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1. 发明申请

WO2023285294A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023285294A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/068983
申请日：2022-07-07
申请人： DSM IP ASSETS B.V.
发明人： VUGT- VAN LUTZ, Ingrid Maria , SCHMITZ, Jozef Petrus Johannes , JANSEN, Mickel Leonardus August , DE BRUIJN, Hans Marinus Charles Johannes , ROSSELL-ARAGORT, Sergio Luis , VAN RIJ, Evert Tjeerd , BUREMAN, Phillip E.
IPC分类号： C12N15/81
摘要： A recombinant yeast cell that functionally expresses:- a nucleic acid sequence encoding a protein having glycerol dehydrogenase activity;- a nucleic acid sequence encoding a protein having dihydroxyacetone kinase activity; and- a nucleic acid sequence encoding a protein having glycerol transporter activity, wherein the expression of the nucleic acid sequence encoding the protein having glycerol transporter activity is under control of a promoter (the "GT promoter"), which GT promoter has an anaerobic/aerobic expression ratio for the glycerol transporter of 2 or more, and a process for the production of ethanol using such recombinant yeast cell.

2. 发明申请

WO2023285281A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023285281A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/068918
申请日：2022-07-07
申请人： DSM IP ASSETS B.V.
发明人： ROSSELL-ARAGORT, Sergio Luis , JANSEN, Mickel Leonardus August , VUGT- VAN LUTZ, Ingrid Maria , SCHMITZ, Jozef Petrus Johannes , VAN RIJ, Evert Tjeerd , DE JONG, René Marcel
IPC分类号： C12N15/81
摘要： A recombinant yeast cell functionally expressing:a) a nucleic acid sequence encoding a protein comprising phosphoketolase (PKL) activity (EC 4.1.2.9 or EC 4.1.2.22) and/or a nucleic acid sequence encoding a protein having phosphotransacetylase (PTA) activity (EC 2.3.1.8) and/or a nucleic acid sequence encoding a protein having acetate kinase (ACK) activity (EC 2.7.2.12); and0b) a nucleic acid sequence encoding a protein having transketolase activity (EC 2.2.1.1),wherein the expression of the nucleic acid sequence encoding the protein havingtransketolase activity is under control of a promoter (the "TKL promoter"), which TKLpromoter has an anaerobic/aerobic expression ratio for the transketolase of (2) or more.

3. 发明申请

WO2023285297A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023285297A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/068996
申请日：2022-07-07
申请人： DSM IP ASSETS B.V.
发明人： ROSSELL-ARAGORT, Sergio Luis , JANSEN, Mickel Leonardus August , VUGT- VAN LUTZ, Ingrid Maria , SCHMITZ, Jozef Petrus Johannes , VAN RIJ, Evert Tjeerd , DE JONG, René Marcel , DE BRUIJN, Hans Marinus Charles Johannes , BUREMAN, Phillip E.
IPC分类号： C12N1/18 , C12N9/02 , C12N9/06 , C12N9/10 , C12P7/06
摘要： A recombinant yeast cell functionally expressing: a) a nucleic acid sequence encoding an enzyme having NADH-dependent nitrate reductase activity and/or a nucleic acid sequence encoding an enzyme having NADH-dependent nitrite reductase activity; and b) a nucleic acid sequence encoding a protein having transketolase activity (EC 2.2.1.1),wherein the expression of the nucleic acid sequence encoding the protein having transketolase activity is under control of a promoter (the "TKL promoter"), which TKL promoter has an anaerobic/aerobic expression ratio for the transketolase of 2 or more.

