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1. 发明申请

WO2007126641A1 PEPTIDE-BASED BODY SURFACE COLORING REAGENTS 审中-公开
标题翻译：基于肽的身体表面色素试剂
公开(公告)号：WO2007126641A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/006942
申请日：2007-03-20
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , O'BRIEN, John, P. , WANG, Hong , WU, Ying
发明人： O'BRIEN, John, P. , WANG, Hong , WU, Ying
IPC分类号： A61K8/64 , A61Q5/06 , A61Q19/00 , C07K7/00
CPC分类号： A61K8/64 , A61K2800/42 , A61K2800/57 , A61K2800/94 , A61Q1/02 , A61Q3/00 , A61Q5/065 , A61Q11/00 , A61Q19/04 , C07K7/06 , C07K7/08
摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Diblock and triblock peptide-based body surface coloring reagents formed by coupling a body surface binding peptide to a pigment binding peptide, either directly or through a spacer, are described. The peptide-based body surface coloring reagents may be used in conjunction with pigments to color body surfaces.
摘要翻译：已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿，牙龈和口腔表面的肽。描述了通过直接或通过间隔物将身体表面结合肽偶联到颜料结合肽而形成的二嵌段和基于三嵌段肽的体表着色试剂。基于肽的体表着色剂可以与颜料结合使用以使身体表面着色。

2. 发明申请

WO2006094093A3 A METHOD FOR IDENTIFYING SKIN CARE COMPOSITION-RESISTANT SKIN-BINDING PEPTIDES 审中-公开
公开(公告)号：WO2006094093A3
公开(公告)日：2006-09-08
申请号：PCT/US2006/007362
申请日：2006-02-28
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , WANG, Hong , WU, Ying , O'BRIEN, John, P.
发明人： WANG, Hong , WU, Ying , O'BRIEN, John, P.
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/00 , C07H21/02
摘要： A method for identifying skin care composition-resistant skin-binding peptides is described. The skin care composition-resistant skin-binding peptides bind strongly to skin from a skin care composition matrix and are stable therein. Peptide-based skin benefit agents, such as skin conditioners and skin colorants, based on the skin care composition-resistant skin binding peptides are described. The peptide-based skin conditioners and skin colorants consist of skin care composition-resistant skin-binding peptide coupled to a skin conditioning agent or a coloring agent, either directly or through an optional spacer. Skin care and skin coloring product compositions comprising these peptide-based skin conditioners and colorants are also described.

3. 发明申请

WO2006094094A3 A METHOD FOR IDENTIFYING HAIR CONDITIONER-RESISTANT HAIR-BINDING PEPTIDES AND HAIR BENEFIT AGENTS THEREFROM 审中-公开
公开(公告)号：WO2006094094A3
公开(公告)日：2006-09-08
申请号：PCT/US2006/007364
申请日：2006-02-28
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , WANG, Hong , WU, Ying , O'BRIEN, John, P.
发明人： WANG, Hong , WU, Ying , O'BRIEN, John, P.
IPC分类号： G01N33/53
摘要： A method for identifying hair conditioner-resistant hair-binding peptides is described. The hair conditioner-resistant hair-binding peptides bind strongly to hair from a hair conditioner matrix and are stable therein. Peptide-based benefit agents, such as hair conditioners and hair colorants, based on the hair conditioner-resistant hair binding peptides are described. The peptide-based hair conditioners and hair colorants consist of a hair conditioner-resistant hair-binding peptide coupled to a hair conditioning agent or a coloring agent, either directly or through an optional spacer. Hair care and hair coloring product compositions comprising these peptide-based hair conditioners and colorants are also described.

