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1. 发明申请

WO2014159652A2 DETECTING NEOPLASM 审中-公开
标题翻译：检测NEOPLASM
公开(公告)号：WO2014159652A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/024589
申请日：2014-03-12
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES CORPORATION
发明人： AHLQUIST, David A. , KISIEL, John B. , TAYLOR, William R. , YAB, Tracy C. , MAHONEY, Douglas W. , LIDGARD, Graham, P. , ALLAWI, Hatim, T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
摘要翻译：本文提供了涉及检测瘤形成的技术，特别但并非排他地涉及用于检测恶变和恶性肿瘤如胰腺癌和结肠直肠癌的方法，组合物和相关用途。

2. 发明申请

WO2012106525A2 DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION 审中-公开
标题翻译： DNA甲基化数字序列分析
公开(公告)号：WO2012106525A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023646
申请日：2012-02-02
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , AHLQUIST, David A. , TAYLOR, William R. , ZOU, Hongzhi , LIDGARD, Graham P.
发明人： AHLQUIST, David A. , TAYLOR, William R. , ZOU, Hongzhi , LIDGARD, Graham P.
IPC分类号： C40B20/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6858 , C12Q2600/154 , C12Q2521/331 , C12Q2523/125 , C12Q2563/159
摘要： The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
摘要翻译：本发明涉及用于确定和使用指示腺瘤和癌症的特异性甲基化模式的方法和组合物。特别地，本发明涉及在来自癌症和腺瘤样品的DNA中配位甲基化的定义的CpG基因座的分析，用于鉴定配位甲基化位点的方法以及在设计中的一个或多个标记区域中使用配位甲基化位点分析的方法腺瘤和癌症检测。

3. 发明申请

WO2017192221A1 DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA 审中-公开
标题翻译：甲基化DNA分析法检测肺巨核细胞增多症
公开(公告)号：WO2017192221A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/024468
申请日：2017-03-28
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： ALLAWI, Hatim , LIDGARD, Graham P. , GIAKOUMOPOULOS, Maria , AHLQUIST, David A. , TAYLOR, William R. , MAHONEY, Douglas
IPC分类号： C12Q1/68
摘要： Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
摘要翻译：本文提供了用于肺瘤形成筛选的技术，并且具体但非排他地涉及用于检测肺癌存在的方法，组合物和相关用途。

4. 发明申请

WO2016160454A1 DETECTING ESOPHAGEAL DISORDERS 审中-公开
标题翻译：检测食管疾病
公开(公告)号：WO2016160454A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/023782
申请日：2016-03-23
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： AHLQUIST, David A. , TAYLOR, William R. , KISIEL, John B. , MAHONEY, Douglas W. , YAB, Tracy C. , LIDGARD, Graham P. , ALLAWI, Hatim T.
IPC分类号： C12M1/34 , C12Q1/68 , C40B30/00 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/112 , C12Q2600/154 , C12Q2600/166 , G01N33/57407 , G01N2440/12 , G01N2800/14
摘要： Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
摘要翻译：本文提供了用于食管障碍筛查的技术，特别地但不排他地涉及用于检测食管疾病（例如Barrett食管，Barrett食管发育不良等）的存在的方法，组合物和相关用途。此外，该技术提供了用于区分Barrett食道和Barrett食管发育异常之间的方法，组合物和相关用途，以及Barrett食管低度发育不良，Barrett食管高级别异型增生和通过内窥镜刷洗或非内镜整体获得的样品中的食管腺癌之间的方法，组合物和相关用途使用系留装置（例如胶囊海绵，球囊或其他装置）进行食管刷洗或擦拭。

5. 发明申请

WO2017040627A1 DETECTING GASTRIC NEOPLASM 审中-公开
标题翻译：检测胃肠神经
公开(公告)号：WO2017040627A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049653
申请日：2016-08-31
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES CORPORATION
发明人： ALLAWI, Hatim T. , AHLQUIST, David A. , TAYLOR, William R. , KISIEL, John B. , YAB, Tracy C. , MAHONEY, Douglas W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
摘要翻译：本文提供了涉及检测瘤形成的技术，特别是但不排他地涉及用于检测癌前期恶变和恶性肿瘤的方法，组合物和相关用途。