4. 发明申请

WO2023285282A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023285282A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/068921
申请日：2022-07-07
申请人： DSM IP ASSETS B.V.
发明人： ROSSELL-ARAGORT, Sergio Luis , JANSEN, Mickel Leonardus August , VUGT- VAN LUTZ, Ingrid Maria , SCHMITZ, Jozef Petrus Johannes , VAN RIJ, Evert Tjeerd , DE JONG, René Marcel
IPC分类号： C12N15/81
摘要： A recombinant yeast cell functionally expressing:a) a nucleic acid sequence encoding a protein having NAD+-dependent acetylating acetaldehyde dehydrogenase activity (EC 1.2.1.10); and b) a nucleic acid sequence encoding a protein having transketolase activity (EC 2.2.1.1),0wherein the expression of the nucleic acid sequence encoding the protein having transketolase activity is under control of a promoter (the "TKL promoter"), which TKLpromoter has an anaerobic/aerobic expression ratio for the transketolase of 2 or more.

5. 发明申请

WO2023285280A1 RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023285280A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/068917
申请日：2022-07-07
申请人： DSM IP ASSETS B.V.
发明人： ROSSELL-ARAGORT, Sergio Luis , JANSEN, Mickel Leonardus August , VUGT- VAN LUTZ, Ingrid Maria , SCHMITZ, Jozef Petrus Johannes , VAN RIJ, Evert Tjeerd , DE JONG, René Marcel , DE BRUIJN, Hans Marinus Charles Johannes , BUREMAN, Phillip E.
IPC分类号： C12N15/81
摘要： A recombinant yeast cell functionally expressing: - a nucleic acid sequence encoding a native protein having transketolase activity (EC 2.2.1.1); and - a nucleic acid sequence encoding a heterologous protein having transketolase activity (EC 2.2.1.1).

6. 发明申请

WO2023079049A1 VARIANT POLYPEPTIDE AND RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023079049A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080763
申请日：2022-11-04
申请人： DSM IP ASSETS B.V.
发明人： DE BRUIJN, Hans Marinus Charles Johannes , VAN RIJ, Evert Tjeerd , JANSEN, Mickel Leonardus August , VAN DER WEERT, Marco Richard , KROES, Wouter , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12N9/26 , C12N9/34 , C12P7/06 , C12N1/16
摘要： A variant polypeptide of a parent polypeptide,wherein the parent polypeptide comprises the amino acid sequence of SEQ ID NO: 1, and wherein the variant polypeptide comprises an amino acid sequence which, when aligned with the amino acid sequence of SEQ ID NO: 1, comprises an amino acid substitution of V202I, A203N, V333S, Y335M and/or D336G, the positions of said amino acids being defined with reference to the amino acid sequence of SEQ ID NO: 1.A recombinant yeast cell functionally expressing a nucleotide encoding the variant polypeptide and a process for the production of ethanol using the variant polypeptide and/or recombinant yeast.

7. 发明申请

WO2011023700A3 DICARBOXYLIC ACID FERMENTATION PROCESS 审中-公开
公开(公告)号：WO2011023700A3
公开(公告)日：2011-03-03
申请号：PCT/EP2010/062345
申请日：2010-08-24
申请人： DSM IP Assets B.V. , JANSEN, Mickel Leonardus August , VERWAAL, René
发明人： JANSEN, Mickel Leonardus August , VERWAAL, René
IPC分类号： C12P7/46 , C12N1/16
摘要： The present invention relates to a process for producing a dicarboxylic acid, comprising fermenting a recombinant fungal cell in a suitable fermentation medium, in the presence of high carbon dioxide concentrations.

