专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2021084102A1 FLUID ANALYSIS ARRANGEMENT AND METHOD 审中-公开
公开(公告)号：WO2021084102A1
公开(公告)日：2021-05-06
申请号：PCT/EP2020/080583
申请日：2020-10-30
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： NIESS, Alexander Fidelis , LEBOUC-HAEFLIGER, Vanessa , LEMA MARTINEZ, Carmen , LUEMKEMANN, Joerg , AMRHEIN, Sven , JOHN, Jasmin , ZUMSTEIN, Thomas , BURRI, Sven , STEINER, Roger , WERK, Tobias
IPC分类号： G01N35/10 , G01N35/00
摘要： A fluid analysis arrangement (1) comprises a particle quantifying device (4), a holder (6), a robot (3), a washing station (5) and a control unit (2). The particle quantifying device (4) has a sensor unit (42) with a sensing stick (421) to be arranged in a fluid to sense for particles in the fluid, and an evaluation unit (41). The holder (6) has a plurality of seats each configured to receive a container in which a sample fluid is arranged. The control unit (2) is connected to the particle quantifying device (4) and the robot (3). The sensor unit (42) is mounted to the robot (3). The control unit (2) is configured to control the robot (3) to arrange the sensing stick (421) in one of the sample fluids of each container received in the seats of the holder (6) after another, activate the particle quantifying device to sense for particles in the sample fluids, and control the robot (3) to arrange the sensing stick (421) in the washing station (5) after each sensing for particles in one of the sample fluids and before arranging the sensing stick (421) in a next one of the sample fluids.

2. 发明申请

WO2022090399A1 MICROPLATE SYSTEM AND CONTAINMENT 审中-公开
公开(公告)号：WO2022090399A1
公开(公告)日：2022-05-05
申请号：PCT/EP2021/079994
申请日：2021-10-28
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BURRI, Sven , CANESSO, Rolf , HOFER, Pascal Markus , LUZIO, Jonas , SCHMIDLI, Dieter , ZUMSTEIN, Thomas
IPC分类号： B01L3/00 , B01L9/06
摘要： A microplate system (1) comprising a microplate (2) and a plurality of containments (3).The microplate (2) has a length in a range between about 127 mm and about 129 mmand a width in a range between about 84 mm and about 86 mm. The microplate (2) has 384 or 1536 receptacles (21). Each receptacle (21) of the microplate (2) extends through the microplate (2) such that it has a first open end and a second open end. Each receptacle (21) of the microplate (2) forms a seat to hold one of the plurality of containments (3). Each of the plurality of containments (3) comprises a cap (32) and a tube (31) shaped to be held in the seat of one of the receptacles (21) of the microplate (2). The plurality of containments (3) and the receptacles (21) of the microplate (2) are shaped such that, in order to be arranged in the microplate (2), each of the plurality of containments (3) is introducible through the first open end of the one of the receptacles (21) into the one of the receptacles (21) until it is held in the seat (212) of the one of the receptacles (21). The tube (31) and the cap (32) of each of the containments (3) are configured to be multiply connected to each other and disconnected from each other.

3. 发明申请

WO2020109195A1 MANUFACTURING A FLEXIBLE CONTAINER 审中-公开
公开(公告)号：WO2020109195A1
公开(公告)日：2020-06-04
申请号：PCT/EP2019/082342
申请日：2019-11-25
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： LEMA MARTINEZ, Carmen , LUEMKEMANN, Joerg , WERK, Tobias , ZUMSTEIN, Thomas , KULLMANN, Daniel
IPC分类号： A61J1/10 , A61J1/14 , A61J1/20 , A61J1/06
摘要： A method of manufacturing a flexible container (1) housing a drug substance, comprises: forming a first compartment (11) of the container (1) out of a flexible sheet-like material, filling a liquid (2) into the first compartment (11) of the container (1), sealing the first compartment (11), forming a second compartment (12) of the container (1) out of the flexible sheet-like material, filling a dry drug formulation (3) into the second compartment (12), and sealing the second compartment (12). The method further involves lyophilizing the drug formulation inside a tubular cartridge such that the dry drug formulation (3) is generated and held in the tubular cartridge, wherein filling the dry drug formulation (3) into the second compartment (12) comprises: introducing the tubular cartridge holding the dry drug formulation (3) through an opening of the second compartment (12) of the container (1) such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment (12), providing the dry drug formulation (3) out of the open end of the tubular cartridge into the second compartment (12), and withdrawing the tubular cartridge out of the opening of the second compartment (12) of the container (1). The first compartment (11) is separated from the second compartment (12) by a frangible seal (14) which opens when the first compartment (11) is compressed.

