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1. 发明申请

WO2008057767A2 REDUCTION OF NON-SPECIFIC BINDING IN IMMUNOASSAYS 审中-公开
标题翻译：减少免疫接种中的非特异性结合
公开(公告)号：WO2008057767A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/082364
申请日：2007-10-24
申请人： DADE BEHRING INC. , WEI, Tie , SINGH, Pratap , DUFFY, James , POSEY, Amy
发明人： WEI, Tie , SINGH, Pratap , DUFFY, James , POSEY, Amy
IPC分类号： G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/535 , G01N33/563 , G01N33/566
CPC分类号： G01N33/54313 , C07K16/26 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample wherein one of the reagents for conducting the binding assay is an antibody reagent. The methods comprise treating the antibody reagent at a pH of about 2.0 to about 3.5. The method may further comprise treating the antibody reagent with a reducing agent in an amount sufficient to reduce non-specific binding of the antibody reagent. In some embodiments the reducing agent may be a thiol-containing reducing agent or a combination of two or more thiol-containing reducing agents.
摘要翻译：公开了用于减少用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的一种试剂是抗体试剂。该方法包括在约2.0至约3.5的pH下处理抗体试剂。该方法可以进一步包括用足以减少抗体试剂的非特异性结合的量的还原剂处理抗体试剂。在一些实施方案中，还原剂可以是含巯基的还原剂或两种或更多种含巯基还原剂的组合。

2. 发明申请

WO1988001696A1 TROCHOIDAL GAS PROCESSING DEVICES 审中-公开
标题翻译： TROCHOIDAL气体加工装置
公开(公告)号：WO1988001696A1
公开(公告)日：1988-03-10
申请号：PCT/US1986001837
申请日：1986-09-05
申请人： DUFFY, James, T.
IPC分类号： F04C18/22
CPC分类号： F01C21/18 , F01C1/22
摘要： A trochoid-type rotary piston gas processing device comprising a stationary housing (1) having a continuous epitrochoidal sidewall including two semicircular lobes (11, 12) which intersect at a pair of opposed transition edges (13, 14), rotary piston means (3) having three flank surfaces (26, 27, 28) and rotatably received in the housing on an eccentric portion (5) of a crank shaft (4), one of said flank surfaces always being in engagement with at least one of said transition edges, cooperative mating gear means (26A, 30) on said housing and piston means to control rotation of said piston means and a gas inlet (42) and outlet (41) to each of said lobes. Sealing fluid (90) is admitted between the rotor means and housing. The housing sidewall and piston flank surfaces may be composed of a series of parallel planar surfaces (11A, 26A, 28A) and valve plate means (51, 71, 78, 83) may control the fluid to the gas inlets. The device may operate as a compressor, expander, or vacuum pump.
摘要翻译：一种次摆线式旋转活塞气体处理装置，包括具有连续外旋轴承侧壁的固定壳体（1），该侧壁包括两个在一对相对的过渡边缘（13,14）处相交的半圆形凸角（11,12），旋转活塞装置）具有三个侧面（26,27,28），并且可旋转地容纳在所述壳体中的曲柄轴（4）的偏心部分（5）上，所述侧面之一总是与所述过渡边缘，所述壳体上的协同配合齿轮装置（26A，30）和用于控制所述活塞装置的旋转的活塞装置和用于每个所述凸角的气体入口（42）和出口（41）。密封流体（90）进入转子装置和壳体之间。壳体侧壁和活塞侧面可以由一系列平行的平坦表面（11A，26A，28A）组成，阀板装置（51,71,78,83）可以将流体控制到气体入口。该装置可以作为压缩机，膨胀机或真空泵操作。

