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1. 发明申请

WO2006079504A3 PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 审中-公开
公开(公告)号：WO2006079504A3
公开(公告)日：2006-08-03
申请号：PCT/EP2006/000600
申请日：2006-01-24
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FISCHESSER, Jocelyn , GIRAUDI, Lisa , KARGE, Reinhard
发明人： BONRATH, Werner , FISCHESSER, Jocelyn , GIRAUDI, Lisa , KARGE, Reinhard
IPC分类号： C07D239/42 , C07D417/06
摘要： The present invention relates to a novel process for the manufacture of Grewe-diamine comprising the following step: hydrolyzing a compound of formula (II), wherein R is hydrogen or straight- or branched chain C 1-4 alkyl, with an aqueous alkali or alkaline-earth metal hydroxide solution, characterized in that the hydrolysis is carried out in the presence of an organic solvent.

2. 发明申请

WO2004087640A1 PROCESS FOR THE MANUFACTURE OF N-ALKOXALYL-ALANINATES 审中-公开
标题翻译：制备N-烷氧基 - 兰酸酯的方法
公开(公告)号：WO2004087640A1
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003109
申请日：2004-03-24
申请人： DSM IP ASSETS B.V. , GUM, Andrew, George , FISCHESSER, Jocelyn , HÄRTER, Ralph , KARGE, Reinhard , JEPHCOTE, Vincent, John , BONRATH, Werner
发明人： GUM, Andrew, George , FISCHESSER, Jocelyn , HÄRTER, Ralph , KARGE, Reinhard , JEPHCOTE, Vincent, John , BONRATH, Werner
IPC分类号： C07C233/47
CPC分类号： C07C233/47 , C07C231/02
摘要： A process for the manufacture of alkyl N-alkoxalyl-alaninates of the formula alkylO-CO-CO-NH-CH(CH 3 )-CO-Oalkyl comprises reacting alanine with a dialkyl oxalate under substantially non-acidic conditions, which may be created by carrying out the reaction in the presence of a base. The reaction may furthermore be carried out in the presence of added alkanol, preferably one featuring the alkyl group corresponding to that of the employed dialkyl oxalate. The monoesters N-alkoxalyl-alanine of the formula alkylO-CO-CO-NH-CH(CH 3 )-COOH, which as intermediates in the process can be isolated therefrom, are novel and as such are also an object of the present invention. The alkyl N-alkoxalylalaninates are useful intermediates in the multistep process for the manufacture of vitamin B 6 .
摘要翻译：制备式为烷基O-CO-CO-NH-CH（CH 3）-CO-O烷基的N-烷氧基甲硅烷基烷基酯的方法包括在基本上非酸性条件下使丙氨酸与草酸二烷基酯反应，其可以由在碱的存在下进行反应。此外，反应可以在添加的链烷醇的存在下进行，优选的是具有对应于所使用的草酸二烷基酯的烷基的烷基。作为本方法中的中间体的式为烷基O-CO-CO-NH-CH（CH 3）-COOH的单酯N-烷氧基 - 丙氨酸是新颖的，因此也是本发明的目的。 N-烷氧基烷基丙氨酸烷基酯是制造维生素B6的多步法中有用的中间体。

