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1. 发明申请

WO2007011958A2 INTRAORAL DOSAGE FORMS OF GLUCAGON 审中-公开
标题翻译： GLUCAGON的内服剂量
公开(公告)号：WO2007011958A2
公开(公告)日：2007-01-25
申请号：PCT/US2006027901
申请日：2006-07-17
申请人： EMISPHERE TECH INC , WANG NAI FANG , LIU PUCHUN , DINH STEVEN , GOLDBERG MICHAEL M , ARBIT EHUD
发明人： WANG NAI FANG , LIU PUCHUN , DINH STEVEN , GOLDBERG MICHAEL M , ARBIT EHUD
IPC分类号： A61K38/26
CPC分类号： A61K38/26 , C07K14/605
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a therapeutically effective amount of glucagon and the delivery agent compound. The composition of the present invention facilitates the delivery of glucagon and increases its bioavailability compared to administration without the delivery agent compound.
摘要翻译：本发明提供包含至少一种递送剂化合物和胰高血糖素的组合物（例如药物组合物）。优选地，组合物包含治疗有效量的胰高血糖素和递送剂化合物。本发明的组合物有助于胰高血糖素的递送，并且与不含递送剂化合物的给药相比，其生物利用度增加。

2. 发明申请

WO2006124047A9 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：含有微粒或递送剂纳米颗粒的药物制剂
公开(公告)号：WO2006124047A9
公开(公告)日：2007-06-21
申请号：PCT/US2005028991
申请日：2005-08-15
申请人： EMISPHERE TECH INC , MAJURU SHINGAI , LIU PUCHUN , DINH STEVEN , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHIL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
发明人： MAJURU SHINGAI , LIU PUCHUN , DINH STEVEN , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHIL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and /or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米粒子。本发明还涉及药物制剂和固体剂型，包括控释固体剂型的活性剂和递送剂

3. 发明申请

WO2006124047A2 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：包含递送剂的微量元素或纳米颗粒的药物制剂
公开(公告)号：WO2006124047A2
公开(公告)日：2006-11-23
申请号：PCT/US2005028991
申请日：2005-08-15
申请人： EMISPHERE TECH INC , MAJURU SHINGAI , LIU PUCHUN , DINH STEVE , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHILL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
发明人： MAJURU SHINGAI , LIU PUCHUN , DINH STEVE , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHILL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and /or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂

4. 发明申请

WO0007979A3 COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 审中-公开
标题翻译：用于提供活性剂的化合物和组合物
公开(公告)号：WO0007979A3
公开(公告)日：2000-05-18
申请号：PCT/US9917974
申请日：1999-08-06
申请人： EMISPHERE TECH INC , GSCHNEIDNER DAVID , LEONE BAY ANDREA , WANG ERIC , ERRIGO LYNN , KRAFT KELLY , MOYE SHERMAN DESTARDI , HO KOC KAN , PRESS JEFFREY BRUCE , WANG NAI FANG
发明人： GSCHNEIDNER DAVID , LEONE-BAY ANDREA , WANG ERIC , ERRIGO LYNN , KRAFT KELLY , MOYE-SHERMAN DESTARDI , HO KOC-KAN , PRESS JEFFREY BRUCE , WANG NAI FANG
IPC分类号： A61K9/00 , A61K31/727 , A61K38/22 , A61K38/27 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/22 , A61P5/18 , C07C233/25 , C07C233/51 , C07C233/54 , C07C233/81 , C07C233/83 , C07C235/24 , C07C235/34 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D311/68 , C07D317/68 , C07C237/36 , C07C237/40
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了用于递送活性剂的化合物和组合物。还提供给药方法和制剂。

5. 发明申请

WO2005020925A3 METHOD AND APPARATUS FOR DOSING SOLIDS 审中-公开
标题翻译：给定固体的方法和设备
公开(公告)号：WO2005020925A3
公开(公告)日：2005-07-07
申请号：PCT/US2004028097
申请日：2004-08-27
申请人： EMISPHERE TECH INC , WANG NAI FANG
发明人： WANG NAI FANG
IPC分类号： A61K20060101 , A61M31/00
CPC分类号： A61M37/0069
摘要： An apparatus for selectively dosing a solid is provided and includes (1) a flexible guide tube that include a first end and an opposing second end and has a bore formed therethrough from the first end to the second end; (2) a dispensing tip disposed at the first end of the guide tube and including a bore formed completely therethrough and defining a reservoir fore holding one or more dosing solids until actuation of the apparatus; and (3) a stylet that is dimensioned so as to be slideably received within through the bore of the flexible guide tube, the stylet having a first end and an opposing second end. With the first end of the stylet being for contact with one or more dosing solids to cause discharge thereof through the dispensing tip.
摘要翻译：提供了一种用于选择性地定量供给固体的设备，并且包括：（1）柔性引导管，其包括第一端和相对的第二端并且具有从第一端到第二端贯穿形成的孔; （2）分配尖端，其设置在引导管的第一端并且包括完全穿过其形成的孔并且限定容纳一个或多个剂量固体的储存器，直到致动设备; （3）管心针的尺寸设计成可滑动地容纳在柔性导管的孔内，管心针具有第一端和相对的第二端。使探针的第一端与一个或多个定量固体接触以使其通过分配尖端排出。

6. 发明申请

WO0040203A3 POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS 审中-公开
标题翻译：聚合物输送剂和输送剂化合物
公开(公告)号：WO0040203A3
公开(公告)日：2000-12-14
申请号：PCT/US0000476
申请日：2000-01-07
申请人： EMISPHERE TECH INC , UNIV VIRGINIA COMMONWEALTH , MILSTEIN SAM J , BARANTSEVITCH EUGENE N , WANG NAI FANG , LIAO JUN , SMART JOHN E , CONTICELLO RICHARD D , OTTENBRITE RAPHAEL M
发明人： MILSTEIN SAM J , BARANTSEVITCH EUGENE N , WANG NAI FANG , LIAO JUN , SMART JOHN E , CONTICELLO RICHARD D , OTTENBRITE RAPHAEL M
IPC分类号： A61K9/00 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/10 , A61K47/32 , A61K47/48 , C08F8/30 , C08G65/329 , C08G65/333 , A01N25/00 , A01N37/18 , A01N43/04 , A61K9/50 , A61K38/00
CPC分类号： C08G65/33396 , A61K9/0019 , A61K38/27 , A61K38/29 , A61K47/10 , A61K47/32 , A61K47/56 , A61K47/60 , C08F8/30 , C08G65/329 , C08L2203/02
摘要： Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的聚合物递送剂，递送剂化合物和包含它们的组合物。还提供给药方法和制剂。

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