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1. 发明申请

WO2010033733A4 FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES 审中-公开
标题翻译： ANTIFOLATES的FALATE受体结合偶联物
公开(公告)号：WO2010033733A4
公开(公告)日：2010-05-06
申请号：PCT/US2009057363
申请日：2009-09-17
申请人： ENDOCYTE INC , LEAMON CHRISTOPHER PAUL , VLAHOV IONTCHO RADOSLAVOV , LOW PHILIP STEWART
发明人： LEAMON CHRISTOPHER PAUL , VLAHOV IONTCHO RADOSLAVOV , LOW PHILIP STEWART
IPC分类号： A61K31/517 , A61P11/06
CPC分类号： A61K47/48338 , A61K31/475 , A61K31/517 , A61K47/48061 , A61K47/481 , A61K47/48107 , A61K47/55 , A61K47/551 , C07D487/04
摘要： Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
摘要翻译：描述了抗叶酸剂，可释放连接剂和药物的偶联物，以及含有它们的药物组合物。该缀合物可用于治疗由致病细胞群体引起的疾病。还描述了治疗这些疾病的方法。

2. 发明申请

WO2006071754A3 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD 审中-公开
标题翻译： POSITRON排放图像成像方法
公开(公告)号：WO2006071754A3
公开(公告)日：2007-01-18
申请号：PCT/US2005046708
申请日：2005-12-23
申请人： PURDUE RESEARCH FOUNDATION , ENDOCYTE INC , LOW PHILIP STEWART , VARGHESE BINDU , VLAHOV IONTCHO RADOSLAVOV
发明人： LOW PHILIP STEWART , VARGHESE BINDU , VLAHOV IONTCHO RADOSLAVOV
IPC分类号： A61B6/00
CPC分类号： C07B59/005 , A61B6/037 , A61K51/04 , A61K51/0459 , C07B59/002
摘要： The invention relates to compositions and methods to diagnose/monitor, using positron emission tomography, pathogenic disease states wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. In an illustrative embodiment, vitamins, or analogs thereof, conjugated to a radiophore are used to diagnose/monitor disease states extra-corporeally using positron emission tomography. The disease states that can be diagnosed/monitored in accordance with the invention are cancer and disease states involving activated macrophages, such as disease states involving an inflammatory response.
摘要翻译：本发明涉及使用正电子发射断层摄影技术来诊断/监测病原体疾病的组合物和方法，其中致病细胞独特地表达，优先表达或过度表达维生素受体。在说明性实施例中，使用与放射线相结合的维生素或其类似物来诊断/监测使用正电子发射层析成像的体外疾病状态。可以根据本发明诊断/监测的疾病状态是涉及活化的巨噬细胞的癌症和疾病状态，例如涉及炎症反应的疾病状态。

3. 发明申请

WO2007038346A3 MULTIPHOTON IN VIVO FLOW CYTOMETRY METHOD AND DEVICE 审中-公开
标题翻译：流体细胞计数方法和装置中的多肽
公开(公告)号：WO2007038346A3
公开(公告)日：2008-01-17
申请号：PCT/US2006037112
申请日：2006-09-22
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , HE WEI , HENNE WALTER ANTHONY JR , DOORNEWEERD DEREK DAVID , CHENG JI-XIN
发明人： LOW PHILIP STEWART , HE WEI , HENNE WALTER ANTHONY JR , DOORNEWEERD DEREK DAVID , CHENG JI-XIN
IPC分类号： A61K49/00 , G01N15/14
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group A b comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphotonin vivo flow cytometry.
摘要翻译：本发明涉及一种用于诊断由致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式Ab-X的缀合物或复合物的组合物，其中A组B < SUB>包含与致病细胞结合的配体，组X包含成像剂，并使用多聚肌醇体内流式细胞术检测表达配体受体的致病细胞。

