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1. 发明申请

WO2011131607A1 ISOMERIZATION OF β-KETO-ALLENES 审中-公开
标题翻译： ß-KETO-ALLENES的异构体
公开(公告)号：WO2011131607A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/056106
申请日：2011-04-18
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , KARGE, Reinhard , NETSCHER, Thomas
发明人： BONRATH, Werner , KARGE, Reinhard , NETSCHER, Thomas
IPC分类号： C07C49/203
CPC分类号： C07C45/67 , B01J31/08 , B01J2231/52 , C07C49/203
摘要： Isomerization of β-keto-allenes of the general formula I wherein R 1 is hydrogen, methyl or ethyl, in particular hydrogen or methyl; R 2 is hydrogen or methyl; R 3 is hydrogen or methyl, in particular methyl and R 4 is an aliphatic hydrocarbon residue containing 1 - 37 carbon atoms, into corresponding α,γ-dienones of formula II by treatment with a basic ion exchange resin.
摘要翻译：其中R 1是氢，甲基或乙基，特别是氢或甲基的通式I的β-酮 - 双烯异构化; R2是氢或甲基; R 3是氢或甲基，特别是甲基，R 4是含有1至37个碳原子的脂族烃残基，通过用碱性离子交换树脂处理而形成相应的式II的α-二烯酮。

2. 发明申请

WO2010079123A2 PROCESS FOR RESVERATROL INTERMEDIATE 审中-公开
标题翻译： RESVERATROL INTERMEDIATE过程
公开(公告)号：WO2010079123A2
公开(公告)日：2010-07-15
申请号：PCT/EP2010/000021
申请日：2010-01-06
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , LETINOIS, Ulla , HUGENTOBLER, Max , KARGE, Reinhard , LEHMANN, Hajo
发明人： BONRATH, Werner , LETINOIS, Ulla , HUGENTOBLER, Max , KARGE, Reinhard , LEHMANN, Hajo
IPC分类号： C07C39/215 , C07C69/017 , C07C67/28
CPC分类号： C07C67/29 , C07C69/017 , C07C69/18
摘要： A process for the preparation of 1-(3,5-diacetoxyphenyl)-ethanol by catalytic hydrogenation of 3,5-diacetoxy-acetophenone in the presence of a Ni-alloy as catalyst in a C 1-3 -carboxylic acid ester as solvent.
摘要翻译：在作为溶剂的C 3-羧酸酯中的Ni合金作为催化剂存在下，通过3,5-二乙酰氧基 - 苯乙酮的催化氢化制备1-（3,5-二乙酰氧基苯基） - 乙醇的方法。

3. 发明申请

WO2004087640A1 PROCESS FOR THE MANUFACTURE OF N-ALKOXALYL-ALANINATES 审中-公开
标题翻译：制备N-烷氧基 - 兰酸酯的方法
公开(公告)号：WO2004087640A1
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003109
申请日：2004-03-24
申请人： DSM IP ASSETS B.V. , GUM, Andrew, George , FISCHESSER, Jocelyn , HÄRTER, Ralph , KARGE, Reinhard , JEPHCOTE, Vincent, John , BONRATH, Werner
发明人： GUM, Andrew, George , FISCHESSER, Jocelyn , HÄRTER, Ralph , KARGE, Reinhard , JEPHCOTE, Vincent, John , BONRATH, Werner
IPC分类号： C07C233/47
CPC分类号： C07C233/47 , C07C231/02
摘要： A process for the manufacture of alkyl N-alkoxalyl-alaninates of the formula alkylO-CO-CO-NH-CH(CH 3 )-CO-Oalkyl comprises reacting alanine with a dialkyl oxalate under substantially non-acidic conditions, which may be created by carrying out the reaction in the presence of a base. The reaction may furthermore be carried out in the presence of added alkanol, preferably one featuring the alkyl group corresponding to that of the employed dialkyl oxalate. The monoesters N-alkoxalyl-alanine of the formula alkylO-CO-CO-NH-CH(CH 3 )-COOH, which as intermediates in the process can be isolated therefrom, are novel and as such are also an object of the present invention. The alkyl N-alkoxalylalaninates are useful intermediates in the multistep process for the manufacture of vitamin B 6 .
摘要翻译：制备式为烷基O-CO-CO-NH-CH（CH 3）-CO-O烷基的N-烷氧基甲硅烷基烷基酯的方法包括在基本上非酸性条件下使丙氨酸与草酸二烷基酯反应，其可以由在碱的存在下进行反应。此外，反应可以在添加的链烷醇的存在下进行，优选的是具有对应于所使用的草酸二烷基酯的烷基的烷基。作为本方法中的中间体的式为烷基O-CO-CO-NH-CH（CH 3）-COOH的单酯N-烷氧基 - 丙氨酸是新颖的，因此也是本发明的目的。 N-烷氧基烷基丙氨酸烷基酯是制造维生素B6的多步法中有用的中间体。

