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1. 发明申请

WO2007051725A3 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：用于制备L-甲硫氨酸的微生物和方法
公开(公告)号：WO2007051725A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006067680
申请日：2006-10-23
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
IPC分类号： A23K1/00 , C12N15/52 , C12P13/12
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

2. 发明申请

WO2007020295A3 MICROORGANISMS WITH INCREASED EFFICIENCY FOR METHIONINE SYNTHESIS 审中-公开
标题翻译： MICROORGANISMS对提高蛋氨酸合成的效率
公开(公告)号：WO2007020295A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006065460
申请日：2006-08-18
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
IPC分类号： C12N15/52 , C12P13/12 , C12R1/13 , C12R1/19
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention concerns methods for the production of microorganisms with increased efficiency for methionine synthesis. The present invention also concerns microorganisms with increased efficiency for methionine synthesis. Furthermore, the present invention concerns methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及生产甲硫氨酸合成效率提高的微生物的方法。本发明还涉及甲硫氨酸合成效率提高的微生物。此外，本发明涉及用于确定与甲硫氨酸合成有关的生物体的最佳代谢通量的方法。

3. 发明申请

WO2007135188A2 PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：制备L-甲硫氨酸的方法
公开(公告)号：WO2007135188A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007055056
申请日：2007-05-24
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
摘要翻译：本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。

4. 发明申请

WO2010065863A3 ASSAYS FOR IDENTIFYING GENES ENCODING SALTY TASTE RECEPTORS AND MODULATORS 审中-公开
标题翻译：用于识别编码盐类受体和调节剂的基因的测定
公开(公告)号：WO2010065863A3
公开(公告)日：2010-10-14
申请号：PCT/US2009066788
申请日：2009-12-04
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
IPC分类号： C07K14/705
CPC分类号： G01N33/5008 , A01K2267/03 , C07K14/705 , G01N2333/705
摘要： The present invention relates to rationales for selecting salty taste receptors from a discrete set of taste specific genes disclosed infra by use of methods including electrophysiology, bioiirformatics, and quantitative gene expression assays using transgenic animals as well as functional assays wherein these salty taste receptors may be expressed alone or in association with other taste specific polypeptides such as TRPML3, PKD2L1 or GPRl 13. In addition the invention relates to the use of the identified salty taste receptors in assays, preferably high- throughput, in order to identify modulators which maybe used as flavor additives to modulate salty taste. Preferably, the invention provides high- throughput mammalian and medium- throughput oocyte- based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds maybe used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion.
摘要翻译：本发明涉及通过使用包括电生理学，生物信息学和使用转基因动物的定量基因表达测定的方法以及其中这些咸味受体可能的功能测定法从下文所公开的离散的味道特异性基因组中选择咸味受体的理由单独表达或与其它味道特异性多肽如TRPML3，PKD2L1或GPR113共同表达。此外，本发明涉及鉴定的咸味受体在测定中的应用，优选高通量，以便鉴定可用作风味添加剂调味咸味。优选地，本发明提供用于鉴定人类TRPML3调节剂（优选TRPML3增强子）的高通量哺乳动物和中等通量的基于卵母细胞的电生理测定。在测定中调节TRPML3功能的化合物预期会影响人体的咸味。本发明的电生理测定，例如双电极电压钳技术，有助于鉴定特异性调节人TRPML3的化合物。本发明的测定法提供了一种可用于检测促进（增强）或抑制TRPML3功能的化合物的稳健筛选。增强或阻断TRPML3通道活性的化合物应该调节咸味。此外，这些化合物也可用于调节与钠水平相关的钠排泄，泌尿生产和其他生物学功能。本发明涉及TRPML3涉及包括人和可能的其他哺乳动物在内的灵长类动物的咸味感知（给出钠和其它离子对生理功能和条件的重要性，该表型可能在不同动物中强烈保守）。 TRPML3基因还调节钠代谢，钠排泄，血压，流体保留，心脏功能和尿液功能如尿液产生和排泄中的一种或多种。

5. 发明申请

WO0175605A3 MULTI-CHANNEL, MULTI-SERVICE DEBUG ON A PIPELINED CPU ARCHITECTURE 审中-公开
标题翻译：多通道，多管理CPU架构的多服务调试
公开(公告)号：WO0175605A3
公开(公告)日：2002-03-14
申请号：PCT/US0110251
申请日：2001-03-30
申请人： BROADCOM CORP , JOHNSON KELLY GENE , WILLIAMS MARK
发明人： JOHNSON KELLY GENE , WILLIAMS MARK
IPC分类号： G06F11/36
CPC分类号： G06F11/3628 , G06F11/3648
摘要： A method and system for debugging an executing service on a pipelined CPU architecture are described. In one embodiment, a breakpoint within an executing service is set and a minimum state of the executing service is saved. In addition, a program counter of the executing service is altered. The program counter is restored and the state of the executing service is restored.
摘要翻译：描述了用于在流水线CPU架构上调试执行服务的方法和系统。在一个实施例中，设置执行服务内的断点，并且保存执行服务的最小状态。此外，更改执行服务的程序计数器。程序计数器被恢复，执行服务的状态恢复。

