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1. 发明申请

WO2012092057A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH LIGHT 审中-公开
标题翻译：用于用光激活褐色扁桃体组织的方法和装置
公开(公告)号：WO2012092057A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066409
申请日：2011-12-21
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , HARRIS, Jason, L. , KAPLAN, Lee, M. , PLESCIA, David, N. , ARONHALT, Taylor, W. , VOEGELE, James, W. , STYLOPOULOS, Nicholas
发明人： HARRIS, Jason, L. , KAPLAN, Lee, M. , PLESCIA, David, N. , ARONHALT, Taylor, W. , VOEGELE, James, W. , STYLOPOULOS, Nicholas
IPC分类号： A61N1/00
CPC分类号： A61N5/0613 , A61M5/14276 , A61M2230/06 , A61M2230/201 , A61N5/062
摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.
摘要翻译：提供了用于用光激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。在一个实施方案中，提供了一种医疗装置，其通过使用光来刺激BAT来激发BAT，和/或直接刺激棕色脂肪细胞，从而增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能来激活BAT 。光可以配置成直接或间接刺激神经和/或棕色脂肪细胞。光可以被配置为通过激活施用于患者的光可激活介质并配置为响应于光以引起棕色脂肪组织的激活来间接刺激神经和/或棕色脂肪细胞。

2. 发明申请

WO2014047432A1 CLINICAL PREDICTORS OF WEIGHT LOSS 审中-公开
标题翻译：临床预防重量损失
公开(公告)号：WO2014047432A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060901
申请日：2013-09-20
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
发明人： KAPLAN, Lee, M. , HATOUM, Ida , HARRIS, Jason, L.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Methods and compositions are provided for treating metabolic disorders comprising obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent.
摘要翻译：提供了用于治疗代谢紊乱的方法和组合物，包括从受试者获得生物样品，评估样品中有无遗传指标，其中遗传指标选自单核苷酸多态性和基因表达水平，以及如果存在遗传指标，则执行第一代谢过程，或者如果遗传指标不存在则执行替代的第二代谢过程。

3. 发明申请

WO2011090765A1 DIAGNOSTIC METHODS AND COMBINATION THERAPIES INVOLVING MC4R 审中-公开
标题翻译：涉及MC4R的诊断方法和组合治疗
公开(公告)号：WO2011090765A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/062469
申请日：2010-12-30
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Jason, L.
发明人： KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Jason, L.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , A61K31/00 , C12Q2600/118 , G01N33/74 , G01N2333/726 , G01N2800/04 , G01N2800/52
摘要： Methods and therapeutics are provided for treating metabolic disorders by activation of melanocortin signaling pathways. Generally, the methods and therapeutics can induce activation of melanocortin receptor signaling to increase energy expenditure and induce weight loss. In one embodiment, a method for performing a diagnostic procedure can be chosen, energy expenditure then assess in light of the diagnostic procedure and a definitive procedure(s) can be selected dependent on the outcome of the energy assessment. In another embodiment, a diagnostic procedure can be chosen to activate melanocortin receptor pathways, energy expenditure can be assessed and a definitive procedure(s) can be chosen that selectively and optimally activate melanocortin receptor pathways.
摘要翻译：提供了通过激活黑皮质素信号通路来治疗代谢紊乱的方法和治疗。通常，方法和治疗可以诱导黑皮质素受体信号传导的激活以增加能量消耗并引起体重减轻。在一个实施例中，可以选择用于执行诊断程序的方法，能量消耗然后根据诊断程序进行评估，并且可以根据能量评估的结果选择确定的程序。在另一个实施方案中，可以选择诊断程序以激活黑皮质素受体途径，可以评估能量消耗，并且可以选择选择性和最佳地激活黑皮质素受体途径的确定程序。

4. 发明申请

WO2013115756A3 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH COOLING 审中-公开
公开(公告)号：WO2013115756A3
公开(公告)日：2013-08-08
申请号：PCT/US2011/066415
申请日：2011-12-21
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION d/b/a MASSACHUSETTS GENERAL HOSPITAL , ARONHALT, Taylor, W. , KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Jason, L. , HENNINGER, Dwight , VOEGELE, James, W. , ORTIZ, Mark, S.
发明人： ARONHALT, Taylor, W. , KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Jason, L. , HENNINGER, Dwight , VOEGELE, James, W. , ORTIZ, Mark, S.
IPC分类号： A61F7/00
摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with cooling. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by cooling tissue having a high density of cold sensitive thermoreceptors and/or by cooling BAT depots directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure.

