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1. 发明申请

WO2009107100A2 HIGH MOLECULAR EXTINCTION COEFFICIENT METAL DYES 审中-公开
标题翻译：高分子量放射性系数金属染料
公开(公告)号：WO2009107100A2
公开(公告)日：2009-09-03
申请号：PCT/IB2009/050800
申请日：2009-02-27
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , GAO, Feifei , WANG, Yuan , ZHANG, Jing , WANG, Peng , ZAKEERUDDIN, Shaik Mohammad , GRAETZEL, Michael
发明人： GAO, Feifei , WANG, Yuan , ZHANG, Jing , WANG, Peng , ZAKEERUDDIN, Shaik Mohammad , GRAETZEL, Michael
CPC分类号： H01L51/0086 , C07F15/0053 , C09B57/10 , H01G9/2013 , H01G9/2031 , H01G9/2059 , Y02E10/542 , Y02E10/549
摘要： The present invention relates to novel compounds that are useful as ligands in organometallic dyes. More particularly, the invention relates to dyes comprising the compounds, said dyes being sensitizing dyes useful in solar cell technology. According to an embodiment, the present invention discloses new ruthenium dyes and their application in dye-sensitized solar cells (DSC).The referrerd ruthenium dyes with new structural features can be easily synthesized, show more than 85% light-to-electricity conversion efficiency and a higher than 9% cell efficiency.
摘要翻译：本发明涉及可用作有机金属染料中配体的新化合物。更具体地说，本发明涉及包含该化合物的染料，所述染料是用于太阳能电池技术的敏化染料。根据一个实施方案，本发明公开了新的钌染料及其在染料敏化太阳能电池（DSC）中的应用。可以容易地合成具有新结构特征的引入钌染料，显示出超过85％的光电转换效率和高于9％的电池效率。

2. 发明申请

WO2010033748A1 ELECTRICAL DEVICES WITH ENHANCED ELECTROCHEMICAL ACTIVITY AND MANUFACTURING METHODS THEREOF 审中-公开
标题翻译：具有增强电化学活性的电气装置及其制造方法
公开(公告)号：WO2010033748A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057382
申请日：2009-09-18
申请人： BAYER HEALTHCARE LLC , CHARLTON, Steven, C. , PETEU, Serban , SUN, Steve , WANG, Yuan
发明人： CHARLTON, Steven, C. , PETEU, Serban , SUN, Steve , WANG, Yuan
IPC分类号： G01N27/26
CPC分类号： G01N27/3271 , C12Q1/006 , C12Q1/26 , G01N33/48707
摘要： In some aspects, a device is provided having a member with a region of enhanced electrochemical activity. In one aspect, a sensor of enhanced electrochemical activity is provided for detecting an analyte concentration level in a bio-fluid sample. The sensor may include a sensor member of a semiconductor material wherein the sensor member has a surface region of enhanced electrochemical activity. In other aspects, the member may be made of semiconducting foam having a surface region of enhanced electrochemical activity. In some embodiments, the region may be thermally-induced. Manufacturing methods and apparatus are also provided, as are numerous other aspects.
摘要翻译：在一些方面，提供了具有具有增强的电化学活性区域的构件的装置。在一个方面，提供了增强的电化学活性的传感器，用于检测生物流体样品中的分析物浓度水平。传感器可以包括半导体材料的传感器构件，其中传感器构件具有增强的电化学活性的表面区域。在其它方面，构件可以由具有增强的电化学活性的表面区域的半导体泡沫制成。在一些实施例中，该区域可以是热诱导的。还提供了制造方法和装置以及许多其它方面。

3. 发明申请

WO2009149318A2 MIRNAS AS THERAPEUTIC TARGETS IN CANCER 审中-公开
标题翻译： MIRNAS作为癌症中的治疗目标
公开(公告)号：WO2009149318A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046353
申请日：2009-06-05
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , JU, Jingfang , SONG, Bo , WANG, Yuan
发明人： JU, Jingfang , SONG, Bo , WANG, Yuan
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3' untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
摘要翻译：微RNA（miRNA）是一类非编码小RNA分子，通过与其靶mRNA的3'非翻译区（UTR）相互作用来调节转录后水平的基因表达。本发明涉及miR-192和miR-215的应用。这两种miRNA通过p53-miRNA电路影响细胞增殖，并与二氢叶酸还原酶（DHFR）和胸苷酸合酶（TS）相互作用。特别地，这些miRNA的上调减少细胞增殖。本发明涉及这一发现。例如，抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。此外，测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。因此，本发明涉及与miR-192和miR-215的表达的鉴定，表征和调节相关的组合物和方法。