4. 发明申请

WO2006028503A1 PEPTIDE-BASED BODY SURFACE REAGENTS FOR PERSONAL CARE 审中-公开
标题翻译：用于个人护理的基于肽的身体表面试剂
公开(公告)号：WO2006028503A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/007928
申请日：2005-03-08
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , HUANG, Xueying , O'BRIEN, John, P. , WANG, Hong , WU, Ying
发明人： HUANG, Xueying , O'BRIEN, John, P. , WANG, Hong , WU, Ying
IPC分类号： A61K6/00
CPC分类号： C07K7/08 , A61K8/64 , A61K2800/57 , A61K2800/94 , A61Q3/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q19/00 , A61Q19/04 , C07K7/06
摘要： Peptides have been identified that bind with high affinity to body surfaces, such as hair, skin, nails, teeth, gums, corneal tissue, and oral cavity surfaces. Peptide-based body surface reagents formed by coupling a body surface binding peptide to a benefit agent are described. The peptide-based body surface reagents include peptide-based hair conditioners, hair colorant, skin conditioners, skin colorants, nail colorants and oral care reagents. The peptide-based hair conditioners and hair colorants are comprised of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants are comprised of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants are comprised of a nail-binding peptide coupled to a coloring agent. The peptide-based oral care reagents are comprised of an oral cavity surface-binding peptide coupled to an oral care benefit agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.
摘要翻译：已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿，牙龈，角膜组织和口腔表面的肽。描述了通过将身体表面结合肽偶联到有益剂形成的基于肽的体表试剂。基于肽的体表试剂包括基于肽的头发调理剂，毛发着色剂，皮肤调理剂，皮肤着色剂，指甲着色剂和口腔护理试剂。基于肽的头发调理剂和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。基于肽的口腔护理试剂由与口腔护理有益剂偶联的口腔表面结合肽组成。在所有这些组合物中，肽可以直接与活性剂偶联，或者偶联可以经由间隔物。还描述了含有这些基于肽的调理剂和着色剂的个人护理组合物。

5. 发明申请

WO2011150855A1 MICRO-RNA BIOMARKERS AND METHODS FOR DIAGNOSIS OF EARLY COLORECTAL CARCINOMA AND HIGH-GRADE ADENOMA 审中-公开
标题翻译： MICRO-RNA生物标记物和早期色素沉着症和高级腺病毒诊断方法
公开(公告)号：WO2011150855A1
公开(公告)日：2011-12-08
申请号：PCT/CN2011/075132
申请日：2011-06-02
申请人： FUDAN UNIVERSITY , WU, Ying , ZHU, Hongguang , WANG, Shuyang , NA, Yima , LI, Jian
发明人： WU, Ying , ZHU, Hongguang , WANG, Shuyang , NA, Yima , LI, Jian
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/7105 , A61P35/00
CPC分类号： C12Q1/6886 , C12N15/111 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/12 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： The invention provides diagnostic kits for identifying one or more mammalian target cells exhibiting early colorectal carcinoma or high-grade adenoma. The kits comprise a plurality of nucleic acid molecules encoding microRNA sequences, wherein the nucleic acid molecules are differentially expressed in target cells and control cells, and the nucleic acid molecules together represent a nucleic acid expression biomarker that is indicative for the presence of early colorectal carcinoma or high-grade adenoma. The invention further provides methods for identifying one or more mammalian target cells exhibiting early colorectal carcinoma or high-grade adenoma by using the nucleic acid molecules. Methods and pharmaceutical compositions for preventing or treating early colorectal carcinoma or high-grade adenoma are also disclosed.
摘要翻译：本发明提供用于鉴定表现出早期结肠直肠癌或高级腺瘤的一种或多种哺乳动物靶细胞的诊断试剂盒。试剂盒包含编码微小RNA序列的多个核酸分子，其中核酸分子在靶细胞和对照细胞中差异表达，核酸分子一起代表指示早期结肠直肠癌存在的核酸表达生物标志物或高级腺瘤。本发明还提供了通过使用核酸分子鉴定表现出早期结肠直肠癌或高级腺瘤的一种或多种哺乳动物靶细胞的方法。还公开了用于预防或治疗早期结肠直肠癌或高级腺瘤的方法和药物组合物。

