专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005021771A3 PROCESS FOR THE PRODUCTION OF L-LYSINE 审中-公开
标题翻译：生产L-赖氨酸的方法
公开(公告)号：WO2005021771A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004009385
申请日：2004-08-23
申请人： DEGUSSA , PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
发明人： PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
IPC分类号： C12P13/08
CPC分类号： C12P13/08
摘要： The invention relates to an improved process for the production of L-lysine by fermentation using L-lysine-producing coryneform bacteria.
摘要翻译：本发明涉及通过使用L-赖氨酸生产的棒状细菌发酵生产L-赖氨酸的改进方法。

2. 发明申请

WO03023016A2 METHOD FOR PRODUCING FINE CHEMICALS 审中-公开
标题翻译：生产精细化学品的方法
公开(公告)号：WO03023016A2
公开(公告)日：2003-03-20
申请号：PCT/EP0210174
申请日：2002-09-11
申请人： DEGUSSA , FARWICK MIKE , HERMANN THOMAS
发明人： FARWICK MIKE , HERMANN THOMAS
IPC分类号： C12N1/15 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/88 , C12P13/08 , C12N1/00
CPC分类号： C12N9/93 , C12N9/0006 , C12N9/88 , C12P13/08
摘要： The present invention relates to genetically modified microorganisms, in particular coryneform bacteria and Escherichia coli, in which the phosphorylation state of proteins or polypeptides has been changed such that the bacteria produce a larger amount of a desired fine chemical or a metabolite than the wild type, and to a method for the production of fine chemicals or metabolites.
摘要翻译：本发明涉及基因修饰的微生物，特别是棒状杆菌和大肠杆菌，其中蛋白质或多肽的磷酸化状态已经改变，使得细菌产生比野生型更大量的期望的精细化学品或代谢物，并涉及生产精细化学品或代谢物的方法。

3. 发明申请

WO0229080A3 FERMENTATION PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE FAMILY ENTEROBACTERIACEAE 审中-公开
标题翻译：使用家禽肠杆菌菌株制备L-氨基酸的发酵方法
公开(公告)号：WO0229080A3
公开(公告)日：2002-09-26
申请号：PCT/EP0110209
申请日：2001-09-05
申请人： DEGUSSA
发明人： RIEPING MECHTHILD , BASTUCK CHRISTINE , HERMANN THOMAS , THIERBACH GEORG
IPC分类号： C12N15/52 , C12N15/60 , C12P13/06 , C12P13/08 , C12P13/04 , C12N1/21 , C12N15/11
CPC分类号： C12R1/19 , C12N15/52 , C12P13/06 , C12P13/08
摘要： The invention relates to a fermentation process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-amino acid, in which microorganisms at least the pckA gene and/or the open reading frames yjfA and ytfP are, individually or jointly, attenuated and, in particular, switched off, b) enrichment of the L-amino acid in the medium or in the bacterial cells, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及一种用于制备L-氨基酸，特别是L-苏氨酸的发酵方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物发酵，其中至少pckA基因和/或开放阅读框yjfA和ytfP的微生物单独或共同减弱，特别是关闭，b）富集培养基或细菌细胞中的L-氨基酸，以及 c）分离L-氨基酸。

4. 发明申请

WO2005014843A3 A PROCESS FOR PREPARING L-THREONINE 审中-公开
标题翻译：一种制备L-苏氨酸的方法
公开(公告)号：WO2005014843A3
公开(公告)日：2005-05-19
申请号：PCT/EP2004008470
申请日：2004-07-29
申请人： DEGUSSA , KRUSE DANIELA , HERMANN THOMAS , THIERBACH GEORG , RIEPING MECHTHILD
发明人： KRUSE DANIELA , HERMANN THOMAS , THIERBACH GEORG , RIEPING MECHTHILD
IPC分类号： C12P13/08 , C12N15/00
CPC分类号： C12P13/04 , C12P13/08 , C12R1/19
摘要： The invention provides an improved process for the fermentative preparation of L-threonine using L-threonine-producing bacteria from the family Enterobacteriaceae.
摘要翻译：本发明提供了使用来自肠杆菌科的L-苏氨酸生产菌来发酵制备L-苏氨酸的改进方法。