4. 发明申请

WO2012048202A2 METHOD OF PREPARATION OF ANTIVIRAL COMPOUNDS AND USEFUL INTERMEDIATES THEREOF 审中-公开
标题翻译：制备抗病毒化合物的方法及其有用的中间体
公开(公告)号：WO2012048202A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/055229
申请日：2011-10-07
申请人： INHIBITEX, INC. , WANG, Yanling , WANG, Yuan , HE, Xungui , LIU, Chuanjun , ZHU, Jirang , LI, Jie , CHENG, Qingzhong , YUAN, Mingyong
发明人： WANG, Yanling , WANG, Yuan , HE, Xungui , LIU, Chuanjun , ZHU, Jirang , LI, Jie , CHENG, Qingzhong , YUAN, Mingyong
IPC分类号： C07D491/048 , C07H7/06 , C07H19/06 , C07H19/073 , A61K31/519 , A61P31/12
CPC分类号： C07H19/23 , A61K31/519 , C07B2200/13 , C07H19/073 , C07H19/24
摘要： The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.
摘要翻译：本发明涉及合成双环核苷抗病毒化合物和合成用于该方法的中间体的方法。本发明还涉及用于该方法的新型中间体化合物。抗病毒化合物可用于治疗带状疱疹（即水痘带状疱疹病毒，VZV，带状疱疹）和预防由此病毒感染引起的疱疹后神经痛（PHN）。

5. 发明申请

WO2010033668A1 ANALYTE SENSORS, TESTING APPARATUS AND MANUFACTURING METHODS 审中-公开
标题翻译：分析传感器，测试装置和制造方法
公开(公告)号：WO2010033668A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057264
申请日：2009-09-17
申请人： BAYER HEALTHCARE LLC , FEI, Jiangfeng , GIFFORD, Raeann , PARASNIS, Narasinha , PETEU, Serban , SUN, Steve , WANG, Yuan , WU, Mu
发明人： FEI, Jiangfeng , GIFFORD, Raeann , PARASNIS, Narasinha , PETEU, Serban , SUN, Steve , WANG, Yuan , WU, Mu
IPC分类号： H01L23/58
CPC分类号： G01N27/3272
摘要： In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include a first sensor member coupled to a base, wherein the first sensor member includes a semiconductor material, a second sensor member coupled to the base; and an active region in contact with at least the first sensor member. In some aspects, the first sensor member may be a fiber, and may have a conductive core and a semiconducting cladding surrounding the core. Manufacturing methods and apparatus utilizing the sensors are provided, as are numerous other aspects.
摘要翻译：在一些方面，提供分析物传感器用于检测生物流体样品中的分析物浓度水平。分析物传感器可以包括耦合到基座的第一传感器构件，其中第一传感器构件包括半导体材料，耦合到基座的第二传感器构件; 以及与至少第一传感器构件接触的有源区域。在一些方面，第一传感器构件可以是光纤，并且可以具有围绕芯的导电芯和半导体包层。提供了利用传感器的制造方法和装置，以及许多其它方面。

6. 发明申请

WO2004099152A1 PROCESS FOR THE PREPARATION OF CARBOSTYRIL DERIVATIVES, SUCH AS ARIPIPRAZOLE AND ITS INTERMEDIATES 审中-公开
标题翻译：制备碳氢化合物衍生物的方法，如阿维替唑及其中间体
公开(公告)号：WO2004099152A1
公开(公告)日：2004-11-18
申请号：PCT/CA2004/000605
申请日：2004-04-23
申请人： DELMAR CHEMICALS INC. , SALAMA, Paul , MEUNIER, Jean-Francois , LAFRENIERE, Julie , WANG, Yuan , LIU, Lu Wei
发明人： SALAMA, Paul , MEUNIER, Jean-Francois , LAFRENIERE, Julie , WANG, Yuan , LIU, Lu Wei
IPC分类号： C07D215/227
CPC分类号： C07D487/10
摘要： A process for preparing carbostyril derivatives such as aripiprazole is described. Dichlorophenylpiperazine or an acid addition salt thereof is reacted with a compound of formula X-C 4 H 8 -Y or X-C 4 H 6 -Y to produce a novel quaternary spiro ammonium salt intermediate which is optionally isolated and purified. The quaternary spiro ammonium salt intermediate is reacted with 7-hydroxydihydrocarboxystyryl to produce the carbostyril derivative.
摘要翻译：描述了制备喹诺酮类衍生物如阿立哌唑的方法。使二氯苯基哌嗪或其酸加成盐与式X-C4H8-Y或X-C4H6-Y的化合物反应以产生任选分离和纯化的新型四元螺铵盐中间体。四环螺铵盐中间体与7-羟基二氢甲酰苯乙烯基反应生成喹诺酮衍生物。

