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1. 发明申请

WO0126743A3 GOLF COURSE AND METHOD OF PLAY 审中-公开
标题翻译：高尔夫课程和玩法
公开(公告)号：WO0126743A3
公开(公告)日：2001-06-14
申请号：PCT/CA0001160
申请日：2000-10-11
申请人： TRI PAR COURSES INC , MCBRIDE SCOTT , MCBRIDE EDWARD
发明人： MCBRIDE SCOTT , MCBRIDE EDWARD
IPC分类号： A63B69/36 , A63B71/06
CPC分类号： A63B71/0669 , A63B69/3691 , A63B2102/32
摘要： A golf course including a plurality of holes, where at least one of said holes includes a plurality of initial teeing areas displaced at similar, or different specific par distances from a target cup, and at different directions from a target cup such that plurality of teeing areas are disposed at different acute angles from the taret cup, and encompass different terrain and different trajectories to target cup. A gold hole of the present invention comprises a target green encompassing a target cup, and a middle area between a plurality of initial teeing areas and the target green. A method of playing the golf course and golf hole is also described. The method of sequentially playing a golf game on the present course results in a relatively inexhaustible number of different games of golf thereon.
摘要翻译：一种包括多个孔的高尔夫球场，其中至少一个所述孔包括多个初始发球区域，所述初始发球区域以与目标杯子相似或不同的具体距离移动，并且在与目标杯子不同的方向上移位，使得多个发球区域区域以与锐角杯不同的锐角放置，并且覆盖不同的地形和与目标杯不同的轨迹。本发明的金孔包括包围目标杯的目标绿色和多个初始发球区域与目标绿色之间的中间区域。还描述了打高尔夫球场和高尔夫球洞的方法。在当前课程上顺序打高尔夫游戏的方法导致其上不同游戏的不同游戏的数量不同。

2. 发明申请

WO2010053546A3 CRF1 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CRF1受体化合物
公开(公告)号：WO2010053546A3
公开(公告)日：2010-07-15
申请号：PCT/US2009005975
申请日：2009-11-04
申请人： ANCHOR THERAPEUTICS INC , MCBRIDE EDWARD , KULIOPULOS ATHAN , MCMURRY THOMAS J
发明人： MCBRIDE EDWARD , KULIOPULOS ATHAN , MCMURRY THOMAS J
IPC分类号： C07K1/00 , C07K17/00
CPC分类号： C07K14/57509 , A61K38/00 , A61K47/542 , A61K47/543
摘要： The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) receptor 1, also known as the CRF1, CRHR1, CRFR1, CRHR, CRF-R. The CRF1 receptor compounds are derived from the intracellular loops and domains of CRF1 receptor. The invention also relates to the use of these CRF1 receptor compounds and pharmaceutical compositions comprising the CRF1 receptor compounds in the treatment of diseases and conditions associated with CRF1 receptor modulation, such as inflammatory bowel disease (peripherally acting), irritable bowel syndrome (IBS), stress response (colonic motor activity), anxiety, sleep disorder, addictive behavior, acute and chronic neurodegeneration, preterm labor and pain.
摘要翻译：本发明一般涉及用于促肾上腺皮质激素释放激素（或因子）受体1的G蛋白偶联受体（也称为CRF1）的变构调节剂（例如，阴性和阳性变构调节剂，变构激动剂和前 - 变构调节剂），CRHR1，CRFR1，CRHR，CRF-R。 CRF1受体化合物来源于CRF1受体的细胞内环和结构域。本发明还涉及这些CRF1受体化合物和包含CRF1受体化合物的药物组合物在治疗与CRF1受体调节有关的疾病和病症如炎症性肠病（外周作用），肠易激综合征（IBS），应激反应（结肠运动活动），焦虑，睡眠障碍，成瘾行为，急性和慢性神经变性，早产和疼痛。