6. 发明申请

WO2013142545A1 MARKER PANEL FOR DETECTING CANCER 审中-公开
标题翻译：用于检测癌症的标记面板
公开(公告)号：WO2013142545A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033047
申请日：2013-03-20
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , WEISBURG, William G. , LIDGARD, Graham P. , AHLQUIST, David A. , TAYLOR, William R.
发明人： WEISBURG, William G. , LIDGARD, Graham P. , AHLQUIST, David A. , TAYLOR, William R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： Provided herein is technology relating to detecting cancer and particularly, but not exclusively, to methods for detecting colorectal cancer by evaluating multiple markers in paired plasma and stool samples. In particular, the technology relates to CRC screening by assaying plasma for methylated Septin 9 and assaying stool DNA for methylated vimentin, NDRG4, BMP3 , and/or TFPI2 .
摘要翻译：本文提供了涉及检测癌症的技术，特别地但不排他地涉及通过评估成对的血浆和粪便样品中的多种标记物来检测结肠直肠癌的方法。特别地，该技术涉及通过测定血浆甲基化Septin 9和测定甲基化波形蛋白NDRG4，BMP3和/或TFPI2的粪便DNA的CRC筛选。

7. 发明申请

WO2011126768A2 METHODS AND MATERIALS FOR DETECTING COLORECTAL CANCER AND ADENOMA 审中-公开
标题翻译：检测彩色癌和腺癌的方法和材料
公开(公告)号：WO2011126768A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/029982
申请日：2011-03-25
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , ZOU, Hongzhi , AHLQUIST, David A.
发明人： ZOU, Hongzhi , AHLQUIST, David A.
IPC分类号： C12Q1/68 , C12N15/12
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA ) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal.
摘要翻译：本发明提供与检测与受试者粪便样品相关的结肠直肠肿瘤特异性标志物（例如，与结肠直肠癌相关的标志物，与腺瘤相关的标志物）相关的方法和材料。特别地，本发明提供了通过检测结肠直肠瘤形成指标（例如长DNA（例如，通过Alu PCR定量））的存在和水平来鉴定具有结肠直肠肿瘤的哺乳动物（例如，人）的方法和材料，以及肿瘤相关基因改变（例如，KRAS，APC，黑素瘤抗原基因，p53，BRAF，BAT26，PIK3CA中的突变）或表观遗传改变（例如，DNA甲基化）（例如，CpG甲基化）（例如，CpG 在来自哺乳动物的粪便样品的DNA中，bmp-3，bmp-4，SFRP2，波形蛋白，septin9，ALX4，EYA4，TFPI2，NDRG4，FOXE1的编码或调节区中的甲基化）。

8. 发明申请

WO2021226074A2 DETECTING MELANOMA 审中-公开
公开(公告)号：WO2021226074A2
公开(公告)日：2021-11-11
申请号：PCT/US2021/030638
申请日：2021-05-04
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES DEVELOPMENT COMPANY, LLC
发明人： AHLQUIST, David A. , KISIEL, John B. , TAYLOR, William R. , MAHONEY, Douglas W. , BERGER, Calise K. , ALLAWI, Hatim T. , KATEROV, Viatcheslav
IPC分类号： C07K14/435 , C07K14/78 , C12N5/071 , C12N5/09 , G01N33/574 , C12Q1/6886
摘要： Provided herein is technology for primary cutaneous melanoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of primary cutaneous melanoma.

9. 发明申请

WO2019108626A1 DETECTING BREAST CANCER 审中-公开
公开(公告)号：WO2019108626A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062809
申请日：2018-11-28
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES DEVELOPMENT COMPANY, LLC
发明人： AHLQUIST, David A. , TAYLOR, William R. , MAHONEY, Douglas W. , YAB, Tracy C. , KISIEL, John B. , ALLAWI, Hatim T. , LIDGARD, Graham P. , KAISER, Michael W.
IPC分类号： C12N15/09 , C12Q1/68 , C40B30/04
摘要： Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

10. 发明申请

WO2009102788A3 DETECTING NEOPLASM 审中-公开
公开(公告)号：WO2009102788A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/033793
申请日：2009-02-11
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , TAYLOR, William R. , HARRINGTON, Jonathan J. , QUINT, Patrick S. , ZOU, Hongzhi , BERGEN III, Harold R. , SMITH, David I. , AHLQUIST, David A.
发明人： TAYLOR, William R. , HARRINGTON, Jonathan J. , QUINT, Patrick S. , ZOU, Hongzhi , BERGEN III, Harold R. , SMITH, David I. , AHLQUIST, David A.
IPC分类号： G01N33/574 , G01N33/68 , C12Q1/68
摘要： This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

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