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1. 发明申请

WO2008103722A2 MITRAL VALVE SYSTEM 审中-公开
标题翻译：麻醉阀系统
公开(公告)号：WO2008103722A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/054410
申请日：2008-02-20
申请人： ENDOVALVE, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LAMPHERE, David, G. , NGUYEN, Tuan, Anh , HERRMANN, Howard, C. , TOMBA, Todd, C. , GORMAN, Robert, C. , GORMAN, Joseph, H., III
发明人： LAMPHERE, David, G. , NGUYEN, Tuan, Anh , HERRMANN, Howard, C. , TOMBA, Todd, C. , GORMAN, Robert, C. , GORMAN, Joseph, H., III
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans- catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性的方式放置，例如经由导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的反向血液流动来密封瓣膜假体的周边。

2. 发明申请

WO2008103497A2 VALVE PROSTHESIS SYSTEMS AND METHODS 审中-公开
标题翻译：阀门预测系统和方法
公开(公告)号：WO2008103497A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/050096
申请日：2008-01-03
申请人： ENDOVALVE, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LAMPHERE, David, G. , NGUYEN, Tuan, Anh , HERRMANN, Howard, C.
发明人： LAMPHERE, David, G. , NGUYEN, Tuan, Anh , HERRMANN, Howard, C.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。瓣膜假体还可以包括相对于弹性环安装的阀裙。

3. 发明申请

WO2008103498A2 SYSTEMS AND METHODS FOR PLACEMENT OF VALVE PHOSTHESIS SYSTEM 审中-公开
标题翻译：阀门配置系统的安装方法
公开(公告)号：WO2008103498A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/050113
申请日：2008-01-03
申请人： ENDOVALVE, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ABESAMES, Gregorio Ramon, M. , ANTOCCI, Joseph, D. , LAMPHERE, David, G. , CASTRO, Salvatore , HERRMANN, Howard, C.
发明人： ANTOCCI, Joseph, D. , LAMPHERE, David, G. , CASTRO, Salvatore , HERRMANN, Howard, C.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.
摘要翻译：提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其有助于有效，可靠和微创的递送方式。放置系统和方法允许瓣膜假体的远程操作和定位，使得可以实现相对于解剖结构（例如心脏环）的期望的放置。瓣膜假体包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。递送系统包括终止于瓣膜假体处的第一细长元件，并且可由操作者操纵以相对于柔性环远程旋转定位元件。第二细长元件终止于瓣膜假体处，并且可由操作者操纵以使瓣膜假体向下远进地进入解剖环。第二细长元件可以被操纵以将瓣膜假体远程地推进到解剖环形空间中，以呈现用于支持原位置于瓣膜假体的植入后功能的位置。可以进一步操作第一细长元件以相对于柔性环远程旋转定位元件，以使得定位元件接合与解剖学环带相关联的组织，并由此原位维持瓣膜假体的植入后位置。还提供了用于瓣膜假体部署的方法。

4. 发明申请

WO2010085344A1 METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH THE WALL OF A LUMEN 审中-公开
标题翻译：通过壁面限制流动的方法和装置
公开(公告)号：WO2010085344A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/000159
申请日：2010-01-22
申请人： CORNELL UNIVERSITY , RIINA, Howard , ANDREWS, Robert , STROHL, Clair , MILSOM, Jeffrey , CORNHILL, J., Fredrick , SMITH, Kevin, Thomas , LAMPHERE, David, G. , NGUYEN, Tuan, Anh
发明人： RIINA, Howard , ANDREWS, Robert , STROHL, Clair , MILSOM, Jeffrey , CORNHILL, J., Fredrick , SMITH, Kevin, Thomas , LAMPHERE, David, G. , NGUYEN, Tuan, Anh
IPC分类号： A61F2/82
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/12131 , A61B17/1214 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00867 , A61B2017/00871 , A61B2017/12054 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2002/9505 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.
摘要翻译：一种用于展开在血管或其他体腔中的可扩张的基本上为球形的结构，包括：由细丝的闭合环形成的开放框架，并且构造成采取以下步骤：（i）呈基本上二维细长环的形式的折叠构型结构，以便于插入到血管或其他体腔中，以及（ii）三维大致球形结构形式的扩张构型，以便于保持在血管或其他体腔中的部位; 以及由开放框架承载的流动限制面; 其中，所述开放框架构造成当所述开放框架处于其膨胀构造时允许基本上正常的流过其中，并且进一步其中所述流动限制面被构造成限制流过其中。

5. 发明申请

WO2009076515A1 METHOD AND APPARATUS FOR SEALING AN OPENING IN THE SIDE WALL OF A BODY LUMEN 审中-公开
标题翻译：用于在身体壁的侧壁上打开的方法和装置
公开(公告)号：WO2009076515A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086393
申请日：2008-12-11
申请人： CORNELL UNIVERSITY , RIINA, Howard , ANDREWS, Robert , STROHL, Clair , MILSOM, Jeffrey , CORNHILL, J., Fredrick , SMITH, Kevin, Thomas , LAMPHERE, David, G. , NGUYEN, Tuan, Anh
发明人： RIINA, Howard , ANDREWS, Robert , STROHL, Clair , MILSOM, Jeffrey , CORNHILL, J., Fredrick , SMITH, Kevin, Thomas , LAMPHERE, David, G. , NGUYEN, Tuan, Anh
IPC分类号： A61F2/94
CPC分类号： A61F2/86 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12131 , A61B17/12172 , A61B17/1219 , A61B2017/00867 , A61B2017/12054 , A61F2/82 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame configured to assume a collapsed configuration and an expanded configuration; and a closed face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the closed face is configured so as to obstruct flow therethrough.
摘要翻译：一种用于部署在血管或其他体腔中的可扩张球形结构，包括：开放框架，其构造为呈现收缩构型和扩张构型; 和由开放框架承载的封闭面; 其中所述开放框架构造成当所述开放框架处于其膨胀构型时允许基本上正常的流过其中，并且其中所述闭合面构造成妨碍流过其中。

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