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1. 发明申请

WO2021228796A1 SYSTEM AND METHOD FOR HIGH BEAM QUALITY PULSE GENERATION IN MODE-LOCKED MULTIMODE FIBER LASERS 审中-公开
公开(公告)号：WO2021228796A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062389
申请日：2021-05-11
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： TEGIN, Ugur , PSALTIS, Demetri , MOSER, Christophe
IPC分类号： H01S3/098 , H01S3/067 , H01S3/08 , H01S3/082 , H01S3/16 , H01S3/30
摘要： A system and method to generate ultrashort high beam quality pulses from spatio- temporally mode-locked multimode fiber laser are described. The invention relies on engineering the intra-cavity pulse propagation in a multimode laser cavity to shape the spatial and temporal properties of the output pulses. The invention allows the generation of Kerr-induced self-beam cleaning when mode-locking is obtained. Using this invention, high power ultrashort pulses can be achieved with a Gaussian mode profile by using commercially available multimode fibers.

2. 发明申请

WO2013150453A1 SELF-TRACKING SOLAR CONCENTRATOR 审中-公开
标题翻译：自走式太阳能集中器
公开(公告)号：WO2013150453A1
公开(公告)日：2013-10-10
申请号：PCT/IB2013/052649
申请日：2013-04-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： TREMBLAY, Eric , MOSER, Christophe
IPC分类号： F21V8/00 , F24J2/38 , H01L31/052
CPC分类号： F24S50/20 , G01S17/66 , G02B6/0013 , G02B6/32 , G02B6/4295 , H01L31/0543 , H01L31/0547 , H01L31/0549 , Y02E10/52
摘要： A system for capturing solar light of the sun, whereby the solar light comprises a short wavelength light component and a long wavelength light component. The system comprises at least a lens (101), a light- guide (102), and a self-adaptive coupling feature (103). The at least one lens is arranged adjacent to the light-guide in order to focus the long wavelength component onto the self-adaptive coupling feature, and the self-adaptive coupling feature is configured to couple the short wavelength light component into the light-guide.
摘要翻译：一种用于捕获太阳太阳光的系统，由此太阳光包括短波长光分量和长波长光分量。该系统至少包括透镜（101），光导（102）和自适应耦合特征（103）。所述至少一个透镜被布置为与所述导光体相邻，以便将所述长波长分量聚焦到所述自适应耦合特征上，并且所述自适应耦合特征被配置为将所述短波长光分量耦合到所述光导。

3. 发明申请

WO2013144898A2 METHODS AND APPARATUS FOR IMAGING WITH MULTIMODE OPTICAL FIBERS 审中-公开
标题翻译：用于多模光纤成像的方法和装置
公开(公告)号：WO2013144898A2
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052493
申请日：2013-03-28
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： PAPADOPOULOS, Ioannis , FARAHI, Salma , MOSER, Christophe , PSALTIS, Demetri
IPC分类号： F21V8/00
CPC分类号： H04N1/40 , G01J3/0218 , G01J3/44 , G02B6/0288 , G02B23/26 , G02B26/06 , G02B27/58 , G02F1/011 , G02F1/0136 , G02F1/313 , G03H1/0005 , G03H1/2286 , G03H1/2294 , G03H2001/0434 , G03H2001/0447 , H04B10/2581
摘要： A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode wave¬ guide and a second step consists in projecting a specific pattern on the wave¬ guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by chang¬ ing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros¬ copy or imaging, 3D linear scattering imaging or two-photon imaging. Super- resolution, i.e., resolution below the diffraction limit, is achieved for example but not limited to, using the STimulated Emission Depletion microscopy (STED) technique or the Structured Illumination Microscopy (SIM) technique or a stochastic illumination based method (PALM, STORM) in combination with the multimode waveguide imaging method.
摘要翻译：多模波导照明器和成像器依赖于波前整形系统，其用于补偿多模波导的模式加扰和光色散。第一步包括校准多模波导，第二步包括将特定图案投影在波导近端上，以在其远端产生期望的光图案。可以通过改变在波导的近端处投影的相位图案来动态扫描或改变照明图案。第三和最后一步是通过相同的波导收集由样品产生的光学信息，以形成图像。已知的自由空间显微技术可以适用于多模波导的内窥镜检查，例如但不限于荧光成像或拉曼光谱复制或成像，3D线性散射成像或双光子成像。超分辨率，即低于衍射极限的分辨率，例如但不限于使用受激发射耗尽显微镜（STED）技术或结构照明显微镜（SIM）技术或基于随机照明的方法（PALM，STORM ）结合多模波导成像方法。

