPC分类号： B01D65/10 , A61M1/16 , G01M3/26 , B01D61/24 , B01D63/02 , G01N15/08
摘要： The present disclosure relates to a process for testing the integrity of membranes in a filter module. Specifically, the process is applied to filters for extracorporeal blood treatment, in particular, filters comprising both filter membranes and particulate material.

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