专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015095689A1 SYNTHETIC NUCLEIC ACID CONTROL MOLECULES 审中-公开
标题翻译：合成核酸控制分子
公开(公告)号：WO2015095689A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071460
申请日：2014-12-19
申请人： EXACT SCIENCES CORPORATION
发明人： TYLER, Ilse A. , YAEGER, Keith , DOMANICO, Michael J. , ALLAWI, Hatim , LIDGARD, Graham P.
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/6876 , C12Q2600/154 , C12Q2600/156 , C12Q2600/166
摘要： The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
摘要翻译：本发明提供可用作对照或核酸测试方法的合成DNA链。特别地，本文提供了已知组合物的合成DNA链，其用作粪便DNA测试中的对照分子，例如从粪便样品中分离的DNA的突变和/或甲基化。

2. 发明申请

WO2017075061A1 MULTIPLEX AMPLIFICATION DETECTION ASSAY AND ISOLATION AND DETECTION OF DNA FROM PLASMA 审中-公开
标题翻译：多重扩增检测分析及血浆DNA的分离和检测
公开(公告)号：WO2017075061A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058875
申请日：2016-10-26
申请人： EXACT SCIENCES CORPORATION
发明人： ALLAWI, Hatim , LIDGARD, Graham P. , AIZENSTEIN, Brian , SANDER, Tamara J. , GIAKOUMOPOULOS, Maria , KAISER, Michael W. , GRAY, Melissa M. , VACCARO, Abram Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/1006 , C12Q1/6837 , C12Q1/686 , C12Q2600/154 , C12Q2600/166 , C12Q2523/125 , C12Q2527/146 , C12Q2537/143 , C12Q2563/159 , C12Q2537/149 , C12Q2561/109 , C12Q2521/537 , C12Q2527/125 , C12Q2563/149
摘要： Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g. , plasma samples.
摘要翻译：本文提供了与基于扩增的亚硫酸氢盐处理的DNA检测有关的技术，并且特别但不排他地涉及用于多重扩增低水平样品DNA的方法和组合物，样品DNA。该技术还提供了从血液或血液产品样品，例如血浆样品中分离DNA的方法。

3. 发明申请

WO2013025917A1 SAMPLE COLLECTION DEVICE 审中-公开
标题翻译：样品收集装置
公开(公告)号：WO2013025917A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/051159
申请日：2012-08-16
申请人： EXACT SCIENCES CORPORATION , LIDGARD, Graham P. , DOMANICO, Michael J. , FOURRIER, Keith , LIGHT, II, James P. , CASTANON, Scott , KOPITZKE, Keith
发明人： LIDGARD, Graham P. , DOMANICO, Michael J. , FOURRIER, Keith , LIGHT, II, James P. , CASTANON, Scott , KOPITZKE, Keith
IPC分类号： G01N35/00 , G01N1/00 , A61B10/02
CPC分类号： A61B10/0038 , B01L3/50825 , G01N1/38
摘要： Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.
摘要翻译：本文提供了与收集和制备样品相关的技术。例如，该技术尤其涉及但不排他地涉及允许受试者收集和准备用于分析的样品的装置，系统和试剂盒。

4. 发明申请

WO2017192221A1 DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA 审中-公开
标题翻译：甲基化DNA分析法检测肺巨核细胞增多症
公开(公告)号：WO2017192221A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/024468
申请日：2017-03-28
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： ALLAWI, Hatim , LIDGARD, Graham P. , GIAKOUMOPOULOS, Maria , AHLQUIST, David A. , TAYLOR, William R. , MAHONEY, Douglas
IPC分类号： C12Q1/68
摘要： Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
摘要翻译：本文提供了用于肺瘤形成筛选的技术，并且具体但非排他地涉及用于检测肺癌存在的方法，组合物和相关用途。

5. 发明申请

WO2016160454A1 DETECTING ESOPHAGEAL DISORDERS 审中-公开
标题翻译：检测食管疾病
公开(公告)号：WO2016160454A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/023782
申请日：2016-03-23
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： AHLQUIST, David A. , TAYLOR, William R. , KISIEL, John B. , MAHONEY, Douglas W. , YAB, Tracy C. , LIDGARD, Graham P. , ALLAWI, Hatim T.
IPC分类号： C12M1/34 , C12Q1/68 , C40B30/00 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/112 , C12Q2600/154 , C12Q2600/166 , G01N33/57407 , G01N2440/12 , G01N2800/14
摘要： Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
摘要翻译：本文提供了用于食管障碍筛查的技术，特别地但不排他地涉及用于检测食管疾病（例如Barrett食管，Barrett食管发育不良等）的存在的方法，组合物和相关用途。此外，该技术提供了用于区分Barrett食道和Barrett食管发育异常之间的方法，组合物和相关用途，以及Barrett食管低度发育不良，Barrett食管高级别异型增生和通过内窥镜刷洗或非内镜整体获得的样品中的食管腺癌之间的方法，组合物和相关用途使用系留装置（例如胶囊海绵，球囊或其他装置）进行食管刷洗或擦拭。

