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1. 发明申请

WO2013004250A1 CHEWING GUM HAVING SUSTAINED RELEASE OF NICOTINE 审中-公开
标题翻译： CHEWING GUM HAS持续释放NICOTINE
公开(公告)号：WO2013004250A1
公开(公告)日：2013-01-10
申请号：PCT/DK2012/050256
申请日：2012-07-06
申请人： FERTIN PHARMA A/S , NIELSEN, Bruno Provstgaard , NEERGAARD, Jesper
发明人： NIELSEN, Bruno Provstgaard , NEERGAARD, Jesper
IPC分类号： A61K9/00 , A61K31/465 , A23G4/20 , A23G4/06 , A23G4/12
CPC分类号： A61K31/465 , A23G4/066 , A23G4/12 , A61K9/0058 , A61K31/787
摘要： The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1 –10% of C8 –C10 triglycerides by weight of the chewing gum.
摘要翻译：本发明涉及具有高表面积/体积比（SAV比）的口香糖，其中所述口香糖包括水不溶性胶基基质，水溶性本体部分和尼古丁，其中胶基基质，尼古丁和将本体部分混合并挤出以形成具有高于0.7的SAV比率的最终挤出的口香糖产品，并且其中通过加入口香糖重量的0.1-10％的C8-C10甘油三酯来促进尼古丁的持续释放。

2. 发明申请

WO2019110074A1 NICOTINE MOUTH SPRAY 审中-公开
公开(公告)号：WO2019110074A1
公开(公告)日：2019-06-13
申请号：PCT/DK2018/050337
申请日：2018-12-07
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , NIELSEN, Kent Albin
IPC分类号： A61K47/10 , A61K9/00 , A61K47/22 , A61K9/08 , A61K31/465 , A61P25/34
CPC分类号： A61K9/006 , A61K9/08 , A61K31/465 , A61K47/10 , A61K47/22 , A61P25/34
摘要： The invention relates to a liquid nicotine mouth spray formulation for oral mucosal delivery and fast onset nicotine craving relief, the mouth spray formulation being designed to adhere to the oral mucosa, and the mouth spray formulation being designed to utilize free nicotine base as both a source of nicotine and a source of pH regulating agent, wherein the mouth spray formulation does not contain any further pH regulating agent other than said free nicotine base.

3. 发明申请

WO2019110076A1 HIGH NICOTINE ABSORPTION 审中-公开
公开(公告)号：WO2019110076A1
公开(公告)日：2019-06-13
申请号：PCT/DK2018/050339
申请日：2018-12-07
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , NIELSEN, Kent Albin
IPC分类号： A61K47/02 , A61K9/00 , A61K9/08 , A61K9/14 , A61K9/20 , A61K31/465 , A61P25/34
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/08 , A61K9/143 , A61K9/2009 , A61K31/465 , A61K47/02 , A61P25/34
摘要： The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation is designed for the content of nicotine to dissolve in the oral saliva within a period of less than 90 seconds upon oral administration, and wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa.

4. 发明申请

WO2016050245A1 ELECTRONIC NICOTINE DELIVERY SYSTEM 审中-公开
标题翻译：电子尼古丁输送系统
公开(公告)号：WO2016050245A1
公开(公告)日：2016-04-07
申请号：PCT/DK2014/050313
申请日：2014-10-03
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard
IPC分类号： A24F47/00
CPC分类号： A24F47/008 , A61M11/04 , A61M11/044 , A61M15/0001 , A61M15/0021
摘要： An electronic nicotine delivery system (ENDS) is disclosed, said electronic nicotine delivery system (ENDS) comprising a mouth piece (MP), an atomizer arrangement (AA), a power supply (PS), and a container arrangement (CA) containing nicotine, the atomizer arrangement (AA) comprising an inlet from the container arrangement (CA), the atomizer arrangement (AA) comprising at least one atomizer, the atomizer being electrically connected to the power supply (PS), the container arrangement (CA) further containing pH-controlling agent and the atomizer arrangement producing aerosols comprising pH-controlling agent and nicotine.
摘要翻译：公开了一种电子尼古丁输送系统（ENDS），所述电子尼古丁输送系统（ENDS）包括口器（MP），雾化器装置（AA），电源（PS）和容纳装置（CA），其包含尼古丁所述雾化器装置（AA）包括来自所述容器装置（CA）的入口，所述雾化器装置（AA）包括至少一个雾化器，所述雾化器电连接到所述电源（PS），所述容器装置含有pH控制剂和雾化器装置，其产生包含pH控制剂和尼古丁的气溶胶。

5. 发明申请

WO2016004952A1 ORAL DELIVERY SYSTEM COMPRISING TWO COMPARTMENTS 审中-公开
标题翻译：包含两个间隔的口腔传送系统
公开(公告)号：WO2016004952A1
公开(公告)日：2016-01-14
申请号：PCT/DK2015/050192
申请日：2015-06-30
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard
IPC分类号： A61J1/00 , A61J7/00 , A61M11/00 , A61K9/70 , A61K31/465 , A61K47/36 , A61M15/00
CPC分类号： A61K9/7015 , A61K9/006 , A61K31/465 , A61K47/36 , A61M11/006 , A61M15/0003 , A61M15/0065 , A61M15/009 , A61M15/06 , A61M2202/04 , A61M2202/064 , A61M2205/3386 , A61M2205/50 , A61M2205/583 , A61M2205/8206 , A61M2210/0625
摘要： An oral delivery system (ODS) is disclosed, the oral delivery system (ODS) comprising a first compartment (FCO) and a second compartment (SCO), said first compartment (FCO) comprising a first component (FC) comprising natural unbranched polysaccharide, said second compartment (SCO) comprising a second component (SC) comprising multivalent cations, wherein the oral delivery system (ODS) is adapted for administering the first and second components (FC, SC) in a synchronized manner to the oral cavity, whereby a bioadhesive gel is formed from said natural unbranched polysaccharide and said multivalent cationsin a cross-linking reaction.
摘要翻译：公开了一种口服递送系统（ODS），包括第一隔室（FCO）和第二隔室（SCO）的口服递送系统（ODS），所述第一隔室（FCO）包括包含天然未分支多糖的第一组分（FC）所述第二隔室（SCO）包括包含多价阳离子的第二组分（SC），其中所述口服递送系统（ODS）适于以与所述口腔同步的方式施用所述第一和第二组分（FC，SC），由此生物粘附凝胶由所述天然未分支多糖和所述多价阳离子在交联反应中形成。