5. 发明申请

WO02072840A3 PROCESS FOR THE FERMENTATIVE PRODUCTION OF D-PANTOTHENIC ACID 审中-公开
标题翻译： D-泛酸的生产方法
公开(公告)号：WO02072840A3
公开(公告)日：2003-08-28
申请号：PCT/EP0200213
申请日：2002-01-11
申请人： DEGUSSA
发明人： RIEPING MECHTHILD , HERMANN THOMAS , PFEFFERLE WALTER
IPC分类号： A23K20/174 , C12N1/21 , C12N15/52 , C12N15/54 , C12P13/02 , A23K1/16 , C12N9/10 , C12N15/70
CPC分类号： C12P13/02 , A23K20/174 , C12N15/52
摘要： The invention provides a process for the enzymatic production of D-pantothenic acid and/or its salts or feedstuffs additives containing the latter by fermentation of microorganisms of the family Enterobacteriaceae, in particular those that already produce D-pantothenic acid, wherein the nucleotide sequence(s) coding for the serC gene is/are enhanced, in particular overexpressed, in the microorganisms.
摘要翻译：本发明提供了通过发酵肠杆菌科的微生物，特别是已经生产D-泛酸的微生物来酶促生产D-泛酸和/或其盐或饲料添加剂的方法，其中核苷酸序列（ s）编码serC基因在微生物中被增强，特别是过表达。

6. 发明申请

WO03008603A3 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERI ACEA FAMILY WHICH CONTAIN AN ATTENUATED ASPA GENE 审中-公开
标题翻译：使用含有ASPA基因的肠内寄生虫家系的菌株制备L-氨基酸的方法
公开(公告)号：WO03008603A3
公开(公告)日：2003-07-31
申请号：PCT/EP0207351
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/22 , C12P13/24
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aspA gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及一种制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物发酵，其中所述aspA基因或其编码的核苷酸序列被减弱，特别是被消除，b）所述L-氨基酸在培养基中或细菌中的浓度，和c）L-氨基酸的分离。

7. 发明申请

WO03008616A2 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ATTENUATED aceK GENE 审中-公开
标题翻译：使用含有减毒的aceK基因的肠杆菌属家族的菌株制备L-氨基酸的方法
公开(公告)号：WO03008616A2
公开(公告)日：2003-01-30
申请号：PCT/EP0207353
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aceK gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物的发酵，并且其中 aceK基因或编码它的核苷酸序列被减弱，特别是被消除，b）L-氨基酸在培养基或细菌细胞中的浓度，以及c）分离L-氨基酸。

8. 发明申请

WO03008604A2 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ATTENUATED ACEB GENE 审中-公开
标题翻译：使用含有ACEB基因的肠杆菌家族的菌株制备L-氨基酸的方法
公开(公告)号：WO03008604A2
公开(公告)日：2003-01-30
申请号：PCT/EP0207352
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08 , C12P13/00
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aceB gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及一种制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物发酵，其中 aceB基因或其编码的核苷酸序列被减弱，特别是消除，b）L-培养基或细菌细胞中L-氨基酸的浓度，和c）L-氨基酸的分离。

9. 发明申请

WO02074966A2 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS BY USING CORYNEFORM BACTERIA 审中-公开
标题翻译：通过使用CORYNEFORM BACTERIA制备L-氨基酸的方法
公开(公告)号：WO02074966A2
公开(公告)日：2002-09-26
申请号：PCT/EP0202568
申请日：2002-03-08
申请人： DEGUSSA
发明人： FARWICK MIKE , BATHE BRIGITTE , HERMANN THOMAS , PFEFFERLE WALTER
IPC分类号： C12N1/21 , C12N9/88 , C12N15/60 , C12P13/08 , C12N1/20 , C12P13/04
CPC分类号： C12R1/15 , C12N9/88 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, wherein the following steps are implemented: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the fda gene is attenuated, b) enrichment of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and optionally bacteria are employed in which, in addition, further genes of the biosynthetic pathway of the desired L-amino acid are enhanced, or bacteria are employed in which the metabolic pathways that diminish the formation of the desired L-amino acid are at least partly switched off.
摘要翻译：本发明涉及一种制备L-氨基酸的方法，其中实施以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中至少fda基因被减弱，b）富集在培养基或细菌细胞中的所需L-氨基酸，和c）分离L-氨基酸，并且任选地使用细菌，其中另外还需要所需L的生物合成途径的其它基因 - 氨基酸被增强，或者使用细菌，其中减少所需L-氨基酸形成的代谢途径至少部分地被切断。

10. 发明申请

WO0218428A2 SEQUENCES WHICH CODE FOR THE SIGE GENE 审中-公开
标题翻译：序列符号代码
公开(公告)号：WO0218428A2
公开(公告)日：2002-03-07
申请号：PCT/EP0108146
申请日：2001-07-14
申请人： DEGUSSA
发明人： MOECKEL BETTINA , HERMANN THOMAS , FARWICK MIKE , BINDER MICHAEL , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12N1/21 , C12P13/08 , C07K14/195
CPC分类号： C12R1/15 , C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the sigE gene is present in enhanced form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码多肽的多核苷酸的程度相同，所述多核苷酸包含SEQ ID No的氨基酸序列 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少sigE 基因以增强形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式