6. 发明申请

WO2007133501A2 FIXED-BED REACTORS AND CATALYTIC PROCESSES 审中-公开
标题翻译：固定床反应器和催化过程
公开(公告)号：WO2007133501A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011025
申请日：2007-05-08
申请人： MILLENNIUM CELL, INC. , ZHANG, Qinglin , WU, Ying
发明人： ZHANG, Qinglin , WU, Ying
IPC分类号： G01N23/00
CPC分类号： C01B3/38 , B01J8/008 , B01J8/0221 , B01J8/025 , B01J8/0278 , B01J2208/00663 , B01J2208/00681 , B01J2208/0069 , B01J2208/00734 , B01J2208/00752 , B01J2208/00769 , B01J2208/00796 , B01J2208/00805 , C01B3/0005 , C01B3/065 , C01B3/384 , C01B3/503 , C01B2203/02 , C01B2203/0227 , C01B2203/041 , C01B2203/0495 , C01B2203/066 , C01B2203/0805 , C01B2203/1011 , C01B2203/1041 , C01B2203/1047 , C01B2203/1052 , C01B2203/1058 , C01B2203/1064 , C01B2203/107 , C01B2203/1076 , C01B2203/1082 , C01B2203/1235 , C01B2203/1252 , H01M8/0618 , Y02E60/324 , Y02E60/362
摘要： Reactors with a dynamic compression elements that control the catalyst bed structure and hydrodynamic conditions inside the reactor in response to physical and structural changes in the catalyst bed, and methods of operating catalytic reactors are provided. The reactors are adjustable and/or can self -adjust in response to changes in the packing of the catalyst bed due, for example, to the attrition of the catalyst. The catalyst reactor designs improve operation of fixed bed reactors and enable the use of a variety of catalysts and supports, including materials that would not typically be considered for use in fixed bed reactors, such as those with limited durability or with moderate mechanical strength.
摘要翻译：提供了具有动态压缩元件的反应器，其响应于催化剂床中的物理和结构变化以及操作催化反应器的方法来控制反应器内的催化剂床结构和流体动力学条件。反应器是可调节的和/或可以响应于催化剂床的填充物的变化而自我调节，例如由于催化剂的磨损。催化剂反应器设计改进了固定床反应器的操作，并且能够使用各种催化剂和载体，包括通常不被认为用于固定床反应器的材料，例如具有有限耐用性或具有中等机械强度的那些。

7. 发明申请

WO2011076142A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF COLORECTAL CANCER 审中-公开
标题翻译：彩色血浆等离子体快速成像分析的组合物和方法
公开(公告)号：WO2011076142A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080233
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
发明人： LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/7105 , B82Y5/00 , B82Y15/00 , C12Q2600/178
摘要： The present invention relates to compositions and methods for microRNA (miRNA) expression profiling in plasma of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, monitoring the cancer therapy and/or treating colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a microRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of colorectal cancer and healthy control plasma, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结直肠癌血浆中的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于诊断结肠直肠癌，监测癌症治疗和/或治疗结直肠癌的血液中的分子标记物的诊断试剂盒，所述试剂盒包含多个核酸分子，编码微小RNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在结肠直肠癌和健康对照血浆的血浆中差异表达，并且其中所述一个或多个差异表达的核酸分子一起代表指示存在结肠直肠的核酸表达特征癌症。本发明还涉及使用这种核酸表达特征鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

8. 发明申请

WO2005065119A2 FUEL BLENDS FOR HYDROGEN GENERATORS 审中-公开
标题翻译：氢发生器的燃料混合物
公开(公告)号：WO2005065119A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/040691
申请日：2004-12-03
申请人： MILLENNIUM CELL, INC. , KELLY, Michael, T. , WU, Ying , BRADY, Jason, C. , HAWTHORNE, Frederick, M.
发明人： KELLY, Michael, T. , WU, Ying , BRADY, Jason, C. , HAWTHORNE, Frederick, M.
IPC分类号： C01B3/06 , C10L1/32
CPC分类号： C01B3/065 , Y02E60/362
摘要： The present invention relates to improved aqueous fuels for hydrogen generators and a method for using them in the production of hydrogen. The present invention also relates to a system of using the subject aqueous fuels to generate hydrogen gas for use in a fuel cell or other device. The subject fuels contain a mixture of boron hydrides, at least one of which is a metal salt, including metal borohydrides, higher boranes and metal higher boron hydrides. The subject aqueous fuels contain a mixture of boron hydrides having a positive ionic charge ( + IC) to boron ratio of between 0.2 and 0.4 or between 0.6 and 0.99. Preferred fuels contain a mixture of boron hydrides having an ( + IC) to boron ratio between 0.2 and 0.3 or between 0.7 and 0.8. Mixtures containing a metal borohydride also contain a metal hydroxide to stability it against premature hydrolysis in the aqueous fuel media.
摘要翻译：本发明涉及用于氢气发生器的改进的含水燃料及其在生产氢气中的使用方法。本发明还涉及使用本发明的含水燃料产生用于燃料电池或其它装置的氢气的系统。目标燃料含有氢化硼的混合物，其中至少一种是金属盐，包括金属硼氢化物，较高硼烷和较高级的氢化金属氢化物。本发明的含水燃料包含具有正离子电荷（<+> IC）与硼比为0.2-0.4或0.6-0.99的硼氢化物的混合物。优选的燃料包含具有0.2-0.3或0.7和0.8之间（（+）IC）与硼的比例的硼氢化物的混合物。含有金属硼氢化物的混合物还含有金属氢氧化物以稳定其在水性燃料介质中的过早水解。