3. 发明申请

WO2008107478A1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS 审中-公开
标题翻译：喹诺酮衍生物作为PARP和坦克抑制剂
公开(公告)号：WO2008107478A1
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052764
申请日：2008-03-07
申请人： JANSSEN PHARMACEUTICA NV , VIALARD, Jorge Eduardo , ANGIBAUD, Patrick René , MEVELLEC, Laurence Anne , MEYER, Christophe , FREYNE, Eddy Jean Edgard , PILATTE, Isabelle Noëlle Constance , ROUX, Bruno , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ADELINET, Christophe Denis , MARCONNET-DECRANE, Laurence Françoise Bernadette , MACRITCHIE, Jacqueline Anne , DUFFY, James Edward Stewart , OWENS, Andrew Pate , STORCK, Pierre-Henri , PONCELET, Virginie Sophie
发明人： VIALARD, Jorge Eduardo , ANGIBAUD, Patrick René , MEVELLEC, Laurence Anne , MEYER, Christophe , FREYNE, Eddy Jean Edgard , PILATTE, Isabelle Noëlle Constance , ROUX, Bruno , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ADELINET, Christophe Denis , MARCONNET-DECRANE, Laurence Françoise Bernadette , MACRITCHIE, Jacqueline Anne , DUFFY, James Edward Stewart , OWENS, Andrew Pate , STORCK, Pierre-Henri , PONCELET, Virginie Sophie
IPC分类号： C07D215/22 , A61K31/4704
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , n, m and X have defined meanings.
摘要翻译：本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述化合物的药物组合物，其中R 1，R 2， R 3，R 4，R 5，R 6，R 7，R 7，R 7， / sup>，n，m和X定义了含义。

4. 发明申请

WO2007118903A1 TRISUBSTITUTED 1,2,4-TRIAZOLES 审中-公开
标题翻译：分离的1,2,4-TRIAZOLES
公开(公告)号：WO2007118903A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053829
申请日：2007-04-19
申请人： JANSSEN PHARMACEUTICA N.V. , THURING, Johannes Wilhelmus John F. , MACDONALD, Gregor, James , LESAGE, Anne Simone Josephine , ZHUANG, Wei , DE BRUYN, Marcel Frans Leopold , VAN DEN KEYBUS, Frans Alfons Maria , VAN ROOSBROECK, Yves Emiel Maria , DINKLO, Theodorus , DUFFY, James Edward Stewart
发明人： THURING, Johannes Wilhelmus John F. , MACDONALD, Gregor, James , LESAGE, Anne Simone Josephine , ZHUANG, Wei , DE BRUYN, Marcel Frans Leopold , VAN DEN KEYBUS, Frans Alfons Maria , VAN ROOSBROECK, Yves Emiel Maria , DINKLO, Theodorus , DUFFY, James Edward Stewart
IPC分类号： C07D401/04 , C07D249/08 , C07D405/04 , A61K31/4196 , A61P25/00
CPC分类号： C07D249/08 , C07D249/14 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D491/044 , C07D491/048
摘要： The present invention relates to 3-aniIine-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
摘要翻译：本发明涉及3-苯胺-5-芳基三唑衍生物及其类似物或药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途，根据式（I）。本发明特别涉及烟碱乙酰胆碱受体的正变构调节剂，这种正变构调节剂具有增加烟碱受体激动剂功效的能力。

5. 发明申请

WO1983003581A1 SPEED SENSITIVE POWER STEERING PUMP UNLOAD VALVE 审中-公开
标题翻译：速度敏感动力转向泵卸载阀
公开(公告)号：WO1983003581A1
公开(公告)日：1983-10-27
申请号：PCT/US1982000486
申请日：1982-04-16
申请人： FORD MOTOR COMPANY , FORD-WERKE AKTIENGESELLSCHAFT , FORD FRANCE S.A. , FORD MOTOR COMPANY LIMITED , DUFFY, James, J.
发明人： FORD MOTOR COMPANY , FORD-WERKE AKTIENGESELLSCHAFT , FORD FRANCE S.A. , FORD MOTOR COMPANY LIMITED
IPC分类号： B62D05/04
CPC分类号： F04C14/26 , B62D6/02
摘要： A positive displacement pump for a vehicle power steering system comprising a rotor (42) rotatable in and cooperating with a stator (20) to define a pump cavity (52), (54), inlet and outlet ports (56), (58) and (34), (36) communicating with the pump cavity and a flow control valve (96) located in the flow delivery circuit wherein provision is made for opening the flow delivery ciruit to a bypass circuit (72) upon an increase in the speed of the vehicle beyond a design point thereby reducing the pump back pressure and power usage which results in incrased "road feel" at increased speeds while maintaining normal power assist during steering maneuvers at low speeds.
摘要翻译：一种用于车辆动力转向系统的容积式泵，包括可旋转并与定子（20）配合以定义泵腔（52），（54），入口和出口（56），（58）的转子（42）和与泵腔连通的（34），（36）和位于流量输送回路中的流量控制阀（96），其中设置用于在速度增加时将流量传递电路打开到旁路回路（72）的车辆超出设计点，从而减少了泵背压和动力使用，导致在增加的速度下增加了“道路感觉”，同时在低速的转向机动过程中保持正常的动力辅助。

