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1. 发明申请

WO2007141208A3 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID 审中-公开
标题翻译：微生物制剂3-羟基异
公开(公告)号：WO2007141208A3
公开(公告)日：2008-03-20
申请号：PCT/EP2007055394
申请日：2007-06-01
申请人： EVONIK DEGUSSA GMBH , UNIV ALBERT LUDWIGS FREIBURG , MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
发明人： MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
IPC分类号： C12P7/42 , C07C57/04 , C12N9/02 , C12P7/52
CPC分类号： C12P7/42 , C08F120/06 , C08F120/10 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/16 , C12N9/88 , C12P7/40 , C12P7/52 , C12P7/625 , C12Y102/04004 , C12Y103/99012 , C12Y206/01042 , C12Y301/02004 , C12Y402/01017
摘要： The present invention relates to a cell which has been genetically modified by comparison with its wild type in such a way that it is able to form more, by comparison with its wild type, 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method for producing a genetically modified cell, to the genetically modified cell obtainable by this method, to a method for producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method for producing methacrylic acid or methacrylic esters, and to a method for producing polymethacrylic acid or polymethacrylic esters. The present invention further relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
摘要翻译：是能够形成作为前体，本发明涉及已经被改变在这样的基因相比，它的野生型，即，相对于它的野生型更3-羟基异丁酸或基于3-羟基聚羟基烷酸酯甲基丙二酸半醛或3-羟基丁酰基辅酶A细胞，本发明还涉及一种方法，用于通过该方法生产遗传修饰的细胞，获得遗传修饰的细胞，为3-羟基异丁酸的制备方法或基于3-羟基异丁酸，用于生产甲基丙烯酸或甲基丙烯酸酯的方法，和一种方法对于聚甲基丙烯酸或聚甲基丙烯酸的制备。本发明还涉及一种分离的DNA，载体，用于细胞，转化的细胞的转化使用这种载体的，和多肽。

2. 发明申请

WO2007042494A2 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID 审中-公开
标题翻译： 3-羟基丙酸的微生物制备
公开(公告)号：WO2007042494A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006067182
申请日：2006-10-09
申请人： DEGUSSA , FORSCHUNGSZENTRUM JUELICH GMBH , MARX ACHIM , WENDISCH VOLKER F , RITTMANN DORIS , BUCHHOLZ STEFAN
发明人： MARX ACHIM , WENDISCH VOLKER F , RITTMANN DORIS , BUCHHOLZ STEFAN
IPC分类号： C12N15/52 , C12P7/18 , C12P7/40 , C12P13/06
CPC分类号： C12P7/40 , C12P7/42 , C12P7/44
摘要： The invention relates to a cell which is genetically modified in relation to a wild type and exhibits at least one following properties: a) the activity of an enzyme E 1 , which is used for catalysing the conversion of pyruvate into oxalacetate or of an enzyme E 1b for catalysing the conversion of phosphoenolpyruvate into oxalacetate, and which is greater than the wild type activity and b) the activity of an enzyme E 2 , which is used for catalysing the conversion of aspartate into beta-alanine and which is greater than the wild type activity, wherein the inventive cell, in addition to the a) and b) properties, is characterised in that it exhibits at least one following property: c) the genetically modified cell is capable to eject beta-alanine therefrom and d) the genetically modified cell is capable to convert the beta-alanine into the 3-hydrixypropionic acid. A method for producing a genetically modified cell, the genetically modified cells obtainable by said method, a method for producing the 3-hydrixypropionic acid, a method for producing an acrylic acid, a method for producing polyacrylates, a method for producing acrylic acid esters and the use of cells for producing the 3-hydrixypropionic acid are also disclosed.
摘要翻译：本发明涉及一种比其野生型遗传修饰的细胞，其包含的特征a）或b）至少一种的：相比于它的野生型，酶E _{1 的，该方法包括使一）催化丙酮酸成草酰乙酸，或酶E _{图1b ，其催化磷酸烯醇丙酮酸转化成草酰乙酸的，b）相比，其野生型，酶E的_{2 ，这催化天冬氨酸向β-丙氨酸的转化，其中，除了a的属性）或b）由所述性质中的至少一种）或d）的特征在于c中的细胞：c）中经遗传修饰的细胞能够从β-丙氨酸去除细胞; d）经遗传修饰的细胞能够将β-丙氨酸转化为3-羟基丙酸。本发明还涉及一种用于制造经遗传修饰的细胞的方法，通过该方法获得的遗传修饰的细胞，产生3-羟基丙酸，为生产丙烯酸的过程中，聚丙烯酸酯的制备方法，用于Acrylsäureestern的制备方法的方法和细胞用于生产3-羟基丙酸的用途。}}}

