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1. 发明申请

WO2017097897A1 BETA-GLUCOSIDASE AND USES THEREOF 审中-公开
公开(公告)号：WO2017097897A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080242
申请日：2016-12-08
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
发明人： WIJMA, Hein Jacob , JANSSEN, Dirk Barend , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12P19/02 , C12P19/14 , C12N9/42
CPC分类号： C12P19/14 , C12N9/2445 , C12P7/10 , C12P7/46 , C12P19/02 , Y02E50/16
摘要： The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses.

2. 发明申请

WO2023079049A1 VARIANT POLYPEPTIDE AND RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023079049A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080763
申请日：2022-11-04
申请人： DSM IP ASSETS B.V.
发明人： DE BRUIJN, Hans Marinus Charles Johannes , VAN RIJ, Evert Tjeerd , JANSEN, Mickel Leonardus August , VAN DER WEERT, Marco Richard , KROES, Wouter , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12N9/26 , C12N9/34 , C12P7/06 , C12N1/16
摘要： A variant polypeptide of a parent polypeptide,wherein the parent polypeptide comprises the amino acid sequence of SEQ ID NO: 1, and wherein the variant polypeptide comprises an amino acid sequence which, when aligned with the amino acid sequence of SEQ ID NO: 1, comprises an amino acid substitution of V202I, A203N, V333S, Y335M and/or D336G, the positions of said amino acids being defined with reference to the amino acid sequence of SEQ ID NO: 1.A recombinant yeast cell functionally expressing a nucleotide encoding the variant polypeptide and a process for the production of ethanol using the variant polypeptide and/or recombinant yeast.

3. 发明申请

WO2017097895A1 BETA-GLUCOSIDASE AND USES THEREOF 审中-公开
标题翻译： β-葡糖苷酶及其用途
公开(公告)号：WO2017097895A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080240
申请日：2016-12-08
申请人： DSM IP ASSETS B.V.
发明人： VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12P19/02 , C12P19/14 , C12N9/42
CPC分类号： C12P19/14 , C12N9/2445 , C12P19/02
摘要： The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses.
摘要翻译：本申请涉及具有β-葡糖苷酶活性的多肽，其生产方法及其用途。

4. 发明申请

WO2023079048A1 PROCESS FOR THE PRODUCTION OF ETHANOL AND RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023079048A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080762
申请日：2022-11-04
申请人： DSM IP ASSETS B.V.
发明人： DE BRUIJN, Hans Marinus Charles Johannes , VAN RIJ, Evert Tjeerd , JANSEN, Mickel Leonardus August , VAN DER WEERT, Marco Richard , KROES, Wouter , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12P7/06 , C12P19/14 , C12N15/81 , C12N9/88 , C12N9/34 , C12N9/24
摘要： A process for the production of ethanol, comprising: fermentation of a feed, under anaerobic conditions, wherein the feed contains a di-saccharide, oligo-saccharide and/or poly-saccharide and wherein the fermentation is carried out in the presence of a recombinant yeast cell, which recombinant yeast produces a combination of proteins having glucosidase activity; and recovery of ethanol, and a recombinant yeast cell for use therein.

5. 发明申请

WO2022122721A1 IMPROVED PREBIOTIC FORMULATIONS 审中-公开
公开(公告)号：WO2022122721A1
公开(公告)日：2022-06-16
申请号：PCT/EP2021/084563
申请日：2021-12-07
申请人： DSM IP ASSETS B.V. [NL]/[NL]
发明人： VAN LEEUWEN, Johannes Gustaaf Ernst , WIENS, Frank , VAN DEN BERG, Marco Alexander
IPC分类号： A23L33/00 , A61K31/702 , C12P19/00
摘要： Process comprising reducing a fermentation broth comprising 2'-fucosyllactose to produce a treated fermentation broth comprising 2'-fucosyllactose and 2'-fucosyllactitol; isolating a stream comprising 2'-fucosyllactose and 2'-fucosyllactitol from the treated fermentation broth; purifying the isolated stream; concentrating the purified isolated stream; dewatering the concentrated purified isolated stream, thereby forming a prebiotic solids product comprising 2'-fucosyllactose and 0.2 to 6.0 wt.% of 2'-fucosyllactitol based on the total wt.% of the prebiotic solids product, wherein the concentrating step and dewatering step can be performed in any order.

6. 发明申请

WO2023079050A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023079050A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080764
申请日：2022-11-04
申请人： DSM IP ASSETS B.V.
发明人： DE BRUIJN, Hans Marinus Charles Johannes , VAN RIJ, Evert Tjeerd , JANSEN, Mickel Leonardus August , VAN DER WEERT, Marco Richard , KROES, Wouter , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12N9/34 , C12P7/06 , C12R1/865
摘要： A recombinant yeast cell comprising a nucleotide sequence encoding a protein, which protein comprises an amino acid sequence of SEQ ID NO: 01 or an amino acid sequence which has at least 90% sequence identity, preferably at least 95%, 98%, or 99% sequence identity with the amino acid sequence of SEQ ID NO: 01.

7. 发明申请

WO2018019948A1 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有纤维素分解增强活性的多肽及其用途
公开(公告)号：WO2018019948A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/069049
申请日：2017-07-27
申请人： DSM IP ASSETS B.V.
发明人： VAN LEEUWEN, Johannes Gustaaf Ernst , BEVERS, Loes Elizabeth
IPC分类号： C12N15/52 , C12P19/04 , C12P19/14 , C12N9/42 , C12P7/10
摘要： The invention relates to a polypeptide having cellulolytic enhancing activity, wherein the polypeptide is selected from the group consisting of: (a) a polypeptide comprising an amino acid sequence having at least 60% sequence identity with the amino acid sequence of SEQ ID NO: 2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32, 35, 38, 41, 44 and/or 47; (b) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 60% sequence identity to the nucleotide sequence of SEQ ID NO: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 and/or 48; (c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence which hybridises under at least high stringency conditions with the complementary strand of SEQ ID NO: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 and/or 48; and (d) a fragment of the polypeptide of (a), (b), or (c), that has cellulolytic enhancing activity.
摘要翻译：本发明涉及具有纤维素分解增强活性的多肽，其中所述多肽选自：（a）包含与氨基酸序列具有至少60％序列同一性的氨基酸序列的多肽 SEQ ID NO：2,5,8,11,14,17,20,23,26,29,32,35,38,41,44和/或47的氨基酸序列; （b）由多核苷酸编码的多肽，所述多核苷酸包含与SEQ ID NO：3,6,9,12,15,18,21,24,27,30,33的核苷酸序列具有至少60％序列同一性的核苷酸序列，36,39,42,45和/或48; （c）由包含核苷酸序列的多核苷酸编码的多肽，所述核苷酸序列在至少高度严格条件下与SEQ ID NO：3,6,9,12,15,18,21,24,27,30， 33,36,39,42,45和/或48; 和（d）具有纤维素分解增强活性的（a），（b）或（c）的多肽片段。

8. 发明申请

WO2017097896A1 BETA-GLUCOSIDASE AND USES THEREOF 审中-公开
公开(公告)号：WO2017097896A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080241
申请日：2016-12-08
申请人： DSM IP ASSETS B.V.
发明人： VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12P19/02 , C12P19/14 , C12N9/42
CPC分类号： C12N9/2445 , C07K14/37 , C12P19/02 , C12P19/14 , C12P2203/00
摘要： The application relates to a polypeptide having beta-glucosidase activity, its method of production and its uses.

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