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    • 7. 发明申请
    • OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
    • 用于可植入设备的氧气增强膜系统
    • WO2005011520A3
    • 2005-12-15
    • PCT/US2004023454
    • 2004-07-21
    • DEXCOM INCPETISCE JAMES RTAPSAK MARK ASIMPSON PETER CCARR-BRENDEL VICTORIA
    • PETISCE JAMES RTAPSAK MARK ASIMPSON PETER CCARR-BRENDEL VICTORIA
    • A61B5/00A61B5/05A61F20060101G01N27/327
    • A61B5/1473A61B5/145A61B5/14503A61B5/14532A61B5/14546A61B5/1468A61B5/14735A61B5/14865
    • The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system (18) configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. The membrane system (18) can include a cell disruptive domain (40), a cell impermeable domain (42), a resistance domain (44), an enzyme domain (46), an interference domain (48), and an electrolyte domain (50) adjacent to the electrochemically reactive surfaces. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
    • 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统(18),其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂,其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置,以便在缺氧期间动态地保持氧利用源的高氧可利用性。 膜系统(18)可以包括细胞破碎结构域(40),细胞不可渗透结构域(42),电阻结构域(44),酶结构域(46),干扰结构域(48)和电解质结构域 邻近电化学反应的表面。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用,例如基于酶的电化学传感器和细胞移植装置是有用的。