7. 发明申请

WO2003023042A1 REKOMBINANTES MVA MIT DER FÄHIGKEIT ZUR EXPRESSION VON HCV STRUKTUR-ANTIGENEN 审中-公开
标题翻译：符合表达结构HCV抗原的能力重组MVA
公开(公告)号：WO2003023042A1
公开(公告)日：2003-03-20
申请号：PCT/EP2002/009958
申请日：2002-09-05
申请人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH , SUTTER, Gerd , ERFLE, Volker , STAIB, Caroline , WANG, Yuan , LI, Guangdi , ZHU, Lixin
发明人： SUTTER, Gerd , ERFLE, Volker , STAIB, Caroline , WANG, Yuan , LI, Guangdi , ZHU, Lixin
IPC分类号： C12N15/863
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C12N15/86 , C12N2710/24143 , C12N2770/24234 , C12N2770/24243
摘要： Die Erfindung betrifft rekombinantes MVA, welches in der Lage ist, HCV-Struktur-Antigene, funktionelle Teile dieser Struktur-Antigene oder Epitope dieser Struktur-Antigene zu exprimieren. Die Erfindung beschreibt weiterhin eine pharmazeutische Zubereitung, die insbesondere in Form einer Vakzine vorliegt und ein rekombinantes MVA gemäss der Erfindung enthält, Eukaryontenzellen, die das erfindungsgemässe rekombinante MVA enthalten sowie verschiedene Verwendungen des rekombinanten MVA, beispielsweise zur Produktion rekombinanter Strukturproteine, zur Herstellung einer pharmazeutischen Zubereitung, die insbesondere zur Therapie und Prophylaxe von HCV-Infektionen und hierdurch verursachter Erkrankungen geeignet ist, Verfahren zur Herstellung von rekombinantem MVA und von rekombinanten HCV-Struktur-Polypeptiden, die von diesem rekombinanten MVA kodiert werden, sowie DNA oder RNA dieses rekombinanten MVA.
摘要翻译：本发明涉及一种重组MVA所有能表达结构HCV抗原，所述结构的抗原或所述结构的抗原的表位的功能部件。本发明进一步涉及一种药物组合物，爱特别是在疫苗的形式，并且包含所述重组MVA雅丁本发明，真核细胞也包含本发明的重组MVA和所述重组MVA的各种用途，例如用于制备重组结构蛋白质，制备药物制剂确实适合于治疗和HCV感染和疾病的预防由此引起。本发明进一步涉及一种用于生产重组MVA和由所述重组MVA编码重组HCV结构多肽的方法，以及所说的重组MVA的DNA或RNA。

8. 发明申请

WO2011143627A2 PHENOL CROSSLINK FOR SENSOR MEMBRANE 审中-公开
标题翻译：用于传感器膜的PHENOL CROSSLINK
公开(公告)号：WO2011143627A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/036538
申请日：2011-05-13
申请人： BAYER HEALTHCARE LLC , WANG, Yuan , GIFFORD, Raeanne
发明人： WANG, Yuan , GIFFORD, Raeanne
IPC分类号： G01N27/31 , B01D71/06 , G01N27/40
CPC分类号： B01D71/72 , A61B5/14532 , A61B2562/12 , B01D67/0006 , B01D2323/30 , C12Q1/003 , G01N27/3274 , G01N27/40
摘要： Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.
摘要翻译：本文的实施方案提供了一种膜，其是与一种或多种含有烯丙基的化合物交联的酚的产物。苯酚可以与含烯丙基的化合物电聚合以形成交联的聚合物。合适的含烯丙基化合物包括烯丙基苯酚，烯丙醇，烯丙胺和烯丙基氨基甲酰胺。膜可以具有一种类型的含烯丙基化合物，或者两种或更多种类型的化合物。如在分析物感测装置中使用的，由交联苯酚形成的膜可以提供改进的干扰排除，过氧化物反应，稳定性和/或耐溶剂性。