6. 发明申请

WO1986005840A1 FLUID EXPANSION DEVICE 审中-公开
标题翻译：流体膨胀装置
公开(公告)号：WO1986005840A1
公开(公告)日：1986-10-09
申请号：PCT/US1985000521
申请日：1985-03-25
申请人： DUFFY, James, T.
IPC分类号： F01C01/22
CPC分类号： F01C1/22 , F01C21/18
摘要： A trochoid-type rotary piston gas expansion device including a stationary housing and endwalls (7, 8) defining an epitrochoidal cavity closing, a rotatable crank shaft (4) extending through the cavity, a rotary piston (2) mounted on an eccentric portion of the shaft. At least two inlets (21, 22) are provided to the stationary housing to admit a compressed/expandable fluid into the chamber defined between the trochoidal cavity and a surface of the piston where the piston is in a first segment of its arc of rotation and outlets from the cavity for emission of fluid from the stationary housing when the piston is in a selected position in its arc of rotation. A rotary valve member (51) is provided outside the housing to be rotated by the shaft having a valve port communicating with a supply of compressed fluid and periodically coming in alignment with the inlet to the chamber to sequentially open and close the inlet to the chamber.

7. 发明申请

WO1983004008A1 SPEED SENSITIVE POWER STEERING SYSTEM 审中-公开
标题翻译：速度敏感动力转向系统
公开(公告)号：WO1983004008A1
公开(公告)日：1983-11-24
申请号：PCT/US1982000687
申请日：1982-05-19
申请人： FORD-WERKE AKTIENGESSELSCHAFT , FORD MOTOR COMPANY LIMITED , FORD MOTOR COMPANY , DUFFY, James, J.
发明人： FORD-WERKE AKTIENGESSELSCHAFT , FORD MOTOR COMPANY LIMITED , FORD MOTOR COMPANY
IPC分类号： B62D05/08
CPC分类号： B62D6/02
摘要： A power steering mechanism for controlling the dirigible wheels of an automotive vehicle comprising a fluid motor that provides a power assist to manual steering effort applied to the steering gear mechanism wherein a hydraulic reaction mechanism (44) applies a reaction torque to the driver operated steering controls (82) to effect variable steering effort thus making it possible to reduce the steering effort at low vehicle speeds (e.g., while parking the vehicle) and increasing the steering effort as the vehicle speed increases, the variable effort being accomplished by reaction pistons (96, 98, 100, 102) that are subjected to steering pressure.

8. 发明申请

WO2009146166A3 BIOTIN-RECEPTOR REAGENTS FOR SENSITIVITY MODULATION IN ASSAYS 审中-公开
标题翻译：用于测定灵敏度调节的生物受体试剂
公开(公告)号：WO2009146166A3
公开(公告)日：2010-02-25
申请号：PCT/US2009040465
申请日：2009-04-14
申请人： SIEMENS HEALTHCARE DIAGNOSTICS , LEWISCH SANDRA A , SINGH PRATAP , DESAI VIRAL , KRAKOWSKI KAREN L , DUFFY JAMES E
发明人： LEWISCH SANDRA A , SINGH PRATAP , DESAI VIRAL , KRAKOWSKI KAREN L , DUFFY JAMES E
IPC分类号： G01N33/53
CPC分类号： G01N33/532 , G01N33/54393 , G01N33/566
摘要： Methods are disclosed for designing antibody reagents for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophilicity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody. The method may comprise preparing two or more conjugates by selecting a set of parameters for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要翻译：公开了用于设计用于检测分析物以测定最佳测定灵敏度和/或动态范围的测定中的抗体试剂的方法。抗体试剂是通过间隔基团与分析物的抗体连接的小分子的缀合物。该方法包括在共轭物的制备中控制包括间隔基团的疏水性或亲水性，间隔基团的长度，与抗体连接的小分子的分子数目和小分子到抗体。该方法可以包括通过为每个缀合物选择一组参数来制备两种或更多种缀合物，使用每种缀合物进行分析物的测定，并选择用于测定提供最佳测定灵敏度和/或动态范围的缀合物。