4. 发明申请

WO2007139815A2 IMAGING AND THERAPEUTIC METHOD USING PROGENITOR CELLS 审中-公开
标题翻译：使用原型细胞的成像和治疗方法
公开(公告)号：WO2007139815A2
公开(公告)日：2007-12-06
申请号：PCT/US2007012269
申请日：2007-05-23
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , HILGENBRINK ANDREW RICHARD
发明人： LOW PHILIP STEWART , HILGENBRINK ANDREW RICHARD
IPC分类号： G01N33/50 , A61K47/48 , G01N33/566 , G01N33/58 , G01N33/82
CPC分类号： G01N33/5005 , A61K47/551 , A61K47/6415 , A61K47/65 , A61K47/6911 , A61K49/0021 , A61K49/0032 , A61K49/0041 , A61K49/0043 , A61K49/0052 , G01N33/82 , G01N2500/10 , G01N2800/00
摘要： The invention relates to a method of treating or diagnosing a disease state worsened by progenitor cells. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group Ab comprises a vitamin, or an analog thereof, that binds to progenitor cells, and when the conjugate is being used for treatment of the disease state, the group X comprises an antigen, a cytotoxin, or a compound capable of altering progenitor cell function, and when the conjugate is being used for diagnosing the disease state, the group X comprises a quantifiable marker.
摘要翻译：本发明涉及治疗或诊断由祖细胞恶化的疾病状态的方法。该方法使用包含通式A SUB b -X的缀合物或复合物的组合物，其中组Ab包含与祖细胞结合的维生素或其类似物，并且当缀合物为用于治疗疾病状态，组X包含抗原，细胞毒素或能够改变祖细胞功能的化合物，并且当缀合物用于诊断疾病状态时，组X包含可量化标记。

5. 发明申请

WO2010045598A2 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING 审中-公开
标题翻译： PSMA绑定连接器连接器和使用方法
公开(公告)号：WO2010045598A2
公开(公告)日：2010-04-22
申请号：PCT/US2009061067
申请日：2009-10-16
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , KULARATNE SUMITH A
发明人： LOW PHILIP STEWART , KULARATNE SUMITH A
IPC分类号： A61K48/00
CPC分类号： A61K51/088 , C12N15/111 , C12N2310/351 , C12N2320/32
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for targeting prostate cancer cells. Also described herein are compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译：本文描述了可用于靶向前列腺癌细胞的前列腺特异性膜抗原（PSMA）结合缀合物。本文还描述了含有它们的组合物和使用共轭物和组合物的方法。还描述了制备缀合物和含有它们的组合物的方法。

6. 发明申请

WO2008098112A3 POSITRON EMISSION TOMOGRAPHY IMAGING METHOD 审中-公开
标题翻译： POSITRON排放图像成像方法
公开(公告)号：WO2008098112A3
公开(公告)日：2009-04-30
申请号：PCT/US2008053293
申请日：2008-02-07
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , KULARATNE SUMITH A
发明人： LOW PHILIP STEWART , KULARATNE SUMITH A
IPC分类号： A61K51/04
CPC分类号： A61K51/088 , A61K51/0497 , C07B59/002 , C07D475/04
摘要： Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor- binding analogs and derivatives.
摘要翻译：本文描述了使用正电子发射断层扫描来诊断和/或监测致病性疾病状态的组合物和方法，其中致病细胞独特地表达，优先表达或过量表达维生素受体。本文还描述了维生素和维生素受体结合的类似物和衍生物的18F缀合物。

7. 发明申请

WO2007006041A8 IMAGING AND THERAPEUTIC METHOD USING MONOCYTES 审中-公开
标题翻译：用单细胞成像和治疗方法
公开(公告)号：WO2007006041A8
公开(公告)日：2007-07-12
申请号：PCT/US2006026484
申请日：2006-07-05
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , HILGENBRINK ANDREW RICHARD
发明人： LOW PHILIP STEWART , HILGENBRINK ANDREW RICHARD
IPC分类号： A61P37/00 , A61K33/24 , A61K35/14 , A61K38/00 , A61K38/03 , A61K38/08 , A61K39/00 , A61K39/395 , A61K49/06 , A61P29/00
CPC分类号： A61K51/044 , A61K38/19 , A61K38/47 , A61K47/545 , A61K47/551 , A61K47/64 , A61K47/6911 , A61K49/0021 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K51/0459 , C09B11/24
摘要： The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group A b comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.
摘要翻译：本发明涉及治疗或诊断由单核细胞介导的疾病状态的方法。该方法利用包含通式A b SUB -X的缀合物或复合物的组合物，其中基团A b包含结合单核细胞的配体，并且当缀合物是用于治疗疾病状态，基团X包含免疫原，细胞毒素或能够改变单核细胞功能的化合物，并且当所述缀合物用于诊断疾病状态时，基团X包含显像剂。

