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1. 发明申请

WO2007084637A1 MANUFACTURE OF POLYTRIMETHYLENE ETHER GLYCOL 审中-公开
标题翻译：聚乙二醇醚甘油的制备
公开(公告)号：WO2007084637A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001374
申请日：2007-01-19
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei , WU, Zhihong
发明人： SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei , WU, Zhihong
IPC分类号： C08G65/30
CPC分类号： C08G65/46
摘要： The present invention relates to a process of manufacture of poly-trimethylene ether glycol, in which one or more inorganic compounds are utilized during certain purification steps to reduce phase separation time.
摘要翻译：本发明涉及一种制备聚三亚甲基醚二醇的方法，其中在某些纯化步骤中使用一种或多种无机化合物以减少相分离时间。

2. 发明申请

WO2007084636A2 PROCESS FOR PRODUCING POLYTRIMETHYLENE ETHER GLYCOL 审中-公开
标题翻译：生产聚乙二醇醚甘油的方法
公开(公告)号：WO2007084636A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001373
申请日：2007-01-19
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei
发明人： SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei
CPC分类号： C08G65/34 , C07C41/09 , C07C43/13
摘要： A process for producing polytrimethylene ether glycol by polycondensing 1,3-propanediol using a catalyst comprising an acid and a base, at a temperature of from about 165 to about 175°C.
摘要翻译：在约165至约175℃的温度下使用包含酸和碱的催化剂缩聚1,3-丙二醇制备聚三亚甲基醚二醇的方法。

3. 发明申请

WO2007021954A1 MANUFACTURE OF POLYTRIMETHYLENE ETHER GLYCOL 审中-公开
标题翻译：聚乙二醇醚甘油的制备
公开(公告)号：WO2007021954A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/031409
申请日：2006-08-11
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei
发明人： SUNKARA, Hari, Babu , NG, Howard, C. , ZHENG, Wei
IPC分类号： C08G65/34 , C08G65/46
CPC分类号： C08G18/4825 , C08G65/34 , C08G65/46
摘要： The present invention relates to a process for manufacturing polytrimethylene ether glycol with improved purity.
摘要翻译：本发明涉及纯度提高的聚三亚甲基醚二醇的制造方法。

4. 发明申请

WO2013148333A1 SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS 审中-公开
标题翻译：作为葡萄糖激酶活化剂有用的盐酸衍生物
公开(公告)号：WO2013148333A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032253
申请日：2013-03-15
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE UNIVERSITY OF KANSAS , MARUGAN, Juan, Jose , ZHENG, Wei , PATNAIK, Samarjit , SOUTHALL, Noel , SIDRANSKY, Ellen , GOLDIN, Ehud , WESTBROEK, Wendy , AFLAKI, Elma , ROGERS, Steven, Andrew , SCHOENEN, Frank, John
发明人： MARUGAN, Juan, Jose , ZHENG, Wei , PATNAIK, Samarjit , SOUTHALL, Noel , SIDRANSKY, Ellen , GOLDIN, Ehud , WESTBROEK, Wendy , AFLAKI, Elma , ROGERS, Steven, Andrew , SCHOENEN, Frank, John
IPC分类号： C07C235/64 , A61K31/167 , A61P3/00 , C07C237/22
CPC分类号： C07C235/64 , C07B2200/07 , C07C235/60 , C07C237/22
摘要： Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R 1 -R 13 , m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐。变量。本文公开了R1-R13，m，n，o和p。该化合物可用于治疗戈谢病并抑制具有GBA基因突变的患者和治疗帕金森病的戈谢病症状发作。还公开了含有式（I）化合物和包括施用式（I）化合物的治疗方法的药物组合物。

