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1. 发明申请

WO2005062057A1 KONJUGATE UND DEREN VERWENDUNG IN NACHWEISVERFAHREN 审中-公开
标题翻译：偶联物及其它们在检测方法
公开(公告)号：WO2005062057A1
公开(公告)日：2005-07-07
申请号：PCT/EP2004/012647
申请日：2004-11-09
申请人： DADE BEHRING MARBURG GMBH , TRIER, Michael , SCHELP, Carsten , ACKERMANN, Harald , HALL, Lee , SINGH, Pratap , SWANN, Susan
发明人： TRIER, Michael , SCHELP, Carsten , ACKERMANN, Harald , HALL, Lee , SINGH, Pratap , SWANN, Susan
IPC分类号： G01N33/58
CPC分类号： G01N33/533 , G01N33/536 , G01N33/542 , G01N33/582
摘要： Die Erfindung betrifft Verfahren zum quantitativen oder qualitativen Nachweis eines Analyten in einer Probe und geeignete Reagenzien hierfür, insbesondere ein Trägermolekül, an das ein oder mehrere analytspezifische Bindungspartner gebunden sind und das zusätzliche Bindungsstellen für einen spezifischen Bindungspartner X oder Y aufweist, der mit einer Komponente eines signalbildenden System assoziiert ist, und die Verwendung eines solchen Konjugates insbesondere in homogenen Bindungstesten.
摘要翻译：本发明涉及一种用于此目的的样本中的分析物的定性或定量检测的方法和适当的试剂，特别是载体分子，其中一个或多个分析物特异性的结合配偶体结合，并且具有用于特异性结合配偶X或Y中，一个与组件的额外的结合位点信号产生系统相关联，并且使用这样的缀合物，特别是在均匀的结合测定法。

2. 发明申请

WO2010104683A1 IMMUNOASSAYS EMPLOYING NON-PARTICULATE CHEMILUMINESCENT REAGENT 审中-公开
标题翻译：免费使用非颗粒性发光试剂
公开(公告)号：WO2010104683A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/025433
申请日：2010-02-25
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , SINGH, Pratap , ZHENG, Yi, Feng , GENG, Liping , JANZEN, Roland , SCHELP, Carsten
发明人： SINGH, Pratap , ZHENG, Yi, Feng , GENG, Liping , JANZEN, Roland , SCHELP, Carsten
IPC分类号： G01N33/50
CPC分类号： G01N33/78 , G01N33/582 , G01N2333/59
摘要： Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
摘要翻译：公开了用于进行测定的方法和试剂。本发明方法和试剂的实施方案涉及用于确定怀疑含有分析物的样品中分析物的存在和/或量的化学发光试剂。试剂是非颗粒的并且包含用于分析物的结合配偶体和包含烯属化合物和金属螯合物的化学发光组合物。在测定的实施方案中，提供了包含疑似含有分析物的样品，如上所述的化学发光试剂和能够产生单线态氧的敏化剂的组合。该组合经受用于将分析物与分析物的结合配偶体结合的条件。敏化剂被激活，并且检测由化学发光组合物产生的发光量，其中发光量与样品中分析物的量相关。