6. 发明申请

WO2012178028A2 PORTABLE TOBACCO VAPORIZER 审中-公开
标题翻译：便携式烟草挥发器
公开(公告)号：WO2012178028A2
公开(公告)日：2012-12-27
申请号：PCT/US2012043776
申请日：2012-06-22
申请人： NWT HOLDING LLC , ALEXANDER ROBINSON , TAYLOR JOSEPH , WILLIAMS MARK
发明人： ALEXANDER ROBINSON , TAYLOR JOSEPH , WILLIAMS MARK
IPC分类号： A24F47/00 , A24D1/14 , A61M15/06
CPC分类号： A61M15/06 , A61M11/042 , A61M16/108 , A61M2205/3368 , A61M2205/3653 , A61M2205/8206
摘要： A vaporizer and method of vaporizing a botanical material, such as tobacco, is described. Embodiments of the apparatus include a self-contained, fully enclosed, battery operated vaporizer having an air inlet and a mouthpiece. The vaporizer includes a window for viewing a botanical material contained therein and a heating element that is also visible through the window and through an air inlet. The vaporizer also includes a push-button switch that rapidly provides power to heat air, which is then drawn through the botanical material by inhaling. Embodiments of the method include utilizing a push-button switch for heating vaporizer air and viewing the glow of the heating element as a signal that the vaporizer is ready for use.
摘要翻译：描述蒸发器和蒸发植物材料如烟草的方法。该装置的实施例包括具有空气入口和吹口的独立的，完全封闭的电池操作的蒸发器。蒸发器包括用于观察容纳在其中的植物材料的窗口和也可通过窗口并通过空气入口可见的加热元件。蒸发器还包括按钮开关，其快速地提供加热空气的功率，然后通过吸入将其吸入植物材料。该方法的实施例包括利用按钮开关来加热蒸发器空气并观察加热元件的辉光，作为蒸发器准备使用的信号。

7. 发明申请

WO2009008950A3 IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE IN ASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THAT MODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/OR VASOPRESSIN PRODUCTION OR REL 审中-公开
标题翻译：鉴定作为盐酸受体的TRPML3（MCOLN3）和用于鉴定调节运输，吸收或/或阿尔斯酮和/或维生素C生产或替代物的硫酸盐（SALTY）调节剂和/或治疗剂的测定中的用途
公开(公告)号：WO2009008950A3
公开(公告)日：2009-12-30
申请号：PCT/US2008007101
申请日：2008-06-06
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK , KALABAT DALIA , WHITE EVAN CARL , SAGANICH MICHAEL , LAITA BIANCA , DAHAN DAVID
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK , KALABAT DALIA , WHITE EVAN CARL , SAGANICH MICHAEL , LAITA BIANCA , DAHAN DAVID
IPC分类号： C12N5/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5044 , G01N33/566 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： High-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers are disclosed Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans The electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3 The assays provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function and thereby modulate salty taste In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels
摘要翻译：公开了用于鉴定人TRPML3调节剂（优选TRPML3增强子）的高通量哺乳动物和中等吞吐量的基于卵母细胞的电生理测定法，优选调节TRPML3功能的化合物预期影响人体的咸味。电生理测定，例如两电极电压钳技术，有助于鉴定特异性调节人TRPML3的化合物。该测定提供了一个强大的屏幕，可用于检测促进（增强）或抑制TRPML3功能，从而调节咸味的化合物。此外，这些化合物可用于调节钠排泄，泌尿生产等与钠水平相关的生物功能