3. 发明申请

WO2014044488A3 ESTER WITH EPOXIDE AND CARBONATE GROUPS 审中-公开
标题翻译： ESTER用环氧树脂和碳酸
公开(公告)号：WO2014044488A3
公开(公告)日：2014-05-15
申请号：PCT/EP2013067524
申请日：2013-08-23
申请人： EVONIK INDUSTRIES AG , BUCHHOLZ STEFAN , GRASS MICHAEL , WOLDT BENJAMIN , GEVERS ANDREAS , SCHÄFFNER BENJAMIN , BLUG MATTHIAS , MARTIN ANDREAS , POLYAKOV MYKOLA , KÖCKRITZ ANGELA
发明人： BUCHHOLZ STEFAN , GRASS MICHAEL , WOLDT BENJAMIN , GEVERS ANDREAS , SCHÄFFNER BENJAMIN , BLUG MATTHIAS , MARTIN ANDREAS , POLYAKOV MYKOLA , KÖCKRITZ ANGELA
IPC分类号： C07D407/06 , C07D407/14 , C08K5/00
CPC分类号： C07D407/06 , C07D407/14 , C08K5/12 , C08L67/04 , C08L75/04 , C08L27/04 , C08L29/14 , C08L33/10
摘要： The invention relates to an ester and ester mixtures with at least one epoxide group and at least one carbonate group on the acid chain. The invention also relates to a method for producing said type of ester and to the use of the ester as a plasticizer for polymers.
摘要翻译：酯和具有至少一个环氧基团并在链酸的至少一种碳酸酯基团，这类酯的制备方法，以及使用所述酯作为用于聚合物的增塑剂酯混合物。

4. 发明申请

WO2009146991A3 CITRIC ACID ESTER MIXTURES AND USE THEREOF 审中-公开
标题翻译：柠檬酸酯混合物及其用途
公开(公告)号：WO2009146991A3
公开(公告)日：2010-02-04
申请号：PCT/EP2009055410
申请日：2009-05-05
申请人： EVONIK OXENO GMBH , GRASS MICHAEL , BUCHHOLZ STEFAN , BUESCHKEN WILFRIED
发明人： GRASS MICHAEL , BUCHHOLZ STEFAN , BUESCHKEN WILFRIED
IPC分类号： C07C69/704 , C08K5/00
CPC分类号： C07C69/704 , C08K5/0016 , C08K5/11
摘要： The present invention relates to mixtures of citric acid esters of the formula I, where R1, R2 and R3 each are aliphatic C5 or C9 groups, characterized in that the average chain length of the aliphatic groups in the mixture is in the range between greater than 5 and 7 and the average degree of branching of the aliphatic C9 groups is in the range between 0.9 and 2.2. The present invention also relates to the use of the citric acid ester mixture according to the invention as a plasticizer in plastic compositions. The present invention furthermore relates to a composition containing the citric acid ester mixture according to the invention in a mixture with additional components, containing plasticizers from the group of the alkyl esters of aromatic polycarboxylic acids, cyclohexane polycarboxylic acids, benzoic acid, or adipic acid, and to the use of such a plasticizer composition in plastic compositions, adhesives, sealing compounds, lacquers, paints, plastisols or inks. Plastic products produced from the plasticizers according to the invention can include profiled sections, seals, food packaging, films, toys, medical articles, sheet roofing, synthetic leather, floor coverings, underbody sealers, coated fabrics, wallpaper, cables and wire sheathings.
摘要翻译：本发明是的式的柠檬酸酯的混合物：其中R1，R2和R3各自是脂族C5或C9基团，其特征在于，在大于5和7之间的范围内的脂族基团的平均链长度，并且在混合物中的平均在该范围内所述脂族C9-基团的支化0.9至2.2的程度。同样地，本发明是根据本发明的如在塑料组合物中的增塑剂的使用柠檬酸酯混合物的。此外，本发明是根据本发明与含有选自芳族多羧酸，环己烷多羧酸，苯甲酸或己二酸的烷基酯的增塑剂的其它组分的混合物包含柠檬酸酯混合物的组合物，而在塑料组合物，粘合剂，密封剂使用这样的软化组合物的，油漆，涂料，塑料溶胶，或油墨。由该新型增塑剂制成例如可以是塑料制品：型材，垫片，食品包装，薄膜，玩具，医疗，屋顶片材，合成皮革，地板覆盖物，底板保护，涂层织物，墙纸，电缆和电线护套。