5. 发明申请

WO2008021543A2 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强的农艺性状的转基因植物
公开(公告)号：WO2008021543A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/018368
申请日：2007-08-17
申请人： MONSANTO TECHNOLOGY, LLC , ABAD, Mark , ADAMS, Tom, R. , ALVAREZ, Julie , ANURADHA, Mahindra , AUGUSTINE, Alice, Clara , BADAMI, Pranesh , BELL, Erin , BENNETT, Kristen , BENSEN, Robert , CASTIGLIONI, Paolo , CERNY, R., Eric , CHEN, Xianfeng , CHITTOOR, Jaishree , DEEBA, Farah , DEIKMAN, Jill , DENG, Molian , DUFF, Stephen , FABBRI, Bradon , FENNER, Jason , FERNANDES, Mary , GABBERT, Karen , GALLIGAN, Megan , GOLDMAN, Barry , HAWKINS, Debbie , HEARD, Jacqueline , KARUNANANDAA, Bala , KE, Dangyang , LEDEAUX, John , LEE, Gary , MADAPPA, Savitha , NELSON, Donald , PATTY, Obed , QI, Qungang , RAJANI, M., S. , RAMACHANDRA, Dhanalakshmi , RAMAMOHAN, G. , RUFF, Thomas , SANDERS, Rick , SANGEETHA, S. , SAVAGE, Thomas, J. , SAVIDGE, Beth , SHOBHA, Char , SUDARSHANA, Padmini , SUMA, S., Navarathna , SUN, Jindong , THOMPSON, Rebecca , VAL, Dale , VENKATACHALAYYA, Srikanth , VENKATESH, T. , VIDYA, Kr , WU, Jingrui , XIE, Zhidong , XU, Nanfei , ZHENG, Wei
发明人： ABAD, Mark , ADAMS, Tom, R. , ALVAREZ, Julie , ANURADHA, Mahindra , AUGUSTINE, Alice, Clara , BADAMI, Pranesh , BELL, Erin , BENNETT, Kristen , BENSEN, Robert , CASTIGLIONI, Paolo , CERNY, R., Eric , CHEN, Xianfeng , CHITTOOR, Jaishree , DEEBA, Farah , DEIKMAN, Jill , DENG, Molian , DUFF, Stephen , FABBRI, Bradon , FENNER, Jason , FERNANDES, Mary , GABBERT, Karen , GALLIGAN, Megan , GOLDMAN, Barry , HAWKINS, Debbie , HEARD, Jacqueline , KARUNANANDAA, Bala , KE, Dangyang , LEDEAUX, John , LEE, Gary , MADAPPA, Savitha , NELSON, Donald , PATTY, Obed , QI, Qungang , RAJANI, M., S. , RAMACHANDRA, Dhanalakshmi , RAMAMOHAN, G. , RUFF, Thomas , SANDERS, Rick , SANGEETHA, S. , SAVAGE, Thomas, J. , SAVIDGE, Beth , SHOBHA, Char , SUDARSHANA, Padmini , SUMA, S., Navarathna , SUN, Jindong , THOMPSON, Rebecca , VAL, Dale , VENKATACHALAYYA, Srikanth , VENKATESH, T. , VIDYA, Kr , WU, Jingrui , XIE, Zhidong , XU, Nanfei , ZHENG, Wei
IPC分类号： A01C11/00 , A01H1/00 , A01H5/00 , C07H21/04 , C07K16/00 , C12N5/04
CPC分类号： C12N15/8275 , A01H1/02 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12Q1/6895 , C12Q2600/13 , C12Q2600/158 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
摘要翻译：本发明提供了具有重组DNA的转基因植物细胞，用于表达可用于赋予转基因作物植物增强的农学性状的蛋白质。本发明还提供了包含转基因植物细胞的转基因植物和子代种子，其中选择植物具有选自增强的水分利用效率，增强的冷耐受性，提高的产量，提高的氮利用效率，增强的增强性状种子蛋白质和增强的种子油。还公开了用于制造具有增强的性状的转基因种子和植物的方法。

6. 发明申请

WO2016130774A1 BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS 审中-公开
标题翻译： NPC1用于NEIMANN-PICK疾病和其他LYSOSOMAL存储障碍的苯二甲酰胺补体
公开(公告)号：WO2016130774A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017504
申请日：2016-02-11
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , PATNAIK, Samarjit , TAYLOR, Mercedes , CALVO, Raul Rolando , MARUGAN, Juan Jose , SOUTHALL, Noel , ZHENG, Wei , FERRER-ALEGRE, Marc , DEHDASTHI, Seameen , DRANCHAK, Patricia
发明人： PATNAIK, Samarjit , TAYLOR, Mercedes , CALVO, Raul Rolando , MARUGAN, Juan Jose , SOUTHALL, Noel , ZHENG, Wei , FERRER-ALEGRE, Marc , DEHDASTHI, Seameen , DRANCHAK, Patricia , CHEN, Fannie , IOANNOU, Yiannis
IPC分类号： A61K31/18 , A61K31/165 , A61P3/00 , A61P3/06
CPC分类号： C07C311/21 , A61K31/165 , A61K31/4164 , A61K31/44 , C07D207/335 , C07D213/46 , C07D233/64
摘要： Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula I:
摘要翻译：公开了用于治疗溶酶体储存障碍的方法和组合物。所述方法包括给予苯磺酰胺类，特别是N- [3-（氨基磺酰基）苯基] - 苯甲酰胺和杂芳基酰胺。合适的化合物属于式I所示：

