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1. 发明申请

WO2005093081A1 PROCESS FOR PREPARING OPTICALLY ACTIVE AMINO ACIDS USING A WHOLE-CELL CATALYST 审中-公开
标题翻译：使用全细胞催化剂制备光活性氨基酸的方法
公开(公告)号：WO2005093081A1
公开(公告)日：2005-10-06
申请号：PCT/EP2005/002933
申请日：2005-03-18
申请人： DEGUSSA AG , GRÖGER, Harald , WERNER, Helge , ALTENBUCHNER, Josef , MENZEL, Anne , HUMMEL, Werner
发明人： GRÖGER, Harald , WERNER, Helge , ALTENBUCHNER, Josef , MENZEL, Anne , HUMMEL, Werner
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12P41/002
摘要： The present invention relates to a process for preparing, in particular, enantiomerically enriched L-α-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are converted into the desired products using a whole-cell catalyst which comprises an amino acid dehydrogenase and a cofactor-regenerating enzyme.
摘要翻译：本发明涉及特别是制备对映体富集的L-α-氨基酸，特别是通式（I）的方法。在这方面，根据本发明的方法使用2-酮羧酸，其使用包含氨基酸脱氢酶和辅因子再生酶的全细胞催化剂转化成所需产物。

2. 发明申请

WO2004085662A1 COUPLED COFACTOR-DEPENDENT ENZYMATIC REACTION SYSTEMS IN AQUEOUS MEDIA 审中-公开
标题翻译：水性媒体中的辅助因子依赖性酶反应体系
公开(公告)号：WO2004085662A1
公开(公告)日：2004-10-07
申请号：PCT/EP2004/002726
申请日：2004-03-17
申请人： DEGUSSA AG , GRÖGER, Harald , ROLLMANN, Claudia , HÜSKEN, Hendrik , WERNER, Helge , CHAMOULEAU, Francoise , HAGEDORN, Chad , DRAUZ, Karlheinz , HUMMEL, Werner
发明人： GRÖGER, Harald , ROLLMANN, Claudia , HÜSKEN, Hendrik , WERNER, Helge , CHAMOULEAU, Francoise , HAGEDORN, Chad , DRAUZ, Karlheinz , HUMMEL, Werner
IPC分类号： C12P7/22
CPC分类号： C12N9/0004 , C12P7/02 , C12P7/22
摘要： The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.
摘要翻译：本申请涉及一种反应体系，其中借助于偶联的酶操作转化方法，可以以高对映异构体浓度获得化学有价值的化合物。偶联的酶反应体系包括有机化合物的辅因子依赖性酶转化和辅因子的酶促再生，其中反应体系在含有高于其溶解度极限的底物量的水溶液中操作。在优选的实施方案中，醇脱氢酶是辅因子依赖性酶，并且辅因子（例如NADH或NADPH）的再生是通过甲酸脱氢酶进行的。

3. 发明申请

WO2003080854A3 PROCESS FOR PREPARING OPTICALLY ACTIVE BETA-AMINOCARBOXYLIC ACIDS FROM RACEMIC N-ACYLATED BETA-AMINOCARBOXYLIC ACIDS 审中-公开
公开(公告)号：WO2003080854A3
公开(公告)日：2003-10-02
申请号：PCT/EP2003/002336
申请日：2003-03-07
申请人： DEGUSSA AG , GRÖGER, Harald , TRAUTHWEIN, Harald , DRAUZ, Karlheinz , BUCHHOLZ, Stefan , SACHERER, Christiane , WERNER, Helge
发明人： GRÖGER, Harald , TRAUTHWEIN, Harald , DRAUZ, Karlheinz , BUCHHOLZ, Stefan , SACHERER, Christiane , WERNER, Helge
IPC分类号： C12P41/00
摘要： A process is described for preparing optically active β-aminocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by enantioselective hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R 1 , R 2 are each selected, independently of one another, from H, halogen, alkyl residues, OH, alkoxy residues and aryloxy residues; R 3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.

4. 发明申请

WO2003040439A2 A PROCESS FOR CRYSTALLISING OXONORLEUCINACETAL 审中-公开
标题翻译：一种结晶过氧化物的方法
公开(公告)号：WO2003040439A2
公开(公告)日：2003-05-15
申请号：PCT/EP2002/010568
申请日：2002-09-20
申请人： DEGUSSA AG , SCHWARM, Michael , ROOS, Jürgen , GRÖGER, Harald , WERNER, Helge , RIPPEL, Corinna
发明人： SCHWARM, Michael , ROOS, Jürgen , GRÖGER, Harald , WERNER, Helge , RIPPEL, Corinna
IPC分类号： C30B
CPC分类号： C07C227/42 , C07C229/22
摘要： The present invention provides a process for crystallising oxonorleucinacetals (Ona) of the general formula (I). In particular, precipitation is performed from an aqueous medium with the addition of organic solvents which do not possess any free hydroxyl groups. This leads, after filtration etc., to a crystalline material with little residual moisture.
摘要翻译：本发明提供了使通式（I）的氧杂亮氨酸缩醛（Ona）结晶的方法。特别地，通过添加不具有任何游离羟基的有机溶剂，从水性介质进行沉淀。这在过滤等之后导致具有很少残留水分的结晶材料。