8. 发明申请

WO2010118932A1 DICARBOXYLIC ACID PRODUCTION PROCESS 审中-公开
标题翻译：二羧酸生产工艺
公开(公告)号：WO2010118932A1
公开(公告)日：2010-10-21
申请号：PCT/EP2010/053753
申请日：2010-03-23
申请人： DSM IP ASSETS B.V. , JANSEN, Mickel Leonardus August , GRAAF, VAN DE, Maarten Job , VERWAAL, René
发明人： JANSEN, Mickel Leonardus August , GRAAF, VAN DE, Maarten Job , VERWAAL, René
IPC分类号： C12P7/46
CPC分类号： C12P7/46
摘要： The present invention relates to a process for the production of a dicarboxylic acid and ethanol which comprises fermenting a genetically modified yeast in a suitable fermentation medium under anaerobic conditions at a pH value of between 1 and 5 and producing the dicarboxylic acid and ethanol. The invention also relates to a process for crystallizing succinic acid from an aqueous solution having a pH of between 1 and 5 and comprising succinic acid, comprising removing part of the aqueous solution by evaporation to obtain a concentrated solution, and bringing the temperature of the concentrated solution to a value of between 10 and 30 degrees Celsius, wherein succinic acid crystals are formed.
摘要翻译：本发明涉及一种生产二羧酸和乙醇的方法，其包括在pH为1至5的厌氧条件下，在合适的发酵培养基中发酵经遗传修饰的酵母并产生二羧酸和乙醇。本发明还涉及一种从琥珀酸pH值介于1和5之间的水溶液中结晶琥珀酸的方法，包括通过蒸发除去部分水溶液以获得浓缩溶液，并使浓缩的溶液达到10至30摄氏度的值，其中形成琥珀酸晶体。

9. 发明申请

WO2023079048A1 PROCESS FOR THE PRODUCTION OF ETHANOL AND RECOMBINANT YEAST CELL 审中-公开
公开(公告)号：WO2023079048A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080762
申请日：2022-11-04
申请人： DSM IP ASSETS B.V.
发明人： DE BRUIJN, Hans Marinus Charles Johannes , VAN RIJ, Evert Tjeerd , JANSEN, Mickel Leonardus August , VAN DER WEERT, Marco Richard , KROES, Wouter , VAN LEEUWEN, Johannes Gustaaf Ernst
IPC分类号： C12P7/06 , C12P19/14 , C12N15/81 , C12N9/88 , C12N9/34 , C12N9/24
摘要： A process for the production of ethanol, comprising: fermentation of a feed, under anaerobic conditions, wherein the feed contains a di-saccharide, oligo-saccharide and/or poly-saccharide and wherein the fermentation is carried out in the presence of a recombinant yeast cell, which recombinant yeast produces a combination of proteins having glucosidase activity; and recovery of ethanol, and a recombinant yeast cell for use therein.

10. 发明申请

WO2016202880A1 FERMENTATION PROCESS 审中-公开
标题翻译：发酵过程
公开(公告)号：WO2016202880A1
公开(公告)日：2016-12-22
申请号：PCT/EP2016/063792
申请日：2016-06-15
申请人： DSM IP ASSETS B.V.
发明人： JANSEN, Mickel Leonardus August , WINTER, Remko Tsjibbe
IPC分类号： C12P7/46 , C12P19/02 , C12P39/00
CPC分类号： C12P7/46 , C12P39/00
摘要： The invention relates to a process for the production of a compound of interest, which process comprises fermenting a first cell capable of producing the compound of interest in a suitable fermentation medium under conditions which allow for production of the compound of interest, wherein the fermentation medium comprises disaccharides and/or oligosaccharides which are not completely fermentable by the first cell; and wherein the fermentation is carried out in the presence of an enzyme which is capable of hydrolyzing, at least in part, the disaccharides and/or the oligosaccharides; and, optionally, recovering the compound of interest from the reaction medium. The invention also relates to a fermentation broth obtainable by such a process.
摘要翻译：本发明涉及一种生产感兴趣的化合物的方法，该方法包括在允许生产目标化合物的条件下，在合适的发酵培养基中发酵能够产生感兴趣的化合物的第一个细胞，其中发酵培养基包括不能被第一细胞完全发酵的二糖和/或寡糖; 并且其中所述发酵在能够至少部分地水解二糖和/或寡糖的酶的存在下进行; 和任选地，从反应介质中回收目标化合物。本发明还涉及通过这种方法可获得的发酵液。

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