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1. 发明申请

WO2005010059A1 RANDOM ETHYLENE/ALKYL ACRYLATE COPOLYMERS, COMPOUNDS AND ELASTOMERIC COMPOSITIONS THEREOF WITH IMPROVED LOW TEMPERATURE PROPERTIES 审中-公开
标题翻译：随机乙烯/丙烯酸烯丙酯共聚物，其化合物和弹性体组合物具有改善的低温特性
公开(公告)号：WO2005010059A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/023669
申请日：2004-07-22
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , WU, Yun-Tai , STEWART, Mark, Aaron , MITCHELL, David, John , MCBRIDE, Edward
发明人： WU, Yun-Tai , STEWART, Mark, Aaron , MITCHELL, David, John , MCBRIDE, Edward
IPC分类号： C08F10/02
CPC分类号： C08L33/08 , C08F220/12
摘要： Disclosed are random copolymers derived from ethylene and at least two different alkyl acrylate comonomers, with or without an acid cure site-containing comonomer. In particular, disclosed are copolymers derived from copolymerization of (a) from 10 to 50 weight % of ethylene; (b) from 5 to 55 weight % of a first alkyl acrylate; (b) from 15 to 80 weight % of a second alkyl acrylate; and (d) from 0 to 7 weight % of a monoalkyl ester of 1,4-butene-dioic acid. Such copolymers exhibit lower glass transition temperatures (Tg) relative to previous ethylene copolymers comprising a single alkyl acrylate comonomer and maintain the good heat and fluid resistance when employed to produce cured elastomeric compositions as well as the improved low temperature properties. This invention also provides compounded compositions comprising these copolymers, and cured compositions (i.e., vulcanizates) as well as rubber articles formed from these compounded compositions, such as hoses, dampers, seals, gaskets, constant velocity joint (CVJ) boots and shaft boots.
摘要翻译：公开了衍生自乙烯和至少两种不同的丙烯酸烷基酯共聚单体的无规共聚物，具有或不具有含酸固化位点的共聚单体。特别地，公开了衍生自（a）10至50重量％的乙烯的共聚合的共聚物; （b）5至55重量％的第一丙烯酸烷基酯; （b）15至80重量％的第二丙烯酸烷基酯; 和（d）0至7重量％的1,4-丁二烯酸的单烷基酯。这种共聚物相对于包含单一烷基丙烯酸酯共聚单体的先前乙烯共聚物显示较低的玻璃化转变温度（Tg），并且当用于产生固化的弹性体组合物以及改进的低温性能时，保持良好的耐热和耐流体性。本发明还提供了包含这些共聚物和固化的组合物（即硫化橡胶）的复合组合物以及由这些复合组合物形成的橡胶制品，例如软管，阻尼器，密封件，垫圈，等速万向节（CVJ）靴和轴靴。

2. 发明申请

WO2010053546A2 CRF1 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CRF1受体化合物
公开(公告)号：WO2010053546A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/005975
申请日：2009-11-04
申请人： ANCHOR THERAPEUTICS, INC. , MCBRIDE, Edward , KULIOPULOS, Athan , MCMURRY, Thomas, J.
发明人： MCBRIDE, Edward , KULIOPULOS, Athan , MCMURRY, Thomas, J.
IPC分类号： A61K38/08
CPC分类号： C07K14/57509 , A61K38/00 , A61K47/542 , A61K47/543
摘要： The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) receptor 1, also known as the CRF1, CRHR1, CRFR1, CRHR, CRF-R. The CRF1 receptor compounds are derived from the intracellular loops and domains of CRF1 receptor. The invention also relates to the use of these CRF1 receptor compounds and pharmaceutical compositions comprising the CRF1 receptor compounds in the treatment of diseases and conditions associated with CRF1 receptor modulation, such as inflammatory bowel disease (peripherally acting), irritable bowel syndrome (IBS), stress response (colonic motor activity), anxiety, sleep disorder, addictive behavior, acute and chronic neurodegeneration, preterm labor and pain.
摘要翻译：本发明一般涉及用于促肾上腺皮质激素释放激素（或因子）受体1（也称为CRF1）的G蛋白偶联受体的变构调节剂（例如，负变构和正变构调节剂，变构兴奋剂和前变体调节剂），CRHR1，CRFR1，CRHR，CRF-R。 CRF1受体化合物衍生自CRF1受体的细胞内环和结构域。本发明还涉及这些CRF1受体化合物和包含CRF1受体化合物的药物组合物在治疗与CRF1受体调节相关的疾病和病症（例如炎性肠病（外周作用）），肠易激综合征（IBS），压力反应（结肠运动活动），焦虑症，睡眠障碍，成瘾行为，急性和慢性神经变性，早产和疼痛。

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