4. 发明申请

WO2018078129A1 PREPARING AND ANALYZING SOLID FORM PROPERTIES OF A SUBSTANCE 审中-公开
标题翻译：一种物质的固体形态的制备和分析
公开(公告)号：WO2018078129A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077665
申请日：2017-10-27
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： SCHWITTER, Urs , RAN, Frédéric , ALKER, André , KISSLING, Tom , ZUMSTEIN, Thomas
IPC分类号： B01L3/00 , B01L3/06
摘要： In a method of analyzing solid form properties of a substance, which comprising the step of solidifying the substance, the solidified substance is obtained in one of a plurality of wells (1, 46) of a multi-well plate (4). In the multi-well plate (4) the at least one of the plurality of wells (1, 46) has a bottom (22) made of a thermoplastic polyimide. The method further comprises analyzing the solidified substance in the well (1, 46) of the multi-well plate (4) by X-ray diffraction. Thereby, said analysis comprises providing X-ray through the solidified substance and a bottom (22) of the well (1, 46) and evaluating the X-ray which passed the solidified substance and the bottom (22) of the well (1, 46). Such method and multi-well plate (4) provide a durable and cost efficient system allowing a high quality analysis of solid form properties of the substance and an efficient and safe processing of the substance.
摘要翻译：在分析包括固化物质的步骤的物质的固体形态性质的方法中，固化的物质在多级多孔体（1,46）中的一个中获得，（4）。在多孔板（4）中，多个井（1,46）中的至少一个具有由热塑性聚酰亚胺制成的底部（22）。该方法还包括通过X射线衍射分析多孔板（4）的孔（1,46）中的固化物质。因此，所述分析包括提供穿过固化物质和井（1,46）的底部（22）的X射线并且评估穿过固化物质和井（1，46）的底部（22）的X射线， 46）。这种方法和多孔板（4）提供了耐用且成本有效的系统，允许高质量地分析该物质的固体形式特性以及该物质的有效且安全的处理。

5. 发明申请

WO2022038273A1 LYOPHILISATE RETAINER, METHOD OF MANUFACTURING THEREOF AND PROCEDURE OF DRYING A SUBSTRATE 审中-公开
公开(公告)号：WO2022038273A1
公开(公告)日：2022-02-24
申请号：PCT/EP2021/073167
申请日：2021-08-20
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： KULLMANN, Daniel , LEMA MARTINEZ, Carmen , SCHWACH, Gregoire , LUEMKEMANN, Joerg , ZUMSTEIN, Thomas , HOFER, Pascal, Markus , LUZIO, Jonas
IPC分类号： A61K9/19 , F26B5/06
摘要： A lyophilisate retainer (10) for lyophilizing a substrate comprises a three dimensional scaffold body (110) having pores (1120). The pores (1120) of the scaffold body (110) are configured to receive and hold the substrate. The scaffold body (110) is made of a scaffold material providing heat transfer properties in lyophilisation to induce heat transfer to the substrate held in the pores (1120) of the scaffold body (110).

6. 发明申请

WO2020109194A1 LYOPHILISATE CONTAINER AND INFUSION KIT 审中-公开
公开(公告)号：WO2020109194A1
公开(公告)日：2020-06-04
申请号：PCT/EP2019/082340
申请日：2019-11-25
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： LEMA MARTINEZ, Carmen , LUEMKEMANN, Joerg , ZUMSTEIN, Thomas , KULLMANN, Daniel
IPC分类号： A61J1/10 , A61J1/16 , A61J1/20 , A61J1/06
摘要： A lyophilisate container (39) comprising a compartment; a wall (3119, 3129) limiting the compartment; and a lyophilisate arranged inside the compartment. At least a portion of the wall (3119, 3129) is semipermeable allowing vapour permeation in one direction out of the compartment through the wall (3119, 3129) and preventing vapour permeation in an opposite direction into the compartment through the wall (3119, 3129).

7. 发明申请

WO2018078116A1 SAMPLE HOLDER FOR ANALYZING SOLID FORM PROPERTIES OF A SUBSTANCE 审中-公开
标题翻译：样品架用于分析物质的固体形态特性
公开(公告)号：WO2018078116A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077646
申请日：2017-10-27
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： SCHWITTER, Urs , RAN, Frédéric , ALKER, André , KISSLING, Tom , ZUMSTEIN, Thomas
IPC分类号： B01L3/00 , B01L3/06
摘要： A sample holder (1) for containing a substance in a solid form screening process comprises a body (2) with a sidewall portion (21), a bottom portion (22) and a hollow interior limited by the sidewall portion (21) and the bottom portion (22). The bottom portion (22) is made of a thermoplastic polyimide. The sample holder (1) allows for providing a high quality analysis of solid form properties of a substance and an efficient and safe processing of the substance.
摘要翻译：一种用于在固体形式筛选过程中容纳物质的样品架（1），包括具有侧壁部分（21），底部部分（22）和由侧壁部分（21）和底部部分（22）。底部（22）由热塑性聚酰亚胺制成。样品架（1）允许提供物质的固体形态特性的高质量分析以及物质的有效和安全处理。