9. 发明申请

WO2011031751A1 ELECTROCHEMICAL TEST SENSOR 审中-公开
标题翻译：电化学测试传感器
公开(公告)号：WO2011031751A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048120
申请日：2010-09-08
申请人： BAYER HEALTHCARE LLC , WANG, Yuan , GIFFORD, Raeann , JIANG, Hualin , REYNOLDS, Jeffery, S. , FEI, Jiangfeng
发明人： WANG, Yuan , GIFFORD, Raeann , JIANG, Hualin , REYNOLDS, Jeffery, S. , FEI, Jiangfeng
IPC分类号： C12Q1/00 , G01N33/487
CPC分类号： G01N27/3272
摘要： An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing (102) that has a first end (106) and a second opposing end (104). The housing includes an opening at the first end (106) to receive a fluid test sample. An electrode assembly (108) includes a substrate (110), a working electrode (116), a counter electrode (118) and a reagent. The substrate has a first surface (112) and an opposing second surface (114). The working electrode (116) is disposed on the first surface (112) of the substrate (110), and the counter electrode (118) is disposed on the second surface (114) of the substrate (112). The electrode assembly (108) is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.
摘要翻译：一种用于检测流体样品中分析物浓度的电化学测试传感器。电化学测试传感器包括具有第一端（106）和第二相对端（104）的壳体（102）。壳体包括在第一端（106）处的开口，用于容纳流体测试样品。电极组件（108）包括基板（110），工作电极（116），对电极（118）和试剂。衬底具有第一表面（112）和相对的第二表面（114）。工作电极（116）设置在基板（110）的第一表面（112）上，对电极（118）设置在基板（112）的第二表面（114）上。电极组件（108）定位在壳体内以限定反应通道。电化学测试传感器可与可拆卸的柳叶刀机构一起使用或集成在刺血针机构内以形成一个整体单元。

10. 发明申请

WO2010033741A1 ANALYTE SENSORS, SYSTEMS, TESTING APPARATUS AND MANUFACTURING METHODS 审中-公开
标题翻译：分析传感器，系统，测试装置和制造方法
公开(公告)号：WO2010033741A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057372
申请日：2009-09-18
申请人： BAYER HEALTHCARE LLC , CHINNAYELKA, Swetha , FEI, Jiangfeng , PARASNIS, Narasinha , PETEU, Serban , WANG, Yuan
发明人： CHINNAYELKA, Swetha , FEI, Jiangfeng , PARASNIS, Narasinha , PETEU, Serban , WANG, Yuan
IPC分类号： A61B5/157
CPC分类号： A61B5/150389 , A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/150007 , A61B5/150022 , A61B5/150297 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/15113 , A61B5/15115 , A61B5/15117 , A61B5/15123 , A61B5/1513 , A61B5/15151 , A61B5/15159 , A61B5/157 , A61B2562/08 , A61B2562/085 , G01N27/308 , G01N27/3272 , G01N27/3273 , G01N27/403 , Y10T29/49002
摘要： In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include one or more conductors received in a hollow portion of a hollow member. The first conductor may be made, at least in part, of a semiconductor material and an active region may be provided in contact with at least the first conductor. The analyte sensor may, in one aspect, include a lancet and an integrated sensor. Manufacturing methods and apparatus and systems utilizing the analyte sensors are provided, as are numerous other aspects.
摘要翻译：在一些方面，提供分析物传感器用于检测生物流体样品中的分析物浓度水平。分析物传感器可以包括容纳在中空构件的中空部分中的一个或多个导体。第一导体可以至少部分地由半导体材料制成，并且可以提供与至少第一导体接触的有源区。在一个方面，分析物传感器可以包括刺血针和集成传感器。提供了利用分析物传感器的制造方法和装置和系统，以及许多其它方面。

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