专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005009987A1 PIPERIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：哌啶化合物和含有它们的药物组合物
公开(公告)号：WO2005009987A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/023912
申请日：2004-07-23
申请人： EURO-CELTIQUE S.A. , SUN, Qun , WEN, Xin , ZHOU, Xiaoming
发明人： SUN, Qun , WEN, Xin , ZHOU, Xiaoming
IPC分类号： C07D401/04
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar 1 , Ar 2 , X, R 3 , R 4 , and m are as disclosed herein.
摘要翻译：哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。在实施方案中，哌啶化合物具有下式及其药学上可接受的盐，其中Ar1，Ar2，X，R3，R4和m如本文所公开。

2. 发明申请

WO2004011439A2 ARYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译： ARYL取代苯并咪唑及其作为钠通道阻断剂
公开(公告)号：WO2004011439A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023828
申请日：2003-07-31
申请人： EURO-CELTIQUE S.A. , SUN, Qun , ZHOU, Xiaoming , KYLE, Donald, J.
发明人： SUN, Qun , ZHOU, Xiaoming , KYLE, Donald, J.
IPC分类号： C07D235/00
CPC分类号： C07D403/06 , C07D235/08 , C07D235/12
摘要： This invention relates aryl substituted benzimidazoles of Formula (I), or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R 1 , R 2 , R 10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及式（I）的芳基取代的苯并咪唑或其药学上可接受的盐，前药或溶剂合物，其中R1，R2，R10和n在本说明书中定义。本发明还涉及式（I）化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善急性或慢性疼痛，作为抗惊厥剂，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药，以及用于治疗或预防糖尿病性神经病变。

3. 发明申请

WO2005007641A1 2-PYRIDINE ALKYNE DERIVATIVES USEFUL FOR TREATING PAIN 审中-公开
标题翻译：用于治疗疼痛的2-吡啶烷基衍生物
公开(公告)号：WO2005007641A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/021246
申请日：2004-07-01
申请人： EURO-CELTIQUE S.A. , KYLE, Donald, j. , SUN, Qun , ZHOU, Xiaoming
发明人： KYLE, Donald, j. , SUN, Qun , ZHOU, Xiaoming
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R 1, Q, A and R 2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2在本文中公开）或其药学上可接受的盐（“吡啶 - 炔基化合物”）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

4. 发明申请

WO2004002983A2 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2004002983A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/020509
申请日：2003-06-27
申请人： EURO-CELTIQUE, S.A. , KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , ZHANG, Chongwu , ZHOU, Xiaoming
发明人： KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , ZHANG, Chongwu , ZHOU, Xiaoming
IPC分类号： C07D401/00
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula (I): wherein A, Ar, R 3 , R 6 , and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a "Cyanoiminopiperazine Compound"), cornposition, comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndi - oine, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke. a sc z , are, a prurifc condition, psychosis, a cognitive disorder;`a memory deficit, restricted brain function. R rnfington's chorea., arsiyotrophic lateral sclerosis, dementia, retinopathy, a muscie ,spasm„ a migraine, vomiting, dyskinesia or depression in an animal comprising administek - irgT . b ati animal in need thereof an effective amount of a Cyanoi:irinopiperazine Compound are disclosed.
摘要翻译：式（I）化合物：其中A，Ar，R 3，R 6和m在本文中公开，或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量氰酰亚哌嗪化合物，以及治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风的方法。是一种瘙痒症状，精神病，认知障碍，记忆障碍，脑功能受限。 Rnfington的舞蹈病，arsiyotrophial侧索硬化症，痴呆症，视网膜病变，肌肉，痉挛“偏头痛，呕吐，运动障碍或抑郁症包括有需要的有效量的Cyanoi 公开了伊立哌嗪化合物。

5. 发明申请

WO2003093236A1 1-(PYRID-2-YL)-PIPERAZINE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR INHIBITOR 审中-公开
标题翻译： 1-（PYRID-2-YL） - 哌嗪化合物作为代谢型谷氨酸受体抑制剂
公开(公告)号：WO2003093236A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/013964
申请日：2003-05-02
申请人： EURO-CELTIQUE, S.A. , GHARAGOZLOO, Parviz , ISLAM, Khondaker , KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , WHITEHEAD, John, William, Frank , YANG, Ji , ZHOU, Xiaoming
发明人： GHARAGOZLOO, Parviz , ISLAM, Khondaker , KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , WHITEHEAD, John, William, Frank , YANG, Ji , ZHOU, Xiaoming
IPC分类号： C07D213/74
CPC分类号： C07D213/74 , C07D213/80 , C07D213/85 , C07D401/04 , C07D401/14 , C07D405/12
摘要： A compound of formula: (I) (wherein A, R 1 , R 2 , R 6 , m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a "Piperazine Compound"); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (Ul), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.
摘要翻译：式（I）（其中A，R 1，R 2，R 6，m和n在本文中公开）的化合物或其药学上可接受的盐（“哌嗪化合物”）; 包含哌嗪化合物的药物组合物; 治疗疼痛，尿失禁（Ul），成瘾性障碍，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈症，肌萎缩性侧索硬化（ALS），痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍和抑郁症，包括向有需要的动物施用有效量的哌嗪化合物。

