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1. 发明申请

WO2006007839A1 COMPOSITION COMPRISING MINERALS AND USES THEREOF 审中-公开
标题翻译：包含矿物的组合物及其用途
公开(公告)号：WO2006007839A1
公开(公告)日：2006-01-26
申请号：PCT/DK2005/000454
申请日：2005-07-01
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , JORSAL, Lene
发明人： ANDERSEN, Carsten , JORSAL, Lene
IPC分类号： A23G3/30
CPC分类号： A61K33/06 , A23G3/343 , A23G4/064 , A23G4/20 , A23G2200/04 , A23G2210/00 , A23L33/16 , A23V2002/00 , A61K9/0058 , A61K9/282 , A61K31/592 , A61K31/593 , A61K2300/00 , A23V2200/22 , A23V2250/1578 , A23V2250/71
摘要： The present invention relates to a composition comprising an inner core which e.g. may be a chewing gum core, said composition furthermore comprising a coating comprising a very high load of a mineral. The invention furthermore pertains to processes for preparing the composition and to various medical uses.
摘要翻译：本发明涉及包含内核的组合物，可以是口香糖芯，所述组合物还包含包含非常高的矿物质负荷的涂层。本发明还涉及制备组合物和各种医疗用途的方法。

2. 发明申请

WO2006058536A1 METHOD OF PROVIDING FAST RELIEF TO A USER OF A NICOTINE CHEWING GUM 审中-公开
标题翻译：向用户提供快速消费的方法
公开(公告)号：WO2006058536A1
公开(公告)日：2006-06-08
申请号：PCT/DK2004/000833
申请日：2004-11-30
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten
发明人： ANDERSEN, Carsten
IPC分类号： A61K9/68 , A61K31/465 , A61P25/34
CPC分类号： A61K31/465 , A61K9/0058
摘要： The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2 1/2 minutes from initiation of said chewing process.
摘要翻译：本发明涉及一种减轻尼古丁渴望的方法，包括以下步骤：向使用者提供包含烟草生物碱的至少一种口香糖，通过将烟草生物碱从口香糖转移到所述口腔内的人体，使所述使用者缓解尼古丁渴望用户咀嚼所述口香糖，所述咀嚼所述口香糖包括咀嚼过程，该咀嚼过程涉及从所述口香糖转移烟草生物碱高于阈值转移速率，在约0.5分钟至约2 1/2分钟的时间段内说咀嚼过程。

3. 发明申请

WO2009080024A1 COMPRESSED CHEWING GUM COMPRISING AN INCRETIN MIMETIC 审中-公开
标题翻译：压缩的包装增稠的凝胶
公开(公告)号：WO2009080024A1
公开(公告)日：2009-07-02
申请号：PCT/DK2007/050200
申请日：2007-12-20
申请人： FERTIN PHARMA A/S , KAARSHOLM, Niels C. , ANDERSEN, Carsten
发明人： KAARSHOLM, Niels C. , ANDERSEN, Carsten
IPC分类号： A61K9/68 , A61K9/20 , A61K38/22 , A61P3/10
CPC分类号： A61K38/22 , A61K9/0058 , A61K9/2086 , A61K38/2278 , A61K38/26
摘要： The present invention relates to compressed medicament-containing chewing gum compositions. In particular, the present invention is directed to compressed chewing gum compositions comprising an incretin mimetic. Such compositions are useful in the treatment of diabetes or ameliorating the symptoms of diabetes, in particular diabetes type II.
摘要翻译：本发明涉及含压缩药物的口香糖组合物。特别地，本发明涉及包含肠降血糖素模拟物的压缩口香糖组合物。这样的组合物可用于治疗糖尿病或改善糖尿病症状，特别是II型糖尿病。

4. 发明申请

WO2009080021A1 COMPRESSED CHEWING GUM TABLET 审中-公开
标题翻译：压缩式茶叶片
公开(公告)号：WO2009080021A1
公开(公告)日：2009-07-02
申请号：PCT/DK2007/000562
申请日：2007-12-20
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORFF, Helle
发明人： ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORFF, Helle
IPC分类号： A61K9/68 , A61K9/20
CPC分类号： A61K9/2072 , A23G4/043 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/146 , A61K9/2077 , A61K9/2086 , A61K31/465 , A61K38/00
摘要： The invention relates to a compressed chewing gum tablet comprising at least a first and a second chewing gum module, said first chewing gum module comprising a first chewing gum composition comprising at least a first active ingredient and chewing gum granules containing gum base, said second chewing gum module comprising a second chewing gum composition comprising at least a second active ingredient and chewing gum granules containing gum base, wherein said first active ingredient is a pharmaceutically active ingredient, and said second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of said first and second chewing gum modules is different.
摘要翻译：本发明涉及包含至少第一和第二口香糖组件的压缩口香糖片，所述第一口香糖组件包含第一口香糖组合物，所述第一口香糖组合物至少包含第一活性成分和含有胶基的口香糖颗粒，所述第二咀嚼口香糖组合物，其包含第二口香糖组合物，其包含至少第二活性成分和含有胶基的口香糖颗粒，其中所述第一活性成分是药物活性成分，所述第二活性成分选自药物活性成分和增强剂，其中所述第一和第二口香糖模块的胶基含量不同。