5. 发明申请

WO2003080854A2 PROCESS FOR PREPARING OPTICALLY ACTIVE BETA-AMINOCARBOXYLIC ACIDS FROM RACEMIC N-ACYLATED BETA-AMINOCARBOXYLIC ACIDS 审中-公开
标题翻译：用于制备来自异构N-酰化的氨基甲酰氧基酸的光学活性的氨基甲酰氧基酸的方法
公开(公告)号：WO2003080854A2
公开(公告)日：2003-10-02
申请号：PCT/EP2003/002336
申请日：2003-03-07
申请人： DEGUSSA AG , GRÖGER, Harald , TRAUTHWEIN, Harald , DRAUZ, Karlheinz , BUCHHOLZ, Stefan , SACHERER, Christiane , WERNER, Helge
发明人： GRÖGER, Harald , TRAUTHWEIN, Harald , DRAUZ, Karlheinz , BUCHHOLZ, Stefan , SACHERER, Christiane , WERNER, Helge
IPC分类号： C12P41/00
CPC分类号： C12P41/007
摘要： A process is described for preparing optically active β-aminocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by enantioselective hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R 1 , R 2 are each selected, independently of one another, from H, halogen, alkyl residues, OH, alkoxy residues and aryloxy residues; R 3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.
摘要翻译：描述了通过生物催化剂在水解酶存在下通过N-酰化的β-氨基羧酸的对映选择性水解从外消旋N-酰化的β-氨基羧酸制备光学活性β-氨基羧酸的方法，其中N-酰基取代基的N-酰化的β-氨基羧酸（I）表示结构I，其中R 1，R 2各自彼此独立地选自H，卤素，烷基残基，OH，烷氧基残基和芳氧基残基 ; R 3选自卤素，烷氧基残基和芳氧基残基; （II）结构IIA或IIB或相应盐的结构或（III）结构III或相应盐的结构。

6. 发明申请

WO2005017171A2 PROCESS FOR THE PRODUCTION OF D-AMINO ACIDS 审中-公开
标题翻译：生产D-氨基酸的方法
公开(公告)号：WO2005017171A2
公开(公告)日：2005-02-24
申请号：PCT/EP2004/009000
申请日：2004-08-12
申请人： DEGUSSA AG , HUMMEL, Werner , GEUEKE, Birgit , KUZU, Mutlu , GRÖGER, Harald
发明人： HUMMEL, Werner , GEUEKE, Birgit , KUZU, Mutlu , GRÖGER, Harald
IPC分类号： C12P13/00
CPC分类号： C12P41/006 , C12P13/04
摘要： The present invention focuses on a process for the production of enantiopure D-amino acids. In particular, a mixture of D- and L-amino acids is treated with an enzymatic reaction system in such a way that the L-form of the amino acid is removed from the system, leaving only the D-form of the amino acid. The present invention also provides a reaction system that operates in such a way and a whole-cell catalyst that can be used for the process according to the invention.
摘要翻译：本发明集中于制备对映体纯的D-氨基酸的方法。具体而言，用酶反应系统处理D-和L-氨基酸的混合物，使得L-型氨基酸从系统中除去，仅留下D-型氨基酸。本发明还提供了以这种方式操作的反应体系和可用于本发明方法的全细胞催化剂。

7. 发明申请

WO2004009825A1 COUPLED ENZYMATIC REACTION SYSTEM USING A FORMATE DEHYDROGENASE DERIVED FROM CANDIDA BOIDINII 审中-公开
标题翻译：使用从坎地迪派生物中衍生出的脱氢酶联合酶联合反应体系
公开(公告)号：WO2004009825A1
公开(公告)日：2004-01-29
申请号：PCT/EP2003/007246
申请日：2003-07-07
申请人： DEGUSSA AG , GRÖGER, Harald , HUMMEL, Werner
发明人： GRÖGER, Harald , HUMMEL, Werner
IPC分类号： C12P1/00
CPC分类号： C12N9/0008 , C12N9/0006 , C12P7/02
摘要： The present process relates to a coupled enzymatic reaction system which is implemented in a two-phase system consisting of organic phase and aqueous phase. The system operates with cofactor-dependent enzymes, the cofactor being continually regenerated enzymatically by an FDH derived from C. boidinii .
摘要翻译：本发明涉及一种在由有机相和水相组成的两相体系中实施的偶联酶反应体系。该系统与辅因子依赖性酶一起运行，辅因子通过来自C. boidinii的FDH酶促连续再生。