5. 发明申请

WO2012092056A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH TARGETED SUBSTANCE DELIVERY 审中-公开
标题翻译：用于对具有指定物质输送功能的褐色组织进行活化的方法和装置
公开(公告)号：WO2012092056A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066399
申请日：2011-12-21
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Lason, L. , ARONHALT, Taylor, W. , VOEGELE, James, W. , HENNINGER, Dwight
发明人： KAPLAN, Lee, M. , STYLOPOULOS, Nicholas , HARRIS, Lason, L. , ARONHALT, Taylor, W. , VOEGELE, James, W. , HENNINGER, Dwight
IPC分类号： A61N1/00
CPC分类号： A61F5/0003 , A61K9/0014 , A61K9/0019 , A61K9/7023 , A61M5/14 , A61M5/14276 , A61M35/00 , A61M37/00 , A61M2005/1726 , A61M2205/50 , A61M2230/06 , A61M2230/201
摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.
摘要翻译：提供了用于激活具有靶向物质递送的棕色脂肪组织的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。在一个实施方案中，可以将配置成刺激活动BAT和/或直接刺激棕色脂肪细胞的神经的化学物质递送给患者，由此增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能。化学品可以局部和/或全身地递送到患者以刺激神经和/或棕色脂肪细胞。

6. 发明申请

WO2013130773A2 COMPOSITIONS OF MICROBIOTA AND METHODS RELATED THERETO 审中-公开
标题翻译：微生物组合物及其相关方法
公开(公告)号：WO2013130773A2
公开(公告)日：2013-09-06
申请号：PCT/US2013/028271
申请日：2013-02-28
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPTIAL , KAPLAN, Lee, M. , LIOU, Alice, P. , TURNBAUGH, Peter, J. , HARRIS, Jason, L.
发明人： KAPLAN, Lee, M. , LIOU, Alice, P. , TURNBAUGH, Peter, J. , HARRIS, Jason, L.
IPC分类号： A61K35/74 , A61K45/06 , C12Q1/68
CPC分类号： A61K35/74 , A61K9/0053 , A61K35/741 , A61K45/06 , A61K2035/11 , C12Q1/689 , Y02A50/451 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia . Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by substantially increasing or decreasing a relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure. Also provided are methods of altering microbiota in a subject by administering a composition to the subject thereby altering a microbiota in the subject so that the microbiota mimics a microbiota found in a subject responsive to a gastric bypass or other gastrointestinal bariatric or metabolic procedure. Methods and compositions of altering a relative abundance of microbiota to alter metabolic function and of altering a relative abundance of short chain fatty acids to alter metabolic function are also provided.
摘要翻译：提供了通过改变受试者中的微生物群来治疗体重相关病症和代谢疾病的方法和组合物。一个方面提供了通过向受试者施用包括来自门的基本上纯化的微生物群的组合物，例如细菌属，变形杆菌属，紧密菌属和Verrucomicrobia或诸如类杆菌属，Verrucomicrobial，梭菌和肠杆菌属或类属的序列，从而改变受试者中的微生物群的方法和组合物如Alistipes，Clostridium，Escherichia和Akkermansia。另一方面包括用于改变微生物群的药物组合物，其包括治疗有效量的基本上纯化的微生物群和药学上可接受的载体。另一方面包括在需要这种治疗的受试者中通过基本上增加或减少受试者的胃肠道中的微生物群的相对丰度而无需外科手术或除外科手术之外，来治疗病症（例如肥胖症）的方法。还提供了通过向受试者施用组合物从而改变受试者中的微生物群的方式来改变受试者中的微生物群的方法，使得微生物群模拟响应于胃旁路或其他胃肠减肥或代谢过程的受试者中发现的微生物群。还提供了改变微生物群的相对丰度以改变代谢功能并改变短链脂肪酸的相对丰度以改变代谢功能的方法和组合物。

7. 发明申请

WO2011090764A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE USNIG ELECTRICAL ENERGY 审中-公开
标题翻译：用于激活褐色组织组织的电极的方法和装置
公开(公告)号：WO2011090764A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/062464
申请日：2010-12-30
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A , HARRIS, Jason, L. , STYLOPOULOS, Nicholas , KAPLAN, Lee, M. , BAYNHAM, Tamara, C. , SUBBAROYAN, Jeyakumar , VOEGELE, James, W. , ARONHALT, Taylor , DIUBALDI, Anthony , PLESCIA, David, N. , ORTIZ, Mark, S. , STEPHENS, Theodore, L.
发明人： HARRIS, Jason, L. , STYLOPOULOS, Nicholas , KAPLAN, Lee, M. , BAYNHAM, Tamara, C. , SUBBAROYAN, Jeyakumar , VOEGELE, James, W. , ARONHALT, Taylor , DIUBALDI, Anthony , PLESCIA, David, N. , ORTIZ, Mark, S. , STEPHENS, Theodore, L.
IPC分类号： A61N1/18
CPC分类号： A61N1/0456 , A61N1/0492 , A61N1/0504 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/3606 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36196 , A61N1/3787
摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.
摘要翻译：提供了用于激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热量产生，其随着时间的推移可导致体重减轻。在一个实施方案中，提供了通过电刺激直接激活BAT和/或电刺激棕色脂肪细胞的神经来激活BAT的医疗装置，从而增加BAT中的产热并通过能量消耗引起体重减轻。

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