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1. 发明申请

WO2010115015A1 MODIFIED-RELEASE PHARMACEUTICAL DRUG COMPOSITION 审中-公开
标题翻译：改性释放药物药物组合物
公开(公告)号：WO2010115015A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029652
申请日：2010-04-01
申请人： COATING PLACE, INC. , HALL, Harlan, S. , MADSEN, J., Scott
发明人： HALL, Harlan, S. , MADSEN, J., Scott
IPC分类号： A61K9/00 , A61K9/16 , A61K31/137 , A61K47/48
CPC分类号： A61K47/48184 , A61K9/0095 , A61K9/146 , A61K9/5047 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/585 , A61K2300/00
摘要： The present invention provides compositions and methods for a modified-release pharmaceutical drug composition having a first charged active agent and a second charged active agent at least partially surrounded by a rate controlling membrane. The first charged active agent and the second charged active agent interact to form a modified release pharmaceutical complex within the rate controlling membrane and the modified release pharmaceutical complex has a release characteristic different from the release characteristic of the first active agent or the second active agent alone.
摘要翻译：本发明提供了具有至少部分被速率控制膜包围的第一带电活性剂和第二带电活性剂的改性释放药物组合物的组合物和方法。第一带电活性剂和第二带电活性剂相互作用以在速率控制膜内形成改性释放药物复合物，并且所述调释释放药物复合物具有与第一活性剂或第二活性剂单独的释放特性不同的释放特征。

2. 发明申请

WO2016001937A3 MODIFIED RELEASE PHARMACEUTICAL PREPARATIONS 审中-公开
标题翻译：改良释放药物制剂
公开(公告)号：WO2016001937A3
公开(公告)日：2016-03-03
申请号：PCT/IN2015000270
申请日：2015-06-30
申请人： RUBICON RES PRIVATE LTD
发明人： PILGAONKAR PRATIBHA SUDHIR , RUSTOMJEE MAHARUKH TEHMASP , GANDHI ANILKUMAR SURENDRAKUMAR , JAIN PARAS RAMESHLAL
IPC分类号： A61K45/08
CPC分类号： A61K9/5047 , A61K9/10 , A61K9/5015 , A61K31/137 , A61K31/216 , A61K31/496 , A61K45/06 , A61K47/48184 , A61K47/585
摘要： The present invention relates to modified release compositions comprising multitude of modified release beads. The modified release beads comprise a matrix of at least one active ingredient, at least one ion exchange resin, at least one non polymeric multifunctional excipient; substantially coated with at least one outer release rate modifying layer.
摘要翻译：本发明涉及包含大量改性释放珠的改性释放组合物。所述改性释放珠粒包含至少一种活性成分，至少一种离子交换树脂，至少一种非聚合多功能赋形剂的基质; 基本上涂覆有至少一个外释放速率调节层。

3. 发明申请

WO2007033281A3 ION EXCHANGE RESIN TREATED TO CONTROL SWELLING 审中-公开
标题翻译：离子交换树脂处理以控制溶胀
公开(公告)号：WO2007033281A3
公开(公告)日：2007-10-25
申请号：PCT/US2006035739
申请日：2006-09-13
申请人： COATING PLACE INC , HALL HARLAN , MADSEN SCOTT J
发明人： HALL HARLAN , MADSEN SCOTT J
IPC分类号： A61K9/14
CPC分类号： A61K47/48184 , A61K9/0095 , A61K9/146 , A61K31/137 , A61K31/192 , A61K47/585 , A61K2300/00
摘要： The present invention provides a method and composition are provided that includes an ion exchange resin treated with from between about 0.01 to about 10 percent by weight of one or more sugar alcohols in contact with one or more ionic pharmaceutically active drug.
摘要翻译：本发明提供了一种方法和组合物，其包括用约0.01重量％至约10重量％的一种或多种与一种或多种离子药物活性药物接触的糖醇处理的离子交换树脂。