6. 发明申请

WO2015153284A1 DETECTING COLORECTAL NEOPLASM 审中-公开
标题翻译：检测大肠杆菌NEOPLASM
公开(公告)号：WO2015153284A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/022751
申请日：2015-03-26
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES CORPORATION
发明人： AHLQUIST, David Alan , TAYLOR, William Russell , MAHONEY, Douglas W. , LIDGARD, Graham P. , ALLAWI, Hatim T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
摘要翻译：
此提供的是与检测肿瘤和特别的技术，但不排他地涉及方法，组合物，以及用于检测癌前和恶性肿瘤例如结肠直肠癌相关用途。

7. 发明申请

WO2015153283A1 DETECTING COLORECTAL NEOPLASM 审中-公开
标题翻译：检测颜色近视
公开(公告)号：WO2015153283A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/022749
申请日：2015-03-26
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES CORPORATION
发明人： AHLQUIST, David Alan , TAYLOR, William Russell , MAHONEY, Douglas W. , LIDGARD, Graham P. , ALLAWI, Hatim T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
摘要翻译：本文提供了涉及检测瘤形成的技术，特别是但不排他地涉及用于检测恶化前和恶性肿瘤如结肠直肠癌的方法，组合物和相关用途。

8. 发明申请

WO2012155072A3 ISOLATION OF NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2012155072A3
公开(公告)日：2012-11-15
申请号：PCT/US2012/037581
申请日：2012-05-11
申请人： EXACT SCIENCES CORPORATION , BRUINSMA, Janelle J. , DOMANICO, Michael J. , LIDGARD, Graham P. , ZOU, Hongzhi , WEISBURG, William G. , SHENOI, Hemanth D. , LIGHT, II, James P.
发明人： BRUINSMA, Janelle J. , DOMANICO, Michael J. , LIDGARD, Graham P. , ZOU, Hongzhi , WEISBURG, William G. , SHENOI, Hemanth D. , LIGHT, II, James P.
IPC分类号： C12Q1/68 , C12M1/12 , C12N15/10 , C12S3/20
摘要： Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.

9. 发明申请

WO2019190787A1 METHOD FOR STABILIZING HEMOGLOBIN AND REAGENTS FOR PERFORMING THE SAME 审中-公开
公开(公告)号：WO2019190787A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/022598
申请日：2019-03-15
申请人： EXACT SCIENCES CORPORATION
发明人： FOURRIER, Keith D. , HENNEK, Jacquelyn T. , DOMANICO, Michael J. , WEISBURG, William G. , LIDGARD, Graham P. , HARINGS, Kathleen S. , SIMPSON, Daniel J.
IPC分类号： A61B10/02 , A61J1/05 , A61J1/14 , G01N1/28 , G01N33/48 , G01N33/68
摘要： A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin,or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.

10. 发明申请

WO2016094813A1 COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS 审中-公开
标题翻译：用于进行甲基化检测测定的组合物和方法
公开(公告)号：WO2016094813A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065272
申请日：2015-12-11
申请人： EXACT SCIENCES CORPORATION
发明人： ALLAWI, Hatim T. , LIDGARD, Graham P.
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6881 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/166
摘要： Provided herein is technology relating compositions and methods for detecting tissue cell-specific DNA, such as epithelial cell-specific DNA, in blood or blood products from a subject. The technology also relates to use of tissue cell-specific DNAs as internal controls for methylation assays. Provided herein is technology relating to characterizing samples, e.g., blood samples, stool samples, etc., for the presence or absence of, and/or the amounts of different species of nucleic acids that, for example, may be associated with a health status of a subject. For example, in some embodiments, the technology relates to detecting and measuring DNA associated with a particular tissue in a sample type that does not typically contain DNA from that tissue. In preferred embodiments, the technology is directed to detecting and/or measuring epithelial cells and/or epithelial cell-specific DNA in blood or blood product samples.
摘要翻译：本文提供了用于检测来自受试者的血液或血液制品中的组织细胞特异性DNA（例如上皮细胞特异性DNA）的组合物和方法的技术。该技术还涉及使用组织细胞特异性DNA作为甲基化测定的内部对照。本文提供的技术涉及表征样品，例如血样，粪便样品等，用于存在或不存在不同种类的核酸，例如可能与健康状况相关联的主题。例如，在一些实施方案中，该技术涉及检测和测量与通常不含有来自该组织的DNA的样品类型中的特定组织相关的DNA。在优选实施方案中，该技术涉及检测和/或测量血液或血液制品样品中的上皮细胞和/或上皮细胞特异性DNA。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式