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1. 发明申请

WO2007084545A1 PROCESS FOR MAKING AMINO ACIDS 审中-公开
标题翻译：制备氨基酸的方法
公开(公告)号：WO2007084545A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001207
申请日：2007-01-17
申请人： DOW GLOBAL TECHNOLOGIES INC. , LLOYD, Michael, C. , DAUGS, Edward, D. , RAND, Cynthia, L. , PENG, Wei-jun
发明人： LLOYD, Michael, C. , DAUGS, Edward, D. , RAND, Cynthia, L. , PENG, Wei-jun
IPC分类号： C07C227/32 , C07D317/30 , C12P41/00
CPC分类号： C07C227/32 , C07D317/30 , C12P13/04 , C12P41/006
摘要： A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds comprising a masked amino acid derivative which may be selected from the group consisting of amino nitrile, N-acyl amino acid, amino amide, hydantoin and amino ester; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R 1 and R 2 are the same or different alkyl groups and wherein R 1 and R 2 may be fused.
摘要翻译：通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生包含可以选自氨基腈，N-酰基氨基酸，氨基酰胺，乙内酰脲和氨基酯; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1， SO 2和R 2是相同或不同的烷基，其中R 1和R 2和R 2可以是稠合的。

2. 发明申请

WO2005110986A1 HYDROFORMYLATION PROCESS FOR PHARMACEUTICAL INTERMEDIATE 审中-公开
标题翻译：药物中间体的水解过程
公开(公告)号：WO2005110986A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/014349
申请日：2005-04-26
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D. , PENG, Wei-Jun , RAND, Cynthia, L.
发明人： DAUGS, Edward, D. , PENG, Wei-Jun , RAND, Cynthia, L.
IPC分类号： C07D209/48
CPC分类号： C07D401/06 , C07D209/48 , C07D471/04
摘要： The invention relates to an improved process for the preparation of an advanced synthetic intermediate of ACE inhibitors. In one aspect, the present invention is based on a novel process for the preparation of an aldehyde of formula (I), wherein (N) PrG is a protected amino group, R is an alkyl or aralkyl group and X 1-4 are each independently H or a non-reacting substituent, which comprises hydroformylation of an α-olefin of formula (II), by reaction with syngas (CO/H 2 ) in the presence of, as catalyst, a group VIII transition metal complex of a phosphorus-containing ligand. Aldehyde (I), the product of linear hydroformylation, is formed in preference to aldehyde (III). In another aspect of the invention, α-olefin (II) is a novel composition. The process to convert (II) to (I) enables an efficient manufacturing route to MDL 28,726 and analogues.
摘要翻译：本发明涉及用于制备ACE抑制剂的高级合成中间体的改进方法。一方面，本发明是基于制备式（I）的醛的新方法，其中（N）PrG是被保护的氨基，R是烷基或芳烷基，X <1-4> 各自独立地是H或非反应性取代基，其包括式（II）的α-烯烃的羰基化，通过在作为催化剂的催化剂存在下与合成气（CO / H 2）反应的第VIII族过渡金属络合物含磷配体。醛（I）是线性加氢甲酰化的产物，优选醛（III）。在本发明的另一方面，α-烯烃（II）是一种新的组合物。将（II）转化为（I）的过程能够实现MDL 28,726和类似物的有效制造路线。

3. 发明申请

WO2011008570A2 SULFONATE SURFACTANTS AND METHODS OF PREPARATION AND USE 审中-公开
标题翻译：磺化表面活性剂及其制备和使用方法
公开(公告)号：WO2011008570A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/040570
申请日：2010-06-30
申请人： DOW GLOBAL TECHNOLOGIES, INC. , YU, Wanglin , RAND, Cynthia, L. , DAUGS, Edward, D. , CHENG, Yang , GRAF, Irina, V. , ARGENTON, Andre, B. , PHILLIPSON, Kari, S.
发明人： YU, Wanglin , RAND, Cynthia, L. , DAUGS, Edward, D. , CHENG, Yang , GRAF, Irina, V. , ARGENTON, Andre, B. , PHILLIPSON, Kari, S.
IPC分类号： C07C309/10
CPC分类号： C07C309/10 , C08F2/26 , C09K8/035 , C09K8/584 , C11D1/143
摘要： Provided are new anionic surfactants and methods of their preparation and use. The surfactants are compounds of the formula I: wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein.
摘要翻译：提供了新的阴离子表面活性剂及其制备和使用方法。表面活性剂是式I化合物：其中R，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。