9. 发明申请

WO2009146166A2 BIOTIN-RECEPTOR REAGENTS FOR SENSITIVITY MODULATION IN ASSAYS 审中-公开
标题翻译：用于测定灵敏度调节的生物受体试剂
公开(公告)号：WO2009146166A2
公开(公告)日：2009-12-03
申请号：PCT/US2009/040465
申请日：2009-04-14
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , LEWISCH, Sandra, A. , SINGH, Pratap , DESAI, Viral , KRAKOWSKI, Karen, L. , DUFFY, James, E.
发明人： LEWISCH, Sandra, A. , SINGH, Pratap , DESAI, Viral , KRAKOWSKI, Karen, L. , DUFFY, James, E.
IPC分类号： G01N33/536 , G01N33/566
CPC分类号： G01N33/532 , G01N33/54393 , G01N33/566
摘要： Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophiHcity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody to obtain an optimum assay sensitivity and/or dynamic range. In some embodiments the method comprises preparing two or more conjugates by selecting a set of parameters for each conjugate wherein the set of parameters is different for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要翻译：公开了设计用于分析物检测以获得最佳测定灵敏度和/或动态范围的测定中的抗体试剂的方法。抗体试剂是通过间隔基团与分析物的抗体连接的小分子的缀合物。该方法包括在共轭物的制备中控制包含间隔基团的疏水性或亲水性，间隔基团的长度，与抗体连接的小分子的分子数目和小分子到抗体以获得最佳测定灵敏度和/或动态范围。在一些实施方案中，该方法包括通过为每个缀合物选择一组参数来制备两种或更多种缀合物，其中该组参数对于每个缀合物是不同的，使用每个缀合物进行分析物的测定，并选择用于测定缀合物提供最佳测定灵敏度和/或动态范围。

10. 发明申请

WO2009100236A1 RETRACTABLE EARPLUG ASSEMBLY FOR A HARDHAT 审中-公开
标题翻译： HARDHAT可回收耳机组件
公开(公告)号：WO2009100236A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033242
申请日：2009-02-05
申请人： STREAMWORKS, INC , BRAUNER, Bill E. , DUFFY, James E. , CLAUSEN, Eivind
发明人： BRAUNER, Bill E. , DUFFY, James E. , CLAUSEN, Eivind
IPC分类号： A42B3/16
CPC分类号： A42B3/166 , A61F11/12
摘要： A retractable earplug assembly is provided that is configured to retrofit to a hardhat that includes a protective housing removably mountable to the hardhat. The earplug assembly further includes a guide base slideably cooperating with a guide portion of the housing for movement thereof along a fixed path. The earplug assembly includes an elongated flexible tether having a distal portion thereof mounted to an earplug device, and a proximal portion thereof mounted to the guide base. When the guide base is selectively moved along the fixed path, the tether and the earplug device move between a retracted condition and an extended condition, enabling usable access to the earplug device.
摘要翻译：提供可伸缩耳塞组件，其被配置成改装为包括可移除地安装到硬帽的保护壳体的硬帽。耳塞组件还包括可滑动地与壳体的引导部分配合的引导基座，用于沿固定路径移动。耳塞组件包括细长的柔性系绳，其具有其远端部分安装到耳塞装置，并且其近端部分安装到导向基座。当导向台选择性地沿着固定路径移动时，系绳和耳塞装置在缩回状态和延伸状态之间移动，使得能够接近耳塞装置。

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