5. 发明申请

WO2009006892A1 STABLE MEDICATED CHEWING GUM COMPRISING ANTIOXIDANT 审中-公开
标题翻译：含有抗氧化剂的稳定的药用茶叶
公开(公告)号：WO2009006892A1
公开(公告)日：2009-01-15
申请号：PCT/DK2007/050093
申请日：2007-07-11
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , LAO, My Ly
发明人： ANDERSEN, Carsten , LAO, My Ly
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0058 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/205 , A61K9/2086 , A61K31/00 , A61K31/495
摘要： The present invention provides medicament-containing chewing gums comprising one or more active compound(s) according to formula I, such as cetirizine, and an antioxidant which effectively stabilise the active compound, and methods for preparing such chewing gum the general formula (I): selected from 2- [4-(diphenylmethyl)-1-piperazine] derivatives having wherein R 1 is selected from the group consisting of -CH 2 CH 2 -O-CH 2 -R 2 , -CH 2 CH=CH-Ar 1 , CH2-Ar 2 and R 2 may be selected from the group consisting of a -CH 2 OH group, a -COOH group and a -CONH 2 group; Ar 1 and Ar 2 are independently an aromatic or heteroaromaticring with 5 or 6 atoms in the ring, said heteroaromatfc ring having 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, said ring being unsubstituted or substituted with C 1-4 alkyl, preferably methyl or tertiary butyl, and A r2 preferably being unsubstituted phenyl or phenyl substituted with C 1-4 alkyl, preferably methyl or tertiary butyl; and X 1 and X 2 may independently be selected from the group consisting of a hydrogen atom, a halogen atom, a straight-chain or branched C 1 -C 4 alkoxy group or a tnfluoromethyl group; as well as pharmaceutically acceptable salts, geometrical isomers, eπantiomers, diastereomers and mixtures thereof;
摘要翻译：本发明提供了含有一种或多种式I的活性化合物（如西替利嗪）和有效稳定活性化合物的抗氧化剂的药物含有口香糖，以及制备通式（I）的口香糖的方法，：选自其中R 1选自-CH 2 CH 2 -O-CH 2 -R 2，-CH 2 CH = CH-Ar 1，CH 2 -Ar 2和R 2的2- [4-（二苯基甲基）-1-哌嗪]衍生物由-CH 2 OH基，-COOH基和-CONH 2基组成的基团; Ar 1和Ar 2独立地是在环中具有5或6个原子的芳族或杂芳族化合物，所述杂芳环具有1,2或3个选自氮，氧和硫的杂原子，所述环是未取代的或被C 1-4烷基优选甲基或叔丁基，Ar 2优选为未取代的苯基或被C 1-4烷基取代的苯基，优选甲基或叔丁基; X 1和X 2可以独立地选自氢原子，卤素原子，直链或支链C 1 -C 4烷氧基或全氟甲基; 以及药学上可接受的盐，几何异构体，对映异构体，非对映异构体及其混合物;

6. 发明申请

WO2011150959A1 FORMULATION COMPRISING NICOTINE AND A CATION EXCHANGE RESIN 审中-公开
标题翻译：包含NICOTINE和交换树脂的配方
公开(公告)号：WO2011150959A1
公开(公告)日：2011-12-08
申请号：PCT/EP2010/057560
申请日：2010-05-31
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten
发明人： ANDERSEN, Carsten
IPC分类号： A61K9/08 , A61K31/465
CPC分类号： A61K31/465 , A61K9/0058 , A61K9/08
摘要： The present invention provides a method of producing a nicotine delivery product, the method comprising: combining (i) a mixture comprising nicotine, a cation exchange resin and water, wherein the water content of the mixture is between 5 and 75 wt. % relative to the whole mixture; and (ii) further components of the nicotine delivery product.
摘要翻译：本发明提供了一种生产尼古丁输送产物的方法，该方法包括：（i）包含尼古丁，阳离子交换树脂和水的混合物，其中混合物的水含量为5-75wt。％相对于整个混合物; 和（ii）尼古丁递送产品的其它组分。