3. 发明申请

WO2005049618A1 MANUFACTURE OF VITAMIN B6 审中-公开
标题翻译：维生素B6的制备
公开(公告)号：WO2005049618A1
公开(公告)日：2005-06-02
申请号：PCT/EP2004/012655
申请日：2004-11-09
申请人： DSM IP ASSETS B.V. , FISCHESSER, Jocelyn , FRITSCH, Helmut , GUM, Andrew, George , KARGE, Reinhard , KEUPER, Ralf
发明人： FISCHESSER, Jocelyn , FRITSCH, Helmut , GUM, Andrew, George , KARGE, Reinhard , KEUPER, Ralf
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , Y02P20/582
摘要： A process for manufacturing a 3-unsubstituted, 3-monosubstituted or 3,3-disubstituted 9-acyloxy-1,5-dihydro-8-methylpyrido[3,4-e] [1,3]dioxepin (I) and optionally for manufacturing pyridoxine involves performing an addition reaction between a 4-methyl-5-alkoxy-oxazole (II) and a 2-unsubstituted, 2-monosubstituted or 2,2-disubstituted 4,7-dihydro-(1,3)-dioxepin (III) in the substantial absence of a solvent and a catalyst to give a product mixture consisting essentially of the appropriate Diels-Alder adduct (IV) in a major proportion and the appropriate 3-unsubstituted, 3-monosubstituted or 3,3-disubstituted 1,5-dihydro-8-methylpyrido[3,4-e] [1,3]dioxepin 9-ol (V) in a minor proportion, removal of a substantial proportion of the unreacted oxazole and dioxapin starting materials from the product mixture by distillation under reduced pressure, addition of a substantially anhydrous organic acid to said product mixture and rearrangement of the Diels-Alder adduct IV to further V in the presence of said substantially anhydrous organic acid with removal of the generated alkanol by distillation under reduced pressure, and acylation of the resultingly enriched quantity of V with an added carboxylic acid anhydride to produce the desired I, and optionally converting this so-manufactured acylation product I to pyridoxine by acid hydrolysis for achieving deprotection and deacylatiom. Pyridoxine is a well known form of vitamin B 6 with well established utility.
摘要翻译：制备3-未取代的3-单取代的或3,3-二取代的9-酰氧基-1,5-二氢-8-甲基吡啶并[3,4-e] [1,3]二氧杂环庚烯（I）的方法，制备吡哆醛涉及在4-甲基-5-烷氧基 - 恶唑（II）和2-未取代的2-单取代或2,2-二取代的4,7-二氢 - （1,3）二氧杂环己烷 III）在基本上不存在溶剂和催化剂的情况下得到基本上由主要比例的合适的狄尔斯 - 阿尔德加合物（IV）组成的产物混合物和合适的3-未取代的3-单取代的或3,3-二取代的1 ，5-二氢-8-甲基吡啶并[3,4-e] [1,3]二氧杂环庚烷-9-醇（V），少量比例地从产物混合物中除去大部分未反应的恶唑和二氧杂环己烯起始原料在减压下蒸馏，向所述产物混合物中加入基本上无水的有机酸，并且将狄尔斯 - 阿尔德加合物IV重新排列成pr 通过减压蒸馏除去生成的链烷醇，然后用加入的羧酸酐酰化所得的富集量的V，从而产生所需的I，并且任选地将这样制得的酰化产物I 通过酸水解获得吡哆醛，以实现去保护和脱酰基。吡哆素是众所周知的维生素B6形式，具有很好的实用性。

4. 发明申请

WO2008148549A2 NOVEL REACTION WITH A GOLD CATALYST 审中-公开
标题翻译：与金催化剂的新反应
公开(公告)号：WO2008148549A2
公开(公告)日：2008-12-11
申请号：PCT/EP2008/004485
申请日：2008-06-05
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FISCHESSER, Jocelyn
发明人： BONRATH, Werner , FISCHESSER, Jocelyn
IPC分类号： C07C59/105 , C07H3/02 , C07H7/027 , C07H9/04
CPC分类号： C07H3/02 , C07B2200/07 , C07C51/235 , C07H7/027 , C07H9/04 , C07C57/03 , C07C63/06
摘要： The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
摘要翻译：本发明涉及在溶剂中含有金的催化剂存在下，碳水化合物，醇，醛或多羟基化合物的催化转化方法。

5. 发明申请

WO2012175304A1 PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE 审中-公开
标题翻译： 4-甲氧基噻唑-5-羧酰胺的方法
公开(公告)号：WO2012175304A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/060221
申请日：2012-05-31
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FISCHESSER, Jocelyn
发明人： BONRATH, Werner , FISCHESSER, Jocelyn
IPC分类号： C07D263/34
CPC分类号： C07D263/34 , C07D213/69
摘要： A process for the preparation of 4-methyl-oxazole-5-carboxamide, an intermediate in the synthesis of pyridoxine, by reacting lower alkyl 4-methyl-oxazole-5-carboxy-late with a molar excess of anhydrous, liquid ammonia.
摘要翻译：通过将4-甲基 - 恶唑-5-羧基 - 低级烷基与摩尔过量的无水液氨反应，制备4-甲基 - 恶唑-5-甲酰胺（合成吡哆醇的中间体）的方法。