8. 发明申请

WO2007047127A3 OPTIMIZED TRPM8 NUCLEIC ACID SEQUENCES AND THEIR USE IN CELL BASED ASSAYS AND TEST KITS TO IDENTIFY TRPM8 MODULATORS 审中-公开
标题翻译：优化的TRPM8核酸序列及其在基于细胞的测定和试剂盒中识别TRPM8调节子的应用
公开(公告)号：WO2007047127A3
公开(公告)日：2007-07-26
申请号：PCT/US2006038962
申请日：2006-10-04
申请人： SENOMYX INC , SERVANT GUY , BRUST PAUL , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , DAHAN DAVID , ZOLLER MARK , WILLIAMS MARK , KIMMICH RACHEL , KAMDAR POONIT , DITSCHUN TANYA , PATRON ANDREW
发明人： SERVANT GUY , BRUST PAUL , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , DAHAN DAVID , ZOLLER MARK , WILLIAMS MARK , KIMMICH RACHEL , KAMDAR POONIT , DITSCHUN TANYA , PATRON ANDREW
IPC分类号： G01N33/53 , C07H21/04 , C07K1/00
CPC分类号： C07K14/705
摘要： Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.
摘要翻译：提供了在人细胞中有效表达的修饰的人TRPM8核酸序列和基于细胞的测定法以及包含其的测试试剂盒。这些测定法使用表达根据本发明的修饰的人TRPM8核酸序列的细胞鉴定TRPM8调节剂，其中所述序列相对于野生型人TRPM8核酸序列进行了修饰以优化所需细胞中的离子通道表达。已显示使用这些修饰的TRPM8序列的测定鉴定了比已知的冷却剂如薄荷醇和icilin更好或更可比的调节人TRPM8离子通道的化合物。

9. 发明申请

WO2012178028A8 PORTABLE TOBACCO VAPORIZER 审中-公开
标题翻译：便携式烟草挥发器
公开(公告)号：WO2012178028A8
公开(公告)日：2014-02-20
申请号：PCT/US2012043776
申请日：2012-06-22
申请人： NWT HOLDINGS LLC , ROBINSON ALEXANDER , TAYLOR JOSEPH , WILLIAMS MARK
发明人： ROBINSON ALEXANDER , TAYLOR JOSEPH , WILLIAMS MARK
IPC分类号： A24F47/00 , A24D1/14 , A61M15/06
CPC分类号： A61M15/06 , A61M11/042 , A61M16/108 , A61M2205/3368 , A61M2205/3653 , A61M2205/8206
摘要： A vaporizer and method of vaporizing a botanical material, such as tobacco, is described. Embodiments of the apparatus include a self-contained, fully enclosed, battery operated vaporizer having an air inlet and a mouthpiece. The vaporizer includes a window for viewing a botanical material contained therein and a heating element that is also visible through the window and through an air inlet. The vaporizer also includes a push-button switch that rapidly provides power to heat air, which is then drawn through the botanical material by inhaling. Embodiments of the method include utilizing a push-button switch for heating vaporizer air and viewing the glow of the heating element as a signal that the vaporizer is ready for use.
摘要翻译：描述蒸发器和蒸发植物材料如烟草的方法。该装置的实施例包括具有空气入口和吹口的独立的，完全封闭的电池操作的蒸发器。蒸发器包括用于观察容纳在其中的植物材料的窗口和也可通过窗口并通过空气入口可见的加热元件。蒸发器还包括按钮开关，其快速地提供加热空气的功率，然后通过吸入将其吸入植物材料。该方法的实施例包括利用按钮开关来加热蒸发器空气并观察加热元件的辉光，作为蒸发器准备使用的信号。

10. 发明申请

WO9928342A3 LOW-VOLTAGE ACTIVATED CALCIUM CHANNEL COMPOSITIONS AND METHODS 审中-公开
标题翻译：低压激活的钙通道组合物和方法
公开(公告)号：WO9928342A3
公开(公告)日：1999-08-26
申请号：PCT/US9825671
申请日：1998-12-03
申请人： SIBIA NEUROSCIENCES INC , WILLIAMS MARK , STAUDERMAN KENNETH , HARPOLD MICHAEL , HANS MICHAEL , URRUTIA ARTURO , WASHBURN MARK S
发明人： WILLIAMS MARK , STAUDERMAN KENNETH , HARPOLD MICHAEL , HANS MICHAEL , URRUTIA ARTURO , WASHBURN MARK S
IPC分类号： G01N33/483 , A61K38/00 , A61K45/00 , A61P1/16 , A61P5/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P25/00 , C07K14/705 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12Q1/00 , C12Q1/68 , G01N33/566 , C12N15/12 , C07K16/28 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acid encoding low voltage activated calcium channel subunits, including subunits encoded by nucleic acid that arises as splice variants of primary transcripts, is provided. Cells and vectors containing the nucleic acid and methods for identifying compounds that modulate the activity of calcium channels that contain these subunits are also provided.
摘要翻译：提供了编码低电压活化钙通道亚基的分离的核酸，包括由作为初级转录物的剪接变体产生的核酸编码的亚基。还提供了含有核酸的细胞和载体以及鉴定调节含有这些亚基的钙通道活性的化合物的方法。

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