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1. 发明申请

WO2012116992A2 ORAL USE 审中-公开
标题翻译：口服使用
公开(公告)号：WO2012116992A2
公开(公告)日：2012-09-07
申请号：PCT/EP2012053374
申请日：2012-02-28
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , GRAEUB REMO
发明人： GORALCZYK REGINA , GRAEUB REMO
IPC分类号： A61K8/60 , A61K8/63 , A61K8/97 , A61Q17/04 , A61Q19/04
CPC分类号： A61Q19/04 , A61K8/36 , A61K8/602 , A61K2800/92 , A61Q17/04 , A61Q19/08
摘要： The invention relates to the use of an oral composition comprising Steviol or Isosteviol as skin tanning agent. It further relates to methods of enhancing the natural skin tan by oral administration of an effective amount of Steviol or Isosteviol.
摘要翻译：本发明涉及包含甜菊醇或异头二醇的口腔组合物作为皮肤鞣剂的用途。本发明进一步涉及通过口服施用有效量的甜菊醇或异硫酚来增强天然皮肤褐变的方法。

2. 发明申请

WO2012010624A3 TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE 审中-公开
标题翻译：在头发护理中使用史蒂芬或衍生物
公开(公告)号：WO2012010624A3
公开(公告)日：2012-09-27
申请号：PCT/EP2011062425
申请日：2011-07-20
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , GRAEUB REMO , MAYNE-MECHAN ANNIS OLIVIA , PIUSSI JENNY , RIEGER HENRY , MOHAJERI HASAN
发明人： GORALCZYK REGINA , GRAEUB REMO , MAYNE-MECHAN ANNIS OLIVIA , PIUSSI JENNY , RIEGER HENRY , MOHAJERI HASAN
IPC分类号： A61K8/365 , A61K8/60 , A61Q5/00 , A61Q7/00
CPC分类号： A61K8/365 , A61Q5/00 , A61Q5/002 , A61Q5/006 , A61Q5/06 , A61Q5/065 , A61Q5/10 , A61Q5/12 , A61Q7/00 , A61Q17/00
摘要： The present invention relates to the use of steviol and/or isosteviol, or a salt, ester, a diester, or an ether thereof as depicted in formula (I), formula (I): R1 wherein R1 is hydrogen (H) or a saturated, straight or branched C1-C8 alkyl group non substituted or substituted with up to 3 hydroxyl-, alkoxy-, amino-, alkylamino- or dialkylamino- groups, R2 is independently a saturated, straight or branched C1-C8 alkyl group, -O-C1-C8 alkyl group, -OH group, a -O-C(O)-C1-C8 alkyl, or, -COO(C1-C8 alkyl) group, R3 is independently CH2, O, or CH-(C1-C7 alkyl), wherein the enhancement of the appearance of hair is selected from the group consisting of: restoring hair color and delaying the onset of greyness in hair, lessening hair loss, restoring hair growth after the onset of baldness has occurred, increasing the thickness of hair, counteracting age-associated hair thinning, preventing premature hair loss, or delaying the onset or severity of age-associated hair loss and thinning, maintaining of the natural hair colour, increasing hair shininess, glossiness or volume. In particular, the compound is applied topically.
摘要翻译：本发明涉及式（I），式（I）所示的甜菊醇和/或异硬脂醇或其盐，酯，二酯或其醚的用途：其中R1是氢（H）或未被取代或被至多3个羟基，烷氧基，氨基，烷基氨基或二烷基氨基取代的饱和，直链或支链C 1 -C 8烷基，R 2独立地为饱和的，直链或支链的C 1 -C 8烷基， O-C 1 -C 8烷基，-OH基团，-OC（O）-C 1 -C 8烷基或-COO（C 1 -C 8烷基）基团，R 3独立地是CH 2，O或CH-（C 1 -C 7 烷基），其中提高毛发的外观选自：恢复头发颜色并延迟头发中的灰色发作，减少脱发，恢复发秃后恢复毛发生长，增加毛发的厚度头发，抵抗年龄相关的头发变薄，防止过早的脱发，或延迟年龄相关脱发和变薄的发作或严重程度，维持 g的天然头发颜色，增加头发光泽，光泽度或体积。特别地，化合物局部施用。