4. 发明申请

WO2021191331A1 MULTI-MODAL RETINAL IMAGING PLATFORM 审中-公开
公开(公告)号：WO2021191331A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057680
申请日：2021-03-25
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： KÜNZI, Matthieu , LAFOREST, Timothé , MOSER, Christophe
IPC分类号： A61B3/00 , A61B3/10 , A61B3/12 , A61B3/18 , A61B3/0008 , A61B3/1015 , A61B3/102 , A61B3/1225 , A61B3/1241
摘要： The invention relates to oblique transscleral illumination of an eye fundus with at least one physical point light source around the eye allowing for dark field imaging combined with optical coherence tomography imaging.

5. 发明申请

WO2021152476A1 SYSTEM AND METHOD FOR A MICROFLUIDIC JET GENERATION FROM A COMPACT DEVICE 审中-公开
公开(公告)号：WO2021152476A1
公开(公告)日：2021-08-05
申请号：PCT/IB2021/050625
申请日：2021-01-27
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： KRIZEK, Jan , MOSER, Christophe , DE GOUMOËNS, Frédéric
IPC分类号： A61B18/26 , A61M5/20
摘要： The invention discloses systems and methods for generation of microfluidic jets providing a tool for very precise and localized delivery of e.g., medicaments. The proposed solution overcomes shortcomings related to miniaturization of a jet injection technology by implementing laser energy as a driving mechanism and optical fibers for its delivery. Solving the step of miniaturization can allow building new tools compatible with minimally invasive surgical techniques, high parallelization of jet injection units or design of new ergonomic injection devices.

6. 发明申请

WO2021023452A1 METHOD AND APPARATUS FOR VOLUMETRIC ADDITIVE MANUFACTURING OF CELL-LOADED RESINS 审中-公开
公开(公告)号：WO2021023452A1
公开(公告)日：2021-02-11
申请号：PCT/EP2020/069099
申请日：2020-07-07
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： DELROT, Paul , LOTERIE, Damien , MOSER, Christophe
IPC分类号： B29C64/124 , B29C64/264 , B29C64/314 , B33Y10/00 , B33Y30/00 , B33Y40/10 , B33Y70/10 , B29C64/106
摘要： The present invention is related to a method and apparatus for the volumetric fabrication of three-dimensional objects or articles from photoresponsive materials loaded with scattering particles, by adjusting the refractive index of said photoresponsive material (12) so as to match the refractive index of said scattering particles (30), and/or using a light source emitting light of a wavelength longer than 630 nm, preferably in a range from 630 nm to 1050 nm, more preferably in a range from 650 nm to 900 nm.

7. 发明申请

WO2019043529A1 METHODS AND APPARATUS FOR THREE-DIMENSIONAL FABRICATION BY TOMOGRAPHIC BACK PROJECTIONS 审中-公开
公开(公告)号：WO2019043529A1
公开(公告)日：2019-03-07
申请号：PCT/IB2018/056389
申请日：2018-08-23
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： LOTERIE, Damien , DELROT, Paul , MOSER, Christophe
IPC分类号： B33Y50/00 , B29C64/386 , B29C64/10 , H04N1/40
摘要： A method for producing a three-dimensional object comprising computing a sequence of back-projections describing the three-dimensional object to be formed from different orientation angles of said object, defining a sequence of patterns of light using said back-projections, and irradiating with each of said patterns of light at the respective corresponding orientation angle and according to the defined sequence a photoresponsive material that is capable of alteration of its material phase upon irradiation by light, thereby creating a three-dimensional distribution of alterations within the photoresponsive medium which physically reproduces said three- dimensional object, thereby creating the three-dimensional object.