7. 发明申请

WO2016011019A1 COMPOSITIONS AND METHODS FOR INHIBITING BMP 审中-公开
标题翻译：用于抑制BMP的组合物和方法
公开(公告)号：WO2016011019A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040366
申请日：2015-07-14
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , LEE, Arthur , MCKEW, John, C. , PATEL, Paresma, R. , YU, Paul, B. , MOHEDAS, Agustin, H. , SANDERSON, Philip, E. , ZHENG, Wei , HUANG, Xiuli , UNIVERSITY OF HOUSTON SYSTEM
发明人： LEE, Arthur , MCKEW, John, C. , PATEL, Paresma, R. , YU, Paul, B. , MOHEDAS, Agustin, H. , SANDERSON, Philip, E. , ZHENG, Wei , HUANG, Xiuli , CUNY, Gregory, D.
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00 , A61P3/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P33/00 , A61K31/53 , A61P21/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
摘要翻译：本发明提供了BMP信号的小分子抑制剂以及用于抑制BMP信号传导的组合物和方法。这些化合物和组合物可用于调节细胞生长，分化，增殖和凋亡，因此可用于治疗与BMP信号相关的疾病或病症，包括炎症，心血管疾病，血液病，癌症和骨骼疾病，如以及调节细胞分化和/或增殖。这些化合物和组合物也可用于降低ApoB-100或LDL的循环水平并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症; 与脂质吸收或代谢缺陷相关的疾病，病症或综合征; 或由高脂血症引起的疾病，病症或综合征。

9. 发明申请

WO2012027843A1 PROCESS FOR IMPROVING THE HYDROLYSIS OF CELLULOSE IN HIGH CONSISTENCY SYSTEMS 审中-公开
标题翻译：改进高度一致性体系中纤维素水解的方法
公开(公告)号：WO2012027843A1
公开(公告)日：2012-03-08
申请号：PCT/CA2011/050526
申请日：2011-08-30
申请人： IOGEN ENERGY CORPORATION , HARLICK, Peter, J.E. , ZHENG, Wei
发明人： HARLICK, Peter, J.E. , ZHENG, Wei
IPC分类号： C12P19/14 , C12M1/00 , C12M1/40 , C12P19/02
CPC分类号： C12M45/06 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , Y02E50/16
摘要： Provided is a process for the enzymatic hydrolysis of cellulose to produce glucose from a pretreated cellulosic feedstock. The process comprises providing an aqueous slurry of the pretreated cellulosic feedstock that has a water content that is less than about 140% of the maximum water holding capacity of the pretreated cellulosic feedstock. The aqueous slurry of the pretreated cellulosic feedstock is fed to one or more unmixed hydrolysis reactors and hydrolyzed with cellulase enzymes therein. In the unmixed hydrolysis reactor(s), the cellulase enzymes hydrolyze a portion of the cellulose to produce soluble sugars, thereby producing a mixture of partially hydrolyzed cellulose containing soluble sugars. The hydrolysis of the cellulose to glucose is continued by feeding the mixture of partially hydrolyzed cellulose to one or more mixed hydrolysis reactors. Also provided are systems for carrying out the foregoing enzymatic hydrolysis.
摘要翻译：提供了一种纤维素酶水解从预处理的纤维素原料产生葡萄糖的方法。该方法包括提供预处理的纤维素原料的水性浆料，其含水量小于预处理的纤维素原料的最大保水能力的约140％。将预处理的纤维素原料的含水浆料进料到一个或多个未混合的水解反应器中，并用其中的纤维素酶水解。在未混合的水解反应器中，纤维素酶水解一部分纤维素以产生可溶性糖，从而产生含有可溶性糖的部分水解的纤维素的混合物。通过将部分水解的纤维素的混合物加入到一个或多个混合水解反应器中，将纤维素水解成葡萄糖。还提供了用于进行上述酶水解的系统。

10. 发明申请

WO2012012473A1 USE OF DELTA TOCOPHEROL FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS 审中-公开
标题翻译：使用DELTA TOCOPHEROL治疗LYSOSOMAL存活障碍
公开(公告)号：WO2012012473A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/044590
申请日：2011-07-19
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , ZHENG, Wei , MARUGAN, Juan Jose , LIU, Ke , SOUTHALL, Noel Terrence , AUSTIN, Christopher P.
发明人： ZHENG, Wei , MARUGAN, Juan Jose , LIU, Ke , SOUTHALL, Noel Terrence , AUSTIN, Christopher P.
IPC分类号： A61K31/355 , A61P43/00
CPC分类号： A61K31/355 , A61K31/36 , A61K31/496 , A61K31/724 , A61K36/185 , A61K45/06 , A61K2300/00
摘要： This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.
摘要翻译：本公开一般涉及溶酶体储存障碍的治疗。具体地，本公开涉及δ生育酚在治疗与溶酶体贮积障碍相关的疾病和病症中的新用途。包括在本公开内容中的是调节胆固醇回收的方法。此外，本公开涉及诸如Niemann-Pick C型疾病，Farber病，Niemann-Pick型A型疾病，Wolman病和Tay Sachs病的病症。本公开内容中还包括用于治疗包括施用δ-生育酚的溶酶体储存障碍的方法。本公开内容还包括用于治疗溶酶体贮积障碍的方法，其包括与需要的患者一起向环糊精施用δ生育酚。

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