3. 发明申请

WO2011018477A3 CARNOSOL FOR HAIR AND SKIN CARE 审中-公开
标题翻译： CARNOSOL用于护理头发和皮肤
公开(公告)号：WO2011018477A3
公开(公告)日：2011-10-27
申请号：PCT/EP2010061684
申请日：2010-08-11
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , MAYNE-MECHAN ANNIS OLIVIA , MOHAJERI HASAN , PIUSSI JENNY , RIEGER HENRY , SCHWAGER JOSEPH
发明人： GORALCZYK REGINA , MAYNE-MECHAN ANNIS OLIVIA , MOHAJERI HASAN , PIUSSI JENNY , RIEGER HENRY , SCHWAGER JOSEPH
IPC分类号： A61K8/368 , A61Q5/00 , A61Q19/00
CPC分类号： A61Q19/00 , A23K20/111 , A23K20/121 , A23L2/39 , A23L2/52 , A23L7/126 , A23L33/105 , A23V2002/00 , A61K8/02 , A61K8/0216 , A61K8/498 , A61K2800/92 , A61Q5/00 , A23V2250/628 , A23V2250/61 , A23V2250/21 , A23V2250/032 , A23V2200/318 , A23V2250/642 , A23V2250/1842 , A23V2250/708 , A23V2250/211
摘要： This invention relates to the use of an oral composition comprising carnosol which enhances the appearance of hair and skin, and particularly has an anti-greying effect. It further relates methods of improving the appearance of hair and skin by oral administration of an effective amount of carnosol.
摘要翻译：本发明涉及包含鼠尾草酚的口服组合物在增强头发和皮肤外观方面的用途，特别是具有抗灰白效果。它进一步涉及通过口服有效量的鼠尾草酚改善头发和皮肤外观的方法。

4. 发明申请

WO2007134868A3 3,5-DIHYDROXY-2,4-CYCLOHEXADIENONES AND THEIR DERIVATIVES, DIETARY COMPOSITIONS AND FORTIFIED FOOD CONTAINING THEM AND THEIR USES 审中-公开
标题翻译： 3,5-DIHYDROXY-2,4-CYCLOHEXADENENESES及其衍生物，膳食组合物和含有它们的食品及其用途
公开(公告)号：WO2007134868A3
公开(公告)日：2008-06-12
申请号：PCT/EP2007004628
申请日：2007-05-24
申请人： DSM IP ASSETS BV , DE SAIZIEU ANTOINE , GORALCZYK REGINA , FOWLER ANN , SCHUELER GOEDE
发明人： DE SAIZIEU ANTOINE , GORALCZYK REGINA , FOWLER ANN , SCHUELER GOEDE
IPC分类号： A23L1/30 , A23K1/16 , A23K1/18 , A61K31/00 , A61P25/24
CPC分类号： A61K31/122 , A23K20/10 , A23K50/10 , A23K50/30 , A23K50/42 , A23K50/48 , A23K50/75 , A23L33/105
摘要： The present invention refers especially to 3,5-dihydroxy-2,4-cyclohexadienones of the general formula(I) wherein R 1 and R 2 are independently from each other C 1-6 -alkyl, C 2-6 -alkenyl or x-oxo-C x -alkyl with x being an integer from 1 to 6, preferably R 1 and R 2 are independently from each other C 2-6 -alkenyl or y-oxo-C y -alkyl with y being an integer from 2 to 5, and wherein R 3 and R 4 are independently from each other hydroxy, C 1-6 -alkyl, C 2-6 -alkenyl or x-oxo-C x -alkyl with x being an integer from 1 to 6, preferably R 3 and R 4 are independently from each other hydroxy or y-oxo-C y -alkyl with y being an integer from 2 to 5, for use as mood balancing agents and stress relievers, as well as to dietary compositions and fortified food/feed/beverages containing such 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I), and their uses.
摘要翻译：本发明特别涉及通式（I）的3,5-二羟基-2,4-环己二烯酮，其中R 1和R 2彼此独立地为C C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C≡C-烷基，其中x是1至 6，优选R 1和R 2彼此独立地为C 2-6 - 烯基或γ-氧代-Cy 其中y为2至5的整数，并且其中R 3和R 4彼此独立地为羟基，C 1〜 6个 - 烷基，C 2-6 - 烯基或x-氧代-C 0 - - - 烷基，x为1至6的整数， SO 3和R 4彼此独立地为羟基或γ-氧代-C 0 - 烷基，y为2至5的整数，对于用作情绪平衡剂和应激缓解剂，以及含有这种一般的3,5-二羟基-2,4-环己二烯酮的饮食组合物和强化食品/饲料/饮料公式（I）及其用途。

