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1. 发明申请

WO2009143420A2 IMPLANTS WITH ROUGHENED SURFACES 审中-公开
标题翻译：具有粗糙表面的植入物
公开(公告)号：WO2009143420A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044970
申请日：2009-05-22
申请人： DEPUY PRODUCTS , SMITH, Bryan , RYBOLT, Jeffrey, A. , LIU, Hengda , MARTIN, Andrew, James
发明人： SMITH, Bryan , RYBOLT, Jeffrey, A. , LIU, Hengda , MARTIN, Andrew, James
IPC分类号： B22F3/00 , B22F5/00
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/30968 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00095 , A61F2310/00101 , A61F2310/00131 , A61L27/04 , A61L27/50 , A61L2400/18 , B22F3/1121 , B22F3/1146 , B22F2998/10 , C22C14/00 , B22F3/02 , B24C1/08 , B22F3/10
摘要： Provided are methods for processing a green body that includes compacted metal powder, comprising impacting the green body with a particulate material for a time and under conditions effective to displace a portion of the metal powder from the green body. The present methods can be used to prepare green bodies that have "roughened" surfaces and that can be used to make orthopedic implants displaying low movement relative to bone when installed in situ, which corresponds to higher stability upon implantation and decreases the time required for biological fixation of the implant. Also provided are implants comprising a metallic matrix, and methods comprising surgically installing an implant prepared from a "surface roughened" green body in accordance with the present invention.
摘要翻译：提供了一种加工生坯体的方法，其包括压实的金属粉末，包括一段时间和在有效地将一部分金属粉末从生坯体移位的条件下，用生物体冲击生坯。本发明的方法可用于制备具有“粗糙化”表面的生坯，并且可用于使矫形植入物在原位安装时显示相对于骨的低运动，这对应于植入时更高的稳定性并减少生物学所需的时间固定植入物。还提供了包括金属基质的植入物，以及包括手术安装由根据本发明的“表面粗糙化”生坯体制备的植入物的方法。

2. 发明申请

WO2015069266A1 METHODS FOR INHIBITING TIE2 KINASE USEFUL IN THE TREATMENT OF CANCER 审中-公开
标题翻译：抑制TIE2激酶治疗癌症的方法
公开(公告)号：WO2015069266A1
公开(公告)日：2015-05-14
申请号：PCT/US2013/069005
申请日：2013-11-07
申请人： FLYNN, Daniel L. , KAUFMAN, Michael D. , SMITH, Bryan , RUDOLTZ, Marc S.
发明人： FLYNN, Daniel L. , KAUFMAN, Michael D. , SMITH, Bryan , RUDOLTZ, Marc S.
IPC分类号： A01N43/56 , A01N47/28 , C07D231/00
CPC分类号： A61K31/357 , A61K31/337 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1Hpyrazol- 5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.
摘要翻译：本发明涉及抑制TIE2激酶治疗肿瘤生长，侵袭，侵袭，传播，转移和免疫抑制的方法。具体地说，本发明涉及使用1-（3-叔丁基-1-（喹啉-6-基）-1H-吡唑-5-基）-3-（2-氟-4-（2-（甲基氨基甲酰基）吡啶-4-基氧基）苯基）脲及其盐。

3. 发明申请

WO2012092161A3 SYSTEMS AND METHODS FOR UTILIZATION OF RISK ZONES 审中-公开
公开(公告)号：WO2012092161A3
公开(公告)日：2012-07-05
申请号：PCT/US2011/067037
申请日：2011-12-22
申请人： THE TRAVELERS INDEMNITY COMPANY , COLLINS, Dean, M. , SMITH, Bryan , O'CONNER, John
发明人： COLLINS, Dean, M. , SMITH, Bryan , O'CONNER, John
IPC分类号： G06Q50/10 , G01C21/26 , G08G1/0969
摘要： Systems, apparatus, methods, and articles of manufacture that provide for outputting and utilization of risk zone information are provided. In some embodiments, risk zone information may be utilized to select, price, and/or manage an insurance policy.

4. 发明申请

WO2011146466A2 MONITORING CUSTOMER-SELECTED VEHICLE PARAMETERS 审中-公开
标题翻译：监控客户选择的车辆参数
公开(公告)号：WO2011146466A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/036786
申请日：2011-05-17
申请人： THE TRAVELERS COMPANIES, INC. , COLLINS, Dean, M. , SMITH, Bryan , KRYSINSKI, William
发明人： COLLINS, Dean, M. , SMITH, Bryan , KRYSINSKI, William
CPC分类号： G06Q10/10 , G06Q40/08
摘要： Vehicle insurance customers select parameters for monitoring using one or more telematics devices. The parameters may comprise an operating characteristic associated with at least one vehicle associated with an insurance product. In one embodiment, an apparatus causes, based on a user selection of at least one of a plurality of menu-selectable options, a remotely programmable memory of at least one monitoring device to store an indication of the monitoring parameters represented by the user selection.
摘要翻译：车辆保险客户选择使用一个或多个远程信息处理设备进行监控的参数。这些参数可以包括与与保险产品相关联的至少一个车辆相关联的操作特性。在一个实施例中，设备基于用户选择多个菜单可选择选项中的至少一个，使至少一个监视设备的远程可编程存储器存储由用户选择表示的监视参数的指示。

5. 发明申请

WO2006108054A3 DIFFUSION DELIVERY SYSTEM AND METHODS OF FABRICATION 审中-公开
公开(公告)号：WO2006108054A3
公开(公告)日：2006-10-12
申请号：PCT/US2006/012700
申请日：2006-04-05
申请人： THE OHIO STATE UNIVERSITY , FERRARI, Mauro , LIU, Xuewu , SINHA, Piyush Mohan , SMITH, Bryan , SHARMA, Sadhana
发明人： FERRARI, Mauro , LIU, Xuewu , SINHA, Piyush Mohan , SMITH, Bryan , SHARMA, Sadhana
IPC分类号： G01N21/64
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nano engineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.