5. 发明申请

WO2004111227A3 SCREENING PROCESS FOR HYDANTOIN RACEMASES 审中-公开
标题翻译： HYDANTOIN RACEMASES的筛选方法
公开(公告)号：WO2004111227A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004005239
申请日：2004-05-15
申请人： DEGUSSA , MAY OLIVER , DRAUZ KARLHEINZ , BUCHHOLZ STEFAN
发明人： MAY OLIVER , DRAUZ KARLHEINZ , BUCHHOLZ STEFAN
IPC分类号： C12N9/90 , C12N11/16 , C12N15/61 , C12P13/04 , C12P41/00 , G01N33/573 , C12N5/10 , C12N15/63 , C12Q1/34 , C12Q1/533
CPC分类号： G01N33/573 , C12N9/90 , C12N11/16 , C12P13/04 , C12P41/009
摘要： The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connection with the production of enantiomerically enriched amino acids from racemic hydantoins.
摘要翻译：本发明涉及乙内酰脲消旋酶和新型乙内酰脲消旋酶的筛选方法，编码该核酸序列的核酸序列以及用于诱变的过程。海参蛋白消旋酶与从外消旋乙内酰脲生产对映体富集的氨基酸有关。

6. 发明申请

WO2004067738A2 NITRILE HYDRATASES FROM RHODOCOCCUS ERYTHROPOLIS AND THEIR APPLICATION 审中-公开
标题翻译：鼻炎红细胞生成素及其应用
公开(公告)号：WO2004067738A2
公开(公告)日：2004-08-12
申请号：PCT/EP2004000338
申请日：2004-01-17
申请人： DEGUSSA , SYLDATK CHRISTOPH , BRANDAO PEDRO , BULL ALAN T , VERSECK STEFAN , ERFURTH JEANNETTE , BUCHHOLZ STEFAN , OSSWALD STEFFEN , DRAUZ KARLHEINZ
发明人： SYLDATK CHRISTOPH , BRANDAO PEDRO , BULL ALAN T , VERSECK STEFAN , ERFURTH JEANNETTE , BUCHHOLZ STEFAN , OSSWALD STEFFEN , DRAUZ KARLHEINZ
IPC分类号： C12N9/88 , C12P13/02 , C12R1/01
CPC分类号： C12P13/02 , C12N9/88
摘要： The present invention is directed to polypeptides exhibiting nitrile hydratase activity and the respective encoding nucleic acids from Rhodococcus erythropolis. Furthermore, micoorganisms, plasmids and vectors comprising the polypetides are also embraced by this invention.
摘要翻译：本发明涉及显示腈水合酶活性的多肽和来自红串红球菌的相应编码核酸。此外，包含多肽的微生物，质粒和载体也包含在本发明中。

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