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1. 发明申请

WO2008101857A3 CORYNEFORM BACTERIA WITH FORMATE-THF-SYNTHETASE AND/OR GLYCINE CLEAVAGE ACTIVITY 审中-公开
标题翻译：具有四氢呋喃 - 合成酶和/或甘氨酸清除活性的角质细菌细菌
公开(公告)号：WO2008101857A3
公开(公告)日：2008-12-11
申请号：PCT/EP2008051795
申请日：2008-02-14
申请人： EVONIK DEGUSSA GMBH , YOCUM R ROGERS , ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN , PATTERSON THOMAS A , PERO JANICE G
发明人： ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN , PATTERSON THOMAS A , PERO JANICE G
IPC分类号： C12P13/12 , C12N15/52 , C12N15/77
CPC分类号： C12P13/12 , C12N15/52
摘要： The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5, N10 -methylene-THF is increased. The present invention also relates to the use of such microorganisms for producing methionine.
摘要翻译：本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。本发明还涉及这种微生物用于生产甲硫氨酸的用途。

2. 发明申请

WO2009133063A3 PRODUCTION PROCESS FOR METHIONINE USING MICROORGANISMS WITH REDUCED ISOCITRATE DEHYDROGENASE ACTIVITY 审中-公开
标题翻译：使用具有降低的异硫氰酸脱氢酶活性的微生物生产蛋氨酸的方法
公开(公告)号：WO2009133063A3
公开(公告)日：2009-12-23
申请号：PCT/EP2009055051
申请日：2009-04-27
申请人： EVONIK DEGUSSA GMBH , ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN
发明人： ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine.
摘要翻译：本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物生产甲硫氨酸的方法。

3. 发明申请

WO2008080900A3 METHIONINE SYNTHASES WITH REDUCED PRODUCT INHIBITION 审中-公开
标题翻译：具有减少产品抑制的甲硫氨酸合成
公开(公告)号：WO2008080900A3
公开(公告)日：2009-01-22
申请号：PCT/EP2007064471
申请日：2007-12-21
申请人： EVONIK DEGUSSA GMBH , ZELDER OSKAR , GRABARSE WOLFGANG , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KNIETSCH ANJA , HEROLD ANDREA
发明人： ZELDER OSKAR , GRABARSE WOLFGANG , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KNIETSCH ANJA , HEROLD ANDREA
IPC分类号： C12N15/09
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of suchnucleotide sequences.
摘要翻译：本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核苷酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。

4. 发明申请

WO2008152016A1 MICROORGANISMS WITH DEREGULATED VITAMIN B12 SYSTEM 审中-公开
标题翻译：具有DEREGULATED维生素B12系统的MICROORGANISMS
公开(公告)号：WO2008152016A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008057158
申请日：2008-06-09
申请人： EVONIK DEGUSSA GMBH , ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN , PATTERSON THOMAS
发明人： ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA , HAEFNER STEFAN , PATTERSON THOMAS
IPC分类号： C12P13/12 , C12R1/15
CPC分类号： C12P13/12 , C07K14/34 , C12P19/40
摘要： The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization.
摘要翻译：本发明涉及具有提高维生素B12利用效率的微生物。

5. 发明申请

WO2008101850A8 METHOD OF PRODUCING METHIONINE IN CORYNEBACTERIA BY OVER-EXPRESSING ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY 审中-公开
标题翻译：通过超量表达磷酸酯途径的酶的生产甲硝酸的方法
公开(公告)号：WO2008101850A8
公开(公告)日：2009-10-29
申请号：PCT/EP2008051762
申请日：2008-02-13
申请人： EVONIK DEGUSSA GMBH , ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA
发明人： ZELDER OSKAR , SCHROEDER HARTWIG , KLOPPROGGE CORINNA , HEROLD ANDREA
IPC分类号： C07K14/34 , C12N15/77 , C12P13/12
CPC分类号： C12N9/1022 , C12N9/0006 , C12P13/12
摘要： The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over - expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over - expressed.
摘要翻译：本发明涉及一种在棒状细菌中产生甲硫氨酸的方法，其中戊糖磷酸途径的酶被过度表达。本发明还涉及用于产生甲硫氨酸的棒状细菌，其中戊糖磷酸途径的至少两种酶被过度表达。

6. 发明申请

WO2007051725A3 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：用于制备L-甲硫氨酸的微生物和方法
公开(公告)号：WO2007051725A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006067680
申请日：2006-10-23
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
IPC分类号： A23K1/00 , C12N15/52 , C12P13/12
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

7. 发明申请

WO2007020295A3 MICROORGANISMS WITH INCREASED EFFICIENCY FOR METHIONINE SYNTHESIS 审中-公开
标题翻译： MICROORGANISMS对提高蛋氨酸合成的效率
公开(公告)号：WO2007020295A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006065460
申请日：2006-08-18
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
IPC分类号： C12N15/52 , C12P13/12 , C12R1/13 , C12R1/19
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention concerns methods for the production of microorganisms with increased efficiency for methionine synthesis. The present invention also concerns microorganisms with increased efficiency for methionine synthesis. Furthermore, the present invention concerns methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及生产甲硫氨酸合成效率提高的微生物的方法。本发明还涉及甲硫氨酸合成效率提高的微生物。此外，本发明涉及用于确定与甲硫氨酸合成有关的生物体的最佳代谢通量的方法。

8. 发明申请

WO2007135188A2 PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：制备L-甲硫氨酸的方法
公开(公告)号：WO2007135188A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007055056
申请日：2007-05-24
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
摘要翻译：本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。

9. 发明申请

WO2007011845A3 USE OF A BACILLUS METI GENE TO IMPROVE METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开
标题翻译：使用芽孢杆菌METI基因改善微生物中的蛋氨酸生产
公开(公告)号：WO2007011845A3
公开(公告)日：2007-04-12
申请号：PCT/US2006027617
申请日：2006-07-18
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
IPC分类号： C12P13/12 , C07K14/32 , C07K14/34 , C12N5/10
CPC分类号： C12P13/12 , C07K14/32 , C07K14/34 , C12P3/00 , C12P5/023 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/28 , C12P7/48 , C12P7/52 , C12P7/54 , C12P7/56 , C12P13/04 , C12P23/00 , Y02E50/10 , Y02E50/17 , Y02E50/343
摘要： The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metl gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a fashion that allows for co-production of a water soluble compound such as methionine or other amino acid and a caortenoid compound.
摘要翻译：本发明涉及使用来自枯草芽孢杆菌的metl基因或与metI有关的基因来生产甲硫氨酸和其他含硫精细化学品的改良微生物和方法。在本发明的一些实施方案中，metI基因或另一基因以允许共同产生水溶性化合物如甲硫氨酸或其他氨基酸和类胡萝卜素化合物的方式整合。

10. 发明申请

WO2007011939A3 USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开
标题翻译：二甲基磺脲在微生物中的生产中的应用
公开(公告)号：WO2007011939A3
公开(公告)日：2007-07-05
申请号：PCT/US2006027855
申请日：2006-07-18
申请人： BASF AG , ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
发明人： ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ?metF organism or a ?metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/Met? and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ?metF ?metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，metF生物体或αmetE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫（DMDS）作为硫的来源和甲基，绕过MetH / Met？和MetF活性以及减少硫酸盐的需要，用于合成甲硫氨酸。该专利中还描述了涉及MetY（也称为MetZ）的数据，其作为将甲基封端的硫化物源（例如DMDS）并入甲硫氨酸中的酶。谷氨酸棒状芽孢杆菌的ΔFIFFmetB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过度产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

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