3. 发明申请

WO2010053546A2 CRF1 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CRF1受体化合物
公开(公告)号：WO2010053546A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/005975
申请日：2009-11-04
申请人： ANCHOR THERAPEUTICS, INC. , MCBRIDE, Edward , KULIOPULOS, Athan , MCMURRY, Thomas, J.
发明人： MCBRIDE, Edward , KULIOPULOS, Athan , MCMURRY, Thomas, J.
IPC分类号： A61K38/08
CPC分类号： C07K14/57509 , A61K38/00 , A61K47/542 , A61K47/543
摘要： The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) receptor 1, also known as the CRF1, CRHR1, CRFR1, CRHR, CRF-R. The CRF1 receptor compounds are derived from the intracellular loops and domains of CRF1 receptor. The invention also relates to the use of these CRF1 receptor compounds and pharmaceutical compositions comprising the CRF1 receptor compounds in the treatment of diseases and conditions associated with CRF1 receptor modulation, such as inflammatory bowel disease (peripherally acting), irritable bowel syndrome (IBS), stress response (colonic motor activity), anxiety, sleep disorder, addictive behavior, acute and chronic neurodegeneration, preterm labor and pain.
摘要翻译：本发明一般涉及用于促肾上腺皮质激素释放激素（或因子）受体1（也称为CRF1）的G蛋白偶联受体的变构调节剂（例如，负变构和正变构调节剂，变构兴奋剂和前变体调节剂），CRHR1，CRFR1，CRHR，CRF-R。 CRF1受体化合物衍生自CRF1受体的细胞内环和结构域。本发明还涉及这些CRF1受体化合物和包含CRF1受体化合物的药物组合物在治疗与CRF1受体调节相关的疾病和病症（例如炎性肠病（外周作用）），肠易激综合征（IBS），压力反应（结肠运动活动），焦虑症，睡眠障碍，成瘾行为，急性和慢性神经变性，早产和疼痛。

4. 发明申请

WO2005010059A1 RANDOM ETHYLENE/ALKYL ACRYLATE COPOLYMERS, COMPOUNDS AND ELASTOMERIC COMPOSITIONS THEREOF WITH IMPROVED LOW TEMPERATURE PROPERTIES 审中-公开
标题翻译：随机乙烯/丙烯酸烯丙酯共聚物，其化合物和弹性体组合物具有改善的低温特性
公开(公告)号：WO2005010059A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/023669
申请日：2004-07-22
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , WU, Yun-Tai , STEWART, Mark, Aaron , MITCHELL, David, John , MCBRIDE, Edward
发明人： WU, Yun-Tai , STEWART, Mark, Aaron , MITCHELL, David, John , MCBRIDE, Edward
IPC分类号： C08F10/02
CPC分类号： C08L33/08 , C08F220/12
摘要： Disclosed are random copolymers derived from ethylene and at least two different alkyl acrylate comonomers, with or without an acid cure site-containing comonomer. In particular, disclosed are copolymers derived from copolymerization of (a) from 10 to 50 weight % of ethylene; (b) from 5 to 55 weight % of a first alkyl acrylate; (b) from 15 to 80 weight % of a second alkyl acrylate; and (d) from 0 to 7 weight % of a monoalkyl ester of 1,4-butene-dioic acid. Such copolymers exhibit lower glass transition temperatures (Tg) relative to previous ethylene copolymers comprising a single alkyl acrylate comonomer and maintain the good heat and fluid resistance when employed to produce cured elastomeric compositions as well as the improved low temperature properties. This invention also provides compounded compositions comprising these copolymers, and cured compositions (i.e., vulcanizates) as well as rubber articles formed from these compounded compositions, such as hoses, dampers, seals, gaskets, constant velocity joint (CVJ) boots and shaft boots.
摘要翻译：公开了衍生自乙烯和至少两种不同的丙烯酸烷基酯共聚单体的无规共聚物，具有或不具有含酸固化位点的共聚单体。特别地，公开了衍生自（a）10至50重量％的乙烯的共聚合的共聚物; （b）5至55重量％的第一丙烯酸烷基酯; （b）15至80重量％的第二丙烯酸烷基酯; 和（d）0至7重量％的1,4-丁二烯酸的单烷基酯。这种共聚物相对于包含单一烷基丙烯酸酯共聚单体的先前乙烯共聚物显示较低的玻璃化转变温度（Tg），并且当用于产生固化的弹性体组合物以及改进的低温性能时，保持良好的耐热和耐流体性。本发明还提供了包含这些共聚物和固化的组合物（即硫化橡胶）的复合组合物以及由这些复合组合物形成的橡胶制品，例如软管，阻尼器，密封件，垫圈，等速万向节（CVJ）靴和轴靴。

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