4. 发明申请

WO2015188934A8 CONJUGATE COMPRISING A NEUROTENSIN RECEPTOR LIGAND AND USE THEREOF 审中-公开
标题翻译：包含神经递质受体配体并与其一起使用
公开(公告)号：WO2015188934A8
公开(公告)日：2016-11-24
申请号：PCT/EP2015001166
申请日：2015-06-10
申请人： 3B PHARMACEUTICALS GMBH
发明人： OSTERKAMP FRANK , HAASE CHRISTIAN , REINEKE ULRICH , SMERLING CHRISTIANE , PASCHKE MATTHIAS , UNGEWIΒ JAN
IPC分类号： A61P35/00 , A61K47/48
CPC分类号： A61K51/0482 , A61K31/337 , A61K47/48061 , A61K47/48146 , A61K47/48184 , A61K47/48369 , A61K47/545 , A61K47/555 , A61K47/557 , A61K47/585 , A61K47/68 , A61K49/0043 , A61K51/04 , A61K51/0497 , A61K51/088
摘要： The present invention is related to a conjugate comprising a structure of general formula (1) [TM1] - [AD1] - [LM] - [AD2] - [TM2] (1), wherein TM1 is a first targeting moiety, wherein the first targeting moiety is capable of binding to a first target, AD1 is a first adapter moiety or is absent, LM is a linker moiety or is absent, AD2 is a second adapter moiety or is absent, and TM2 is a second targeting moiety, wherein the second targeting moiety is capable of binding to a second target; wherein the first targeting moiety and/or the second targeting moiety is a compound of formula (2): wherein R1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethyl; AA-COOH is an amino acid selected from the group consisting of 2-amino-2 adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9 carboxylic acid; R2 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3C8)cycloalkylmethyl, halogen, nitro and trifluoromethyl; ALK' is (C2-C5)alkylidene; R3, R4 and R5 are each and independently selected from the group consisting of hydrogen and (C1-C4)alkyl under the proviso that one of R3, R4 and R5 is of the following formula (3) wherein ALK' is (C2-C5)alkylidene; R6 is selected from the group consisting of hydrogen and (C1-C4)alkyl; and R7 is a bond; or a pharmacologically acceptable salt, solvate or hydrate thereof.
摘要翻译：本发明涉及包含通式（1）[TM1] - [AD1] - [LM] - [AD2] - [TM2]（1）的结构的缀合物，其中TM1是第一靶向部分，其中第一靶向部分能够结合第一靶标，AD1是第一接头部分或不存在，LM是接头部分或不存在，AD2是第二接头部分或不存在，而TM2是第二靶向部分，其中第二靶向部分能够结合第二靶标; 其中所述第一靶向部分和/或所述第二靶向部分是式（2）的化合物：其中R 1选自氢，甲基和环丙基甲基; AA-COOH是选自2-氨基-2-金刚烷羧酸，环己基甘氨酸和9-氨基 - 双环[3.3.1]壬烷-9羧酸的氨基酸; R2选自（C1-C6）烷基，（C3-C8）环烷基，（C3C8）环烷基甲基，卤素，硝基和三氟甲基; ALK'为（C2-C5）亚烷基; R3，R4和R5各自独立地选自氢和（C1-C4）烷基，条件是R3，R4和R5之一具有下式（3），其中ALK'是（C2-C5 ）亚烷基; R 6选自氢和（C 1 -C 4）烷基; 而R7是一个键; 或其药理学上可接受的盐，溶剂合物或水合物。

5. 发明申请

WO2015037019A2 MODIFIED RELEASE PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：改性释放药物制剂
公开(公告)号：WO2015037019A2
公开(公告)日：2015-03-19
申请号：PCT/IN2014/000592
申请日：2014-09-12
申请人： RUBICON RESEARCH PRIVATE LIMITED
发明人： PILGAONKAR, Pratibha Sudhir , RUSTOMJEE, Maharukh Tehmasp , GANDHI, Anilkumar Surendrakumar
CPC分类号： A61K31/13 , A61K9/0095 , A61K9/10 , A61K9/5047 , A61K9/5084 , A61K31/445 , A61K45/06 , A61K47/48184 , A61K47/585 , A61K2300/00
摘要： The present invention relates to modified release compositions comprising plurality of modified release units. Particularly, the modified release units comprise at least one anti-Alzheimer's agent, at least one ion exchange resin and at least one release modifier.
摘要翻译：本发明涉及包含多个调节释放单元的调节释放组合物。特别地，改变释放单元包含至少一种抗阿尔茨海默氏剂，至少一种离子交换树脂和至少一种释放调节剂。

6. 发明申请

WO2006128468A1 A METHOD OF MANUFACTURING A NICOTINE DELIVERY PRODUCT 审中-公开
标题翻译：一种制备非甾体类递送产品的方法
公开(公告)号：WO2006128468A1
公开(公告)日：2006-12-07
申请号：PCT/DK2006/000307
申请日：2006-06-01
申请人： FERTIN PHARMA A/S , ANDERSEN, Carsten
发明人： ANDERSEN, Carsten
IPC分类号： A61K31/465 , A61K47/48 , A61K47/10 , A61K9/68
CPC分类号： A61K47/48184 , A61K9/0058 , A61K31/465 , A61K47/585
摘要： A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45 % by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.
摘要翻译：一种制造尼古丁和阳离子交换树脂的尼古丁递送产品的方法。更准确地说，对于制备尼古丁递送产品的方法，所述方法包括（a）将尼古丁，阳离子交换树脂，有机多元醇和水混合以形成混合物，其中水的总量为26-45重量％总混合物，和（b）从混合物中除去水以产生所述尼古丁递送产物。