6. 发明申请

WO2021069036A1 COMPRESSED NICOTINE LOZENGE 审中-公开
公开(公告)号：WO2021069036A1
公开(公告)日：2021-04-15
申请号：PCT/DK2020/050103
申请日：2020-04-17
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , BOESEN, Dorthe Schackinger , BRUUN, Heidi Ziegler , NIELSEN, Kent Albin , PRANGER-RASMUSSEN, Rikke
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24
摘要： A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.

7. 发明申请

WO2016050246A1 ELECTRONIC NICOTINE DELIVERY SYSTEM 审中-公开
标题翻译：电子尼古丁输送系统
公开(公告)号：WO2016050246A1
公开(公告)日：2016-04-07
申请号：PCT/DK2014/050314
申请日：2014-10-03
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard
IPC分类号： A24F47/00
CPC分类号： A24F47/008
摘要： Electronic nicotine delivery system (ENDS) is disclosed, the electronic nicotine delivery system comprising a mouth piece (MP), an atomizer arrangement (AA), an electronic power supply (PS), and a container arrangement (CA) containing a nicotine solution, the atomizer arrangement (AA) comprises an inlet from the container arrangement (CA), the atomizer arrangement (AA) comprising at least one atomizer, the atomizer being electrically connected to the power supply (PS), the atomizer producing aerosols, the aerosols comprising nicotine; and wherein the container arrangement (CA) is formed at least partly of plastic. Furthermore, a nicotine container (NC) is disclosed.
摘要翻译：公开了电子尼古丁输送系统（ENDS），包括口器（MP），雾化器装置（AA），电子电源（PS）和包含尼古丁溶液的容器装置（CA）的电子尼古丁输送系统，雾化器装置（AA）包括来自容器装置（CA）的入口，雾化器装置（AA）包括至少一个雾化器，雾化器电连接到电源（PS），雾化器产生气溶胶，气溶胶包括尼古丁; 并且其中所述容器装置（CA）至少部分地由塑料形成。此外，公开了尼古丁容器（NC）。

8. 发明申请

WO2015090337A1 NICOTINE POWDER COMPOSITION 审中-公开
标题翻译：尼古丁粉末组合物
公开(公告)号：WO2015090337A1
公开(公告)日：2015-06-25
申请号：PCT/DK2014/050444
申请日：2014-12-18
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , BØJE, Niels Ramskov
IPC分类号： A61K9/00 , A61K9/51 , A61K31/465
CPC分类号： A61K9/006 , A61K9/0058 , A61K9/5123 , A61K9/5138 , A61K9/5176 , A61K31/465
摘要： The present invention relates to unexpected and improved powder compositions for oromucosal delivery of nicotine comprising a plurality of solid lipid particles, the solid lipid particles having a content of nicotine and at least one surfactant, and the powder composition having a content of water below 10.0% by weight of the powder composition.
摘要翻译：本发明涉及用于粘膜递送尼古丁的预期和改进的粉末组合物，其包含多个固体脂质颗粒，所述固体脂质颗粒具有尼古丁含量和至少一种表面活性剂，并且所述粉末组合物的水含量低于10.0％的粉末组合物。

9. 发明申请

WO2019110075A1 HIGH NICOTINE CONCENTRATION 审中-公开
公开(公告)号：WO2019110075A1
公开(公告)日：2019-06-13
申请号：PCT/DK2018/050338
申请日：2018-12-07
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , NIELSEN, Kent Albin
IPC分类号： A61K47/02 , A61K9/00 , A61K9/08 , A61K9/14 , A61K9/20 , A61K31/465 , A61P25/34
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/08 , A61K9/143 , A61K9/2009 , A61K31/465 , A61K47/02 , A61P25/34
摘要： The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation provides a peak saliva concentration of nicotine of more than 0.3 mg/mL and a peak saliva pH of more than 7.5 during the first 120 seconds upon oral administration.

10. 发明申请

WO2019110073A1 SOLID ORAL NICOTINE FORMULATION 审中-公开
公开(公告)号：WO2019110073A1
公开(公告)日：2019-06-13
申请号：PCT/DK2018/050336
申请日：2018-12-07
申请人： FERTIN PHARMA A/S
发明人： NIELSEN, Bruno Provstgaard , NIELSEN, Kent Albin
IPC分类号： A61K47/02 , A61K9/00 , A61K9/14 , A61K9/20 , A61K31/465 , A61P25/34
CPC分类号： A24B15/16 , A24B15/243 , A61K9/0056 , A61K9/0095 , A61K9/143 , A61K9/2009 , A61K31/465 , A61K47/02 , A61P25/34
摘要： The invention relates to a solid oral nicotine formulation for fast onset nicotine craving relief comprising nicotine and a pH regulating agent, wherein the formulation is designed to release the content of nicotine within a period of 90 seconds in contact with oral saliva and the formulation is designed to release the content of pH regulating agent within a period of 60 seconds in contact with oral saliva.

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