8. 发明申请

WO2004110250A3 DIAGNOSTIC METHOD FOR ATHEROSCLEROSIS 审中-公开
标题翻译：诊断心脏病的诊断方法
公开(公告)号：WO2004110250A3
公开(公告)日：2005-04-28
申请号：PCT/US2004016667
申请日：2004-05-27
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART
发明人： LOW PHILIP STEWART
IPC分类号： A61B20060101 , A61K39/395 , A61K49/00 , G01N33/50 , G01N33/53 , G01N33/92
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0052 , A61K49/006 , A61K51/0474 , A61K51/0497 , G01N33/5061 , G01N33/92 , G01N2800/323
摘要： The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.
摘要翻译：本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置检测由发色团发出的光来识别活性斑块。本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

9. 发明申请

WO2004100983A2 CONJUGATES AND USE THEREOF 审中-公开
标题翻译：联合使用
公开(公告)号：WO2004100983A2
公开(公告)日：2004-11-25
申请号：PCT/US2004014097
申请日：2004-05-06
申请人： PURDUE RES FOUNDATION INC , LOW PHILIP STEWART , VARGHESE BINDU
发明人： LOW PHILIP STEWART , VARGHESE BINDU
IPC分类号： A61K47/48 , A61K51/04 , A61K39/00
CPC分类号： A61K51/0497 , A61K47/551 , A61K47/646 , A61K47/6849
摘要： The invention relates to a method of treating lupus erythematosus. In one embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate or complex of the general formula L-X where the group L comprises a ligand capable of binding to activated macrophages or other stimulated immune cells, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function. In another embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate of the general formula L-X where the group L comprises a vitamin, or a vitamin-receptor binding analog or derivative thereof, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function.
摘要翻译：本发明涉及一种治疗红斑狼疮的方法。在一个实施方案中，该方法包括向患有红斑狼疮的患者施用有效量的包含通式LX的缀合物或复合物的组合物的步骤，其中组L包含能够结合活化的巨噬细胞的配体或其它刺激的免疫细胞，并且组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的另一种化合物。在另一个实施方案中，该方法包括向患有红斑狼疮的患者施用有效量的组合物的步骤，所述组合物包含通式LX的缀合物，其中组L包含维生素或维生素受体结合类似物或其衍生物，并且组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的另一种化合物。

10. 发明申请

WO2008148001A3 METHOD OF IMAGING LOCALIZED INFECTIONS 审中-公开
标题翻译：成像局部感染的方法
公开(公告)号：WO2008148001A3
公开(公告)日：2010-07-15
申请号：PCT/US2008064711
申请日：2008-05-23
申请人： PURDUE RESEARCH FOUNDATION , LOW PHILIP STEWART , HENNE WALTER ANTHONY , VARGHESE BINDU , ROTHENBUHLER RYAN
发明人： LOW PHILIP STEWART , HENNE WALTER ANTHONY , VARGHESE BINDU , ROTHENBUHLER RYAN
IPC分类号： A61K51/04
CPC分类号： A61K51/0459
摘要： The invention relates to a method for targeting an imaging agent to cells of an animal to detect localized infections. More particularly, localized infections are detected by targeting imaging agents to inflammatory cells having receptors for a vitamin by using vitamin-imaging agent conjugates.
摘要翻译：本发明涉及将成像剂靶向动物细胞以检测局部感染的方法。更具体地，通过使用维生素 - 成像剂缀合物将成像剂靶向具有维生素受体的炎性细胞来检测局部感染。

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