5. 发明申请

WO2006042441A3 NOVEL AGENTS FOR PREVENTING AND TREATING DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION 审中-公开
标题翻译：防止和治疗与神经传导障碍有关的新药
公开(公告)号：WO2006042441A3
公开(公告)日：2006-07-13
申请号：PCT/CH2005000621
申请日：2005-10-21
申请人： DSM IP ASSETS BV , DE SAIZIEU ANTOINE , FOWLER ANN , GORALCZYK REGINA , MUSSLER BERND , SCHUELER GOEDE
发明人： DE SAIZIEU ANTOINE , FOWLER ANN , GORALCZYK REGINA , MUSSLER BERND , SCHUELER GOEDE
IPC分类号： A61K31/37
CPC分类号： A61K31/37 , A23L2/39 , A23L7/126 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2200/322
摘要： The present invention refers to coumarin ethers of the formula (I), wherein R 1 is H, OH or (E)-3-methyl-but-2-enyl, R 2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R 3 is H, R 1 and R 2 O together for the group -O-C(C(=CH 2 )CH 3 )H-CH 2 -O- or the group -C(H)=C(H)-C(CH 3 ) 2 -O- or R 2 O and R 3 together form the group -O-C(H)(C(CH 3 ) 2 (H)-O-C(O)CH 3 )-CH 2 -, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.
摘要翻译：本发明涉及式（I）的香豆素醚，其中R 1是H，OH或（E）-3-甲基 - 丁-2-烯基，R 2是氢，选自甲基，3-（4,5-二氢-5,5-二甲基-4-呋喃酮-2-基）-2-（E / Z） - 丁烯基，（E / Z） -3,7-二甲基辛-2,6-二烯基，7-羟基-3,7-二甲基-2-辛烯-6-酮基和（E / Z，E / Z）-11-乙酰氧基-3 ，7,11,11-四甲基 - 十一碳-2,7-二烯-10-基 - ，R 3是H，R 1和R 2相同或不同，（C（= CH _{2 ）CH _{3 ）H-CH _{2 -O-或基团-C（H）= C（H）-C（CH 3）2 -O-或R 2 O和R 2，（H）-C（CH 3）2（H）-OC（O）CH 3（CH 3）） - CH 2 - ，优选地用作药物，用作药物，特别是用于治疗和/或预防与神经传递受损相关的病症，以及饮食和药物组合物和含有香豆素醚的植物提取物及其用途。}}}