3. 发明申请

WO2007113066A1 GAS-FILLED SACHET 审中-公开
标题翻译：气体填充SACHET
公开(公告)号：WO2007113066A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/052093
申请日：2007-03-06
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN UNILEVER LIMITED , DEEP, Gagan , SINGH, Pratap , THORAT, Abhay Parkash
发明人： DEEP, Gagan , SINGH, Pratap , THORAT, Abhay Parkash
IPC分类号： B65B9/00 , B65B9/02 , B65B9/20 , B65D81/20 , B65D81/32 , B65D75/58 , A61Q11/00 , B65D75/48 , B65D35/24
CPC分类号： B29C66/4312 , B29C65/04 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/18 , B29C65/3656 , B29C65/368 , B29C65/7451 , B29C65/7457 , B29C66/004 , B29C66/1122 , B29C66/133 , B29C66/244 , B29C66/348 , B29C66/43129 , B29C66/4322 , B29C66/71 , B29C66/712 , B29C66/72321 , B29C66/81427 , B29C66/81431 , B29C66/81433 , B29C66/83221 , B29C66/849 , B65B9/2056 , B65B9/213 , B65B51/303 , B65B61/007 , B65B61/18 , B65B2220/08 , B65D75/48 , B65D75/5811 , B65D81/2084 , B29K2023/00 , B29K2023/06 , B29K2023/0633 , B29K2023/12 , B29K2067/00 , B29K2067/003 , B29K2077/00
摘要： A gas-filled sachet containing an extrudable composition, said composition comprising plurality of distinct phases that are not separated by a barrier.
摘要翻译：一种含有可挤出组合物的充气小袋，所述组合物包含多个不被隔离物隔开的不同相。

4. 发明申请

WO2008057767A2 REDUCTION OF NON-SPECIFIC BINDING IN IMMUNOASSAYS 审中-公开
标题翻译：减少免疫接种中的非特异性结合
公开(公告)号：WO2008057767A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/082364
申请日：2007-10-24
申请人： DADE BEHRING INC. , WEI, Tie , SINGH, Pratap , DUFFY, James , POSEY, Amy
发明人： WEI, Tie , SINGH, Pratap , DUFFY, James , POSEY, Amy
IPC分类号： G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/535 , G01N33/563 , G01N33/566
CPC分类号： G01N33/54313 , C07K16/26 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample wherein one of the reagents for conducting the binding assay is an antibody reagent. The methods comprise treating the antibody reagent at a pH of about 2.0 to about 3.5. The method may further comprise treating the antibody reagent with a reducing agent in an amount sufficient to reduce non-specific binding of the antibody reagent. In some embodiments the reducing agent may be a thiol-containing reducing agent or a combination of two or more thiol-containing reducing agents.
摘要翻译：公开了用于减少用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的一种试剂是抗体试剂。该方法包括在约2.0至约3.5的pH下处理抗体试剂。该方法可以进一步包括用足以减少抗体试剂的非特异性结合的量的还原剂处理抗体试剂。在一些实施方案中，还原剂可以是含巯基的还原剂或两种或更多种含巯基还原剂的组合。

5. 发明申请

WO2013096528A1 COATED SUBSTRATES FOR HIGH ENERGY CAPTURE PHASE BINDING AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：用于高能量捕获相结合的涂覆基材及其生产和使用方法
公开(公告)号：WO2013096528A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/070763
申请日：2012-12-20
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , PUGIA, Michael, J. , SINGH, Pratap
发明人： PUGIA, Michael, J. , SINGH, Pratap
IPC分类号： G06F19/20 , C40B60/00 , C40B60/12 , B05D3/00
CPC分类号： G01N33/54306 , B01J19/0046 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , C40B60/12 , G01N33/54393
摘要： A substrate, which is useful for performing biological, chemical and diagnostic assays, and a method for preparing the substrate are provided. The substrate has an upper surface with a coating disposed thereon. The coating comprises a charged polymer, a non- ionic polyether, and a silicate compound. The substrate can increase capture phase binding and reduce non-specific binding of biomolecules for a biological microarray.
摘要翻译：提供了可用于进行生物，化学和诊断测定的底物和制备基质的方法。基板具有设置在其上的涂层的上表面。涂层包含带电聚合物，非离子聚醚和硅酸盐化合物。底物可以增加捕获相结合并降低生物微阵列的生物分子的非特异性结合。