4. 发明申请

WO2009137282A1 PROCESS FOR OLEFIN ETHERIFICATION 审中-公开
标题翻译：烯烃加工方法
公开(公告)号：WO2009137282A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/041747
申请日：2009-04-27
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D. , FLICK, Derrick, W. , RAND, Cynthia, L. , TULCHINSKY, Michael, L. , YU, Wanglin
发明人： DAUGS, Edward, D. , FLICK, Derrick, W. , RAND, Cynthia, L. , TULCHINSKY, Michael, L. , YU, Wanglin
IPC分类号： C07C41/06 , C07C43/12
CPC分类号： C07C41/06 , C07C41/42 , Y02P20/127 , C07C43/12
摘要： The invention relates to processes for the etherification of olefins with alcohols. According to one aspect, a heterogeneous etherification catalyst is used under conditions that permit limiting the contact time between the desired product and the catalyst, thereby mitigation reverse reactions. According to a second aspect, a recycling process is used that significantly increases the yield of desired product.
摘要翻译：本发明涉及烯烃与醇醚化的方法。根据一个方面，在允许限制所需产物和催化剂之间的接触时间的条件下使用异相醚化催化剂，从而减轻逆向反应。根据第二方面，使用显着增加所需产物的产率的再循环方法。

5. 发明申请

WO2011056448A1 VINYL ETHER COMPOUNDS AND METHODS OF THEIR PREPARATION AND USE 审中-公开
标题翻译：乙烯化合物及其制备和使用方法
公开(公告)号：WO2011056448A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/053535
申请日：2010-10-21
申请人： DOW GLOBAL TECHNOLOGIES LLC. , OBER, Matthias, S. , DAUGS, Edward, D. , YU, Wanglin , RAND, Cynthia, L.
发明人： OBER, Matthias, S. , DAUGS, Edward, D. , YU, Wanglin , RAND, Cynthia, L.
IPC分类号： C07C43/16 , C07C43/313 , C07C217/46 , C07D295/084 , C07C41/24
CPC分类号： C07D295/088 , C07C41/16 , C07C41/24 , C07C43/16 , C07C43/17 , C07C43/188 , C07C43/215 , C07C217/08 , C07C217/46 , C07C2602/42 , C07C43/192
摘要： Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R 1 , R 2 , and R 3 are as defined herein.
摘要翻译：提供了新的官能化表面活性剂及其制备和使用方法。表面活性剂是式I化合物：其中R 1，R 2和R 3如本文所定义。

6. 发明申请

WO2004074294A1 PREPARATION OF A TRANS-CALANOLIDE KETONE INTERMEDIATE AND CHIRAL SEPATATION OF CALANOLIDE ALCOHOLS TO GIVE RACEMIC CALANOLIDE A 审中-公开
标题翻译：转化乙酸钾中间体的制备和丙醇酸醇的马来酸盐分离以产生聚氨酯
公开(公告)号：WO2004074294A1
公开(公告)日：2004-09-02
申请号：PCT/US2004/002068
申请日：2004-01-27
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D.
发明人： DAUGS, Edward, D.
IPC分类号： C07D493/04
CPC分类号： C07D493/14
摘要： The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanol.ide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.
摘要翻译：本发明的方法包括合成用于合成外消旋反式正切内酯A的反式 - 正己内酯A酮中间体的方法。本发明还包括一种从丙醇胺A和在通过结晶合成甘洛酸A的最后步骤中形成的甘露糖苷B非对映异构体。

7. 发明申请

WO2009076275A1 PROCESS FOR THE CONTINUOUS PRODUCTION OF HIGH PURITY PHENOLIC GLYCOL ETHER 审中-公开
标题翻译：连续生产高纯度酚醛树脂的方法
公开(公告)号：WO2009076275A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/085822
申请日：2008-12-08
申请人： DOW GLOBAL TECHNOLOGIES INC. , TIRTOWIDJOJO, Max , DAUGS, Edward, D.
发明人： TIRTOWIDJOJO, Max , DAUGS, Edward, D.
IPC分类号： C07C41/03 , C07C43/205
CPC分类号： C07C41/03 , Y02P20/582 , C07C43/23
摘要： Phenolic glycol ethers, e.g., ethylene glycol phenyl ether, are prepared by a continuous, nonaqueous process comprising the steps of (A) contacting under isothermal reactive conditions in a first reactor or reaction zone an alkylene oxide, e.g., ethylene oxide, with (i) a stoichiometric molar excess of a phenolic compound, e.g., phenol, and (ii) a catalytic amount of a base, e.g., sodium hydroxide, homogeneously dispersed throughout the phenolic compound, to form a first intermediate phenolic glycol ether product, (Bj transferring the first intermediate phenolic glycol ether product to a second reactor or reaction zone, and ( C) subjecting the first intermediate phenolic glycol ether product to adiabatic reactive conditions in the second reactor or reaction zone to form a second intermediate phenolic glycol ether product comprising phenolic glycol ether, unreacted phenolic compound, catalyst, water and byproduct glycols. In addition, the mono-/di-product weight ratio can be adjusted by increasing or decreasing the amount of base catalyst employed.
摘要翻译：酚醛二醇醚，例如乙二醇苯基醚，通过连续的非水性方法制备，包括以下步骤：（A）在等温反应条件下在第一反应器或反应区中接触环氧烷，例如环氧乙烷与（i ）化学计量摩尔过量的酚类化合物，例如苯酚，和（ii）催化量的碱，例如均匀分散在整个酚类化合物中的氢氧化钠，形成第一中间体酚二醇醚产物（Bj转移将第一中间体酚二醇醚产物加入到第二反应器或反应区中，和（C）使第一中间体酚二醇醚产物在第二反应器或反应区中进行绝热反应条件以形成包含酚二醇的第二中间体酚二醇醚产物醚，未反应的酚类化合物，催化剂，水和副产物二醇，另外，单/二产物重量比可以通过增加或减少所用的碱催化剂的量。