6. 发明申请

WO2007112996A3 USE OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR IMPROVING THE PHYSICAL APPEARANCE 审中-公开
标题翻译：化合物的使用和化合物的组合用于改善物理外观
公开(公告)号：WO2007112996A3
公开(公告)日：2010-07-08
申请号：PCT/EP2007002950
申请日：2007-04-02
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , SCHWAGER JOSEPH , WERTZ KARIN
发明人： GORALCZYK REGINA , SCHWAGER JOSEPH , WERTZ KARIN
IPC分类号： A61Q19/06 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/97 , A61Q19/08
CPC分类号： A61K8/31 , A21D2/36 , A23C9/13 , A23C9/1322 , A23L33/30 , A61K8/345 , A61K8/347 , A61K8/361 , A61K8/498 , A61K8/97 , A61K2800/92 , A61Q19/06
摘要： The present invention is directed inter alia to the use of at least one compound selected from the group consisting of (-)-epigallocatechin gallate, resveratrol, eicosapentaenoic acid, docosahexaenoic acid, rose hip extract/concentrate, hydroxytyrosol, lycopene, lutein, ß-cryptoxanthin, zeaxanthin and derivatives thereof, for the treatment of cellulite, for the prevention of the development of mild cellulite, for the prevention of the progression of mild cellulite to severe cellulite, for smoothening the micro relief of the skin, for maintaining or increasing the tensile properties of the skin, and/or for reducing the fat mass and the circumference at the hips and thighs, as well as to the corresponding cosmetic and medical methods.
摘要翻译：本发明尤其涉及使用至少一种选自（ - ） - 表没食子儿茶素没食子酸酯，白藜芦醇，二十碳五烯酸，二十二碳六烯酸，玫瑰果提取物/浓缩物，羟基酪醇，番茄红素，叶黄素，β- 隐黄质，玉米黄质及其衍生物，用于治疗脂肪团，用于防止轻度脂肪团的发育，用于防止轻度脂肪团进入严重脂肪团的进展，以平滑皮肤的微小浮雕，维持或增加皮肤的拉伸性能和/或用于降低臀部和大腿处的脂肪量和周长，以及相应的美容和医疗方法。

7. 发明申请

WO2009150179A3 PLANT EXTRACT AND PUFA COMBINATIONS 审中-公开
标题翻译：植物提取物和PUFA组合
公开(公告)号：WO2009150179A3
公开(公告)日：2010-02-04
申请号：PCT/EP2009057189
申请日：2009-06-10
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , ETHEVE STEPHANE , PRUDENCE KEVIN , SCHWEIGERT LONI
发明人： GORALCZYK REGINA , ETHEVE STEPHANE , PRUDENCE KEVIN , SCHWEIGERT LONI
IPC分类号： A23L1/30 , A23D7/06 , A23L1/00 , A61K31/201 , A61K31/202 , A61K36/53 , C11B5/00
CPC分类号： A61K36/53 , A23L33/105 , A23L33/115 , A23V2002/00 , A61K31/201 , A61K31/202 , A23V2200/02 , A23V2250/1882 , A23V2250/21 , A23V2250/2124 , A23V2250/2128 , A23V2250/2132
摘要： The present invention relates to the combination of a plant extract, such as oregano extract and a polyunsaturated fatty acid or a derivative (such as an ethyl ester "PUFA EE") which is stable under strorage conditions.
摘要翻译：本发明涉及植物提取物如牛至提取物和多不饱和脂肪酸或其衍生物（例如乙酯“PUFA EE”）的组合，其在保护条件下是稳定的。

8. 发明申请

WO2012116990A3 NOVEL USE 审中-公开
标题翻译：新用途
公开(公告)号：WO2012116990A3
公开(公告)日：2014-05-01
申请号：PCT/EP2012053372
申请日：2012-02-28
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , GRÄUB REMO , IMFELD DOMINIK , VOLLHARDT JÜRGEN H
发明人： GORALCZYK REGINA , GRÄUB REMO , IMFELD DOMINIK , VOLLHARDT JÜRGEN H
IPC分类号： A61K8/365 , A61K8/04 , A61K8/60 , A61Q17/04 , A61Q19/00 , A61Q19/04 , A61Q19/08
CPC分类号： A61K8/365 , A61K8/046 , A61K8/602 , A61Q17/04 , A61Q19/004 , A61Q19/04 , A61Q19/08
摘要： The present invention relates to the use of steviol as well as derivatives thereof as a skin tanning agent. Furthermore, the present invention relates to the cosmetic topical application of steviol and derivatives thereof formulated into a composition comprising a cosmetically acceptable carrier for skin tanning. Finally, the invention relates to the use of steviol for enhancement of melanin formation in human skin cells.
摘要翻译：本发明涉及甜菊醇及其衍生物作为皮肤鞣剂的用途。此外，本发明涉及配制成包含化妆品可接受的皮肤晒黑载体的组合物的甜菊醇及其衍生物的美容局部施用。最后，本发明涉及甜菊醇用于增强人皮肤细胞中黑色素形成的用途。