7. 发明申请

WO2015192030A1 TREPROSTINIL FORMULATIONS 审中-公开
标题翻译： TREPROSTINIL配方
公开(公告)号：WO2015192030A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035595
申请日：2015-06-12
申请人： UNITED THERAPEUTICS CORPORATION
发明人： PHARES, Ken , CHANG, Courtney
IPC分类号： A61K47/32 , A61K9/10 , A61K47/48 , A61K31/557
CPC分类号： A61K31/192 , A61K9/0053 , A61K9/10 , A61K9/20 , A61K9/48 , A61K31/785 , A61K45/06 , A61K47/32 , A61K47/48184 , A61K47/585 , A61K2300/00
摘要： Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.
摘要翻译：提供了包含曲前列素和离子交换树脂的离子络合物，基于这种复合物的药物制剂，以及使用离子络合物和药物制剂治疗疾病和病症的方法。

8. 发明申请

WO2011080683A1 TASTE MASKED DOSAGE FORMS OF BITTER TASTING ANTI-RETROVIRAL DRUGS 审中-公开
标题翻译：叮TE。。。。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：WO2011080683A1
公开(公告)日：2011-07-07
申请号：PCT/IB2010/056065
申请日：2010-12-23
申请人： RANBAXY LABORATORIES LIMITED , KAKUMANU, Vasu Kumar , ISLOOR, Shashikanth , ARORA, Vinod Kumar
发明人： KAKUMANU, Vasu Kumar , ISLOOR, Shashikanth , ARORA, Vinod Kumar
IPC分类号： A61K47/48 , A61K9/00 , A61K31/427 , A61K31/4418 , A61K31/495 , A61K31/513 , A61K31/52
CPC分类号： A61K47/48184 , A61K9/205 , A61K9/2054 , A61K31/427 , A61K31/4418 , A61K31/495 , A61K31/513 , A61K31/52 , A61K47/585
摘要： The present invention relates to taste masked dosage forms of bitter tasting anti- retroviral drugs comprising a complex of the said anti-retroviral drug and an ion-exchange resin and one or more of other pharmaceutically acceptable excipients. It further relates to the processes for the preparation thereof.
摘要翻译：本发明涉及苦味抗逆转录病毒药物的掩味剂类型，其包含所述抗逆转录病毒药物和离子交换树脂与一种或多种其它药学上可接受的赋形剂的复合物。它还涉及其制备方法。

9. 发明申请

WO2010069507A1 NICOTINE-CONTAINING PRODUCT 审中-公开
标题翻译：含NICOTINE的产品
公开(公告)号：WO2010069507A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/008822
申请日：2009-12-10
申请人： SIEGFRIED LTD. , FRANZ, Alexander
发明人： FRANZ, Alexander
IPC分类号： A61K31/465 , A61K47/48
CPC分类号： A61K47/48184 , A61K9/0058 , A61K9/7023 , A61K47/585
摘要： The present invention relates to a nicotine-containing product comprising a pharmaceutically acceptable polymeric substrate, which is able to bind cations, nicotine or a pharmaceutically acceptable nicotine derivative, and pharmaceutically acceptable inorganic cations. It further pertains to a method for the preparation of such a nicotine-containing product and to the use thereof for the preparation of a pharmaceutical product.
摘要翻译：本发明涉及含有尼古丁的产品，其包含能够结合阳离子，尼古丁或药学上可接受的尼古丁衍生物的药学上可接受的聚合物底物和药学上可接受的无机阳离子。它还涉及制备这种含尼古丁的产品的方法及其用于制备药物产品的用途。

10. 发明申请

WO2016015799A8 PEDIATRIC CHEWABLE TABLET CONTAINING ANTIVIRAL AGENT AND METHOD FOR THE PREPARATION THEREOF 审中-公开
标题翻译：含有抗病毒剂的小儿咀嚼片及其制备方法
公开(公告)号：WO2016015799A8
公开(公告)日：2017-05-04
申请号：PCT/EP2015001244
申请日：2015-06-19
申请人： PHARMATHEN SA
发明人： KARAVAS EVANGELOS , KOUTRIS EFTHYMIOS , SAMARA VASILIKI , KOUTRI IOANNA , KALASKANI ANASTASIA , KALANTZI LIDA , KAKOURIS ANDREAS , DIAKIDOU AMALIA , GOTZAMANIS GEORGE , GEORGOUSIS ZAHARIAS , FOUSTERIS MANOLIS
IPC分类号： A61K9/00 , A61K31/522
CPC分类号： A61K31/522 , A61K9/0056 , A61K9/20 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2095 , A61K47/48184 , A61K47/585
摘要： The present invention relates to a pediatric chewable tablet comprising a therapeutically effective amount of an antiviral agent or pharmaceutical acceptable salt or derivative thereof, in particular Valaciclovir in complex with an ion exchange resin in a specific ratio in order to obtain a palatable and child-friendly product. It also relates to a process for the preparation thereof.
摘要翻译：本发明涉及包含治疗有效量的抗病毒剂或其药学上可接受的盐或衍生物，特别是与离子交换树脂以特定比例复合的伐昔洛韦的儿科咀嚼片，以获得可口且对儿童友好的产品。它还涉及其制备方法。

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