6. 发明申请

WO2007085357A1 CYCLOUREA COMPOUNDS AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译： CYCLOUREA化合物作为钙通道阻断剂
公开(公告)号：WO2007085357A1
公开(公告)日：2007-08-02
申请号：PCT/EP2007/000303
申请日：2007-01-15
申请人： EURO-CELTIQUE S.A. , ZHOU, Xiaoming
发明人： ZHOU, Xiaoming
IPC分类号： C07D233/34 , C07D235/02 , C07D235/26 , C07D401/06 , A61K31/41 , A61P29/00 , A61P25/00
CPC分类号： C07D233/34 , C07D235/02 , C07D235/26 , C07D401/06
摘要： The invention relates to cyclourea compounds of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 -R 3 and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式I的环脲化合物：或其药学上可接受的盐或溶剂化物，其中R 1 -R 3和Z如说明书所述定义。本发明还涉及式I化合物用于治疗，预防或改善对阻塞钙通道，特别是N型钙通道有响应的病症的用途。本发明的化合物特别适用于治疗疼痛。

7. 发明申请

WO2007110449A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：苯并呋喃类化合物及其用途
公开(公告)号：WO2007110449A1
公开(公告)日：2007-10-04
申请号：PCT/EP2007/053053
申请日：2007-03-29
申请人： EURO-CELTIQUE S.A. , CHEN, Zhengming , ISLAM, Khondaker , SHAO, Bin , YAO, Jiangchao , ZHOU, Xiaoming , KYLE, Donald J.
发明人： CHEN, Zhengming , ISLAM, Khondaker , SHAO, Bin , YAO, Jiangchao , ZHOU, Xiaoming , KYLE, Donald J.
IPC分类号： C07D207/14 , C07D211/42 , C07D401/12 , A61K31/445 , A61P25/00
CPC分类号： C07D211/42 , C07D207/14 , C07D401/12
摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式I的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R 1〜Z 3和Z为如本说明书中所述。本发明还涉及使用式I的化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道有响应的病症。本发明的化合物特别适用于治疗疼痛。

8. 发明申请

WO2006040181A3 4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS 审中-公开
公开(公告)号：WO2006040181A3
公开(公告)日：2006-04-20
申请号：PCT/EP2005/011105
申请日：2005-10-14
申请人： EURO-CELTIQUE S.A. , BENJAMIN, Elfrida, R. , CHEN, Zhengming , SHA, Deyou , TAFESSE, Laykea , VICTORY, Samuel, F. , WHITEHEAD, John, W., F. , ZHOU, Xiaoming
发明人： BENJAMIN, Elfrida, R. , CHEN, Zhengming , SHA, Deyou , TAFESSE, Laykea , VICTORY, Samuel, F. , WHITEHEAD, John, W., F. , ZHOU, Xiaoming
IPC分类号： C07D211/58 , C07D401/06 , C07D211/98 , A61K31/4468 , A61P29/02
摘要： The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R 1 -R 3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

9. 发明申请

WO2007118853A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS 审中-公开
标题翻译：苯并咪唑化合物及其作为钙通道阻断剂的使用
公开(公告)号：WO2007118853A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053620
申请日：2007-04-13
申请人： EURO-CELTIQUE S.A. , YAO, Jiangchao , SHAO, Bin , KYLE, Donald, J. , SHA, Deyou , CHEN, Zhengming , ISLAM, Khondaker , ZHOU, Xiaoming
发明人： YAO, Jiangchao , SHAO, Bin , KYLE, Donald, J. , SHA, Deyou , CHEN, Zhengming , ISLAM, Khondaker , ZHOU, Xiaoming
IPC分类号： C07D211/58 , A61K31/445 , A61P25/00
CPC分类号： C07D211/58
摘要： The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式（I）的哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R 1，R 3，Z和q是如本说明书中所述。本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。本发明的化合物特别适用于治疗疼痛。

10. 发明申请

WO2004029031A2 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2004029031A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030185
申请日：2003-09-24
申请人： EURO-CELTQUE, S.A. , SUN, Qun , ZHOU, Xiaoming
发明人： SUN, Qun , ZHOU, Xiaoming
IPC分类号： C07D241/00
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar 1 , Ar 2 , R 3 -R 6 , R 13 , m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a "Hydroxyiminopiperazine Compound"); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3-R6，R13，m和t在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式