8. 发明申请

WO2020254068A1 SYSTEM AND METHOD OF USING FEEDBACK FOR CORRECTING THREE DIMENSIONAL OBJECTS IN VOLUMETRIC TOMOGRAPHIC PRINTERS 审中-公开
公开(公告)号：WO2020254068A1
公开(公告)日：2020-12-24
申请号：PCT/EP2020/064405
申请日：2020-05-25
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： DELROT, Paul , LOTERIE, Damien , MOSER, Christophe
IPC分类号： B29C64/129 , B29C64/241 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
摘要： A method for monitoring the generation of a three-dimensional object (5) being formed in a tomographic additive manufacturing system from simulated tomographic two-dimensional back-projections (9) of a desired 3D article comprises the steps of: - illuminating a container (3) comprising a photoresponsive material (103) with a light beam (2a) of two-dimensional light patterns generated from said two-dimensional back-projections (9) at multiple angles, preferably by rotation of the container (3), so as to form the object (5) in the container (3); - capturing images of said object (5) being formed by volumetric printing with an imaging system (6, 7, 8) disposed around the container (3) in which the object (5) is being formed; - determining from said images the shape or extent to which the object has been formed.

9. 发明申请

WO2017195163A1 SYSTEM, METHOD AND APPARATUS FOR RETINAL ABSORPTION PHASE AND DARK FIELD IMAGING WITH OBLIQUE ILLUMINATION 审中-公开
标题翻译：用于具有斜视照明的视网膜吸收和暗场成像的系统，方法和设备
公开(公告)号：WO2017195163A1
公开(公告)日：2017-11-16
申请号：PCT/IB2017/052803
申请日：2017-05-12
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： LAFOREST, Timothé , CARPENTRAS, Dino , MOSER, Christophe , KÜNZI, Mathieu
IPC分类号： A61B3/00 , A61B3/10 , A61B3/12
摘要： A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.
摘要翻译：一种用于对眼睛组织成像的方法，所述方法包括以下步骤：通过光递送装置的多个发光区域向眼睛提供倾斜照明，所述多个发光区域是可独立控制并布置成将光导向眼睛的视网膜和虹膜中的至少一个，使得来自光的输出光束通过倾斜照明从视网膜和虹膜中的至少一个后向散射，从而捕获输出光束成像系统以提供眼睛的眼底的图像序列，并且从眼底的图像序列中检索相位和吸收对比图像，其中捕获步骤的眼底的图像序列是通过顺序地转动在提供倾斜照明的步骤中一次在多个发光区域中的一个或多个发光区域上

10. 发明申请

WO2017060832A2 OPTICAL PROXIMITY SENSING SYSTEM FOR ATRAUMATIC COCHEA IMPLANT SURGERY 审中-公开
标题翻译：用于ATRAUMATIC COCHEA植入手术的光学临近感测系统
公开(公告)号：WO2017060832A2
公开(公告)日：2017-04-13
申请号：PCT/IB2016/055959
申请日：2016-10-05
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： PSALTIS, Demetri , PU, Ye , MOSER, Christophe , STANKOVIC, Konstantina
IPC分类号： A61N1/36 , H04R25/00 , A61B5/00
CPC分类号： A61N1/36036 , A61B5/0075 , A61B5/0084 , A61B5/1072 , A61B5/6817 , A61B5/6867 , A61B2505/05 , H04R2225/67
摘要： The design of a proximity sensor to be integrated into cochlea implants is described. The sensor allows the anticipation of contact between the cochlear implant and intracochlear structures, including the cochlear canal wall and basilar membrane, providing a feedback or an alarm to the surgeon performing the implant insertion such that trauma to the cochlea is avoided. This helps to preserve any residual hearing ability in patients who receive the surgical implant.
摘要翻译：描述了将被整合到耳蜗植入物中的接近传感器的设计。传感器允许预期耳蜗植入物和包括耳蜗管壁和基底膜之间的耳蜗内结构之间的接触向外科医生进行植入物插入提供反馈或报警，从而避免对耳蜗的创伤。这有助于在接受手术植入物的患者中保留残留听力。

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