7. 发明申请

WO2010145653A1 BUFFERED GUM BASE FOR HIGH PH RELEASE 审中-公开
标题翻译：缓释胶囊用于高PH释放
公开(公告)号：WO2010145653A1
公开(公告)日：2010-12-23
申请号：PCT/DK2009/000146
申请日：2009-06-19
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORFF, Helle
发明人： ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORFF, Helle
IPC分类号： A23G4/08 , A23G4/12 , A61K9/00 , A61K31/465 , A23G4/06
CPC分类号： A23G4/064 , A23G4/06 , A23G4/08 , A23G4/126 , A23G4/20 , A61K9/0058
摘要： The invention relates to a chewing gum composition with high pH-release, the chewing gum composition comprising an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, the invention relates to a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix comprises a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion. Finally, the invention relates to a gum base pellet comprising a water insoluble gum base matrix wherein the gum base pellet comprises a first amount of buffer.
摘要翻译：本发明涉及具有高pH释放性的口香糖组合物，所述口香糖组合物包含不溶性胶基基质和可溶性本体部分，其中将胶基基体和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质在与本体部分混合之前被缓冲。此外，本发明涉及一种生产口香糖芯的方法，其中将胶基基质和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质在与本体部分混合之前被缓冲，并且胶基基质包含与本体部分混合之前的胶基基质的2至20重量％的第一量缓冲剂。最后，本发明涉及包含水不溶性胶基基质的胶基颗粒，其中胶基颗粒包含第一量的缓冲液。

8. 发明申请

WO2009080023A1 COMPRESSED CHEWING GUM COMPRISING PEPTIDE 审中-公开
标题翻译：压克隆胶囊包含肽
公开(公告)号：WO2009080023A1
公开(公告)日：2009-07-02
申请号：PCT/DK2007/050198
申请日：2007-12-20
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , ISAGER, Per Pihlmann
发明人： ANDERSEN, Carsten , ISAGER, Per Pihlmann
IPC分类号： A61K9/68 , A61K9/20 , A61K38/04 , A61Q11/00 , A61K8/64
CPC分类号： A61K38/08 , A61K8/64 , A61K9/0058 , A61K9/205 , A61K31/14 , A61Q11/00 , A61Q17/005
摘要： The present invention relates to compressed medicament-containing chewing gum compositions. In particular, the present invention is directed to compressed chewing gum compositions comprising a peptide, such as e.g. peptides with antimicrobial activity.
摘要翻译：本发明涉及含压缩药物的口香糖组合物。特别地，本发明涉及包含肽的压缩口香糖组合物，例如，具有抗菌活性的肽。

9. 发明申请

WO2009080020A1 CHEWING GUM TABLET AND METHOD OF DOSING PHARMACEUTICALLY ACTIVE INGREDIENTS IN SUCH CHEWING GUM TABLET 审中-公开
标题翻译： CHEWING GUM TABLET AND METHOD FOR DOSING PHARMACEUTIVEAL ACTIVE INGREDIENTS IN CHCHING GUM TABLET
公开(公告)号：WO2009080020A1
公开(公告)日：2009-07-02
申请号：PCT/DK2007/000561
申请日：2007-12-20
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORF, Helle
发明人： ANDERSEN, Carsten , LORENZEN, Gitte , ARENT, Nicolai , THORENGAARD, Bitten , WITTORF, Helle
IPC分类号： A61K9/68 , A61K9/20
CPC分类号： A61K9/0058 , A61K8/02 , A61K9/205 , A61K31/155 , A61Q11/00
摘要： The invention relates to a method of dosing pharmaceutically active ingredients in a compressed chewing gum tablet, the method comprising the steps of: providing one or more pharmaceutically active ingredients, mixing a chewing gum composition comprising said one or more pharmaceutically active ingredients and chewing gum granules, said chewing gum granules comprising gum base, and dosing said chewing gum composition to obtain a desired weight of the chewing gum composition and thereby obtaining a desired dose of said pharmaceutically active ingredient in the chewing gum tablet.
摘要翻译：本发明涉及一种将压缩口香糖片剂中的药物活性成分给药的方法，所述方法包括以下步骤：提供一种或多种药物活性成分，将包含所述一种或多种药物活性成分的口香糖组合物和口香糖颗粒，所述口香糖颗粒包含胶基，并给予所述口香糖组合物以获得所需重量的口香糖组合物，从而在口香糖片中获得所需剂量的所述药物活性成分。

10. 发明申请

WO2006128468A1 A METHOD OF MANUFACTURING A NICOTINE DELIVERY PRODUCT 审中-公开
标题翻译：一种制备非甾体类递送产品的方法
公开(公告)号：WO2006128468A1
公开(公告)日：2006-12-07
申请号：PCT/DK2006/000307
申请日：2006-06-01
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten
发明人： ANDERSEN, Carsten
IPC分类号： A61K31/465 , A61K47/48 , A61K47/10 , A61K9/68
CPC分类号： A61K47/48184 , A61K9/0058 , A61K31/465 , A61K47/585
摘要： A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45 % by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.
摘要翻译：一种制造尼古丁和阳离子交换树脂的尼古丁递送产品的方法。更准确地说，对于制备尼古丁递送产品的方法，所述方法包括（a）将尼古丁，阳离子交换树脂，有机多元醇和水混合以形成混合物，其中水的总量为26-45重量％总混合物，和（b）从混合物中除去水以产生所述尼古丁递送产物。

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