6. 发明申请

WO2011015623A2 PROCESS FOR THE MANUFACTURE OF 2-PENTYN-1-OL 审中-公开
标题翻译：制造2-PENTYN-1-OL的方法
公开(公告)号：WO2011015623A2
公开(公告)日：2011-02-10
申请号：PCT/EP2010/061411
申请日：2010-08-05
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FISCHESSER, Jocelyn , PACE, Francesco , WITZGALL, Konrad
发明人： BONRATH, Werner , FISCHESSER, Jocelyn , PACE, Francesco , WITZGALL, Konrad
CPC分类号： C07C41/48 , C07C29/10 , C07C41/54 , C07C33/042 , C07C43/303
摘要： The present invention is directed to a process for the manufacture of 2-pentyn-1-ol starting from 2-propyn-1-ol via the following intermediates (I), (II) wherein R 1 is H or linear C 1-6 alkyl, R 2 is linear C 1-6 alkyl or branched C 3-6 alkyl and R 3 is linear C 1-6 alkyl, as well as to the intermediates themselves.
摘要翻译：本发明涉及由2-丙炔-1-醇经由以下中间体（I），（II）制备2-戊炔-1-醇的方法，其中R 1是H或直链C 1-6烷基，R 2是直链C 1-6烷基或支链C C 3-6烷基和R 3是直链的C 1-6烷基，以及中间体本身。

7. 发明申请

WO2018069458A1 PROCESS FOR THE MANUFACTURE OF 6-METHOXY-2,6-DIMETHYLHEPTANAL 审中-公开
标题翻译：制备6-甲氧基-2,6-二甲基庚烷的方法
公开(公告)号：WO2018069458A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/076089
申请日：2017-10-12
申请人： DSM IP ASSETS B.V.
发明人： BEUMER, Raphael , BONRATH, Werner , FISCHESSER, Jocelyn
IPC分类号： C07C45/58 , C07C45/64 , C07D301/02 , C07C49/175 , C07C47/198
CPC分类号： C07C45/64 , C07C45/58 , C07D301/02 , C07D303/38 , C07D303/40 , C07C49/175 , C07C47/198
摘要： The present invention relates to an improved process for the manufacture of 6-methoxy-2,6-dimethylheptanal.
摘要翻译：本发明涉及制备6-甲氧基-2,6-二甲基庚醛的改进方法。

8. 发明申请

WO2018069454A1 PROCESS FOR THE MANUFACTURE OF 2,6,10-TRIMETHYLUNDEC-9-ENAL 审中-公开
标题翻译：制备2,6,10-三甲基十九烯醛的方法
公开(公告)号：WO2018069454A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/076085
申请日：2017-10-12
申请人： DSM IP ASSETS B.V.
发明人： BEUMER, Raphael , BONRATH, Werner , FISCHESSER, Jocelyn
IPC分类号： C07C45/54 , C07C47/21
CPC分类号： C07C45/54 , C07C47/21
摘要： The present invention relates to an improved process for the manufacture of 2,6,10-trimethylundec-9-enal.
摘要翻译：本发明涉及制备2,6,10-三甲基十一碳-9烯醛的改进方法。

9. 发明申请

WO2018069456A1 PROCESS FOR THE MANUFACTURE OF 2,6-DIMETHYL-5-HEPTEN-1-AL 审中-公开
标题翻译：制备2,6-二甲基-5-庚烯-1-醛的方法
公开(公告)号：WO2018069456A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/076087
申请日：2017-10-12
申请人： DSM IP ASSETS B.V.
发明人： BEUMER, Raphael , BONRATH, Werner , EISELE, Frank , FISCHESSER, Jocelyn , WEHRLI, Christof
IPC分类号： C07C45/54 , C07C47/21
摘要： The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.
摘要翻译：本发明涉及制备2,6-二甲基-5-庚烯-1-醛的改进方法。

10. 发明申请

WO2018069457A1 PROCESS FOR THE MANUFACTURE OF 2,6,10-TRIMETHYLUNDECA-5,9-DIENAL 审中-公开
标题翻译：制备2,6,10-三甲基-5,7-二烯醛的方法
公开(公告)号：WO2018069457A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/076088
申请日：2017-10-12
申请人： DSM IP ASSETS B.V.
发明人： BEUMER, Raphael , BONRATH, Werner , EGGERTSWYLER, Christophe , FISCHESSER, Jocelyn
IPC分类号： C07C45/58 , C07D303/48 , C07C47/21
CPC分类号： C07C45/58 , C07D303/48 , C07C47/21
摘要： The present invention relates to an improved process for the manufacture of 2,6,10-trimethylundeca-5,9-dienal (Darzens reaction, saponification, decarboxylation).
摘要翻译：本发明涉及制备2,6,10-三甲基十一碳-5,9-二烯醛（Darzens反应，皂化，脱羧）的改进方法。

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