9. 发明申请

WO2016124227A1 TIME REGISTER 审中-公开
标题翻译：时间注册
公开(公告)号：WO2016124227A1
公开(公告)日：2016-08-11
申请号：PCT/EP2015/052187
申请日：2015-02-03
申请人： HUAWEI TECHNOLOGIES CO., LTD. , WU, Ying , STASZEWSKI, Robert , MAO, Yihong
发明人： WU, Ying , STASZEWSKI, Robert , MAO, Yihong
IPC分类号： G04F10/00 , H03M1/50
CPC分类号： G04F10/005 , H03H19/004 , H03K5/135 , H03L7/0814 , H03L7/0891 , H03M1/00 , H03M1/12 , H03M1/1225 , H03M1/50 , H03M2201/4233
摘要： A time register (300) includes: a pair of inputs (345, 346) coupled to a pair of input clocks (IN 1 , IN 2 ); a pair of tri-state inverters (301, 302) for producing a pair of level signals (V C1 , V C2 ); and a pair of outputs (347, 348) coupled to the level signals (V C1 , V C2 ) for producing a pair of output clocks (OUT 1 , OUT 2 ), wherein the tri-state inverters (301, 302) are responsive to a pair of state signals (S 1 , S 2 ) and the pair of input clocks (IN 1 , IN 2 ) for holding or discharging the level signals (V C1 , V C2 ).
摘要翻译：时间寄存器（300）包括：耦合到一对输入时钟（IN1，IN2）的一对输入（345,346）; 一对用于产生一对电平信号（VC1，VC2）的三态反相器（301,302）; 以及耦合到电平信号（VC1，VC2）的一对输出（347,348），用于产生一对输出时钟（OUT1，OUT2），其中三态反相器（301,302）响应于一对状态信号（S1，S2）和用于保持或放电电平信号（VC1，VC2）的一对输入时钟（IN1，IN2）。

10. 发明申请

WO2011076147A1 PLASMA-BASED MICRO-RNA BIOMARKERS AND METHODS FOR EARLY DETECTION OF COLORECTAL CANCER 审中-公开
标题翻译：基于血浆的微RNA生物标记物和早期检测色素性癌症的方法
公开(公告)号：WO2011076147A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080247
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Zhaoyong , WU, Ying , ZHU, Hongguang
发明人： LI, Zhaoyong , WU, Ying , ZHU, Hongguang
IPC分类号： C12Q1/68 , A61K31/7088 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/7088 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, and/or monitoring the therapeutic effect for treating colorectal cancer. The kit comprises a plurality of nucleic acid molecules, and each nucleic acid molecule encodes a microRNA biomarker, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of patient and healthy control, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression biomarker that is indicative for the presence of colorectal cancer. The invention further provides corresponding methods using such nucleic acid expression biomarkers for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention provides a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明提供用于诊断结肠直肠癌的血液中的分子标记物的诊断试剂盒和/或监测治疗结肠直肠癌的治疗效果。试剂盒包含多个核酸分子，每个核酸分子编码微小RNA生物标志物，其中多个核酸分子中的一个或多个在患者和健康对照的血浆中差异表达，并且其中所述一个或多个差异表达核酸分子一起代表指示存在结肠直肠癌的核酸表达生物标志物。本发明还提供了使用这种核酸表达生物标志物鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。最后，本发明提供了用于预防和/或治疗结肠直肠癌的药物组合物。

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