4. 发明申请

WO2012022562A1 VERFAHREN ZUR HERSTELLUNG VON PSEUDOJONON 审中-公开
标题翻译：用于生产假性
公开(公告)号：WO2012022562A1
公开(公告)日：2012-02-23
申请号：PCT/EP2011/062299
申请日：2011-07-19
申请人： DSM IP ASSETS B.V. , HÖLDERICH, Wolfgang , RITZERFELD, Verena , RUSSBÜLDT, Bernhard, Markus, Ernst , FLEISCHHAUER, Erhard, Henning , BONRATH, Werner , KARGE, Reinhard , SCHÜTZ, Jan
发明人： HÖLDERICH, Wolfgang , RITZERFELD, Verena , RUSSBÜLDT, Bernhard, Markus, Ernst , FLEISCHHAUER, Erhard, Henning , BONRATH, Werner , KARGE, Reinhard , SCHÜTZ, Jan
IPC分类号： C07C45/74 , C07C49/203 , B01J23/10
CPC分类号： B01J23/10 , B01J23/92 , B01J37/086 , C07C45/00 , C07C45/74 , Y02P20/584 , C07C49/203
摘要： Verwendung von reinem Lanthanoxid, das durch Kalzinierung von sauerstoffhaltigen Lanthansalzen bei Temperaturen von mindestens 700 °C erhalten wird, als heterogener Katalysator bei der Aldolkondensation von Citral und Aceton zu Pseudojonon sowie Verfahren zur Herstellung von Pseudojonon durch Aldolkondensation von Citral und Aceton in flüssiger Phase unter Verwendung von reinem Lathanoxid.
摘要翻译：使用纯氧化镧，其通过含有氧的镧盐的煅烧在至少700℃的温度下获得，如在柠檬醛和丙酮的醛醇缩合的非均相催化剂以假性以及用于使用在液相中由柠檬醛和丙酮的醛醇缩合制备假紫罗兰方法纯Lathanoxid。

5. 发明申请

WO2008087021A1 SYNTHESIS OF 4-AMINO-PYRIMIDINES 审中-公开
标题翻译： 4-氨基吡啶的合成
公开(公告)号：WO2008087021A1
公开(公告)日：2008-07-24
申请号：PCT/EP2008/000320
申请日：2008-01-17
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , HAERTER, Ralph , KARGE, Reinhard , LETINOIS, Ulla
发明人： BONRATH, Werner , HAERTER, Ralph , KARGE, Reinhard , LETINOIS, Ulla
IPC分类号： C07D239/42
CPC分类号： C07D239/42
摘要： Process for the manufacture of a compound of the structure (I) with R 1 = hydrogen, alkyl (C1 - C10, linear, cyclic or branched, aliphatic or aromatic), NR'R" (wherein R' and R" are independently selected from H, alkyl [C1 - C10, linear, cyclic or branched, aliphatic or aromatic] and R 2 = CH 2 R 3 wherein R 3 is selected from NHR1"' (with R"' = C(O)H, C(O)CH 3 , C(O)alkyl, CH 2 C 6 H 2 (OMe) 3 or other saponifiable residues), alkyl (C1 - C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e. g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an α-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.
摘要翻译：制备具有R 1 =氢的结构（I）的化合物的方法，（C1-C10，直链，环状或支链，脂族或芳族）烷基，NR'R“（其中R '和R“独立地选自H，烷基[C1-C10，直链，环状或支链，脂族或芳族]和R 2 = CH 2 3其中R 3选自NHR 1“（R”'= C（O）H，C（O）CH 3 N，C（O ）烷基，CH 2 2 C 6 H 2（OMe）3或其它可皂化残基），烷基（C 1 -C 10，直链，环状或支链）芳族残基，杂芳基残基，取代的芳基残基，例如3,4,5-三甲氧基 - 苯基），其中1当量的α-甲酰基 - 丙腈盐与0.75-2当量的乙脒盐在路易斯酸存在下反应。