6. 发明申请

WO2009146166A2 BIOTIN-RECEPTOR REAGENTS FOR SENSITIVITY MODULATION IN ASSAYS 审中-公开
标题翻译：用于测定灵敏度调节的生物受体试剂
公开(公告)号：WO2009146166A2
公开(公告)日：2009-12-03
申请号：PCT/US2009/040465
申请日：2009-04-14
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , LEWISCH, Sandra, A. , SINGH, Pratap , DESAI, Viral , KRAKOWSKI, Karen, L. , DUFFY, James, E.
发明人： LEWISCH, Sandra, A. , SINGH, Pratap , DESAI, Viral , KRAKOWSKI, Karen, L. , DUFFY, James, E.
IPC分类号： G01N33/536 , G01N33/566
CPC分类号： G01N33/532 , G01N33/54393 , G01N33/566
摘要： Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophiHcity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody to obtain an optimum assay sensitivity and/or dynamic range. In some embodiments the method comprises preparing two or more conjugates by selecting a set of parameters for each conjugate wherein the set of parameters is different for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要翻译：公开了设计用于分析物检测以获得最佳测定灵敏度和/或动态范围的测定中的抗体试剂的方法。抗体试剂是通过间隔基团与分析物的抗体连接的小分子的缀合物。该方法包括在共轭物的制备中控制包含间隔基团的疏水性或亲水性，间隔基团的长度，与抗体连接的小分子的分子数目和小分子到抗体以获得最佳测定灵敏度和/或动态范围。在一些实施方案中，该方法包括通过为每个缀合物选择一组参数来制备两种或更多种缀合物，其中该组参数对于每个缀合物是不同的，使用每个缀合物进行分析物的测定，并选择用于测定缀合物提供最佳测定灵敏度和/或动态范围。

7. 发明申请

WO2005103697A2 IMMUNOASSAYS FOR BUPRENORPHINE AND NORBUPRENORPHINE 审中-公开
标题翻译：抗胰蛋白酶和诺布啡宁的免疫抑制剂
公开(公告)号：WO2005103697A2
公开(公告)日：2005-11-03
申请号：PCT/US2005/010880
申请日：2005-03-31
申请人： DADE BEHRING INC. , ZHENG, Yi, Feng , LIU, Hshiou-ting , SINGH, Pratap , BOLLE, Dorota
发明人： ZHENG, Yi, Feng , LIU, Hshiou-ting , SINGH, Pratap , BOLLE, Dorota
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , G01N33/9486
摘要： Methods, compositions and kits are disclosed directed at haptens, immunogens and immnoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) or norbuprenorphine (norBUP) and (ii) an antibody raised against an immunogen of buprenorphine (BUP) or norbuprenorphine (norBUP). The medium is examined for the presence of a complex comprising a labeled hapten of buprenorphine (BUP) or norbuprenorphine (norBUP) where the presence of such as complex indicates the presence of the compound in the sample.
摘要翻译：公开了针对丁丙诺啡（BUP）和丁丙诺啡（norBUP）的半抗原，免疫原和免疫测定法的方法，组合物和试剂盒。该方法包括在介质中提供（i）怀疑含有丁丙诺啡（BUP）或降丁非诺（norBUP））的样品和（ii）针对丁丙诺啡（BUP）或去诺贝芬（norBUP）的免疫原产生的抗体。检查培养基中是否存在包含丁丙诺啡（BUP）或降丁非诺（norBUP）的标记半抗原的复合物，其中诸如复合物的存在表明样品中存在化合物。