8. 发明申请

WO2010106162A1 PROCESS AND APPARATUS FOR TESTING SUBSTANCES FOR POTENTIAL CARCINOGENICITY 审中-公开
标题翻译：用于测试潜在致癌物质的方法和装置
公开(公告)号：WO2010106162A1
公开(公告)日：2010-09-23
申请号：PCT/EP2010/053605
申请日：2010-03-19
申请人： F. HOFFMANN-LA ROCHE AG , VOEGELIN, Dieter , IAIZA, Patrick , ZUMSTEIN, Thomas , KISSLING, Tom
发明人： VOEGELIN, Dieter , IAIZA, Patrick , ZUMSTEIN, Thomas , KISSLING, Tom
IPC分类号： C12Q1/02 , G01N35/00 , G01N35/10
CPC分类号： G01N35/1067 , G01N35/028
摘要： An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); spinning means (63) for spinning the dishes (60); closing means (62) for placing a lid (600) on each of the dishes; transport means (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
摘要翻译：一种用于致癌物质自动测试的装置（2）包括：板支撑件（3），可在其上放置至少一个微孔板（1）; 包括预定数量的移液管（40）的移动移液单元（4）; 包含液体培养基（50）的多个容器（5），与移液单元（4）的移液管（40）的数量相对应的容器（5）的数量; 其中可以放置相应数量的餐具（60）的餐具支撑件（6），每个具有底部和直立的侧壁（601）; 用于旋转餐具（60）的纺丝装置（63）; 用于将盖（600）放置在每个盘上的关闭装置（62）用于将封闭盘（60）运送到中间储存器（8）的输送装置（64,65）。

9. 发明申请

WO2013113874A1 SAMPLE HANDLING SYSTEM 审中-公开
标题翻译：样品处理系统
公开(公告)号：WO2013113874A1
公开(公告)日：2013-08-08
申请号：PCT/EP2013/052033
申请日：2013-02-01
申请人： F. HOFFMANN-LA ROCHE AG
发明人： FATTINGER, Christof , KISSLING, Tom , ZUMSTEIN, Thomas
IPC分类号： B01L9/06 , G01N35/02 , B01L3/00
CPC分类号： B01L9/06 , B01L3/5082 , B01L3/5085 , B01L3/50855 , B01L2200/02 , B01L2200/025 , B01L2200/028 , B01L2200/0689 , B01L2300/021 , B01L2300/044 , B01L2300/0609 , B01L2300/0829 , G01N35/026 , G01N2035/0405 , G01N2035/041
摘要： Sample handling system for handling samples contained in tubes (4), each tube (4) having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube (4). The system comprises a micro-plate (1) comprising at least one grid insert (2) having a plurality of compartments. Each compartment comprises one or more side walls laterally confining a through-hole for receiving a said tube (4). The through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening. A frame (3) to which the at least one separate grid insert (2) is to be attached to form the micro-plate (1). The frame (3) laterally confines a through-opening which is dimensioned to allow for accessing each compartment (21) of the attached at least one grid insert (2) from above and from below. This allows for moving such tube (4) into and out of each compartment (21) through each of the top opening (202) and the bottom opening (203) of the through-hole (201).
摘要翻译：用于处理包含在管（4）中的样品的样品处理系统，每个管（4）具有中空体，封闭的底部和用于进入容纳在管（4）中的样品）的开口顶部。该系统包括微板（1），其包括具有多个隔室的至少一个栅格插入件（2）。每个隔室包括一个或多个横向限定用于接纳所述管（4）的通孔的侧壁。通孔具有顶部开口和底部开口，并且在顶部开口和底部开口之间延伸。框架（3），所述至少一个单独的栅格插入件（2）将要连接到所述框架（3）以形成所述微板（1）。框架（3）侧向地限制通孔，其尺寸被设计成允许从上方和下方访问附接的至少一个栅格插入物（2）的每个隔间（21）。这允许通过通孔（201）的顶部开口（202）和底部开口（203）中的每一个将这种管（4）移入和移出每个隔室（21）。

10. 发明申请

WO2012117083A2 HANGING DROPLET PLATE 审中-公开
标题翻译：吊挂板
公开(公告)号：WO2012117083A2
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053588
申请日：2012-03-02
申请人： F. HOFFMANN-LA ROCHE AG , FATTINGER, Christof , IAIZA, Patrick , KISSLING, Tom , VOEGELIN, Dieter , ZUMSTEIN, Thomas , MCGINNIS, Claudia
发明人： FATTINGER, Christof , IAIZA, Patrick , KISSLING, Tom , VOEGELIN, Dieter , ZUMSTEIN, Thomas , MCGINNIS, Claudia
IPC分类号： C12M3/00
CPC分类号： G01N33/5014 , B01L3/06 , B01L3/50853 , B01L3/5088 , B01L2300/042 , B01L2300/047 , B01L2300/0829 , C12M23/12 , C12M25/01
摘要： A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
摘要翻译：悬挂的液滴板（1）包括预定数量的液滴隔室（10），每个液滴隔室（10）能够接收液滴。相应的液滴隔室（10）包括周向微流体润湿屏障（102），其被布置成围绕相应的空腔（100）并且防止液滴扩散到微流体润湿屏障（102）之外。相应的隔室（10）包括封闭的底部（101）和至少一个附加的周向微流体润湿屏障（104），每个附加的周向微流体润湿屏障（104）被布置成围绕先前的周向微流体润湿屏障（102）。可湿性区域（103）布置在两个相邻布置的微流体润湿屏障（102,104）之间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式