6. 发明申请

WO2006062500A1 SYSTEM AND PROCESS FOR JOB SCHEDULING TO MINIMIZE CONSTRUCTION COST 审中-公开
标题翻译：作业时间安排的制度和程序，以最小化建筑成本
公开(公告)号：WO2006062500A1
公开(公告)日：2006-06-15
申请号：PCT/US2004/040467
申请日：2004-12-03
申请人： STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION, on behalf of THE UNIVERSITY OF OREGON , BAKER, Andrew, B. , GINSBERG, Matthew, L. , SMITH, Tristan , KEITH, Daniel, B. , PARKES, Andrew, J. , SMITH, Bryan
发明人： BAKER, Andrew, B. , GINSBERG, Matthew, L. , SMITH, Tristan , KEITH, Daniel, B. , PARKES, Andrew, J. , SMITH, Bryan
IPC分类号： G06F17/60
CPC分类号： G06Q10/06
摘要： Increased efficiency and lower cost job scheduling is provided by a system and method that optimizes for cost instead of makespan, and minimizes fluctuations in response utilization. A schedule is constructed using a workflow scheduling system that includes a load leveler (202), a cost minimizer (104), and a manpower planner (106). The load leveler minimizes makespan, subject to resource limits, and then lowers the resource limits, repeating the process in order to create a flatter schedule.
摘要翻译：提高效率和降低成本的作业调度是通过优化成本而不是制造的系统和方法来提供的，并且使响应利用率的波动最小化。使用包括负载均衡器（202），成本最小化器（104）和人力计划器（106）的工作流调度系统构建调度。负载均衡器可以最大程度地减少制造成本，但需要资源限制，然后降低资源限制，重复此过程以创建更平坦的计划。

7. 发明申请

WO2006108053A2 DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION 审中-公开
标题翻译：扩散输送系统和制造方法
公开(公告)号：WO2006108053A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/012699
申请日：2006-04-05
申请人： THE OHIO STATE UNIVERSITY , FERRARI, Mauro , LUI, Xuewu , SINHA, Piyush, Mohan , SMITH, Bryan , SHARMA, Sadhana
发明人： FERRARI, Mauro , LUI, Xuewu , SINHA, Piyush, Mohan , SMITH, Bryan , SHARMA, Sadhana
IPC分类号： H01R13/648
CPC分类号： A61K9/0097 , A61F2/022 , A61M31/002 , A61N1/306 , B82Y30/00
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nano engineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
摘要翻译：本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程装置。该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。本发明还涉及含有扩散递送系统的胶囊。本发明还涉及制造扩散递送系统的方法。

8. 发明申请

WO2002104051A1 METHOD AND APPARATUS FOR A USER TO AVOID UNINTENTIONAL CALLS IN A MOBILE TELEPHONE NETWORK 审中-公开
标题翻译：用于在移动电话网络中避免非正式呼叫的用户的方法和装置
公开(公告)号：WO2002104051A1
公开(公告)日：2002-12-27
申请号：PCT/EP2002/005974
申请日：2002-05-31
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) , SMITH, Bryan
发明人： SMITH, Bryan
IPC分类号： H04Q7/32
CPC分类号： H04W4/02 , H04W88/02 , H04W88/06
摘要： In a mobile telephone network, apparatus and method assist the user of a mobile station registered with a first network (-home network-) to abstain from completing a call when the mobile station gets involved with a foreign/international network other than the first network, which might result in unwanted charges. The mobile station includes first and second settings to identify respectively the first network and the foreign/international network. If the mobile station during roaming is connected to a foreign/international network, before a call is consummated, the mobile station produces an "indication" which may be distinct from a normal ringing tone, e.g., a distinct beep or noise or click or even a vibration of the hand held mobile station casing. Simultaneously and optionally, a graphic display in the user's mobile station indicates the identity of the foreign/international network, to show that the call indeed will be routed through a foreign/international network resulting in additional charges. The user thus has the
摘要翻译：在移动电话网络中，当移动台涉及除了第一网络之外的外国/国际网络时，装置和方法帮助注册在第一网络（-home网络）的移动站的用户不要完成呼叫，这可能会导致不必要的费用。移动台包括分别识别第一网络和外国/国际网络的第一和第二设置。如果漫游期间的移动台连接到外国/国际网络，则在呼叫完成之前，移动台产生可能与正常铃声不同的“指示”，例如，明显的蜂鸣或噪音或点击或甚至手持移动台壳体的振动。同时且可选地，用户移动站中的图形显示器指示外国/国际网络的身份，以显示呼叫确实将通过外部/国际网络路由，导致额外的费用。用户因而拥有

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