8. 发明申请

WO2013101265A1 REDUCING NON-COVALENTLY BOUND POLYSACCHARIDE ON SUPPORTS 审中-公开
标题翻译：在支持下减少非共轭多糖
公开(公告)号：WO2013101265A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/025342
申请日：2012-02-16
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , LELE, Bhalchandra , SINGH, Pratap , CHATTERJEE, Asoke
发明人： LELE, Bhalchandra , SINGH, Pratap , CHATTERJEE, Asoke
IPC分类号： C07H1/00 , B05D3/00
CPC分类号： C08B37/0021 , C08B37/00 , C08L5/06 , C08L25/06
摘要： Methods and reagents are disclosed for reducing an amount of non-covalently bound polysaccharide on a support. The method comprises contacting a support comprising both covalently bound polysaccharide and non-covalently bound polysaccharide with an aqueous solution comprising an amount of a chaotropic agent effective to remove non-covalently bound polysaccharide from the support.
摘要翻译：公开了减少载体上非共价结合多糖的量的方法和试剂。该方法包括将包含共价结合的多糖和非共价结合的多糖的载体与包含一定量的有效从载体中除去非共价结合的多糖的离液剂的水溶液接触。

9. 发明申请

WO2011159548A1 COMPOSITION FOR USE AS AN ASSAY REAGENT 审中-公开
标题翻译：用作测定试剂的组合物
公开(公告)号：WO2011159548A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/039825
申请日：2011-06-09
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , LELE, Bhalchandra , SINGH, Pratap , BARTZ, Raphael , KELLOGG, Jason, A.
发明人： LELE, Bhalchandra , SINGH, Pratap , BARTZ, Raphael , KELLOGG, Jason, A.
IPC分类号： A61K9/00
CPC分类号： C09D133/26 , C08F120/60 , C08F126/10 , C08F220/06 , C08F220/26 , C08F220/38 , C08F220/58 , C08F2800/20 , C09D139/06 , C09D177/06 , C09D179/04 , C09D181/00 , G01N33/533 , G01N33/582
摘要： A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.
摘要翻译：用作测定试剂的组合物包括固体支持物，其包括信号产生系统的成员和合成共聚物的涂层。合成共聚物包含第一聚合单体，其包括包含反应性官能团或反应性官能团的衍生物的侧基部分和包含至少包含1个碳原子和至少2个杂原子的侧链部分的第二聚合单体。在一些实施方案中，共聚物包含包含侧链部分的聚乙烯主链，其包含反应性官能团或反应性官能团的衍生物，并且所述侧链部分包含至少1个碳原子和至少2个杂原子。

10. 发明申请

WO2006018140A1 IMPROVED PACKAGE 审中-公开
标题翻译：改进的包装
公开(公告)号：WO2006018140A1
公开(公告)日：2006-02-23
申请号：PCT/EP2005/008437
申请日：2005-08-03
申请人： UNILEVER PLC , UNILEVER NV , HINDUSTAN LEVER LIMITED , DEEP, Gagan , KUMAR, Amit , RAMASWAMY, Siddharth , SINGH, Pratap
发明人： DEEP, Gagan , KUMAR, Amit , RAMASWAMY, Siddharth , SINGH, Pratap
IPC分类号： B65B9/02
CPC分类号： B65B9/02 , B65B61/065
摘要： The invention provides a process for the manufacture of sachets (1) in a plurality of lanes in a form fill and seal machine, one or more edges of said sachets comprising non-linear profiles (7) over at least 10% of the length of the edge, said sachets manufactured by a process comprising: (i) sealing two films (9,10) in the longitudinal direction to form a plurality of tubes parallel to each other; (ii) sealing the tubes along one end; (iii) filling the tubes with the desired material; (iv) sealing the tubes at the second end to form a plurality of sachets (1), and (v) punching out portions (8) of the sealed edges of the sachets to define the non-linear edges (7).
摘要翻译：本发明提供一种用于在成型填充和密封机器的多个通道中制造小袋（1）的方法，所述小袋的一个或多个边缘包括非线性轮廓（7）的至少10％边缘，所述小袋通过包括以下步骤的方法制造：（i）在纵向方向上密封两个膜（9,10）以形成彼此平行的多个管; （ii）沿着一端密封管子; （iii）用所需材料填充管子; （iv）在第二端处密封管以形成多个小袋（1），和（v）冲压小袋密封边缘的部分（8）以限定非线性边缘（7）。

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