8. 发明申请

WO2007028729A1 NOCARDIA GLOBERULA ALCOHOL DEHYDROGENASE AND USE THEREOF 审中-公开
标题翻译： NOCARDIA GLOBERULA酒精脱氢酶及其用途
公开(公告)号：WO2007028729A1
公开(公告)日：2007-03-15
申请号：PCT/EP2006/065712
申请日：2006-08-28
申请人： DEGUSSA AG , HUMMEL, Werner , SCHÜMERS, Julia , GRÖGER, Harald
发明人： HUMMEL, Werner , SCHÜMERS, Julia , GRÖGER, Harald
IPC分类号： C12N9/04 , C12P7/02
CPC分类号： C12P7/26 , C12N9/0006 , C12P7/02 , C12P7/24
摘要： The present invention concerns a Nocardia globulera alcohol dehydrogenase. The invention relates to novel polypeptides having an alcohol dehydrogenase activity, to nucleic acids encoding these polypeptides, to primers or probes for preparing the nucleic acid sequences, to non-human hosts or host cells and to reaction systems that can be used to prepare desired products. Co-factor-dependent alcohol dehydrogenases of this kind can be used advantageously to obtain alcohols, in particular enantiomerically enriched alcohols, which may be useful when employed in organic synthesis, by using a co-factor- regenerating enzyme in a coupled enzymatic system. Alternatively, it is also possible to employ the polypeptides of the invention for the reverse reaction, i.e. oxidation of alcohols with formation of carbonyl compounds.
摘要翻译：本发明涉及诺卡氏球菌醇脱氢酶。本发明涉及具有醇脱氢酶活性的新型多肽，编码这些多肽的核酸，用于制备核酸序列的引物或探针，非人宿主细胞和可用于制备所需产物的反应体系。这种辅因子依赖性醇脱氢酶可以有利地用于获得醇，特别是对映异构体富集的醇，当用于有机合成时，可以通过在偶联的酶系统中使用辅因子再生酶来实现。或者，也可以使用本发明的多肽进行逆反应，即形成羰基化合物的醇的氧化。

9. 发明申请

WO2004009807A1 TWO-PHASE ALCOHOL DEHYDROGENASE-BASED COUPLED ENZYMATIC REACTION SYSTEM 审中-公开
标题翻译：两相酒精脱乙酰基联合酶联免疫反应系统
公开(公告)号：WO2004009807A1
公开(公告)日：2004-01-29
申请号：PCT/EP2003/007248
申请日：2003-07-07
申请人： DEGUSSA AG , GRÖGER, Harald , HUMMEL, Werner
发明人： GRÖGER, Harald , HUMMEL, Werner
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/02 , Y02E50/17
摘要： The present process relates to a coupled enzymatic reaction system which is implemented in a two-phase system consisting of organic phase and aqueous phase. The system operates with cofactor-dependent enzymes, the cofactor being continually regenerated enzymatically. The key enzyme is the alcohol dehydrogenase.
摘要翻译：本方法涉及一种在由有机相和水相组成的两相体系中实施的偶联酶反应体系。该系统使用辅因子依赖性酶进行操作，辅酶被酶促持续再生。关键酶是醇脱氢酶。

10. 发明申请

WO2003091423A1 ADH FROM RHODOCOCCUS ERYTHROPOLIS 审中-公开
标题翻译： ADH从RHODOCOCCUS ERYTHROPOLIS
公开(公告)号：WO2003091423A1
公开(公告)日：2003-11-06
申请号：PCT/EP2003/003375
申请日：2003-04-01
申请人： DEGUSSA AG , HUMMEL, Werner , ABOKITSE, Kofi , GRÖGER, Harald
发明人： HUMMEL, Werner , ABOKITSE, Kofi , GRÖGER, Harald
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/02 , C12P41/002
摘要： The present invention relates to an alcohol dehydrogenase from Rhodococcus erythropolis. By means of such cofactor-dependent ADHs, chiral alcohols which can be of use for use in organic syntheses can advantageously be obtained with a cofactor-regenerating enzyme in a coupled enzymatic system. A nucleotide sequence, vehicles containing this, a polypeptide sequence and processes for mutation and use of the sequences are claimed.
摘要翻译：本发明涉及红球菌红细胞的醇脱氢酶。通过这种辅因子依赖性ADH，可以有利地在辅助酶系统中用辅因子再生酶获得可用于有机合成的手性醇。要求保护核苷酸序列，含有该载体的载体，多肽序列和突变和使用序列的方法。

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