9. 发明申请

WO2008017491A8 LIGUSTILIDE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译：用于治疗中枢神经系统疾病的LIGESTILIDE衍生物
公开(公告)号：WO2008017491A8
公开(公告)日：2009-05-07
申请号：PCT/EP2007007086
申请日：2007-08-10
申请人： DSM IP ASSETS BV , DE SAIZIEU ANTOINE , GORALCZYK REGINA , SCHUELER GOEDE
发明人： DE SAIZIEU ANTOINE , GORALCZYK REGINA , SCHUELER GOEDE
IPC分类号： A61K31/343 , A61P25/22 , A61P25/24
CPC分类号： A61K31/343
摘要： The present invention refers to compounds of the general formula (I) wherein R1 is hydrogen or hydroxy; R2 is butyl or butyryl if R1 is hydroxy, but R2 is butyl if R1 is hydrogen; or R1 and R2 taken together are 1-propylidene or 1-butylidene optionally substituted by hydroxy, methyl, or 3-(a,ß-dimethylacryloyloxy); the dotted line is an optional bond; X is an optionally substituted aliphatic C4- residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is Xl, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 and R4 are, independently from each other, hydrogen or hydroxy; and R5 is hydroxy or butyryl, for use in the treatment of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions containing such compounds, and their uses.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是氢或羟基; 如果R 1是羟基，则R 2是丁基或丁酰基，但如果R 1是氢，则R 2是丁基; 或R 1和R 2一起为1-羟基，甲基或3-（a，β-二甲基丙烯酰氧基）任意取代的1-亚丙基或1-亚丁基; 虚线是可选的键; X是选自X 1，X 2，X 3，X 4和X 5的任选取代的脂族C 4 - 残基; 其中如果式（I）中的虚线不存在，X是X 2，X 3或X 5; 如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3和R 4彼此独立地为氢或羟基; 和R5是羟基或丁酰基，用于治疗与受损的神经传递相关的疾病，以及含有这些化合物的饮食和药物组合物及其用途。

10. 发明申请

WO2008028631A3 SKIN CARE COMPOSITION 审中-公开
标题翻译：皮肤护理组合物
公开(公告)号：WO2008028631A3
公开(公告)日：2008-06-05
申请号：PCT/EP2007007719
申请日：2007-09-05
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , KLOCK JOCHEN , SCHWEIKERT LONI
发明人： GORALCZYK REGINA , KLOCK JOCHEN , SCHWEIKERT LONI
IPC分类号： A61K8/34 , A61K8/31 , A61K8/36 , A61K8/37 , A61K8/49 , A61Q19/08
CPC分类号： A61K8/361 , A61K8/31 , A61K8/347 , A61K8/37 , A61K8/498 , A61K8/67 , A61K8/673 , A61K31/01 , A61K31/05 , A61K31/202 , A61K2800/92 , A61Q19/08
摘要： The present invention relates to an oral composition containing an optimal combination of polyunsaturated fatty acids and at least one component selected from the carotenoids, water-soluble vitamins, fat-soluble vitamins, ubichinones and polyphenols at high concentrations and at optimal ratios in order to maintain and/or achieve health and/or beautiful look of the skin.
摘要翻译：本发明涉及一种口服组合物，其含有多不饱和脂肪酸和至少一种选自高浓度的类胡萝卜素，水溶性维生素，脂溶性维生素，二琥珀酮和多酚的组分的最佳组合，并以最佳比例保持和/或实现皮肤的健康和/或美丽的外观。

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