8. 发明申请

WO2006028745A1 HIGH PURITY, HIGH MOLECULAR WEIGHT METHOXY-POLYETHYLENGLYCOLS (MPEG) 审中-公开
标题翻译：高纯度，高分子量甲氧基聚乙烯醇（MPEG）
公开(公告)号：WO2006028745A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/030518
申请日：2005-08-25
申请人： DOW GLOBAL TECHNOLOGIES INC. , CHAPPELOW, Christopher, M. , DAUGS, Edward, D. , GATLING, Sterling, C. , SIKKEMA, Kevin, D. , TUROWSKI, Maciej , WALLINGFORD, Ross, A.
发明人： CHAPPELOW, Christopher, M. , DAUGS, Edward, D. , GATLING, Sterling, C. , SIKKEMA, Kevin, D. , TUROWSKI, Maciej , WALLINGFORD, Ross, A.
IPC分类号： C08G65/30 , C08G65/329
CPC分类号： C08G65/30 , C08G65/329
摘要： The invention is directed toward novel high molecular weigh and high purity mPEG alcohol compositions as well as a process for obtaining said compositions by removing PEG diols from the mPEG alcohol after polymerization is complete.
摘要翻译：本发明涉及新颖的高分子量和高纯度mPEG醇组合物，以及通过在聚合完成后从mPEG醇中除去PEG二醇获得所述组合物的方法。

9. 发明申请

WO2012078728A1 APPARATUS AND PROCESS FOR USING OLEFIN AS AN AZEOTROPIC ENTRAINER FOR ISOLATING 1,3-DICHLORO-2-PROPANOL FROM A 2,2'-OXYBIS (1-CHLOROPROPANE) WASTE STREAM 审中-公开
标题翻译：使用烯烃作为AZEOTROPIC设备的装置和方法，用于从2,2'-氧化物（1-氯丙烯）废物流中分离1,3-二氯-2-丙醇
公开(公告)号：WO2012078728A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063697
申请日：2011-12-07
申请人： DOW GLOBAL TECHNOLOGIES LLC , SAWANT, Mahesh, Ratnakar , DAUGS, Edward, D. , SMIT, Mark, R.
发明人： SAWANT, Mahesh, Ratnakar , DAUGS, Edward, D. , SMIT, Mark, R.
IPC分类号： C07C29/80 , C07C29/82 , C07C31/36 , B01D3/36
CPC分类号： B01D3/36 , C07C29/74 , C07C29/78 , C07C29/80 , C07C29/82 , C07C29/86 , C07C31/36
摘要： Disclosed are a process and an apparatus for using an olefin as an azeotropic entrainer to isolate a target organic compound from a waste stream. The olefin may be, for example, 1- decene, 1-dodecene, or 1-tetradecene. The target organic compound may be l,3-dichloro-2- propanol in waste stream comprising a 2,2'-oxybis(l-chloropropane).
摘要翻译：公开了一种使用烯烃作为共沸夹带剂从废物流中分离目标有机化合物的方法和装置。烯烃可以是例如1-癸烯，1-十二碳烯或1-十四碳烯。目标有机化合物可以是包含2,2'-氧双（1-氯丙烷）的废物流中的1,3-二氯-2-丙醇。

10. 发明申请

WO2006036825A1 POLYETHYLENE GLYCOL COMPOUNDS AND PROCESS FOR MAKING 审中-公开
标题翻译：聚乙二醇化合物及其制备方法
公开(公告)号：WO2006036825A1
公开(公告)日：2006-04-06
申请号：PCT/US2005/034251
申请日：2005-09-27
申请人： DOW GLOBAL TECHOLOGIES INC. , DAUGS, Edward, D. , APPELL, Robert, Bruce , HIPPLER, Jeffrey, G. , KEEN, Brian, T.
发明人： DAUGS, Edward, D. , APPELL, Robert, Bruce , HIPPLER, Jeffrey, G. , KEEN, Brian, T.
IPC分类号： C08G65/30
CPC分类号： C08G65/2603 , C08G65/00
摘要： A substituted polyethylene glycol compound and process for making. The compound has the formula RO(C 2 H 4 O) n H wherein R represents a C 1-7 hydrocarbon group and n represents the average number of moles of C 2 H 4 O groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of an aprotic polar solvent. When the aprotic polar solvent is a polyether solvent, then the n value of the compound ranges from 100 to 2000.
摘要翻译：取代的聚乙二醇化合物及其制备方法。化合物具有式RO（C 2 H 4 O）n H H其中R表示C 1-7 - >烃基，n表示C 2 H 4 H 4 O基团的平均摩尔数，范围为500-2000。化合物的重均分子量与数均分子量在1至1.1的范围内。该化合物含有少于10重量％的聚乙二醇。该过程的要点是使用非质子极性溶剂。当非质子极性溶剂是聚醚溶剂时，化合物的n值范围为100-2000。

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