6. 发明申请

WO2006079504A3 PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 审中-公开
公开(公告)号：WO2006079504A3
公开(公告)日：2006-08-03
申请号：PCT/EP2006/000600
申请日：2006-01-24
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FISCHESSER, Jocelyn , GIRAUDI, Lisa , KARGE, Reinhard
发明人： BONRATH, Werner , FISCHESSER, Jocelyn , GIRAUDI, Lisa , KARGE, Reinhard
IPC分类号： C07D239/42 , C07D417/06
摘要： The present invention relates to a novel process for the manufacture of Grewe-diamine comprising the following step: hydrolyzing a compound of formula (II), wherein R is hydrogen or straight- or branched chain C 1-4 alkyl, with an aqueous alkali or alkaline-earth metal hydroxide solution, characterized in that the hydrolysis is carried out in the presence of an organic solvent.

7. 发明申请

WO2013010811A1 PROCESS FOR THE OXIDATION OF SORBOSE 审中-公开
标题翻译： SORBOSE氧化工艺
公开(公告)号：WO2013010811A1
公开(公告)日：2013-01-24
申请号：PCT/EP2012/063205
申请日：2012-07-06
申请人： DSM IP Assets B.V. , BONRATH, Werner , GRÜNEWALD, Elena , KARGE, Reinhard , MEDLOCK, Jonathan , PRÜSSE, Ulf , VORLOP, Klaus
发明人： BONRATH, Werner , GRÜNEWALD, Elena , KARGE, Reinhard , MEDLOCK, Jonathan , PRÜSSE, Ulf , VORLOP, Klaus
IPC分类号： B01J23/52 , C07C51/235 , C07C59/215
CPC分类号： C07H1/00 , B01J23/52 , C07C51/235 , C07H3/02 , C07H7/027 , C07C59/215
摘要： The present invention relates to a process for the oxidation of sorbose using a specific catalyst, as well as to the catalyst as such.
摘要翻译：本发明涉及使用特定催化剂以及催化剂氧化山梨糖的方法。

8. 发明申请

WO2006108636A1 MANUFACTURE OF THIOLACTONES 审中-公开
标题翻译：制造THIOLACTONES
公开(公告)号：WO2006108636A1
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003375
申请日：2006-04-12
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , KARGE, Reinhard , ROESSLER, Felix
发明人： BONRATH, Werner , KARGE, Reinhard , ROESSLER, Felix
IPC分类号： B01J23/46 , C07D495/04
CPC分类号： B01J31/24 , B01J23/468 , B01J2531/827 , C07D495/04
摘要： The present invention relates to a process for the manufacture of cyclic thio esters (thiolactones) and related compounds by hydrogenation of cyclic thioanhydrides in the presence of metal catalysts.
摘要翻译：本发明涉及在金属催化剂存在下通过氢化环硫代氢化物制备环硫代酯（硫代内酯）和相关化合物的方法。

9. 发明申请

WO2006108562A1 MANUFACTURE OF LACTONES 审中-公开
标题翻译：制品的制造
公开(公告)号：WO2006108562A1
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003163
申请日：2006-04-07
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , KARGE, Reinhard , ROESSLER, Felix
发明人： BONRATH, Werner , KARGE, Reinhard , ROESSLER, Felix
IPC分类号： B01J23/46 , C07D491/04
CPC分类号： C07D491/04 , B01J31/24 , B01J2531/822
摘要： The present invention relates to a process for the manufacture of cyclic monocarboxylic esters (lactones) and related compounds by hydrogenation of cyclic dicarboxylic acid anhydrides in the presence of metal catalysts.
摘要翻译：本发明涉及在金属催化剂存在下通过环状二羧酸酐的氢化制备环状单羧酸酯（内酯）和相关化合物的方法。

10. 发明申请

WO2010115950A3 PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2010115950A3
公开(公告)日：2010-10-14
申请号：PCT/EP2010/054629
申请日：2010-04-08
申请人： DSM IP ASSETS B.V. , SCHÜTZ, Jan , KARGE, Reinhard
发明人： SCHÜTZ, Jan , KARGE, Reinhard
IPC分类号： C07D239/42
摘要： A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula (I) wherein R is CONH 2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H 2 N CH = C(R) CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula (I) is transferred into an acid addition salt, and the transformation of a compound of formula (Il) wherein R is CONH 2 into a compound of formula (Il) wherein R is CN by treatment with POCI 3 .

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